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[Sexually transmitted infection as a cause of anal cancer]

https://arctichealth.org/en/permalink/ahliterature21335
Source
Ugeskr Laeger. 1998 Nov 30;160(49):7109-17
Publication Type
Article
Date
Nov-30-1998
Author
M. Frisch
B. Glimelius
A I van den Brule
J. Wohlfahrt
C J Meijer
J M Walboomers
S. Goldman
C. Svensson
H O Adami
M. Melbye
Author Affiliation
Afdeling for epidemiologisk forskning, Statens Serum Institut, København. mfr@ssi.dk
Source
Ugeskr Laeger. 1998 Nov 30;160(49):7109-17
Date
Nov-30-1998
Language
Danish
Publication Type
Article
Keywords
Adenocarcinoma - etiology - virology
Adult
Aged
Anus Neoplasms - etiology - virology
Case-Control Studies
Denmark
English Abstract
Female
Homosexuality, Male
Humans
Male
Middle Aged
Papillomavirus, Human - genetics - isolation & purification
Papovaviridae Infections - complications - transmission
Polymerase Chain Reaction
Questionnaires
Rectal Neoplasms - etiology - virology
Regression Analysis
Research Support, Non-U.S. Gov't
Sexuality
Sexually Transmitted Diseases, Viral - complications
Abstract
Interviews were carried out with 423 women and 93 men with invasive or in situ anal cancer in Denmark and Sweden in a search for clues to the aetiology of this neoplasm. Patients with rectal adenocarcinoma (n = 534) and persons drawn from the background population (n = 554) served as controls. Multivariate logistic regression analyses confirmed previous observations of a strong association between either male homosexual experience or a history of anogenital warts and the risk for anal cancer. Moreover, hitherto unknown, but strong and consistent associations were observed between measures of high heterosexual activity and the risk for anal cancer among both sexes. Polymerase chain reaction analysis revealed human papilloma-virus DNA in the majority (88%) of anal cancer specimens but in none of 20 examined rectal adenocarcinomas. It is concluded that most anal cancers appear to be caused by sexually transmitted types of human papillomaviruses and, consequently, that anal cancer is a potentially preventable neoplasm.
PubMed ID
9850615 View in PubMed
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