Skip header and navigation

Refine By

1 records – page 1 of 1.

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease.

https://arctichealth.org/en/permalink/ahliterature205869
Source
Neuroepidemiology. 1998;17(1):14-20
Publication Type
Article
Date
1998
Author
I L Notkola
R. Sulkava
J. Pekkanen
T. Erkinjuntti
C. Ehnholm
P. Kivinen
J. Tuomilehto
A. Nissinen
Author Affiliation
Department of Public Health and General Practice, University of Kuopio, Finland. notkola@uku.fi
Source
Neuroepidemiology. 1998;17(1):14-20
Date
1998
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Alzheimer Disease - blood - epidemiology - genetics
Apolipoprotein E4
Apolipoproteins E - blood
Cholesterol - blood
Female
Finland - epidemiology
Genotype
Humans
Longitudinal Studies
Male
Middle Aged
Psychiatric Status Rating Scales
Regression Analysis
Risk factors
Abstract
The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the possible role of serum total cholesterol in the pathogenesis of AD in a population-based sample of 444 men, aged 70-89 years, who were survivors of the Finnish cohorts of the Seven Countries Study. Previous high serum cholesterol level (mean level > or = 6.5 mmol/l) was a significant predictor of the prevalence of AD (odds ratio = 3.1; 95% confidence interval = 1.2, 8.5) after controlling for age and the presence of apoE epsilon 4 allele. In men who subsequently developed AD the cholesterol level decreased before the clinical manifestations of AD. We conclude that high serum total cholesterol may be an independent risk factor for AD and some of the effect of the apoE epsilon 4 allele on risk of AD might be mediated through high serum cholesterol.
PubMed ID
9549720 View in PubMed
Less detail