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178 records – page 1 of 18.

Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers.

https://arctichealth.org/en/permalink/ahliterature78655
Source
Clin Hemorheol Microcirc. 2007;36(2):163-71
Publication Type
Article
Date
2007
Author
Rossi M.
Carpi A.
Di Maria C.
Galetta F.
Santoro G.
Author Affiliation
Department of Internal Medicine, University of Pisa, Italy. mrossi@int.med.unipi.it
Source
Clin Hemorheol Microcirc. 2007;36(2):163-71
Date
2007
Language
English
Publication Type
Article
Keywords
Adult
Blood Flow Velocity - drug effects - physiology
Female
Forearm - blood supply
Hemorheology - drug effects
Humans
Ischemia - physiopathology
Laser-Doppler Flowmetry
Male
Matched-Pair Analysis
Microcirculation - drug effects
Middle Aged
Regional Blood Flow
Skin - blood supply
Smoking - adverse effects
Abstract
The aim of the study was to investigate whether chronic cigarette smoke habit is associated with changes of laser Doppler (LD) skin blood flowmotion (SBF). We performed spectral analysis of skin forearm LD signal detected by a LD flowmetry (Periflux PF4, Perimed, Sweden) before and during forearm post-ischemic hyperaemia, in 14 healthy chronic smoker subjects and 14 age and sex matched nonsmoker subjects. Forearm skin ischemia was obtained by a pneumatic cuff, positioned at the right arm and inflated for 3 minutes to 30 mmHg above systolic blood pressure. Power spectral density (PSD) of the SBF total spectrum (0.009-1.6 Hz), as well as 0.009-0.02 Hz , 0.02-0.06 Hz, 0.06-0.2 Hz, 0.2-0.6 Hz and 0.6-1.6 Hz frequency intervals (FI), referred to endothelial, sympathetic, myogenic, respiratory and heart activity, respectively, were measured in LD conventional perfusion units (PU)/Hz. Smokers showed a basal SBF total spectrum PSD mean values not significantly different from nonsmokers (2.14+/-1.58 PU/Hz and 1.93+/-1.35 PU/Hz, respectively). Following ischemia, PSD mean value of SBF total spectrum, as well of five FI considered, significantly increased in nonsmokers (p
PubMed ID
17325440 View in PubMed
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Abstracts from the 14th Congress of the Scandinavian Society of Anaesthesiologists. Uppsala, Sweden, June 28-July 2, 1977.

https://arctichealth.org/en/permalink/ahliterature250477
Source
Ups J Med Sci Suppl. 1977;25:1-170
Publication Type
Conference/Meeting Material
Date
1977

Acute antioxidant supplementation and skeletal muscle vascular conductance in aged rats: role of exercise and fiber type.

https://arctichealth.org/en/permalink/ahliterature101895
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Publication Type
Article
Date
Apr-2011
Author
Daniel M Hirai
Steven W Copp
Peter J Schwagerl
Mark D Haub
David C Poole
Timothy I Musch
Author Affiliation
Department of Anatomy and Physiology, Kansas State University, Manhattan, 66506-5802, USA.
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Date
Apr-2011
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - pharmacology
Blood Pressure - drug effects - physiology
Cyclic N-Oxides - pharmacology
Dietary Supplements
Hindlimb - drug effects - physiology
Male
Muscle Fibers, Skeletal - drug effects - physiology
Muscle, Skeletal - blood supply - drug effects - physiology
Physical Conditioning, Animal - physiology
Rats
Rats, Inbred F344
Regional Blood Flow - drug effects - physiology
Rest - physiology
Spin Labels
Vascular Resistance - drug effects - physiology
Vasodilation - drug effects - physiology
Abstract
Age-related increases in oxidative stress contribute to impaired skeletal muscle vascular control. However, recent evidence indicates that antioxidant treatment with tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) attenuates flow-mediated vasodilation in isolated arterioles from the highly oxidative soleus muscle of aged rats. Whether antioxidant treatment with tempol evokes similar responses in vivo at rest and during exercise in senescent individuals and whether this effect varies based on muscle fiber type composition are unknown. We tested the hypothesis that redox modulation via acute systemic tempol administration decreases vascular conductance (VC) primarily in oxidative hindlimb locomotor muscles at rest and during submaximal whole body exercise (treadmill running at 20 m/min, 5% grade) in aged rats. Eighteen old (25-26 mo) male Fischer 344 x Brown Norway rats were assigned to either rest (n = 8) or exercise (n = 10) groups. Regional VC was determined via radiolabeled microspheres before and after intra-arterial administration of tempol (302 µmol/kg). Tempol decreased mean arterial pressure significantly by 9% at rest and 16% during exercise. At rest, similar VC in 26 out of 28 individual hindlimb muscles or muscle parts following tempol administration compared with control resulted in unchanged total hindlimb muscle VC (control: 0.18 ± 0.02; tempol: 0.17 ± 0.05 ml·min(-1)·100 g(-1)·mmHg(-1); P > 0.05). During exercise, all individual hindlimb muscles or muscle parts irrespective of fiber type composition exhibited either an increase or no change in VC with tempol (i.e., ?11 and ?17 muscles or muscle parts), such that total hindlimb VC increased by 25% (control: 0.93 ± 0.04; tempol: 1.15 ± 0.09 ml·min(-1)·100 g(-1)·mmHg(-1); P = 0.05). These results demonstrate that acute systemic administration of the antioxidant tempol significantly impacts the control of regional vascular tone in vivo presumably via redox modulation and improves skeletal muscle vasodilation independently of fiber type composition during submaximal whole body exercise in aged rats.
PubMed ID
21239634 View in PubMed
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Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature140840
Source
Ann Med. 2010 Dec;42(8):603-11
Publication Type
Article
Date
Dec-2010
Author
Liisa A Saarikoski
Risto K Huupponen
Jorma S A Viikari
Jukka Marniemi
Markus Juonala
Mika Kähönen
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Ann Med. 2010 Dec;42(8):603-11
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adiponectin - blood
Adult
Atherosclerosis - epidemiology - pathology - physiopathology
Biological Markers - blood
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - physiopathology - ultrasonography
Elasticity Imaging Techniques
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Regional Blood Flow
Regression Analysis
Risk factors
Tunica Intima - pathology - ultrasonography
Young Adult
Abstract
Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.
We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P
PubMed ID
20839916 View in PubMed
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Altered regional blood flow responses to submaximal exercise in older rats.

https://arctichealth.org/en/permalink/ahliterature49729
Source
J Appl Physiol. 2004 Jan;96(1):81-8
Publication Type
Article
Date
Jan-2004
Author
Timothy I Musch
Kevin E Eklund
K Sue Hageman
David C Poole
Author Affiliation
Department of Kinesiology, Kansas State University, Manhattan, KS 66506-5602, USA. musch@vet.ksu.edu
Source
J Appl Physiol. 2004 Jan;96(1):81-8
Date
Jan-2004
Language
English
Publication Type
Article
Keywords
Aging - physiology
Animals
Blood pressure
Exertion - physiology
Heart rate
Hindlimb
Microspheres
Muscle, Skeletal - blood supply - physiology
Rats
Rats, Inbred BN
Rats, Inbred F344
Regional Blood Flow - physiology
Renal Circulation - physiology
Research Support, U.S. Gov't, P.H.S.
Rest - physiology
Abstract
Maximal aerobic capacity and the ability to sustain submaximal exercise (Ex) declines with advancing age. Whether altered muscle blood flow (BF) plays a mechanistic role in these effects remains to be resolved. The present investigation determined the effects of aging on the hemodynamic and regional BF response to submaximal Ex in rats. Heart rate (HR), mean arterial pressure (MAP), and BF to different organs (kidneys, splanchnic organs, and 28 hindlimb muscles) were determined at rest and during submaximal treadmill Ex (20 m/min, 5% grade) with radiolabeled microspheres in young (Y; 6-8 mo old, 339 +/- 8 g, n = 9) and old (O; 27-29 mo old, 504 +/- 18 g, n = 7) Fischer 344 x Brown Norway rats. Results demonstrated that HR, MAP, and BF to the pancreas, small and large intestine, and total hindlimb musculature were similar between Y and O rats at rest. BF to the kidneys, spleen, and stomach were 33, 60, and 43% lower, respectively, in O compared with Y rats. BF to the total hindlimb musculature increased (P
PubMed ID
12959955 View in PubMed
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Angiosome-targeted infrapopliteal endovascular revascularization for treatment of diabetic foot ulcers.

https://arctichealth.org/en/permalink/ahliterature118329
Source
J Vasc Surg. 2013 Feb;57(2):427-35
Publication Type
Article
Date
Feb-2013
Author
Maria Söderström
Anders Albäck
Fausto Biancari
Kimmo Lappalainen
Mauri Lepäntalo
Maarit Venermo
Author Affiliation
Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. maria.soderstrom@hus.fi
Source
J Vasc Surg. 2013 Feb;57(2):427-35
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Amputation
Angioplasty, Balloon - adverse effects - mortality
Anti-Infective Agents - therapeutic use
Chi-Square Distribution
Debridement
Diabetic Foot - mortality - physiopathology - radiography - therapy
Female
Finland
Humans
Kaplan-Meier Estimate
Limb Salvage
Logistic Models
Male
Middle Aged
Multivariate Analysis
Negative-Pressure Wound Therapy
Peripheral Arterial Disease - mortality - physiopathology - radiography - therapy
Popliteal Artery - physiopathology - radiography
Propensity Score
Proportional Hazards Models
Regional Blood Flow
Registries
Retrospective Studies
Severity of Illness Index
Skin Transplantation
Surgical Flaps
Time Factors
Treatment Outcome
Wound Healing
Abstract
Because of the prolonged healing time of diabetic foot ulcers, methods for identifying ways to expedite the ulcer healing process are needed. The angiosome concept delineates the body into three-dimensional blocks of tissue fed by specific source arteries. The aim of this study was to evaluate the benefit of infrapopliteal endovascular revascularization guided by an angiosome model of perfusion in the healing process of diabetic foot ulcers.
A total of 250 consecutive legs with diabetic foot ulcers in 226 patients who had undergone infrapopliteal endovascular revascularization in a single center were evaluated. Patient records and periprocedural leg angiograms were reviewed. The legs were divided into two groups depending on whether direct arterial flow to the site of the foot ulcer based on the angiosome concept was achieved (direct group) or not achieved (indirect group). Ulcer healing time was compared between the two groups. A propensity score was used for adjustment of differences in pretreatment covariables in multivariate analysis and for 1:1 matching.
Direct flow to the angiosome feeding the ulcer area was achieved in 121 legs (48%) compared with indirect revascularization in 129 legs. Foot ulcers treated with angiosome-targeted infrapopliteal percutaneous transluminal angioplasty healed better. The ulcer healing rate was mean (standard deviation) 72% (5%) at 12 months for the direct group compared with 45% (6%) for the indirect group (P
PubMed ID
23219512 View in PubMed
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[Antegrade diastolic blood flow and classic reflux in varicose dilatation of the intersaphenous vein].

https://arctichealth.org/en/permalink/ahliterature275525
Source
Angiol Sosud Khir. 2016;22(2):101-8
Publication Type
Article
Date
2016
Author
E V Shaidakov
D A Rosukhovsky
A G Grigoryan
V L Bulatov
E A Ilyukhin
Source
Angiol Sosud Khir. 2016;22(2):101-8
Date
2016
Language
Russian
Publication Type
Article
Keywords
Adult
Diastole
Dilatation, Pathologic - diagnosis - epidemiology - etiology - physiopathology
Female
Hemodynamics
Humans
Leg - blood supply
Male
Prevalence
Regional Blood Flow
Russia
Saphenous Vein - physiopathology - ultrasonography
Severity of Illness Index
Ultrasonography, Doppler, Duplex - methods
Varicose Veins - complications - diagnosis - physiopathology
Venous Insufficiency - diagnosis - epidemiology - etiology - physiopathology
Abstract
In the intersaphenous vein (ISV) there may take place the so-called "antegrade" or "paradoxical" reflux. This type of blood flow is revealed in a series of patients during muscular diastole and is a link of the pathogenesis of varicose disease, but has, as distinct from the "classical" reflux, an antegrade direction. An incompetent saphenopopliteal junction (SPJ) is a source of the antegrade diastolic blood flow (ADBF) through the ISV. Descriptions of possible variants of impaired blood flow through the ISV are fragmentary and their interpretations are controversial. Prevalence and pathogenesis of these disorders impairments have not yet been studied.
A cross-sectional study: over 4 years three centres examined a total of 1,413 patients diagnosed with class C2-C6 varicose veins according the CEAP classification. All patients underwent ultrasound duplex scanning of lower limb veins. The ADBF was determined as a unidirectional antegrade blood flow with the duration of not more than 0.5 second, observed after the crus was relived of compression (in the diastole). Of the patients included into the study who had no varicose veins on the contralateral extremity with the ISV being spotted we sequentially selected 40 subjects including them into the Study Group for the analysis of blood flow and the diameter of the ISV in health.
Impairments of blood flow in the ISV were revealed in 61 (4.8%) of 1,265 extremities included into the study: the "classical" reflux in 9 (14.8%) limbs, ADBF was revealed in 37 (60.7%) limbs, a combination of the "classical" blood flow and ADBF - in 15 (24.6%) limbs. Hence, the patients were subdivided into three groups. Studying the nature of blood flow through the ISV in the control group on 40 lower limbs revealed no blood flow disorders. The mean ISV diameter amounted to 1.68 mm (ME=1 mm). The ISV diameter was considerably higher in all studied groups as compared with the control one (p
PubMed ID
27336341 View in PubMed
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Arterial compliance influences the measurement of flow-mediated vasodilation, but not acetylcholine-mediated forearm blood flow. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

https://arctichealth.org/en/permalink/ahliterature82655
Source
Atherosclerosis. 2007 Jan;190(1):212-5
Publication Type
Article
Date
Jan-2007
Author
Lind Lars
Author Affiliation
Department of Medicine, Uppsala University Hospital and AstraZeneca R&D Mölndal, 751 85 Uppsala, Sweden. lars.lind@medsci.uu.se
Source
Atherosclerosis. 2007 Jan;190(1):212-5
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Acetylcholine - administration & dosage
Aged
Aging - physiology
Carotid Arteries - physiology
Compliance
Coronary Arteriosclerosis - epidemiology - physiopathology
Endothelium, Vascular - physiology
Forearm - blood supply
Humans
Prospective Studies
Regional Blood Flow - drug effects - physiology
Risk factors
Sweden - epidemiology
Sympathomimetics - administration & dosage
Terbutaline - administration & dosage
Vascular Resistance
Vasodilation - drug effects - physiology
Vasodilator Agents - administration & dosage
Abstract
OBJECTIVES: Flow-mediated vasodilation (FMD) is low even in healthy elderly and therefore relations between FMD and cardiovascular risk factors might be hard to evaluate in the elderly. Using data from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we investigated if a reduced arterial distensibility could influence FMD measurements. METHODS: In the population-based PIVUS study (1016 subjects aged 70), assessments of arterial distensibility by ultrasound in the carotid artery (CCA) and FMD were performed. Endothelium-dependent vasodilation was also evaluated with the invasive forearm technique with acetylcholine (EDV) and by pulse wave analysis following terbutaline injection. A poor CCA distensibility was defined as
PubMed ID
16530773 View in PubMed
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Arterial structure and function after recovery from the metabolic syndrome: the cardiovascular risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature146140
Source
Circulation. 2010 Jan 26;121(3):392-400
Publication Type
Article
Date
Jan-26-2010
Author
Juha Koskinen
Costan G Magnussen
Leena Taittonen
Leena Räsänen
Vera Mikkilä
Tomi Laitinen
Tapani Rönnemaa
Mika Kähönen
Jorma S A Viikari
Olli T Raitakari
Markus Juonala
Author Affiliation
Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Finland. jkkosk@utu.fi
Source
Circulation. 2010 Jan 26;121(3):392-400
Date
Jan-26-2010
Language
English
Publication Type
Article
Keywords
Adult
Brachial Artery - physiology
Carotid Arteries - physiology - ultrasonography
Carotid Artery Diseases - epidemiology - prevention & control - ultrasonography
Female
Finland - epidemiology
Follow-Up Studies
Humans
Life Style
Male
Metabolic Syndrome X - epidemiology - therapy
Regional Blood Flow - physiology
Remission, Spontaneous
Risk factors
Risk Reduction Behavior
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Abstract
The reversibility of ultrasonographic vascular changes associated with the metabolic syndrome (MetS) recovery is unknown. We examined whether spontaneous recovery from MetS (according to the International Diabetes Federation definition) has a favorable effect on vascular properties and evaluated the associations between lifestyle factors and MetS recovery.
We measured carotid artery intima-media thickness, distensibility, and brachial flow-mediated dilatation by ultrasound in 1673 subjects of the Young Finns Study cohort (age, 31.5+/-5.0 years in 2001) who participated in follow-up studies in 2001 and 2007. At baseline, no differences in intima-media thickness, carotid artery distensibility, or flow-mediated dilatation were observed between the recovery group (baseline-only MetS) and those with incident (only at follow-up) or persistent (both at baseline and follow-up) MetS. After 6 years, the recovery group had smaller intima-media thickness (mean+/-SEM, 0.62+/-0.01 versus 0.68+/-0.01 mm; P=0.0009) and higher carotid artery distensibility (1.98+/-0.07%/mm Hg versus 1.56+/-0.04%/mm Hg; P=0.001) compared with the persistent group and higher flow-mediated dilatation compared with the control group (9.91+/-0.51% versus 8.57+/-0.12%; P=0.03). The recovery group had reduced intima-media thickness progression compared with the persistent group (0.036+/-0.005 versus 0.079+/-0.010 mm; P=0.001) and reduced carotid artery distensibility change compared with the incident group (-0.12+/-0.05%/mm Hg versus -0.38+/-0.10%/mm Hg; P=0.03) over the 6-year follow-up. Differences in carotid artery distensibility levels were attenuated (P=0.11) after the inclusion of weight change in the models. MetS recovery was paralleled with significant reductions in waist circumference that independently correlated with increased physical activity and increased attention paid to health habits during the follow-up.
Recovery from the MetS was associated with positive effects on vascular properties during a 6-year follow-up period of young adults.
PubMed ID
20065161 View in PubMed
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Assessment of cerebral autoregulation: the quandary of quantification.

https://arctichealth.org/en/permalink/ahliterature122399
Source
Am J Physiol Heart Circ Physiol. 2012 Sep 15;303(6):H658-71
Publication Type
Article
Date
Sep-15-2012
Author
Y C Tzeng
P N Ainslie
W H Cooke
K C Peebles
C K Willie
B A MacRae
J D Smirl
H M Horsman
C A Rickards
Author Affiliation
Cardiovascular Systems Laboratory, University of Otago, Wellington South, New Zealand. shieak.tzeng@otago.ac.nz
Source
Am J Physiol Heart Circ Physiol. 2012 Sep 15;303(6):H658-71
Date
Sep-15-2012
Language
English
Publication Type
Article
Keywords
Adult
Blood Flow Velocity
Blood pressure
British Columbia
Cerebrovascular Circulation
Exercise
Female
Fourier Analysis
Heart rate
Homeostasis
Humans
Hypercapnia - physiopathology
Hypocapnia - physiopathology
Linear Models
Male
Middle Cerebral Artery - physiopathology - ultrasonography
Models, Cardiovascular
New Zealand
Observer Variation
Prospective Studies
Regional Blood Flow
Reproducibility of Results
Respiration
Retrospective Studies
Supine Position
Texas
Tourniquets
Ultrasonography, Doppler, Pulsed
Ultrasonography, Doppler, Transcranial
Young Adult
Abstract
We assessed the convergent validity of commonly applied metrics of cerebral autoregulation (CA) to determine the extent to which the metrics can be used interchangeably. To examine between-subject relationships among low-frequency (LF; 0.07-0.2 Hz) and very-low-frequency (VLF; 0.02-0.07 Hz) transfer function coherence, phase, gain, and normalized gain, we performed retrospective transfer function analysis on spontaneous blood pressure and middle cerebral artery blood velocity recordings from 105 individuals. We characterized the relationships (n = 29) among spontaneous transfer function metrics and the rate of regulation index and autoregulatory index derived from bilateral thigh-cuff deflation tests. In addition, we analyzed data from subjects (n = 29) who underwent a repeated squat-to-stand protocol to determine the relationships between transfer function metrics during forced blood pressure fluctuations. Finally, data from subjects (n = 16) who underwent step changes in end-tidal P(CO2) (P(ET)(CO2) were analyzed to determine whether transfer function metrics could reliably track the modulation of CA within individuals. CA metrics were generally unrelated or showed only weak to moderate correlations. Changes in P(ET)(CO2) were positively related to coherence [LF: ß = 0.0065 arbitrary units (AU)/mmHg and VLF: ß = 0.011 AU/mmHg, both P
PubMed ID
22821992 View in PubMed
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178 records – page 1 of 18.