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Melanocortin-4 receptor gene and physical activity in the Québec Family Study.

https://arctichealth.org/en/permalink/ahliterature176997
Source
Int J Obes (Lond). 2005 Apr;29(4):420-8
Publication Type
Article
Date
Apr-2005
Author
R J F Loos
T. Rankinen
A. Tremblay
L. Pérusse
Y. Chagnon
C. Bouchard
Author Affiliation
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Source
Int J Obes (Lond). 2005 Apr;29(4):420-8
Date
Apr-2005
Language
English
Publication Type
Article
Keywords
Chi-Square Distribution
Exercise - physiology
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Quebec
Receptor, Melanocortin, Type 4 - genetics
Abstract
Physical inactivity is a risk factor for numerous chronic diseases. Low compliance with interventions to increase activity suggests involvement of biological systems.
To examine whether sequence variants in genes encoding neuropeptides and receptors in the arcuate and paraventricular nucleus of the hypothalamus contribute to variations in physical activity level in the Québec Family Study.
We genotyped polymorphisms in the melanocortin-4 receptor (MC4R), melanocortin-3 receptor (MC3R), neuropeptide-Y (NPY), neuropeptide-Y Y1 receptor (NPY Y1R), cocaine- and amphetamine-regulated transcript (CART), agouti-related protein (AGRP), and pro-opiomelanocortin (POMC) genes in 669 subjects (age (X+/-s.d.): parents: 52+/-3.4 y; offspring: 28+/-8.7 y). Total physical activity, moderate-to-strenuous activity, and inactivity phenotypes were estimated from a three-day record. The past year's physical activity level was assessed from a questionnaire. Associations between the physical activity phenotypes and the polymorphisms were analyzed using the MIXED model (SAS).
The MC4R-C-2745T variant showed significant associations with physical activity phenotypes. The lowest moderate-to-strenuous activity scores (P = 0.005) and the highest inactivity scores (P = 0.01) emerged in the T/T genotype. Exclusion of obese subjects increased the association. For inactivity, the association of the MC4R-C-2745T variant was strongest in the offspring (P = 0.002). The T/T offspring had both the highest inactivity score and the lowest body mass index. The CART-A1475G variant modified the associations with MC4R-C-2745T; T/T homozygotes had the lowest activity scores when they also had the A/A CART-A1475G genotype. No significant associations were observed with polymorphisms in the other neuropeptides.
These findings suggest that DNA sequence variation at the MC4R gene locus may contribute to the propensity to be sedentary.
PubMed ID
15597110 View in PubMed
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MC4R marker associated with stature in children and young adults: a longitudinal study.

https://arctichealth.org/en/permalink/ahliterature172027
Source
J Pediatr Endocrinol Metab. 2005 Sep;18(9):859-63
Publication Type
Article
Date
Sep-2005
Author
Nicola Santoro
Tuomo Rankinen
Louis Pérusse
Ruth J F Loos
Claude Bouchard
Author Affiliation
Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808-4124, USA.
Source
J Pediatr Endocrinol Metab. 2005 Sep;18(9):859-63
Date
Sep-2005
Language
English
Publication Type
Article
Keywords
Adolescent
Alleles
Body Height - genetics
Child
Female
Genetic Variation
Genotype
Heterozygote
Homozygote
Humans
Longitudinal Studies
Male
Polymorphism, Genetic
Quebec
Receptor, Melanocortin, Type 4 - genetics
Abstract
We investigated the associations between a polymorphism in the melanocortin 4 receptor (MC4R) gene and changes in body size and composition from childhood to adulthood in the Québec Family Study. Ninety-one subjects (43 males) less than 18 years of age (mean age 13.5 +/- 2.4 years; range 8.4-17.8 years) at baseline were re-measured 11.2 years later on average. The anthropometric variables analyzed were height, weight, body mass index, percent body fat, sum of skinfolds, fat mass index, and fat free mass index (FFMI). All variables were adjusted for age and sex. The subjects were genotyped for the MC4R C-2745T polymorphism. Forty-five subjects were homozygotes for the common allele (C/C), 36 were heterozygotes (C/T) and 10 were homozygotes for the rare allele (T/T). The rare allele was associated with increased height at baseline as well as at the follow-up visit. Although FFMI tended to increase more in subjects carrying the rare allele, no significant differences were found for the changes over time for the other phenotypes. These results suggest that DNA sequence variation in the MC4R locus may contribute to the gain in body height from childhood to adulthood.
PubMed ID
16279363 View in PubMed
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Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults.

https://arctichealth.org/en/permalink/ahliterature181643
Source
J Clin Endocrinol Metab. 2004 Feb;89(2):940-5
Publication Type
Article
Date
Feb-2004
Author
Kaisa Valli-Jaakola
Marita Lipsanen-Nyman
Laura Oksanen
Anthony N Hollenberg
Kimmo Kontula
Christian Bjørbaek
Camilla Schalin-Jäntti
Author Affiliation
Department of Medicine and Research Program in Molecular Medicine, University of Helsinki, FIN-00290 Helsinki, Finland.
Source
J Clin Endocrinol Metab. 2004 Feb;89(2):940-5
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cell Line
Child
Cohort Studies
Female
Finland
Heterozygote
Humans
Male
Middle Aged
Mutation
Obesity, Morbid - genetics - physiopathology
Pedigree
Phenotype
Polymorphism, Genetic
Receptor, Melanocortin, Type 4 - genetics - metabolism
Signal Transduction
Tissue Distribution
Abstract
Two Finnish cohorts, comprising 56 children with severe early-onset obesity (relative weight for height greater than or equal to +70% before age 10) and 252 morbidly obese adults (body mass index, > or = 40 kg/m(2)), were screened for melanocortin-4 receptor (MC4R) mutations. We identified a pathogenic mutation (S127L) in one child, causing severe early-onset obesity. We describe the phenotype of this particular mutation for the first time. We also identified a novel (I226T) polymorphism in the coding and two new variations (-439delGC and 1059C>T) outside the coding region of the MC4R gene. Three previously described polymorphisms (V103I, T112M, and I125L) were identified. In vitro functional studies of variants T112M, S127L, and I226T supported a pathogenic role of the S127L mutation, because signaling properties of the receptor in response to the MC4R agonists alpha-MSH, beta-MSH, and gamma(1)-MSH were impaired. The S127L mutation did not affect receptor inhibition by the antagonist agouti-related protein. Localization of the three variant receptors was similar to that of wild type. In conclusion, a pathogenic MC4R mutation was found among subjects with severe early-onset obesity but not among morbidly obese adults. Impaired function of the S127L receptor was due to reduced activation, not a defect of protein transport to the cell membrane.
PubMed ID
14764818 View in PubMed
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Pregnancy and lactation prevent melanocortin obesity syndrome in mice with Agouti yellow mutation.

https://arctichealth.org/en/permalink/ahliterature82048
Source
Dokl Biol Sci. 2006 Mar-Apr;407:163-5
Publication Type
Article

Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study.

https://arctichealth.org/en/permalink/ahliterature112987
Source
Hepatology. 2013 Dec;58(6):2133-41
Publication Type
Article
Date
Dec-2013
Author
Stefan Stender
Børge G Nordestgaard
Anne Tybjaerg-Hansen
Author Affiliation
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Source
Hepatology. 2013 Dec;58(6):2133-41
Date
Dec-2013
Language
English
Publication Type
Article
Keywords
Aged
Alleles
Body mass index
Confounding Factors (Epidemiology)
Denmark
Female
Gallstones - genetics
Humans
Male
Membrane Proteins - genetics
Middle Aged
Obesity - complications - genetics
Odds Ratio
Proteins - genetics
Random Allocation
Receptor, Melanocortin, Type 4 - genetics
Risk factors
Abstract
Elevated body mass index (BMI) is associated with an increased risk of gallstone disease. Whether this reflects a causal association is unknown. Using a Mendelian randomization approach, we studied 77,679 individuals from the general population. Of these, 4,106 developed symptomatic gallstone disease during up to 34 years of follow-up. Subjects were genotyped for three common variants known to associate with BMI: FTO(rs9939609); MC4R(rs17782313); and TMEM18(rs6548238). The number of BMI-increasing alleles was calculated for each participant. In observational analyses, mean baseline BMI was 55% (11.6 kg/m(2) ) increased in individuals in the fifth quintile versus the first quintile, similar in women and men. The corresponding multifactorially adjusted hazard ratio (HR) for symptomatic gallstone disease was 2.84 (95% confidence interval [CI]: 2.32-3.46) overall, 3.36 (95% CI: 2.62-4.31) in women, and 1.51 (95% CI: 1.09-2.11) in men (P trend: 0.001 to
PubMed ID
23775818 View in PubMed
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[Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population].

https://arctichealth.org/en/permalink/ahliterature263708
Source
Genetika. 2015 Feb;51(2):248-55
Publication Type
Article
Date
Feb-2015
Author
O V Kochetova
G F Korytina
L Z Akhmadishina
E E Semenov
T V Viktorova
Source
Genetika. 2015 Feb;51(2):248-55
Date
Feb-2015
Language
Russian
Publication Type
Article
Keywords
Adult
Alleles
Body mass index
Body Weight
Ethnic Groups - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Middle Aged
Obesity - genetics - pathology
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Receptor, Melanocortin, Type 4 - genetics
Russia
Abstract
Obesity is a chronic relapsing disease that leads to numerous ailments and requires lifelong treatment. Genetic predisposition is one of the mostly discussed aspects of obesity development, and genome-wide association studies have provided evidence that several variants of the FTO and MC4R genes are significantly associated with obesity. In this study the association of FTO (rs9939609, rs7202116, and rs9930506) and MC4R (rs12970134 and rs17782313) genes' SNPs with obesity in Tatar women has been analyzed. In the investigation 340 women with obesity (Body Mass Index (BMI) = 30 kg/m2) and 330 women from a control group (BMI up to 24.9 kg/m2) took part. The FTO rs9939609 (p = 0.0002) and rs9930506 (p = 0.0005) SNPs were shown to be associated with obesity risk following an additive model, while the MC4R rs12970134 (p = 0.0076) and rs1778231 (p = 0.021) SNPs were associated by a recessive model. We also showed an association of quantitative parameters (age, weight, and BMI) with two the FTO rs9939609 and rs9930506 SNPs and the association of age and the MC4R rs12970134 SNP. Our study demonstrates the role of genetic variability in FTO and MC4R genes in obesity development in Tatar women from Russia.
PubMed ID
25966591 View in PubMed
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Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.

https://arctichealth.org/en/permalink/ahliterature147829
Source
Int J Obes (Lond). 2010 Jan;34(1):182-9
Publication Type
Article
Date
Jan-2010
Author
S I I Kring
C. Holst
S. Toubro
A. Astrup
T. Hansen
O. Pedersen
T I A Sørensen
Author Affiliation
Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark.
Source
Int J Obes (Lond). 2010 Jan;34(1):182-9
Date
Jan-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Body Fat Distribution
Body mass index
Cholesterol, HDL - blood - genetics
Denmark - epidemiology
Energy Metabolism - genetics
Genetic Variation - genetics
Genotype
Humans
Male
Middle Aged
Obesity - blood - epidemiology - genetics - physiopathology
Phenotype
Receptor, Melanocortin, Type 4 - genetics
Young Adult
Abstract
Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes. We examined the associations of rs17782313 and rs17700633 in relation to body fat, body fat distribution, metabolic traits, weight development and energy expenditure.
Obese young men (n = 753, BMI > or = 31.0 kg m(-2)) and a randomly selected group (n = 874) identified from a population of 174 800 men were re-examined in three surveys at mean ages 35, 46 and 49 years (S-35, S-46 and S-49). Measurements were available at upto eight times from birth to adulthood. Logistic regression analysis was used to assess odds ratio (OR) for the presence of the carrier allele for a given difference in phenotypic values.
Rs17782313 minor C-allele was associated with overall, abdominal and peripheral fatness (range of OR = 1.06-1.14 per z-score units) at all three surveys, although only consistently significant at S-35 and S-46. Rs17700633 minor A-allele was also associated with the fatness measures, but significantly so only at S-49 for overall and abdominal fatness (range of OR = 1.03-1.15 per z-score units), and peripheral fatness (OR = 1.15-1.20 per z-score units). There were only few significant associations with metabolic traits. The rs17782313 C-allele and the rs17700633 A-allele were both associated with lower high-density lipoprotein cholesterol (range of OR = 0.64-0.84 per mol l(-1)), significantly at S-46. The rs17700633 A-allele was significantly associated with insulin (OR = 1.25 per 50 pmol l(-1)), leptin (OR = 1.42 per 10 ng microl(-1)) and insulin sensitivity (OR = 0.81 per model unit). The rs17782313 C-allele and the rs17700633 A-allele were both associated with BMI in childhood and adolescence (range of OR = 1.04-1.17 per z-score units), significant for the rs17782313 C-allele at the age of 13-19 years and for rs17700633 A-allele at age 7, 10, 13 and 19 years. No significant associations were found for energy expenditure.
Near MC4R variants appear to contribute to body fat, body fat distribution, some metabolic traits, weight development during childhood, but not to energy expenditure.
PubMed ID
19844209 View in PubMed
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Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.

https://arctichealth.org/en/permalink/ahliterature90864
Source
Diabetes. 2009 Mar;58(3):757-64
Publication Type
Article
Date
Mar-2009
Author
Zobel Dorit P
Andreasen Camilla H
Grarup Niels
Eiberg Hans
Sørensen Thorkild I A
Sandbaek Annelli
Lauritzen Torsten
Borch-Johnsen Knut
Jørgensen Torben
Pedersen Oluf
Hansen Torben
Author Affiliation
Steno Diabetes Center, Gentofte, Denmark. dpaj@steno.dk
Source
Diabetes. 2009 Mar;58(3):757-64
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
C-Peptide - blood
Case-Control Studies
Cholesterol - blood
Denmark - epidemiology
Genetic Variation
Genotype
Humans
Insulin - blood
Middle Aged
Obesity - blood - epidemiology - genetics
Quantitative Trait Loci
Receptor, Melanocortin, Type 4 - genetics
Risk assessment
Triglycerides - blood
Waist-Hip Ratio
Abstract
OBJECTIVE: Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals. RESEARCH DESIGN AND METHODS: The variants were investigated for association with obesity-related quantitative traits in 5,807 population-based sampled individuals, obesity in 14,940 individuals, and type 2 diabetes in 8,821 individuals. RESULTS: The minor risk alleles of rs17782313, rs17700633, and rs12970134 were associated with BMI (effect per allele 0.25 kg/m2, P = 0.01; 0.23, P = 0.01; and 0.31, P = 7 x 10(-4), respectively), waist circumference (0.67 cm, P = 0.006; 0.53, P = 0.02; and 0.85, P = 3 x 10(-4)), and body weight (1.04 kg, P = 6 x 10(-4); 0.71, P = 0.01; and 1.16, P = 8 x 10(-5)). In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively). Similarly, the minor A-allele of rs17700633 was associated with overweight/obesity and obesity (1.12, P = 8 x 10(-5) and 1.16, P = 2 x 10(-5)), and the minor A-allele of rs12970134 was also associated with overweight/obesity and obesity (1.13, P = 2 x 10(-5) and 1.15, P = 6 x 10(-5)). rs477181, rs502933, and rs4450508 were not significantly associated with obesity in the Danish population. The frequency of the minor risk alleles of rs17782313 and rs12970134 was higher among patients with type 2 diabetes than among glucose-tolerant individuals (OR 1.08, P = 0.08 and 1.08, P = 0.06, respectively); however, these borderline associations were abolished after adjustment for BMI. CONCLUSIONS: rs17782313, rs17700633, and rs12970134 near MC4R associate with measures of obesity in Danish individuals.
PubMed ID
19073769 View in PubMed
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Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986.

https://arctichealth.org/en/permalink/ahliterature107228
Source
PLoS One. 2013;8(9):e73802
Publication Type
Article
Date
2013
Author
Anne Jääskeläinen
Ursula Schwab
Marjukka Kolehmainen
Marika Kaakinen
Markku J Savolainen
Philippe Froguel
Stéphane Cauchi
Marjo-Riitta Järvelin
Jaana Laitinen
Author Affiliation
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Source
PLoS One. 2013;8(9):e73802
Date
2013
Language
English
Publication Type
Article
Keywords
Adolescent
Alleles
Body mass index
Cohort Studies
Feeding Behavior
Female
Finland
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Meals
Obesity - genetics - physiopathology
Polymorphism, Single Nucleotide
Population Surveillance - methods
Proteins - genetics
Receptor, Melanocortin, Type 4 - genetics
Risk factors
Sex Factors
Abstract
Recent studies suggest that meal frequencies influence the risk of obesity in children and adolescents. It has also been shown that multiple genetic loci predispose to obesity already in youth. However, it is unknown whether meal frequencies could modulate the association between single nucleotide polymorphisms (SNPs) and the risk of obesity. We examined the effect of two meal patterns on weekdays -5 meals including breakfast (regular) and = 4 meals with or without breakfast (meal skipping) - on the genetic susceptibility to increased body mass index (BMI) in Finnish adolescents. Eight variants representing 8 early-life obesity-susceptibility loci, including FTO and MC4R, were genotyped in 2215 boys and 2449 girls aged 16 years from the population-based Northern Finland Birth Cohort 1986. A genetic risk score (GRS) was calculated for each individual by summing the number of BMI-increasing alleles across the 8 loci. Weight and height were measured and dietary data were collected using self-administered questionnaires. Among meal skippers, the difference in BMI between high-GRS and low-GRS (
Notes
Cites: Br J Obstet Gynaecol. 1993 Apr;100(4):310-58494831
Cites: J Am Diet Assoc. 2002 Mar;102(3 Suppl):S40-5111902388
Cites: J Adolesc Health. 1998 Jan;22(1):29-369436064
Cites: J Am Diet Assoc. 2005 May;105(5):743-60; quiz 761-215883552
Cites: Diabetes. 2007 Jan;56(1):276-8017192493
Cites: Science. 2007 May 11;316(5826):889-9417434869
Cites: Nat Genet. 2007 Jun;39(6):724-617496892
Cites: Nat Genet. 2008 Jun;40(6):768-7518454148
Cites: J Nutr. 2008 Dec;138(12):2406-1219022965
Cites: J Mol Med (Berl). 2009 May;87(5):537-4619255736
Cites: Obesity (Silver Spring). 2009 Dec;17(12):2254-719478790
Cites: Br J Nutr. 2010 Feb;103(3):352-919747414
Cites: Crit Rev Food Sci Nutr. 2010 Feb;50(2):100-520112151
Cites: Crit Rev Food Sci Nutr. 2010 Feb;50(2):113-920112153
Cites: Int J Epidemiol. 2011 Jun;40(3):740-5220813862
Cites: Curr Atheroscler Rep. 2002 May;4(3):176-8211931714
Cites: J Am Diet Assoc. 2004 May;104(5):753-6115127060
Cites: Eur J Clin Nutr. 2004 Jul;58(7):1038-4515220946
Cites: J Nutr Educ Behav. 2010 Nov-Dec;42(6):417-2120729150
Cites: Curr Opin Clin Nutr Metab Care. 2010 May;13(3):300-420075720
Cites: PLoS Med. 2011 Nov;8(11):e100111622069379
Cites: J Nutrigenet Nutrigenomics. 2011;4(4):222-3822056736
Cites: Obesity (Silver Spring). 2011 Dec;19(12):2436-921779088
Cites: J Adolesc Health. 2012 Jan;50(1):80-622188838
Cites: Br J Nutr. 2012 Feb;107(4):533-821798115
Cites: Int J Obes (Lond). 2012 Apr;36(4):479-8422158269
Cites: Am J Clin Nutr. 2012 Jun;95(6):1477-8622513296
Cites: Br J Nutr. 2012 Sep;108(5):932-822289518
Cites: PLoS One. 2012;7(11):e4991923209618
Cites: Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):1002-922901841
Cites: Prev Med. 2000 May;30(5):381-9110845747
Cites: Paediatr Perinat Epidemiol. 2001 Jan;15(1):88-9411237120
Cites: J Am Coll Nutr. 2001 Dec;20(6):599-60811771675
Cites: Physiol Behav. 1993 Apr;53(4):777-828511185
PubMed ID
24040077 View in PubMed
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ß2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.

https://arctichealth.org/en/permalink/ahliterature125626
Source
J Clin Endocrinol Metab. 2012 Jun;97(6):E1074-9
Publication Type
Article
Date
Jun-2012
Author
Mette Thomsen
Morten Dahl
Anne Tybjærg-Hansen
Børge G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Source
J Clin Endocrinol Metab. 2012 Jun;97(6):E1074-9
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Cohort Studies
Denmark - epidemiology
Diabetes Mellitus - epidemiology - genetics
Female
Genetic Predisposition to Disease - epidemiology - genetics
Genotype
Humans
Male
Membrane Proteins - genetics
Obesity - epidemiology - genetics
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Receptor, Melanocortin, Type 4 - genetics
Receptors, Adrenergic, beta-2 - genetics
Risk factors
Abstract
The ß(2)-adrenergic receptor (ADRB2) influences regulation of energy balance by stimulating catecholamine-induced lipolysis in adipose tissue. The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes.
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
We conducted a population-based cohort study in Copenhagen, Denmark.
We genotyped more than 64,000 individuals from the Danish general population.
We evaluated body mass index (BMI), obesity (BMI =30 kg/m(2)), and diabetes.
Rare allele frequencies were 0.02 for T for ADRB2rs1800888(Thr164Ile), 0.40 for A for FTOrs9939609, 0.25 for C for MC4Rrs17782313, and 0.20 for T for TMEM18rs6548238. For rare vs. common homozygotes, odds ratio for obesity was 3.32 (95% confidence interval = 1.08-10.19) for ADRB2rs1800888(Thr164Ile), 1.42 (1.35-1.52) for FTOrs9939609, 1.18 (1.06-1.30) for MC4Rrs17782313, and 1.28 (1.10-1.50) for TMEM18rs6548238 (common vs. rare). Corresponding odds ratios for diabetes were 1.85 (0.24-14.29), 1.22 (1.07-1.39), 0.96 (0.80-1.16), and 1.61 (1.17-2.22), respectively. After adjustment for BMI, only TMEM18rs6548238 remained associated with diabetes. BMI was increased in rare vs. common homozygotes in FTOrs9939609, MC4Rrs17782313, and TMEM18rs6548238 (common vs. rare) but not in ADRB2rs1800888(Thr164Ile).
Our results suggest that ADRB2rs1800888(Thr164Ile) rare vs. common homozygotes are not significantly associated with an increase in BMI measured continuously but may be associated with an increased risk of obesity. Also, TMEM18rs6548238 associated with risk of diabetes after adjustment for BMI. These findings need confirmation in other studies.
PubMed ID
22466342 View in PubMed
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18 records – page 1 of 2.