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1088 records – page 1 of 109.

5-Aminosalicylic acid enemas in treatment of distal ulcerative colitis and proctitis in Canada.

https://arctichealth.org/en/permalink/ahliterature234423
Source
Dig Dis Sci. 1987 Dec;32(12 Suppl):64S-66S
Publication Type
Article
Date
Dec-1987
Author
L R Sutherland
F. Martin
Author Affiliation
Department of Gastroenterology, University of Calgary, Canada.
Source
Dig Dis Sci. 1987 Dec;32(12 Suppl):64S-66S
Date
Dec-1987
Language
English
Publication Type
Article
Keywords
Adult
Aminosalicylic Acids - administration & dosage - therapeutic use
Canada
Clinical Trials as Topic
Colitis, Ulcerative - drug therapy
Double-Blind Method
Enema
Female
Humans
Male
Mesalamine
Proctitis - drug therapy
Random Allocation
Time Factors
Abstract
The efficacy and safety of 4 g 5-aminosalicylic acid (5-ASA) enemas were assessed in 59 patients with ulcerative colitis involving up to 50 cm of their distal colon. Twenty-nine patients received 5-ASA and 30 received a placebo. There were 12 dropouts (five in the active and seven in the placebo group) during the study because of insufficient efficacy. After six weeks of therapy, 63% of the patients receiving the 5-ASA were considered to be "much improved" by the study physician compared to 20% patients on placebo (P less than 0.0001). A disease activity index (DAI), based upon patient symptoms and sigmoidoscopic appearance, was used to assess efficacy. Mean DAI declined 75% for patients on 5-ASA enemas and 32% for patients on placebo (P less than 0.05). The 5-ASA enemas are well tolerated and are of benefit in the treatment of ulcerative colitis confined to the distal colon.
PubMed ID
3319459 View in PubMed
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A 10-year follow-up of snoring in men.

https://arctichealth.org/en/permalink/ahliterature10800
Source
Chest. 1998 Oct;114(4):1048-55
Publication Type
Article
Date
Oct-1998
Author
E. Lindberg
A. Taube
C. Janson
T. Gislason
K. Svärdsudd
G. Boman
Author Affiliation
Department of Lung Medicine and Asthma Research Centre, Uppsala University, Akademiska Sjukhuset, Sweden.
Source
Chest. 1998 Oct;114(4):1048-55
Date
Oct-1998
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Body mass index
Comparative Study
Follow-Up Studies
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Questionnaires
Random Allocation
Research Support, Non-U.S. Gov't
Risk factors
Snoring - epidemiology - etiology
Sweden - epidemiology
Weight Gain
Abstract
STUDY OBJECTIVES: Little is known about the natural development of snoring, and this survey was conducted to study the development of snoring in men over a 10-year period. DESIGN: Population-based prospective survey. SETTING: The Municipality of Uppsala, Sweden. PARTICIPANTS AND MEASUREMENTS: In 1984, 3,201 randomly selected men aged 30 to 69 years answered a questionnaire on snoring and sleep disturbances. Of the 2,975 survivors in 1994, 2,668 (89.7%) answered a new questionnaire with identical questions to those used at baseline. Questions about smoking habits, alcohol, and physical activity were also added. RESULTS: Habitual snoring was reported by 393 men (15.0%) in 1984 and by 529 (20.4%) 10 years later. In both 1984 and 1994, the prevalence of snoring increased until age 50 to 60 years and then decreased. Risk factors for being a habitual snorer at the follow-up were investigated using multiple logistic regression with adjustments for previous snoring status, age, body mass index (BMI), weight gain, smoking habits, and physical activity. In men aged 30 to 49 years at baseline, the predictors of habitual snoring at the follow-up, in addition to previous snoring status, were as follows: persistent smoking (adjusted odds ratio, 95% confidence interval) (1.4, 1.1 to 1.9), BMI 1984 (1.1, 1.02 to 1.1/kg/m2) and weight gain (1.1, 1.03 to 1.2/kg/m2). Among men aged 50 to 69 years, after adjustments for previous snoring status and age, weight gain was the only significant risk factor for developing habitual snoring (1.2, 1.05 to 1.4/kg/m2). CONCLUSIONS: In men, the prevalence of snoring increases up to the age of 50 to 60 years and is then followed by a decrease. Weight gain is a risk factor for snoring in all age groups, while smoking is mainly associated with snoring in men
PubMed ID
9792576 View in PubMed
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The Aarhus County Vagotomy Trial: trends in the problem of recurrent ulcer after parietal cell vagotomy and selective gastric vagotomy with drainage.

https://arctichealth.org/en/permalink/ahliterature243689
Source
World J Surg. 1982 Jan;6(1):86-92
Publication Type
Article
Date
Jan-1982

Absence of relationship between tuberculin reactivity and asthmatic symptoms, level of FEV1 and bronchial hyperresponsiveness in BCG vaccinated young adults.

https://arctichealth.org/en/permalink/ahliterature15399
Source
Allergy. 2002 Apr;57(4):336-40
Publication Type
Article
Date
Apr-2002
Author
H F Jentoft
E. Omenaas
G E Eide
A. Gulsvik
Author Affiliation
Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
Source
Allergy. 2002 Apr;57(4):336-40
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Asthma - drug therapy - physiopathology
BCG Vaccine - therapeutic use
Bronchial Hyperreactivity - drug therapy - physiopathology
Comparative Study
Cross-Sectional Studies
Female
Forced Expiratory Volume - physiology
Humans
Logistic Models
Male
Norway - epidemiology
Predictive value of tests
Prevalence
Questionnaires
Random Allocation
Research Support, Non-U.S. Gov't
Sex Factors
Smoking
Treatment Outcome
Tuberculin - drug effects - physiology
Abstract
BACKGROUND: Some recent studies have suggested that bacillus Calmette-Guérin (BCG) vaccination or mycobacterial infection early in life is inversely related to asthma. We wondered if an increase in tuberculin reactivity was inversely related to commonly used indices of asthma in a population of young adults who were BCG vaccinated at age 14. METHODS: Men and women aged 20-44 years, randomly selected from the general population, were tuberculin tested with the epinephrine-Pirquet method with Norwegian-produced synthetic medium tuberculin (n = 588). In addition they were interviewed using eight questions on asthma symptoms and medication. Lung function and bronchial responsiveness were also tested. RESULTS: Altogether 95% of those studied had been BCG vaccinated at age 14 (n = 558). In the 386 subjects with complete examinations, there was no relationship between a positive tuberculin reaction (> or = 4 mm) and asthma symptoms or use of asthma medication. Furthermore we did not observe any relationship between a positive tuberculin reaction and the level of forced expiratory volume (FEV1) or a positive bronchial responsiveness test, assessed as the percent of predicted of FEV1 and PD20
PubMed ID
11906365 View in PubMed
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Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations.

https://arctichealth.org/en/permalink/ahliterature63350
Source
Mol Hum Reprod. 2004 Oct;10(10):763-6
Publication Type
Article
Date
Oct-2004
Author
Min Jiang
Marja-Liisa Savontaus
Henrik Simonsen
Catherine Williamson
Roman Müllenbach
Jörg Gromoll
Nicole Terwort
Maria Alevizaki
Ilpo Huhtaniemi
Author Affiliation
Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. min.jiang@utu.fi
Source
Mol Hum Reprod. 2004 Oct;10(10):763-6
Date
Oct-2004
Language
English
Publication Type
Article
Keywords
Chorionic Gonadotropin, beta Subunit, Human - genetics
Ethnic Groups
Europe
Female
Humans
Methionine - genetics
Polymorphism, Genetic
Pregnancy
Protein Isoforms - genetics
Random Allocation
Reproducibility of Results
Research Support, Non-U.S. Gov't
Sequence Analysis, DNA
Valine - genetics
Abstract
Chorionic gonadotropin (CG) is an essential signal in establishment and maintenance of pregnancy in humans and higher primates. A G-to-A transition in exon 3 of human CGbeta gene 5, changing the naturally occurring valine residue to methionine in codon 79 (Val(79)Met) has been reported at carrier frequency 4.2% in a random population from the Midwest of the United States. The biological activity of the variant hCG was similar to that of wild-type (WT) hCG. However, the Val(79)Met beta-subunit displayed impaired ability to assemble with alpha-subunit, and the amount of hCG alpha/beta heterodimers formed and secreted by transfected cells was seriously impaired in the previous study. Because of these functional implications we found it important to study the occurrence of the Val(79)Met hCGbeta variant in other populations. By using a PCR-RFLP method, a search for the Val(79)Met hCGbeta variant was carried out on a total of 580 DNA samples from five European populations (Finland, Denmark, Greece, Germany and the UK). The results demonstrated an absence of the polymorphism in these populations. Hence, the naturally occurring variant (Val(79)Met) of the hCGbeta gene 5, found previously at high frequency in the US, is clearly less common, or absent, in the European populations studied.
PubMed ID
15299093 View in PubMed
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Acceptability of an experimental intracervical device: results of a study controlling for selection bias.

https://arctichealth.org/en/permalink/ahliterature231958
Source
Contraception. 1989 Jan;39(1):73-84
Publication Type
Article
Date
Jan-1989
Author
R N Shain
K. Ratsula
J. Toivonen
P. Lähteenmäki
T. Luukkainen
A E Holden
M. Rosenthal
Author Affiliation
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284.
Source
Contraception. 1989 Jan;39(1):73-84
Date
Jan-1989
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Clinical Trials as Topic
Consumer Satisfaction
Female
Finland
Humans
Intrauterine Devices, Copper - adverse effects
Intrauterine Devices, Medicated - adverse effects
Levonorgestrel
Norgestrel - administration & dosage - adverse effects
Patient Acceptance of Health Care
Random Allocation
Abstract
We analyzed baseline and 12-month follow-up interview data from 98 women who had volunteered to use an experimental intracervical device (ICD) and from 155 women who had been randomly assigned to two control groups, the levonorgestrel-releasing intrauterine device (LNG-IUD; N = 86) and the copper Nova-T IUD (N = 69). All participants were clinic patients in Helsinki, Finland. Initial analysis of 12-month discontinuation data indicated that a significantly higher percent of ICD users (22.4) discontinued their device than did either LNG-IUD (7.0) or Nova-T (8.7) users. However, we were no longer able to detect significant differences in discontinuation after controlling for baseline variables that assessed predisposition to be dissatisfied with contraception in general. Adjusted probabilities of discontinuing the ICD, LNG-IUD, and Nova-T were 11.8%, 6.2% and 7.9%, respectively. These data indicate that the ICD is likely to be acceptable to Helsinki clinic patients; moreover, they suggest a definite place for hormonal intrauterine devices in the contraceptive armamentarium. Most importantly, the methodology used here can be generalized to acceptability studies of other contraceptive devices and drugs undergoing Phase I and early Phase II clinical trials (in situations where randomization may not be feasible) in order to identify and control for the bias introduced by nonrandom assignment procedures.
PubMed ID
2491982 View in PubMed
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Acceptance of screening and abortion for Down syndrome among Finnish midwives and public health nurses.

https://arctichealth.org/en/permalink/ahliterature200072
Source
Prenat Diagn. 1999 Nov;19(11):1015-22
Publication Type
Article
Date
Nov-1999
Author
P. Jallinoja
P. Santalahti
H. Toiviainen
E. Hemminki
Author Affiliation
Health Services Research Unit, National Research and Development Centre for Welfare and Health, Helsinki, Finland. piia@jallinoja@helsinki.fi
Source
Prenat Diagn. 1999 Nov;19(11):1015-22
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Abortion, Induced - psychology
Adult
Attitude of Health Personnel
Down Syndrome - diagnosis
Female
Finland
Humans
Middle Aged
Nurse Midwives
Pregnancy
Prenatal Diagnosis - psychology
Public health nursing
Questionnaires
Random Allocation
Abstract
In this study we evaluated how well maternal serum screening and abortions for Down syndrome were accepted among midwives and public health nurses, and compared how those who accepted and did not accept abortions for Down syndrome differed from each other. The questionnaire was mailed in 1998 to 400 midwives and 400 public health nurses. 79 per cent responded. The majority said that all pregnant women should be offered a screening test for Down syndrome, but less than half accepted abortion for Down syndrome. Thus, the 'informative part' of the screening (serum screening itself) is supported more often than the 'operative part' (selective abortion)-or at least the 'operative part' was found to be a more difficult question. We suggest that whereas screening may be perceived as a question of more choices, information and self-determination, abortion is more clearly a moral question. The professional background characteristics and attitudes of those accepting and not accepting abortion for Down syndrome were relatively similar, but having a midwife's education, practical involvement in serum screening and having patients with Down syndrome were associated with a somewhat higher percentage of acceptance and a lower percentage of 'don't know' responses.
PubMed ID
10589051 View in PubMed
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Accuracy of clinical data in a population based vascular registry.

https://arctichealth.org/en/permalink/ahliterature182029
Source
Eur J Vasc Endovasc Surg. 2004 Feb;27(2):216-9
Publication Type
Article
Date
Feb-2004
Author
J. Laustsen
L P Jensen
A K Hansen
Author Affiliation
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby Sygehus, Denmark.
Source
Eur J Vasc Endovasc Surg. 2004 Feb;27(2):216-9
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Databases, Factual - standards
Denmark
Humans
Medical Records
Observer Variation
Peripheral Vascular Diseases - epidemiology - surgery
Prospective Studies
Random Allocation
Registries - statistics & numerical data
Reproducibility of Results
Vascular Surgical Procedures
Abstract
Clinical databases are increasingly being employed to evaluate the quality of treatments, including patients with peripheral vascular disease. Valid data is vital to the value of these analyses.
To assess the validity of clinical data in a population-based national vascular registry.
Traditional reproducibility study was supplemented by refilling of data by an independent observer, thereby creating three data sets for comparison.
Twenty prospectively recorded electronic forms from each department were selected randomly from the Danish National Vascular Registry. Data forms were refilled by the surgeons of the department concerned, and by an independent member of the board of the Danish National Vascular Registry. Refilling was performed blinded to the original forms.
A high degree of accuracy of clinical data can be achieved. An independent observer makes it possible to evaluate the classification of observer dependent parameters and explain differences in the reproducibility of data.
PubMed ID
14718906 View in PubMed
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Acetylsalicylic acid in the prevention of stroke in patients with reversible cerebral ischemic attacks. A Danish cooperative study.

https://arctichealth.org/en/permalink/ahliterature242546
Source
Stroke. 1983 Jan-Feb;14(1):15-22
Publication Type
Article
Author
P S Sorensen
H. Pedersen
J. Marquardsen
H. Petersson
A. Heltberg
N. Simonsen
O. Munck
L A Andersen
Source
Stroke. 1983 Jan-Feb;14(1):15-22
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aspirin - adverse effects - therapeutic use
Cerebrovascular Disorders - drug therapy
Clinical Trials as Topic
Denmark
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient - drug therapy
Male
Middle Aged
Patient compliance
Platelet Aggregation - drug effects
Random Allocation
Time Factors
Abstract
Two hundred and three patients, 148 males and 55 females, who during the last month before admission had experienced at least one reversible cerebral ischemic attack of less than 72 hours duration, were randomly assigned to treatment with either acetylsalicylic acid (ASA) 1000 mg daily (101 patients) or placebo (102 patients). The average follow-up period was 25 months. The two treatment groups were comparable with respect to age, sex, associated diseases, risk factors, number and duration of cerebral ischemic attacks. No statistically significant differences were found between the treatment groups as to the primary end point: stroke or death (ASA group 20.8%, placebo group 16.7%). Occurrence of transient ischemic attacks during the treatment period was not reduced by ASA treatment, whereas there was a trend suggesting fewer myocardial infarctions in the ASA group (5.9%) than in the placebo group (13.7%). The difference, however, was not statistically significant (p = 0.10). We were thus unable to demonstrate any favorable influence of ASA 1000 mg daily in patients with reversible ischemic attacks. This study does not, of course, prove that ASA treatment is ineffective in stroke prevention.
PubMed ID
6337425 View in PubMed
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The active fitting (AF) programme of hearing aids: a psychological perspective.

https://arctichealth.org/en/permalink/ahliterature8351
Source
Br J Audiol. 1990 Aug;24(4):277-85
Publication Type
Article
Date
Aug-1990
Author
M. Eriksson-Mangold
A. Ringdahl
A K Björklund
B. Wåhlin
Author Affiliation
Psychological Department, University of Göteborg, Sweden.
Source
Br J Audiol. 1990 Aug;24(4):277-85
Date
Aug-1990
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Consumer Satisfaction
Evaluation Studies
Hearing Aids - psychology
Hearing Disorders - psychology
Humans
Middle Aged
Patients - psychology
Random Allocation
Rehabilitation of Hearing Impaired
Research Support, Non-U.S. Gov't
Sweden
Abstract
Rehabilitation of the majority of hearing handicapped in Sweden consists of hearing aid fitting, provision of technical devices and information during about four visits to a Hearing Centre. Generally there is no structured guidance of the hearing handicapped on how to proceed with the hearing aid at home between appointments. A programme of active fitting (AF) of hearing aids, with a task-oriented diary, 'Try Your Hearing Aid' as a basic part, was therefore developed. We conducted a series of studies from 1985 to 1988 with the aim of investigating the benefit and applicability of the programme. A total of 128 new hearing aid candidates participated in three studies at the Sahlgrens hospital and at four other hearing centres in smaller Swedish towns. In a controlled study the AF group was more positive to their hearing aids and to the fitting period after 10 months. They used their hearing aids more frequently and felt psychologically more secure with them. It was established that the AF programme could well be applied in the clinical routine for a majority of new hearing aid patients. Old age per se was not found to be a relevant exclusion criterion. The positive outcome of the AF programme has stimulated the Swedish Institute of the Handicapped to print 'Try Your Hearing Aid' with a manual, and to introduce it to all hearing centres in Sweden.
PubMed ID
2224293 View in PubMed
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1088 records – page 1 of 109.