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Serious occurrences in the natural history of advanced climatic keratopathy.

https://arctichealth.org/en/permalink/ahliterature5395
Source
Ophthalmology. 1994 Mar;101(3):448-53
Publication Type
Article
Date
Mar-1994
Author
L D Ormerod
E. Dahan
J E Hagele
J P Guzek
Author Affiliation
Kresge Eye Institute, Department of Ophthalmology, Wayne State University, Detroit.
Source
Ophthalmology. 1994 Mar;101(3):448-53
Date
Mar-1994
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Climate
Cornea - pathology - radiation effects
Corneal Diseases - etiology - pathology
Corneal Ulcer - microbiology - pathology
Eye Infections, Bacterial - etiology - pathology
Humans
Male
Middle Aged
Occupational Diseases - etiology - pathology
Occupational Exposure - adverse effects
Radiation Injuries - etiology - pathology
Saudi Arabia
South Africa
Ultraviolet Rays - adverse effects
Abstract
BACKGROUND: Climatic or chronic actinic keratopathy is an important corneal degeneration occurring after prolonged climatic exposure. The advanced stages of disease are confined generally to tropical or arid localities (including the Arctic) with high levels of sunlight. After many years of disease evolution, the advent of stage 3 keratopathy often presages a rapid downhill course. The instability of advanced climatic keratopathy has received little attention. METHODS: Eighteen patients with advanced climatic keratopathy are described from the Transvaal region in South Africa and from Saudi Arabia. Patients with rapid disease progression, spontaneous sterile ulceration, and secondary microbial keratitis are described. RESULTS: The rapid progression characteristic of stage 3 climatic keratopathy is illustrated. Severe, focal, sterile ulceration of the devitalized corneal degeneration may be common. Secondary infection may occur, leading to rapid dissolution of the climatic keratopathy material. Corneal perforation may ensue. The occurrence of yellow or brown fragments of the climatic keratopathy within or adjacent to the corneal inflammatory infiltrate indicates the predisposing cause of the infection, as usually also with examination of the opposite eye. CONCLUSIONS: These observations emphasize the inherent instability of advanced climatic keratopathy, which frequently takes a relentless downhill course. In rural populations of the developing world, climatic keratopathy is an important cause of blindness. Disease pathogenesis, treatment, and prevention deserve greater study.
Notes
Comment In: Ophthalmology. 1994 Oct;101(10):1646-87936561
Comment In: Ophthalmology. 1994 Oct;101(10):1646; author reply 1647-87936560
PubMed ID
8127565 View in PubMed
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[The cytological characteristics of the squamous epithelium of the cervix uteri in women living under the conditions of an elevated radiation background]

https://arctichealth.org/en/permalink/ahliterature23304
Source
Klin Lab Diagn. 1995 Mar-Apr;(2):37-8
Publication Type
Article
Author
K A Agamova
Z D Gladunova
E N Sotnikova
E G Novikova
L M Aleksandrova
Source
Klin Lab Diagn. 1995 Mar-Apr;(2):37-8
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Aged
Cervix Uteri - pathology - radiation effects
English Abstract
Environmental Exposure - adverse effects
Epithelium - pathology - radiation effects
Female
Humans
Middle Aged
Power Plants
Radiation Injuries - etiology - pathology
Russia
Ukraine
Uterine Cervical Dysplasia - etiology - pathology
Vaginal Smears
Abstract
Cytomorphological signs of epithelial cells were analyzed in scraping off the cervix uteri of 607 women living in the zone of increased radiation background. The examined group consisted mainly of women aged 30 to 50. In 9.3% (57 cases) dysplastic changes in the squamous epithelium were revealed, among which slight dysplasia predominated -- basal-cell hyperactivity (40 cases). No cases of malignant transformation were detected. The authors noted some signs which commonly do not occur in the absence of an increased radiation background and may be conditionally regarded as a result of indirect effect of radiation on female cells.
PubMed ID
7620777 View in PubMed
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