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70 K type IV collagenase (gelatinase).

https://arctichealth.org/en/permalink/ahliterature24598
Source
Matrix Suppl. 1992;1:45-50
Publication Type
Article
Date
1992
Author
K. Tryggvason
P. Huhtala
M. Höyhtya
E. Hujanen
T. Hurskainen
Author Affiliation
Biocenter, University of Oulu, Finland.
Source
Matrix Suppl. 1992;1:45-50
Date
1992
Language
English
Publication Type
Article
Keywords
Amino Acid Sequence
Animals
Base Sequence
Basement Membrane - metabolism
Collagenases - chemistry - genetics - immunology - physiology
Gelatinase B
Genes
Humans
Molecular Sequence Data
Molecular Weight
Neoplasm Invasiveness
Neoplasm Proteins - physiology
Rabbits
Rats
Research Support, Non-U.S. Gov't
Sequence Alignment
Substrate Specificity
Abstract
Type IV collagenase (gelatinase) is a 70,000 dalton neutral metalloproteinase that specifically cleaves type IV collagen in addition to degrading denatured collagen (gelatin). It is secreted in a latent proenzyme form that is converted proteolytically in the extracellular space to a 62,000 dalton active enzyme. The primary structure, enzymatic properties as well as gene structure, demonstrate that type IV collagenase is closely related with the other well characterized metalloproteinases, interstitial collagenase and stromelysin. However, the structure of type IV collagenase differs from the others in that it is larger and contains three internal repeats that resemble the type II domains of fibronectin. Also, initial characterization of the promoter region of the gene indicates that its regulation differs from the other proteinase genes. Type IV collagenase is presumably required for the normal turnover of basement membranes. Augmented activity is linked with the invasive potential of tumor cells and the enzyme is believed to play a major role in the penetration of basement membranes by metastatic cells. Measurements of enzyme activity and mRNA levels as well as immunostaining of a variety of tumor cells and tissues suggest that assays for the enzyme may have value in the follow-up of malignant growth.
PubMed ID
1480085 View in PubMed
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[A 100 year old thesis. Amanuensis Hans Christian Geelmuyden]

https://arctichealth.org/en/permalink/ahliterature48136
Source
Tidsskr Nor Laegeforen. 1997 Dec 10;117(30):4410-2
Publication Type
Article
Date
Dec-10-1997
Author
J. Bremer
Author Affiliation
Institutt for medisinsk biokjemi Universitetet i Oslo, Oslo.
Source
Tidsskr Nor Laegeforen. 1997 Dec 10;117(30):4410-2
Date
Dec-10-1997
Language
Norwegian
Publication Type
Article
Keywords
Acetone - metabolism
Animals
Diabetes Mellitus - history
Dissertations, Academic - history
Dogs
English Abstract
History, 19th Century
History, 20th Century
Humans
Norway
Physiology - history
Rabbits
Abstract
Hans Christian Geelmuyden (1861-1945) was amanuensis (assistant professor) at the Institute of Physiology, University of Oslo from 1889 to 1931. In 1897 he was awarded the degree "Doctor of Medicine" for his thesis "Om aceton som stofvexelprodukt" (On acetone as a metabolic product). The Nobel laureate Feodor Lynen referred to this thesis, which was also published in German, stating that Geelmuyden was the first to establish that ketone bodies are formed from fatty acids. Geelmuyden also established that acetone is metabolized in rabbits and dogs. Geelmuyden was a prolific writer on fat metabolism and diabetes and wrote a series of extensive reviews on these topics in Ergebnisse der Physiologie. Geelmuyden was active in the treatment of diabetic patients.
PubMed ID
9456588 View in PubMed
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[Ability of blood protein, typical of normal growth, to activate glycolysis and inhibit the Pasteur reaction]

https://arctichealth.org/en/permalink/ahliterature66133
Source
Ukr Biokhim Zh. 1977 Mar-Apr;49(2):78-82
Publication Type
Article
Author
V N Bila
V P Korotkoruchko
Source
Ukr Biokhim Zh. 1977 Mar-Apr;49(2):78-82
Language
Ukrainian
Publication Type
Article
Keywords
Anaerobiosis
Animals
Animals, Newborn - blood
Beta-Globulins - pharmacology
Blood Proteins - pharmacology
English Abstract
Female
Fetal Blood
Glycolysis - drug effects
Immune Sera - pharmacology
Muscles - metabolism
Oxygen
Pregnancy
Rabbits
Abstract
Formation of lactic acid by the extracts from the healthy rabbit muscles was studied as affected by the sera of embryos, newborn rabbits and pregnant female rabbits. The blood sera and beta-globulin isolated from them are established to activate anaerobic glycolysis and inhibit the Pasteur reaction. It is shown that protein typical of normal growth, belonging to beta-globulins and circulating in blood of the embryos, newborn rabbits from the first to the fifteenth day of development is "responsible" for this phenomena. Correlation is found between the precipitation test for detecting this protein and its biological effect on glycolysis and the Pasteur reaction.
PubMed ID
68614 View in PubMed
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Source
Can Med Assoc J. 1981 Aug 15;125(4):338
Publication Type
Article
Date
Aug-15-1981
Author
P K Basu
Source
Can Med Assoc J. 1981 Aug 15;125(4):338
Date
Aug-15-1981
Language
English
Publication Type
Article
Keywords
Acids - adverse effects
Animals
Canada
Eye Diseases - etiology
Humans
Hydrogen-Ion Concentration
Rabbits
Rain
Swimming
Weather
Notes
Cites: Can J Ophthalmol. 1978 Oct;13(4):247-933753
PubMed ID
7272884 View in PubMed
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[Action of different estrone doses on the trace element content in the myometrium of the pregnant uterus and in the placenta]

https://arctichealth.org/en/permalink/ahliterature66550
Source
Pediatr Akus Ginekol. 1972;4:33-6
Publication Type
Article
Date
1972

[Action of electrical stimulation of the structures of the posterior hypothalamus on the acetylcholinesterase activity of the motor portion of the cortex normally and under pharmacological influences]

https://arctichealth.org/en/permalink/ahliterature13137
Source
Fiziol Zh. 1977 Sep-Oct;23(5):591-8
Publication Type
Article

[Activation of free-radical processes as a factor of ionizing radiation-induced changes in contractile activity of a vascular wall]

https://arctichealth.org/en/permalink/ahliterature11763
Source
Fiziol Zh. 1993 Mar-Jun;39(2-3):23-9
Publication Type
Article
Author
S M Tyshkin
V M Taranenko
M I Rudniev
G S Voronkov
G I Pliushch
I M Isaiechkina
L M Popova
V V Bratus
Source
Fiziol Zh. 1993 Mar-Jun;39(2-3):23-9
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Aorta, Thoracic - physiopathology - radiation effects
Carotid Arteries - physiology - radiation effects
Depression, Chemical
English Abstract
Free Radicals - radiation effects
Muscle Contraction - drug effects - radiation effects
Muscle, Smooth, Vascular - drug effects - radiation effects
Nitroglycerin - pharmacology
Norepinephrine - pharmacology
Potassium Chloride - pharmacology
Rabbits
Radiation Injuries, Experimental - etiology - physiopathology
Stimulation, Chemical
Abstract
The influence of ionizing irradiation (1, 2 and 4 Gy 137Cs) on both the activity of free-radical processes in plasma, formed elements and aorta wall as well as on the character of contractile vascular reactions of isolated rings of thoracic aorta and carotid artery in rabbits has been studied. The experiments were carried out on the 7th day after the whole-body irradiation. The results indicate that simultaneously with the weakening of antioxidant mechanisms both endothelium-dependent and endothelium-independent vascular wall relaxation slightly decreases after 1 Gy exposure. Noradrenaline and KCI-induced contraction is shown to increase. However, these changes are not statistically significant. Irradiation in dose of 2 and 4 Gy considerably decreases endothelium-dependent relaxation. Nitroglycerin-induced relaxation greatly diminishes, KCI- and noradrenaline-induced constriction considerably increases in these conditions. The level of activation of free-radical processes considerably increases too. Thus, already on the 7th day after irradiation significant changes in reactivity of vascular wall are developed. Radiation injures both endothelium and vascular smooth muscle cells. The free-radical processes seem to be the main cause of radiation vascular damage, so there is a pronounced correlation between the changes of vascular contractile properties and the degree of activation of these processes.
PubMed ID
8405541 View in PubMed
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[Activity of glutathione-S-transferase in the blood plasma, liver and crystalline lens tissues as affected by low doses of ionizing radiation and polychromatic light]

https://arctichealth.org/en/permalink/ahliterature51029
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Publication Type
Article
Author
N F Leus
S G Kolomiichuk
V B Lishchenko
Author Affiliation
V.P. Filatov Institute of Eye Diseases and Tissue Therapy, Academy of Medical Sciences of Ukraine, Odessa.
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Language
Russian
Publication Type
Article
Keywords
Animals
Dose-Response Relationship, Radiation
English Abstract
Glutathione Transferase - blood - metabolism - radiation effects
Lens, Crystalline - enzymology - radiation effects
Light
Liver - enzymology - radiation effects
Male
Rabbits
Abstract
The developmental dynamics of pathologic changes in the lenses and activity of glutathione-S-transferase in the blood plasma, liver and lens tissues of rabbits under chronic influence (2 months) of small doses of X-ray radiation (total dose 2 Gy) and polychromatic light have been researched. It was shown, that polychromatic light and X-ray irradiation of rabbits significantly affected the lens nativity and increased the developmental frequency and the intensity of lens opacities. It was determined, that activity of glutathione-S-transferase in blood plasma increased for 1 month after the beginning of X-ray effects. The same effect on the enzymatic activity was shown by the summary influence of polychromatic light and X-ray irradiation. Glutathione-S-transferase activity decreased during 2 months as compared with the initial values, before irradiation of the animals. The enzymatic activity was increased in rabbit-liver cytoplasm by X-ray irradiation in 2 months. A decrease of glutathione-S-transferase activity in the liver, cortex and lens nucleus was determined under the influence of both X-ray radiation and polychromatic light.
PubMed ID
9505362 View in PubMed
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498 records – page 1 of 50.