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Cancer in Circumpolar Inuit. Background information for cancer patterns in Canadian Inuit.

https://arctichealth.org/en/permalink/ahliterature3550
Source
Acta Oncol. 1996;35(5):527-33
Publication Type
Article
Date
1996
Author
L A Gaudette
S. Freitag
R. Dufour
M. Baikie
R N Gao
M. Wideman
Author Affiliation
Health Statistics Division, Statistics Canada, Ottawa, Ontario.
Source
Acta Oncol. 1996;35(5):527-33
Date
1996
Language
English
Publication Type
Article
Keywords
Demography
Diet
Health Services Accessibility
Health Services, Indigenous
Humans
Incidence
Inuits - statistics & numerical data
Life expectancy
Life Style
Neoplasms - epidemiology - ethnology
Northwest Territories - epidemiology - ethnology
Quebec - epidemiology - ethnology
Registries
Research Support, Non-U.S. Gov't
Sex Factors
Topography, Medical
Abstract
The cancer pattern among Inuit in the Circumpolar area is remarkably different from those of other populations in the world. The current paper summarizes the most important risk factors in Canadian Inuit residing in the Northwest Territories, northern Quebec (Nunavik) and Labrador, particularly during the time period 1969-1988 covered by the study. Factors considered include: the geographic area and physical environment; population and human environment, including fertility and life expectancy; lifestyle and diet, including tobacco and alcohol use; other lifestyle factors, and health conditions; and health services and cultural accessibility. Development of the cancer registry and population databases supporting the analysis of cancer rates is described. The information in the present paper is needed to interpret cancer incidence patterns and differences among the Circumpolar Inuit of Canada, Alaska and Greenland.
PubMed ID
8813058 View in PubMed
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Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases.

https://arctichealth.org/en/permalink/ahliterature143660
Source
Arch Neurol. 2010 May;67(5):617-22
Publication Type
Article
Date
May-2010
Author
Lan Xiong
Jacques Montplaisir
Alex Desautels
Amina Barhdadi
Gustavo Turecki
Anastasia Levchenko
Pascale Thibodeau
Marie-Pierre Dubé
Claudia Gaspar
Guy A Rouleau
Author Affiliation
Center of Excellence in Neuromics, Research Centre of the University of Montreal Hospital Centre, and the Department of Medicine, University of Montreal, Montréal, Québec Canada.
Source
Arch Neurol. 2010 May;67(5):617-22
Date
May-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Aged
Anemia, Iron-Deficiency
Child
Child, Preschool
Family Health
Female
Genetic Predisposition to Disease - genetics
Health status
Humans
Infant
Male
Middle Aged
Pedigree
Phenotype
Quebec - epidemiology - ethnology
Questionnaires
Research
Restless Legs Syndrome - epidemiology - ethnology - genetics
Risk factors
Siblings
Young Adult
Abstract
To fully ascertain the familial aggregation of restless legs syndrome (RLS) and to characterize the clinical features of familial RLS (fRLS) cases.
A case series survey with a high response rate.
Academic research center.
Consecutive RLS probands (n = 249) were followed up in a specialized sleep center for 15 years. A total of 671 cases of fRLS met the current standard diagnostic criteria, including 192 probands characterized using multidimensional clinical assessments and 479 affected family members assessed by their responses to a structured questionnaire telephone diagnostic interview.
Sibling and offspring relative risk ratio and clinical and genetic features of patients with fRLS and families.
Our data showed that RLS aggregates in families with a familial rate of 77%, a sibling relative risk of 3.6 (95% confidence interval, 2.8-4.4), and an offspring relative risk of 1.8 (1.0-2.7). Familial RLS is a chronic disorder with a mean (SD) disease duration of 24 (16) years and a wide range of age of onset (mean [SD], 28 [15] years), with most family members having early-onset disease but mild to moderate RLS symptoms. Our clinical data also indicated that fRLS is more prominent among women who also had increased incidence of anemia/iron deficiency, arthritis, and number of pregnancies. Pregnancy-related RLS seems to be a characteristic feature of fRLS, and afflicted women tend to have a much younger age of onset.
Restless legs syndrome significantly aggregated in families with variable phenotypic expressivity, and the siblings of severely affected individuals have an increased risk of developing the disease.
PubMed ID
20457962 View in PubMed
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Genetic consequences of differential demographic behaviour in the Saguenay region, Qu├ębec.

https://arctichealth.org/en/permalink/ahliterature214376
Source
Am J Phys Anthropol. 1995 Sep;98(1):1-11
Publication Type
Article
Date
Sep-1995
Author
E. Heyer
Author Affiliation
Institut Interuniversitaire de Recherches sur les Populations, Chicoutimi, Québec, Canada.
Source
Am J Phys Anthropol. 1995 Sep;98(1):1-11
Date
Sep-1995
Language
English
Publication Type
Article
Keywords
Alleles
Founder Effect
Gene Amplification
Gene Frequency
Gene Pool
Genetic Diseases, Inborn - epidemiology - genetics
Humans
Pedigree
Prevalence
Quebec - epidemiology - ethnology
Time Factors
Abstract
Some rare inherited disorders are found with a high frequency in the population of the Saguenay region (Québec province, Canada, population 300,000). Inbreeding coefficients are too low to be an explanation for these high frequencies. In the first decades of settlement (1842-1870), most of the immigrants came from a small region called Charlevoix (east of Québec city). As most of the genetic disorders found in the Saguenay region are also found in the Charlevoix region, it is strongly suspected that the genes were introduced by these first settlers from Charlevoix. Using the BALSAC database (which contains linked information on the entire Saguenay population) to calculate the number of contemporary descendants and the genetic contribution of each founder to these descendants, we show that: (1) Founders who entered the population before 1870 contribute to 45% of the contemporary gene pool, despite the fact that they represent only 15% of all the 20,012 immigrants with descendants in the contemporary population (individuals born between 1950 and 1971). (2) Their genetic contribution is not homogenous in the contemporary population: 5% of the population have 100% of their gene pool coming from these first founders, while 10% have a zero to 5% contribution from these earliest founders. (3) Fifty percent of the genes introduced in the population were lost. (4) If only 68 immigrants among the first founders (2.0%) were carriers of the same gene, it could reach a frequency of 5% in the contemporary population, which is the frequency of most of the inherited disorders found in the population.
PubMed ID
8579187 View in PubMed
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Hereditary ataxia, spastic paraparesis and neuropathy in the French-Canadian population.

https://arctichealth.org/en/permalink/ahliterature169075
Source
Can J Neurol Sci. 2006 May;33(2):149-57
Publication Type
Article
Date
May-2006
Author
Nicolas Dupré
Jean-Pierre Bouchard
Bernard Brais
Guy A Rouleau
Author Affiliation
Department of Neurological Sciences, CHAUQ-Enfant-Jésus, Quebec City, QC, Canada.
Source
Can J Neurol Sci. 2006 May;33(2):149-57
Date
May-2006
Language
English
Publication Type
Article
Keywords
Central Nervous System - metabolism - pathology - physiopathology
Chromosome Mapping - trends
DNA Mutational Analysis - trends
Genetic Predisposition to Disease - epidemiology - ethnology - genetics
Genetic Testing - trends
Humans
New Brunswick - epidemiology - ethnology
Paraparesis, Spastic - diagnosis - ethnology - genetics
Peripheral Nerves - metabolism - pathology - physiopathology
Peripheral Nervous System Diseases - diagnosis - ethnology - genetics
Quebec - epidemiology - ethnology
Spinocerebellar Degenerations - diagnosis - ethnology - genetics
Abstract
Historical events have shaped the various regional gene pools of the French-Canadian (FC) population, leading to increased prevalence of some rare diseases. The first studies of these founder effects were performed in large part by astute clinicians such as André Barbeau. In collaboration with others, he contributed greatly to the delineation of phenotypic subtypes of these conditions. As such, the following neurogenetic disorders were first identified in patients of FC origin: AOA2, ARSACS, HSAN2, RAB, and HMSN/ACC. We have summarized our current knowledge of the main hereditary ataxias, spastic parapareses and neuropathies that are particular to the FC population. The initial genetic characterization of the more common and homogeneous of these diseases has been largely completed. We predict that the regional populations of Canada will allow the identification of new rare forms of hereditary ataxias, spastic parapareses and neuropathies, and contribute to the unravelling of the genetic basis of these entities.
PubMed ID
16736723 View in PubMed
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Long-term follow-up of chronic hepatitis B virus infection in children of different ethnic origins.

https://arctichealth.org/en/permalink/ahliterature189303
Source
J Infect Dis. 2002 Aug 1;186(3):295-301
Publication Type
Article
Date
Aug-1-2002
Author
George Marx
Steven R Martin
Jean-Francois Chicoine
Fernando Alvarez
Author Affiliation
Division of Gastroenterology, Hepatology and Nutrition, Sainte-Justine Hospital, Montreal, Canada. george.marx@gd.kispi.sg.ch
Source
J Infect Dis. 2002 Aug 1;186(3):295-301
Date
Aug-1-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Alanine Transaminase - blood
Asia - ethnology
Child
Child, Preschool
DNA, Viral - blood - genetics
Ethnic Groups
Europe, Eastern - ethnology
Female
Follow-Up Studies
Hepatitis B Surface Antigens - blood
Hepatitis B e Antigens - blood
Hepatitis B virus - genetics - isolation & purification
Hepatitis B, Chronic - blood - epidemiology - ethnology
Humans
Infant
Latin America - ethnology
Longitudinal Studies
Male
Proportional Hazards Models
Quebec - epidemiology - ethnology
Seroepidemiologic Studies
alpha-Fetoproteins - analysis
Abstract
The natural history of chronic hepatitis B in children is influenced by mode of transmission and varies with regional endemicity. Seroconversion rates were studied in 174 hepatitis B e antigen (HBeAg)-positive children who were of different ethnic origins and living in Canada. Overall, 40.2% became anti-HBeAg positive, and 8.6% were hepatitis B surface-antigen positive during a mean follow-up of 4.5 years. Spontaneous seroconversion rates were lower in Asian-born, mainly vertically infected, children, versus those born either in Canada or where horizontal transmission predominates (24% vs. 44%, P=.015). Kaplan-Meier analysis showed that the cumulative persistence of HBeAg after 13 years was 25% in Asian-born children, versus 6% in all others (P
PubMed ID
12134225 View in PubMed
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Macrosomia, Perinatal and Infant Mortality in Cree Communities in Quebec, 1996-2010.

https://arctichealth.org/en/permalink/ahliterature284786
Source
PLoS One. 2016;11(8):e0160766
Publication Type
Article
Date
2016
Author
Lin Xiao
Dan-Li Zhang
Jill Torrie
Nathalie Auger
Nancy Gros-Louis McHugh
Zhong-Cheng Luo
Source
PLoS One. 2016;11(8):e0160766
Date
2016
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Ethnic Groups - statistics & numerical data
Female
Fetal Macrosomia - ethnology - mortality
Humans
Infant
Infant Mortality - ethnology
Male
Quebec - epidemiology - ethnology
Retrospective Studies
Young Adult
Abstract
Cree births in Quebec are characterized by the highest reported prevalence of macrosomia (~35%) in the world. It is unclear whether Cree births are at greater elevated risk of perinatal and infant mortality than other First Nations relative to non-Aboriginal births in Quebec, and if macrosomia may be related.
This was a population-based retrospective birth cohort study using the linked birth-infant death database for singleton births to mothers from Cree (n = 5,340), other First Nations (n = 10,810) and non-Aboriginal (n = 229,960) communities in Quebec, 1996-2010. Community type was ascertained by residential postal code and municipality name. The primary outcomes were perinatal and infant mortality.
Macrosomia (birth weight for gestational age >90th percentile) was substantially more frequent in Cree (38.0%) and other First Nations (21.9%) vs non-Aboriginal (9.4%) communities. Comparing Cree and other First Nations vs non-Aboriginal communities, perinatal mortality rates were 1.52 (95% confidence intervals 1.17, 1.98) and 1.34 (1.10, 1.64) times higher, and infant mortality rates 2.27 (1.71, 3.02) and 1.49 (1.16, 1.91) times higher, respectively. The risk elevations in perinatal and infant death in Cree communities attenuated after adjusting for maternal characteristics (age, education, marital status, parity), but became greater after further adjustment for birth weight (small, appropriate, or large for gestational age).
Cree communities had greater risk elevations in perinatal and infant mortality than other First Nations relative to non-Aboriginal communities in Quebec. High prevalence of macrosomia did not explain the elevated risk of perinatal and infant mortality in Cree communities.
Notes
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PubMed ID
27517613 View in PubMed
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[Oral health of 15-year-old students living in non-fluoridated public school sectors on l'Ile de Montreal in 1987].

https://arctichealth.org/en/permalink/ahliterature226767
Source
J Dent Que. 1991 Mar;28:97-106
Publication Type
Article
Date
Mar-1991
Author
D. Chabot
R. Plante
M. Payette
Author Affiliation
Département de Santé Communautaire de l'Hôpital Saint-Luc.
Source
J Dent Que. 1991 Mar;28:97-106
Date
Mar-1991
Language
French
Publication Type
Article
Keywords
Adolescent
Cross-Sectional Studies
DMF Index
Dental Caries - epidemiology - ethnology
Dental Restoration, Permanent - statistics & numerical data
Ethnic Groups
Female
Fluoridation
Follow-Up Studies
Humans
Language
Male
Prevalence
Quebec - epidemiology - ethnology
Socioeconomic Factors
Abstract
Using data from a cross-sectional survey on 570 fifteen year old students living in non-fluoridated public school sectors on the Island of Montreal in 1987, the effect of terminating the restorative aspect of public dental health care insurance for twelve to fifteen year old students is examined. This study also highlights the level and quality of dental caries treatment on the twelve to fifteen year old group. The main point to be made is that there was an improvement in the DMFT index values of fourteen and fifteen year old students in metropolitan areas. In reality, fourteen year old children had a DMFT index of 6.45 in 1983-1984, while the fifteen year old children in the 06A region (non-fluoridated area) had a DMFT of 6.07 in 1987. Since the metropolitan fluoridated area had been eliminated from the results in 1987, it is quite obvious that the 6.07 result obtained overestimates the actual prevalence of dental caries in the metropolitan area in 1987. On the other hand, the progress which had been recorded between 1977 and 1984 by francophones in relation to anglophones was partially lost in 1987. Furthermore, this study has demonstrated that the prevalence and level of dental caries treatment are highly associated with the language spoken at home and also with the family's socio-economic status.
PubMed ID
1885824 View in PubMed
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The rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: a population-based study on 17,845 patients.

https://arctichealth.org/en/permalink/ahliterature145729
Source
Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):342-8
Publication Type
Article
Date
Feb-1-2010
Author
Naeem Bhojani
Umberto Capitanio
Nazareno Suardi
Claudio Jeldres
Hendrik Isbarn
Shahrokh F Shariat
Markus Graefen
Philippe Arjane
Alain Duclos
Jean-Baptiste Lattouf
Fred Saad
Luc Valiquette
Francesco Montorsi
Paul Perrotte
Pierre I Karakiewicz
Author Affiliation
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada.
Source
Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):342-8
Date
Feb-1-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
France - ethnology
Humans
Incidence
Kaplan-Meier Estimate
Lung Neoplasms - epidemiology - etiology
Male
Middle Aged
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Second Primary - epidemiology - etiology
Prostatectomy - adverse effects
Prostatic Neoplasms - ethnology - pathology - radiotherapy - surgery
Quebec - epidemiology - ethnology
Radiotherapy - adverse effects
Rectal Neoplasms - epidemiology - etiology
Regression Analysis
Urinary Bladder Neoplasms - epidemiology - etiology
Abstract
External-beam radiation therapy (EBRT) may predispose to secondary malignancies that include bladder cancer (BCa), rectal cancer (RCa), and lung cancer (LCa). We tested this hypothesis in a large French Canadian population-based cohort of prostate cancer patients.
Overall, 8,455 radical prostatectomy (RP) and 9,390 EBRT patients treated between 1983 and 2003 were assessed with Kaplan-Meier and Cox regression analyses. Three endpoints were examined: (1) diagnosis of secondary BCa, (2) LCa, or (3) RCa. Covariates included age, Charlson comorbidity index, and year of treatment.
In multivariable analyses that relied on incident cases diagnosed 60 months or later after RP or EBRT, the rates of BCa (hazard ratio [HR], 1.4; p = 0.02), LCa (HR, 2.0; p = 0.004), and RCa (HR 2.1; p
Notes
Comment In: Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):314-5; author reply 31520708488
Comment In: Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1279; author reply 128020542389
Comment In: Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1607; author reply 160720637987
PubMed ID
20117287 View in PubMed
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8 records – page 1 of 1.