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Urinary growth hormone excretion in 657 healthy children and adults: normal values, inter- and intraindividual variations.

https://arctichealth.org/en/permalink/ahliterature37375
Source
Horm Res. 1991;36(5-6):174-82
Publication Type
Article
Date
1991
Author
K. Main
M. Philips
M. Jørgensen
N E Skakkebaek
Author Affiliation
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Source
Horm Res. 1991;36(5-6):174-82
Date
1991
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Circadian Rhythm
Cross-Sectional Studies
Denmark
Female
Growth Hormone - urine
Humans
Longitudinal Studies
Male
Puberty - urine
Reference Values
Research Support, Non-U.S. Gov't
Sex Characteristics
Abstract
Urinary growth hormone (u-GH) excretion was measured in 547 healthy children and 110 adults by ELISA with a detection limit of 1.1 ng/l u-GH after prior concentration of the urine samples (20- to 30-fold). u-GH excretion values were significantly dependent on the pubertal stage (p less than 0.0001) with maximum values in Tanner stage 3 for girls and 4 for boys. This corresponded to a peak in u-GH excretion between 11.5-14.5 years in girls and 12.5-16 years in boys. Additionally, u-GH excretion in adults was significantly higher than in prepubertal children (p less than 0.001). The day/night ratio of u-GH excretion (pg/h) was significantly higher in females than in males (p less than 0.01). In Tanner stages 1-4, u-GH excretion during the day was lower than that at night, whereas the opposite was true in late puberty and in adult women. The interindividual variation of u-GH excretion within the same Tanner stage was considerable and approximately double the intraindividual variation. The day-to-day variation could be further reduced by collection of three consecutive urine samples. The variations were larger if night samples instead of 24-hour samples were considered. The expression of u-GH excretion in nanograms per gram creatinine did not diminish the observed variation and blunted the pubertal increase in u-GH excretion. In conclusion, (1) u-GH excretion depends significantly on age, sex and pubertal maturation as does the day/night ratio of u-GH excretion. (2) The interindividual variation in u-GH excretion is considerable.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
1823075 View in PubMed
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