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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
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PubMed ID
26252778 View in PubMed
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A 3-year physical activity intervention program increases the gain in bone mineral and bone width in prepubertal girls but not boys: the prospective copenhagen school child interventions study (CoSCIS).

https://arctichealth.org/en/permalink/ahliterature91757
Source
Calcif Tissue Int. 2008 Oct;83(4):243-50
Publication Type
Article
Date
Oct-2008
Author
Hasselstrøm H A
Karlsson M K
Hansen S E
Grønfeldt V.
Froberg K.
Andersen L B
Author Affiliation
Institute for Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark. henrietteh62@hotmail.com
Source
Calcif Tissue Int. 2008 Oct;83(4):243-50
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Anthropometry
Bone Density - physiology
Bone Development - physiology
Bone and Bones - chemistry - physiology
Child
Denmark
Exercise
Female
Humans
Longitudinal Studies
Male
Motor Activity - physiology
Prospective Studies
Puberty - physiology
Sex Factors
Abstract
The aim of this study was to evaluate the effect of increasing the amount of time spent in physical education classes on bone mineral accrual and gain in bone size in prepubertal Danish children. A total of 135 boys and 108 girls, aged 6-8 years, were included in a school-based curriculum intervention program where the usual time spent in physical education classes was doubled to four classes (180 min) per week. The control group comprised age-matched children (62 boys and 76 girls) recruited from a separate community who completed the usual Danish school curriculum of physical activity (90 min/week). Dual-energy X-ray absorptiometry was used to evaluate bone mineral content (BMC; g), bone mineral density (g/cm(2)), and bone width at the calcaneus and distal forearm before and after 3 years of intervention. Anthropometrics and Tanner stages were evaluated on the same occasions. General physical activity was measured with an accelerometer worn for 4 days. In girls, the intervention group had a 12.5% increase (P = 0.04) in distal forearm BMC and a 13.2% increase (P = 0.005) in distal forearm scanned area compared with girls in the control group. No differences were found between the intervention and control groups in boys. Increasing the frequency of physical education classes for prepubertal children is associated with a higher accrual of bone mineral and higher gain in bone size after 3 years in girls but not in boys.
PubMed ID
18839047 View in PubMed
Less detail
Source
Pediatr Akus Ginekol. 1967 Jul-Aug;4:62
Publication Type
Article
Author
B I Ilyna
Source
Pediatr Akus Ginekol. 1967 Jul-Aug;4:62
Language
Ukrainian
Publication Type
Article
Keywords
Child, Preschool
Female
Humans
Puberty, Precocious
PubMed ID
5621165 View in PubMed
Less detail

[A case of precocious puberty in a 5-year-old boy]

https://arctichealth.org/en/permalink/ahliterature44727
Source
Pediatr Akus Ginekol. 1967 Jul-Aug;4:32
Publication Type
Article
Author
O A Benikova
T D Ferdman
Source
Pediatr Akus Ginekol. 1967 Jul-Aug;4:32
Language
Ukrainian
Publication Type
Article
Keywords
Child, Preschool
Humans
Male
Puberty, Precocious
PubMed ID
5621156 View in PubMed
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Accelerated pubertal development in patients with shunted hydrocephalus.

https://arctichealth.org/en/permalink/ahliterature34773
Source
Arch Dis Child. 1996 Jun;74(6):490-6
Publication Type
Article
Date
Jun-1996
Author
T. Löppönen
A L Saukkonen
W. Serlo
P. Tapanainen
A. Ruokonen
M. Knip
Author Affiliation
Department of Paediatrics, University of Oulu, Finland.
Source
Arch Dis Child. 1996 Jun;74(6):490-6
Date
Jun-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Breast - growth & development
Cerebrospinal Fluid Shunts
Child
Cross-Sectional Studies
Female
Gonadal Steroid Hormones - blood
Gonadotropins, Pituitary - blood
Humans
Hydrocephalus - complications - physiopathology - surgery
Male
Menarche - physiology
Puberty - physiology
Puberty, Precocious - etiology
Research Support, Non-U.S. Gov't
Testis - growth & development
Abstract
OBJECTIVE: To evaluate pubertal development and peripheral concentrations of gonadotrophins and sex hormones in children with shunted hydrocephalus compared with healthy controls. STUDY DESIGN: 114 patients (52 females, 62 males) and 73 healthy controls (35 females, 38 males) aged 5 to 20 years were analysed for stage of puberty, age at menarche, testicular volume, basal serum follicle stimulating hormone (FSH), luteinising hormone (LH), sex hormone binding globulin (SHBG), testosterone and oestradiol concentrations, and free androgen index. RESULTS: Male gonadal and male and female pubic hair development occurred significantly earlier in the patients than in the controls. The mean age at menarche was significantly lower in the female patients than in their controls (11.7 v 13.2 years; p
PubMed ID
8758123 View in PubMed
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[Acceleration of development, intragroup distribution and state of health of the school-chidren in Moscow].

https://arctichealth.org/en/permalink/ahliterature252911
Source
Pediatriia. 1974 Dec;(12):50-4
Publication Type
Article
Date
Dec-1974

[Acceleration of the physical development of Moscow schoolchildren].

https://arctichealth.org/en/permalink/ahliterature109607
Source
Gig Sanit. 1970 Mar;35(3):31-4
Publication Type
Article
Date
Mar-1970

[A comparative analysis of the level of the main properties of nervous processes in youths of different age groups]

https://arctichealth.org/en/permalink/ahliterature34984
Source
Fiziol Zh. 1996;42(1-2):59-64
Publication Type
Article
Date
1996
Author
O P Nykonenko
Source
Fiziol Zh. 1996;42(1-2):59-64
Date
1996
Language
Ukrainian
Publication Type
Article
Keywords
Adolescent
Adult
Aging - physiology
Child
Child, Preschool
Comparative Study
English Abstract
Higher Nervous Activity - physiology
Humans
Infant
Male
Photic Stimulation
Puberty - physiology
Abstract
It is found that youths at the ontogenesis stages from 11 to 21 years show a gradual increase in the parameters of their neurodynamic functions. The most significant increase in the growth rate of the functional mobility and of the strength of nervous processes is observed in youths at the initial stages of pubescence (14-15 years). At the final stages of their pubescence (16-17 years) the neurodynamic of youths is maximally approaching the adults' level.
PubMed ID
8991717 View in PubMed
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378 records – page 1 of 38.