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Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment.

https://arctichealth.org/en/permalink/ahliterature82712
Source
Schizophr Res. 2006 Mar;83(1):29-40
Publication Type
Article
Date
Mar-2006
Author
Nordentoft Merete
Thorup Anne
Petersen Lone
Ohlenschlaeger Johan
Melau Marianne
Christensen Torben Østergaard
Krarup Gertrud
Jørgensen Per
Jeppesen Pia
Author Affiliation
Bispebjerg Hospital, Department Psychiatry, Bispebjerg, Bakke 23, DK-2400 Copenhagen NV, Denmark. merete.nordentoft@dadlnet.dk
Source
Schizophr Res. 2006 Mar;83(1):29-40
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Adult
Antipsychotic Agents - therapeutic use
Combined Modality Therapy
Community Mental Health Services - organization & administration
Continuity of Patient Care
Delivery of Health Care, Integrated
Denmark
Disease Progression
Female
Humans
Male
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Psychotherapy - methods
Psychotic Disorders - prevention & control
Schizophrenia - prevention & control
Schizotypal Personality Disorder - physiopathology - therapy
Abstract
BACKGROUND: Only a few randomized clinical trials have tested the effect on transition rates of intervention programs for patients with sub-threshold psychosis-like symptoms. AIM: To examine whether integrated treatment reduced transition to psychosis for first-contact patients diagnosed with schizotypal disorder. METHODS: Seventy-nine patients were randomized to integrated treatment or standard treatment. Survival analysis with multivariate Cox-regression was used to identify factors determinant for transition to psychotic disorder. RESULTS: In the multivariate model, male gender increased risk for transition to psychotic disorder (relative risk=4.47, (confidence interval 1.30-15.33)), while integrated treatment reduced the risk (relative risk=0.36 (confidence interval 0.16-0.85)). At two-year follow-up, the proportion diagnosed with a psychotic disorder was 25.0% for patients randomized to integrated treatment compared to 48.3% for patients randomized to standard treatment. CONCLUSION: Integrated treatment postponed or inhibited onset of psychosis in significantly more cases than standard treatment.
PubMed ID
16504481 View in PubMed
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