Skip header and navigation

Refine By

217 records – page 1 of 22.

1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
Cites: Child Obes. 2012 Dec;8(6):533-4123181919
Cites: Int J Pediatr Obes. 2011 Aug;6(3-4):188-9621529264
Cites: Int J Obes (Lond). 2014 Jan;38(1):40-523828099
Cites: Pediatr Diabetes. 2014 May;15(3):151-6124754463
Cites: Semin Liver Dis. 2001;21(1):3-1611296695
Cites: Pediatr Clin North Am. 2011 Dec;58(6):1375-92, x22093857
Cites: Obesity (Silver Spring). 2012 Feb;20(2):371-521869763
Cites: AJR Am J Roentgenol. 2012 Jul;199(1):2-722733887
Cites: J Clin Endocrinol Metab. 2012 Jul;97(7):E1099-10522508709
Cites: Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):146-5219171470
Cites: Pediatr Diabetes. 2014 Sep;15 Suppl 20:4-1725182305
Cites: Int J Obes Relat Metab Disord. 2001 Feb;25(2):177-8411410817
Cites: J Clin Endocrinol Metab. 2001 Dec;86(12):5755-6111739435
Cites: Diabetes. 2002 Apr;51(4):1022-711916921
Cites: Circulation. 2003 Mar 25;107(11):1562-612654618
Cites: Lancet. 2003 Sep 20;362(9388):951-714511928
Cites: Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-7615286277
Cites: Int J Obes Relat Metab Disord. 2004 Oct;28(10):1257-6315278103
Cites: Nutr Rev. 1981 Feb;39(2):43-557010232
Cites: Stat Med. 1992 Jul;11(10):1305-191518992
Cites: Am J Clin Nutr. 1993 Oct;58(4):463-78379501
Cites: Diabetes. 1997 Jun;46(6):983-89166669
Cites: Diabetologia. 1999 Jan;42(1):113-610027589
Cites: Diabetes. 1999 Oct;48(10):2039-4410512371
Cites: Obesity (Silver Spring). 2006 Mar;14(3):357-6716648604
Cites: Pediatrics. 2006 Oct;118(4):1388-9317015527
Cites: Diabetes Care. 2007 Jan;30(1):89-9417192339
Cites: Eur J Clin Nutr. 2007 Jul;61(7):877-8317151586
Cites: Circulation. 2008 Jul 15;118(3):277-8318591439
Cites: Diabetes Care. 2009 Feb;32(2):342-718957533
Cites: J Clin Endocrinol Metab. 2009 Sep;94(9):3440-719531593
Cites: Am J Epidemiol. 2010 Jun 1;171(11):1195-20220457571
Cites: Eur J Endocrinol. 2010 Sep;163(3):413-920584996
Cites: J Clin Endocrinol Metab. 2010 Dec;95(12):5189-9820829185
Cites: J Clin Res Pediatr Endocrinol. 2010;2(3):100-621274322
Cites: Diabetologia. 2011 Apr;54(4):869-7521181394
Cites: Abdom Imaging. 2013 Apr;38(2):315-922736224
PubMed ID
26252778 View in PubMed
Less detail

1H NMR studies on human plasma lipids from newborn infants, healthy adults, and adults with tumors.

https://arctichealth.org/en/permalink/ahliterature25704
Source
Magn Reson Med. 1989 Jan;9(1):35-8
Publication Type
Article
Date
Jan-1989
Author
S. Eskelinen
Y. Hiltunen
J. Jokisaari
S. Virtanen
K. Kiviniitty
Author Affiliation
Department of Biomedical Physics, University of Oulu, Finland.
Source
Magn Reson Med. 1989 Jan;9(1):35-8
Date
Jan-1989
Language
English
Publication Type
Article
Keywords
Adult
Female
Humans
Hydrogen
Infant, Newborn - blood
Lactates - blood
Lipoproteins - blood
Magnetic Resonance Spectroscopy - diagnostic use
Male
Methane - blood
Neoplasms - blood
Protons
Abstract
The 1H NMR spectra of the lipid region of human plasma from healthy adults, neonates, and patients with malignant and nonmalignant tumors have been recorded on a JNM-GX400 FT spectrometer operating at 399.6 MHz for protons. The chemical shifts of methylene and methyl groups of plasma lipids were measured with respect to the higher field component of the methyl proton resonance of the lactate molecule. The results show that there are changes in the chemical shifts of the methylene proton resonances among the plasma from healthy adults, adults with tumors, and neonates. The shifts observed in the case of cancer patients and neonates are in the direction opposite to the shift measured from the plasma of healthy adults. Thus, the observed changes cannot be explained by the activity in the cell proliferation of tissues which is high in the cases of both healthy neonates and patients with malignant tumors, but they most probably reflect the different lipoprotein compositions of neonates, healthy adults, and adults with tumors.
PubMed ID
2540395 View in PubMed
Less detail

[4 million seek increased use of protons for cancer therapy]

https://arctichealth.org/en/permalink/ahliterature28052
Source
Lakartidningen. 1974 Nov 27;71(48):4943-6
Publication Type
Article
Date
Nov-27-1974
Author
S. Osterberg
Source
Lakartidningen. 1974 Nov 27;71(48):4943-6
Date
Nov-27-1974
Language
Swedish
Publication Type
Article
Keywords
Humans
Neoplasms - radiography
Protons - therapeutic use
Radiotherapy Dosage
Radiotherapy, High-Energy
Sweden
PubMed ID
4218290 View in PubMed
Less detail

A 45-year experience with surgical treatment of peptic ulcer disease in children.

https://arctichealth.org/en/permalink/ahliterature211771
Source
J Pediatr Surg. 1996 Jun;31(6):750-3
Publication Type
Article
Date
Jun-1996
Author
K. Azarow
P. Kim
B. Shandling
S. Ein
Author Affiliation
Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
Source
J Pediatr Surg. 1996 Jun;31(6):750-3
Date
Jun-1996
Language
English
Publication Type
Article
Keywords
Anti-Ulcer Agents - therapeutic use
Chi-Square Distribution
Child
Gastric Outlet Obstruction - etiology - surgery
Gastrointestinal Hemorrhage - etiology - surgery
Histamine H2 Antagonists - therapeutic use
Humans
Intestinal Perforation - etiology - surgery
Ontario
Peptic Ulcer - complications - drug therapy - surgery
Proton Pump Inhibitors
Retrospective Studies
Abstract
Peptic ulcer disease (PUD) requiring surgical treatment has become rare with the availability of modern medical management. A retrospective study of all patients who required operations for PUD between 1949 and 1994 (n = 43) was done. The patients were classified into 3 groups: A (n = 38): pre-histamine-2 (H2) blocker era (1949-1975); B (n = 3): pre-hydrogen-potassium (H-K+) ATPase inhibitor era (1976-1988); C (n = 2): H-K+ ATPase inhibitor era (1989-1994). Data, analyzed using X2 analysis (P .01). Children with PUD can have complications similar to those of adults with PUD. Since the introduction of H2 antagonists, the recognition and treatment of H pylori, and the use of H-K+ ATPase inhibition, the incidence of operations for bleeding and perforation has decreased dramatically. However, the incidence of surgery for obstruction remains the same.
PubMed ID
8783092 View in PubMed
Less detail

Acid-suppressing drugs and gastroesophageal reflux disease as risk factors for acute pancreatitis--results from a Swedish Case-Control Study.

https://arctichealth.org/en/permalink/ahliterature172609
Source
Pharmacoepidemiol Drug Saf. 2006 Mar;15(3):141-9
Publication Type
Article
Date
Mar-2006
Author
Anders Sundström
Kerstin Blomgren
Lars Alfredsson
Bengt-Erik Wiholm
Author Affiliation
Medical Products Agency, Uppsala, Sweden. Anders.Sundstrom@Mpa.se
Source
Pharmacoepidemiol Drug Saf. 2006 Mar;15(3):141-9
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Antacids - administration & dosage - adverse effects - therapeutic use
Case-Control Studies
Enzyme Inhibitors - administration & dosage - adverse effects - therapeutic use
Female
Gastroesophageal Reflux - complications - drug therapy
Histamine H2 Antagonists - administration & dosage - adverse effects - therapeutic use
Humans
Inflammatory Bowel Diseases - complications - drug therapy
Interviews as Topic
Male
Middle Aged
Pancreatitis - epidemiology - etiology
Pharmacoepidemiology
Proton Pump Inhibitors
Registries
Risk factors
Sweden - epidemiology
Abstract
To study risk factors for acute pancreatitis, here with emphasis on gastro-intestinal diseases and their treatments.
Population based case-control study covering four areas in Sweden encompassing 2.2 million inhabitants. Included were 462 incident cases of acute pancreatitis aged 20-85 years, hospitalized from 1 January 1995-31 May 1998, and 1,781 unmatched controls randomly selected from the study base using a population register. Information was captured from medical records and structured telephone interviews.
Current use of H(2) antagonists starting within 6 months of index-date was associated with acute pancreatitis with an adjusted OR of 4.9 (95% confidence interval (CI) 1.6-15), and current use of proton pump inhibitors (PPIs) with an adjusted OR of 3.2 (95%CI 1.4-7.4). For both drug classes, the ORs tended to be higher at higher doses. Gastritis/gastro-esophageal reflux disease (GERD) within the last 12 months not treated with PPIs or H(2)-antagonists and inflammatory bowel disease (IBD) not treated with anti-inflammatory or immunosuppressive drugs were associated with development of acute pancreatitis with adjusted odds ratios (OR) of 1.9 (95%CI 1.2-3.0) and 5.1 (95%CI 2.0-13) respectively.
Current IBD without treatment and gastritis/GERD without treatment were found to be associated with increased risks to develop acute pancreatitis but the nature of the latter association needs to be further evaluated. On balance, we judge that the observed associations between current use of H(2)-antagonists and PPIs and increased risk of acute pancreatitis are unlikely to be explained by bias.
PubMed ID
16200654 View in PubMed
Less detail

Adherence and barriers to H. pylori treatment in Arctic Canada.

https://arctichealth.org/en/permalink/ahliterature105338
Source
Int J Circumpolar Health. 2013;72:22791
Publication Type
Article
Date
2013
Author
Megan Lefebvre
Hsiu-Ju Chang
Amy Morse
Sander Veldhuyzen van Zanten
Karen Jean Goodman
Author Affiliation
Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada.
Source
Int J Circumpolar Health. 2013;72:22791
Date
2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Anti-Bacterial Agents - administration & dosage - adverse effects - therapeutic use
Arctic Regions - epidemiology
Canada - epidemiology
Drug Therapy, Combination
Female
Helicobacter Infections - drug therapy - ethnology
Humans
Indians, North American - statistics & numerical data
Interviews as Topic
Inuits - statistics & numerical data
Male
Medication Adherence - statistics & numerical data
Middle Aged
Proton Pump Inhibitors - administration & dosage - adverse effects - therapeutic use
Sex Distribution
Young Adult
Abstract
Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for common stomach complaints, leading to frequent demand for treatment, which often fails. Moreover, public health authorities identified the need for information to develop locally appropriate H. pylori control strategies. We described adherence and identified barriers to completing treatment among H. pylori-positive participants in a community-based project inspired by local concerns about H. pylori infection risks.
In 2008, 110 H. pylori-positive participants (diagnosed by a breath test, histopathology and/or culture) of the Aklavik H. pylori project were randomised to standard-of-care or sequential treatment. We ascertained adherence by interviewing participants using a structured questionnaire. We estimated adherence frequencies as the proportion of participants who reported taking either 100% of doses (perfect adherence) or =80% of doses (good adherence). To compare the proportion with perfect or good adherence in subgroups, we report proportion differences and 95% confidence intervals (CI).
Of 87 participants who were interviewed, 64% reported perfect adherence and 80% reported good adherence. We observed more frequent perfect adherence for: standard therapy (67%) versus sequential (62%); males (76%) versus females (52%); participants 40-77 years (79%) versus 17-39 (50%). Proportion differences were 5% (CI: -15, 25) for standard versus sequential therapy; 23% (CI: 4, 43) for male versus female; and 29% (CI: 10, 48) for 40-77 versus 15-39 years for perfect adherence. Of the 29 participants who reported poor adherence (
Notes
Cites: J Hypertens Suppl. 1985 Apr;3(1):S3-93916440
Cites: Hypertension. 1980 Nov-Dec;2(6):757-647007235
Cites: Aliment Pharmacol Ther. 2004 Nov 15;20(10):1071-8215569109
Cites: Can J Gastroenterol. 2005 Jul;19(7):412-416010302
Cites: Clin Infect Dis. 2005 Nov 1;41(9):1261-816206100
Cites: Aliment Pharmacol Ther. 2007 Mar 1;25(5):523-3617305754
Cites: Can J Gastroenterol. 2008 Mar;22(3):289-9518354758
Cites: Can J Gastroenterol. 2008 Nov;22(11):912-619018336
Cites: Gastroenterology. 1992 Feb;102(2):493-61732120
Cites: Int J Epidemiol. 1995 Oct;24(5):875-878557443
Cites: Arch Intern Med. 1999 Oct 25;159(19):2312-610547171
Cites: Ann Intern Med. 2001 May 15;134(10):968-7711352698
Cites: Int J Epidemiol. 2002 Feb;31(1):128-3911914309
Cites: Ann Intern Med. 2003 Sep 16;139(6):463-913679322
Cites: Can J Gastroenterol. 2004 Sep;18(9):547-5415457293
Cites: Lancet. 1975 May 31;1(7918):1205-748832
Cites: Aliment Pharmacol Ther. 1999 Aug;13(8):1047-5510468680
PubMed ID
24416723 View in PubMed
Less detail

Aklavik H.pylori project treatment phase: Seeking an effective therapy for a Canadian Arctic hamlet

https://arctichealth.org/en/permalink/ahliterature260317
Source
Page 95 in S. Chatwood, P. Orr and Tiina Ikaheimo, eds. Proceedings of the 14th International Congress on Circumpolar Health, Yellowknife, Canada, July 11-16, 2009. Securing the IPY Legacy: from Research to Action. International Journal of Circumpolar Health 2010; 69 (Suppl 7).
Publication Type
Conference/Meeting Material
Date
2010
setting, taking into account antibiotic sensitivity profiles obtained in earlier phases of this project. Current recommended therapy for first-time H. pylori infection in Canada is multi-drug therapy with 7-10 days of a proton pump inhibitor plus clarithromycin and either amoxicillin or metronidazole
  1 document  
Author
Morse, AL
Goodman, KJ
Munday, R
Morse, JW
Van Zanten, V
Author Affiliation
CANHelp Working Group
Source
Page 95 in S. Chatwood, P. Orr and Tiina Ikaheimo, eds. Proceedings of the 14th International Congress on Circumpolar Health, Yellowknife, Canada, July 11-16, 2009. Securing the IPY Legacy: from Research to Action. International Journal of Circumpolar Health 2010; 69 (Suppl 7).
Date
2010
Language
English
Geographic Location
Canada
Publication Type
Conference/Meeting Material
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
Keywords
Canada
Gastric disease
Proton pump inhibitor
Notes
Part of Abstracts: Oral presentations. Chapter 2. Infectious Diseases and Sexual Health.
Documents
Less detail

[Alternative food fortification during Christmas time].

https://arctichealth.org/en/permalink/ahliterature117566
Source
Ugeskr Laeger. 2012 Dec 3;174(49):3089-91
Publication Type
Article
Date
Dec-3-2012
Author
Michael Patrick Achiam
Jakob Burcharth
Hans-Christian Pommergaard
Author Affiliation
Kirurgisk Afdeling, Køge Sygehus, Lykkebækvej 1, 4600 Køge, Denmark. achiam@dadlnet.dk
Source
Ugeskr Laeger. 2012 Dec 3;174(49):3089-91
Date
Dec-3-2012
Language
Danish
Publication Type
Article
Keywords
Alcohol-Related Disorders - prevention & control
Alcoholic Beverages - analysis
Denmark
Food, Fortified
Holidays
Humans
Meat products
Proton Pump Inhibitors - administration & dosage
Solanum tuberosum
Vitamin B Complex - administration & dosage
Abstract
Alcohol consumption is known to increase during Christmas time and excessive alcohol consumption has been proven to be associated with gastrointestinal bleeding and certain vitamin deficiencies. While food fortification is well known and practiced in most countries, food or beverages fortified with medicine has never been practiced on a wider scale, just as alcohol rarely is fortified. In this article it is speculated how alcohol fortified with proton pump inhibitor and vitamin B would effect alcohol-related morbidity.
PubMed ID
23286727 View in PubMed
Less detail

Apollo-Soyuz light-flash observations.

https://arctichealth.org/en/permalink/ahliterature5367
Source
Life Sci Space Res. 1977;15:141-6
Publication Type
Article
Date
1977
Author
T F Budinger
C A Tobias
R H Huesman
F T Upham
T F Wieskamp
R A Hoffman
Author Affiliation
Lawrence Berkeley Laboratory, University of California, Berkeley, Calif., USA.
Source
Life Sci Space Res. 1977;15:141-6
Date
1977
Language
English
Publication Type
Article
Keywords
Arctic Regions
Atlantic Ocean
Cosmic Radiation
Dark Adaptation
Heavy Ions
Humans
Light
Magnetics
Phosphenes - physiology
Protons
Retina - radiation effects
Solar Activity
South America
Space Flight
Vision - radiation effects
Visual Perception - radiation effects
Weightlessness
Abstract
While dark adapted, two Apollo-Soyuz astronauts saw eighty-two light flash events during a complete 51 degrees orbit which passed near the north magnetic pole and through the South Atlantic Anomaly. The frequency of events at the polar parts of the orbit is 25 times that noted in equatorial latitudes and no increased frequency was noted in the South Atlantic Anomaly at the 225-km altitude. The expected flux of heavy particles at the northern and southern points is 1-2 min-1 per eye, and the efficiency for seeing HZE particles which were below the Cerenkov threshold is 50%.
PubMed ID
11958208 View in PubMed
Less detail

217 records – page 1 of 22.