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789 records – page 1 of 79.

Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia.

https://arctichealth.org/en/permalink/ahliterature63643
Source
BJOG. 2002 Jul;109(7):759-64
Publication Type
Article
Date
Jul-2002
Author
Srdjan Djurovic
Torun Clausen
Ragnhild Wergeland
Frank Brosstad
Kåre Berg
Tore Henriksen
Author Affiliation
Institute of Medical Genetics, University of Oslo, Norway.
Source
BJOG. 2002 Jul;109(7):759-64
Date
Jul-2002
Language
English
Publication Type
Article
Keywords
C-Reactive Protein - analysis
Case-Control Studies
Cohort Studies
Female
Humans
Interleukins - blood
Plasminogen Activator Inhibitor 1 - analysis
Pre-Eclampsia - blood - diagnosis - etiology
Pregnancy
Pregnancy Complications, Infectious - blood - diagnosis
Prospective Studies
Research Support, Non-U.S. Gov't
Sepsis Syndrome - blood - diagnosis
Thromboplastin - analysis
Tumor Necrosis Factor-alpha - analysis
Abstract
OBJECTIVE: To compare indicators of systemic inflammatory response in the second trimester in women who developed pre-eclampsia with normal pregnancies. DESIGN: Prospective nested case control study derived from a cohort of 2190 pregnant women. Blood samples were obtained at 18 weeks of gestation. The following inflammatory parameters were measured: tumour necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1 (PAI-1), interleukin-1beta (IL-1beta), IL-6, IL-10, microCRP and tissue factor (TF). SETTING: Institute of Medical Genetics, University of Oslo, and Department of Medical Genetics, Ullevål University Hospital and Departments of Obstetrics and Gynecology, Aker University Hospital, Oslo, Norway. SAMPLE: The cases were 71 women who subsequently developed pre-eclampsia. The controls were 71 healthy, pregnant women matched for age, parity and first trimester body mass index (BMI). METHODS: Venous blood was drawn from fasting subjects into 5 mL test tubes containing EDTA. Samples were analysed for inflammatory parameters: IL-1-beta, IL-6, IL-10, TNF-alpha, PAI-1, TF (ELISA-technique) and CRP (latex-enhanced immunonephelometric assay), strictly according to the manufacturer's recommendation. MAIN OUTCOME MEASURES: The matched case and control subjects were compared by the paired two-tailed Wilcoxon signed rank test. All P values were two-tailed and P
Notes
Comment In: BJOG. 2002 Dec;109(12):1426-712505001
PubMed ID
12135211 View in PubMed
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Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome.

https://arctichealth.org/en/permalink/ahliterature211852
Source
Neuroreport. 1996 May 31;7(8):1377-81
Publication Type
Article
Date
May-31-1996
Author
R N Kalaria
D L Cohen
B D Greenberg
M J Savage
N E Bogdanovic
B. Winblad
L. Lannfelt
A. Adem
Author Affiliation
Department of Neurology, Case Western Reserve University, Cleveland, OH 44106, USA.
Source
Neuroreport. 1996 May 31;7(8):1377-81
Date
May-31-1996
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alzheimer Disease - genetics - metabolism
Amyloid beta-Peptides - analysis - genetics
Amyloid beta-Protein Precursor - genetics
Cerebral Cortex - chemistry
Cerebrovascular Circulation - physiology
Down Syndrome - genetics - metabolism
Humans
Immunohistochemistry
Middle Aged
Mutation
Nerve Tissue Proteins - analysis - genetics
Periodicity
Sweden
Abstract
Recent studies have demonstrated the deposition of amyloid beta (A beta) protein with carboxyl- and aminoterminal heterogeneity in cortical and cerebrovascular deposits of Alzheimer's disease (AD). Using carboxyl end-terminal specific antibodies to A beta peptides, we examined the immunocytochemical distribution of A beta 40 and A beta 42 species in brain tissue from a Swedish subject with familial AD (FAD) bearing the double mutation at codons 670/671 in the amyloid beta precursor protein (A beta PP), and from subjects with Down's syndrome and sporadic AD. In the Swedish subject, we found profound parenchymal A beta deposits and cerebral amyloid angiopathy in all four cortical lobes and cerebellum. A beta 42 was evident in almost all parenchymal deposits as well as many vascular deposits. Although A beta 40 was present in meningeal and intraparenchymal vessels, deposits containing this shorter peptide reactivity were sparse. Surprisingly, our observations in Swedish FAD showing a remarkable abundance of A beta 42 in both parenchymal and vascular deposits were qualitatively similar to the Down's syndrome and most sporadic AD cases, and to previously published A beta PP717 FAD. While previous transfection studies in different cell cultures indicate substantially increased soluble A beta production and A beta 40 species to be predominant, it would appear that the double A beta PP mutations in Swedish FAD largely result in the deposition of the longer A beta 42 in vivo.
PubMed ID
8856679 View in PubMed
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Activity and activation of the complement system in patients being operated on for cancer of the colon.

https://arctichealth.org/en/permalink/ahliterature23558
Source
Eur J Surg. 1994 Sep;160(9):503-10
Publication Type
Article
Date
Sep-1994
Author
G. Baatrup
N. Qvist
A. Junker
K E Larsen
C. Zimmermann-Nielsen
Author Affiliation
Department of Surgery, Svendborg Hospital, Denmark.
Source
Eur J Surg. 1994 Sep;160(9):503-10
Date
Sep-1994
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Colonic Neoplasms - blood - physiopathology - surgery
Complement Activation
Complement C3c - analysis - physiology
Complement C3d - analysis - physiology
Complement Inactivator Proteins - analysis - physiology
Female
Humans
Intraoperative Period
Male
Middle Aged
Postoperative Period
Preoperative Care
Prospective Studies
Research Support, Non-U.S. Gov't
Serum Albumin - analysis
Abstract
OBJECTIVE: To find out if there was any local activation of complement in the vicinity of a colonic cancer, and any fluctuation in the function of the complement system during operation. DESIGN: Prospective study. SETTING: One university and two district hospitals in Denmark. SUBJECTS: 29 selected patients undergoing emergency and elective operations for colonic cancer. INTERVENTIONS: Measurements of systemic and local complement fixation capacity and complement activation in samples of serum or plasma taken before, during, and after operation. MAIN OUTCOME MEASURES: Changes in complement fixation capacity and complement activation during operation. RESULTS: Haemodilution during operation caused a significant reduction in the complement fixation capacity of serum and in the activation of the complement system as measured by generation of C3c. We were unable to confirm the presence of complement inhibitors during operation. Haemodilution caused a 30% reduction in fixation capacity of C3b (12/29 samples of serum had values more than 2SD below the mean of the reference range compared with 4/29 before operation). The activity of C4 was reduced by 25% during operation and the capacity of the complement system to fix C3b and C4b was restored to baseline nine days postoperatively. Concentration of C3d was significantly higher in serum from tumour venous blood compared with that from peripheral blood during operation. CONCLUSION: The presence of complement activation products in the general circulation reflects local activation of the complement system in the vicinity of the tumour, but this may have been influenced by tissue necrosis or subclinical infection. Haemodilution causes a significant reduction in the capacity of the complement system during operation, whereas inhibitory factors associated with the cancer or operation and anaesthesia could not be demonstrated. We found no correlation between complement activity and clinical data.
PubMed ID
7849170 View in PubMed
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[Actual diet of children in orphanages]

https://arctichealth.org/en/permalink/ahliterature31096
Source
Vopr Pitan. 2002;71(5):7-10
Publication Type
Article
Date
2002
Author
A T Elizarov
L P Volkotrub
Source
Vopr Pitan. 2002;71(5):7-10
Date
2002
Language
Russian
Publication Type
Article
Keywords
Adolescent
Adolescent Nutrition
Calcium - analysis
Child
Child Nutrition
Diet
Dietary Proteins - analysis
Energy intake
English Abstract
Female
Food
Food Services - standards
Humans
Iodine - analysis
Male
Nutrition Surveys
Orphanages
Phosphorus - analysis
Siberia
Trace Elements - analysis
Vitamins - analysis
Abstract
The account of quantitative and qualitative structure of diets of children of children's houses has revealed infringements in organisation of mode of a meals, and also unbalance of diet on structure of food substances, including on iodine, that can promote development of iodine-dependence diseases.
PubMed ID
12599990 View in PubMed
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Acute bronchitis in adults. How close do we come to its aetiology in general practice?

https://arctichealth.org/en/permalink/ahliterature207475
Source
Scand J Prim Health Care. 1997 Sep;15(3):156-60
Publication Type
Article
Date
Sep-1997
Author
J S Jonsson
J A Sigurdsson
K G Kristinsson
M. Guthnadóttir
S. Magnusson
Author Affiliation
Gardabaer Community Health Centre, University of Iceland, Reykjavik, Iceland.
Source
Scand J Prim Health Care. 1997 Sep;15(3):156-60
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Bronchitis - blood - diagnosis - microbiology - virology
C-Reactive Protein - analysis - diagnostic use
Chlamydia Infections
Chlamydophila pneumoniae
Family Practice
Female
Humans
Iceland
Male
Middle Aged
Mycoplasma pneumoniae
Pneumonia, Mycoplasma
Prospective Studies
Virus Diseases - blood - diagnosis
Abstract
To investigate how close we can come to the aetiology of acute bronchitis in adults in a primary care setting.
Prospective study.
General practice population in Gardabaer district, south-western Iceland.
140 patients > or = 16 years old who were diagnosed as having acute bronchitis during a two-year period (1992-1993).
Laboratory investigations (twice with a minimum four-week interval), used in general practice to analyse respiratory tract infections. They included serology for Chlamydia pneumoniae, Mycoplasma pneumoniae, respiratory tract viruses, and the level of C-reactive protein.
Of a total of 140 patients, two blood samples were taken on scheduled time in 113 patients. Serology confirmed recent infection in 18 (16%) of these patients. Only two (2%) had a bacterial infection (one C. pneumoniae, one M. pneumoniae). The others (84%) did not have a significant increase in antibody titres. Only four (4%) had C-reactive protein levels higher than 48 mg/l.
The study indicates that it is difficult to come close to a precise aetiology with respect to infectious agents of acute bronchitis in general practice. We conclude that the disease is rarely caused by atypical bacteria such as C. pneumoniae and M. pneumoniae, and rarely caused by bacterial infections severe enough significantly to increase the level of C-reactive protein.
PubMed ID
9323784 View in PubMed
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Acute haematogenous osteomyelitis in children in Finland. Finnish Study Group.

https://arctichealth.org/en/permalink/ahliterature219697
Source
Ann Med. 1993 Dec;25(6):545-9
Publication Type
Article
Date
Dec-1993
Author
L. Unkila-Kallio
M J Kallio
H. Peltola
Author Affiliation
Children's Hospital, University of Helsinki, Finland.
Source
Ann Med. 1993 Dec;25(6):545-9
Date
Dec-1993
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Bacteremia - diagnosis - epidemiology - microbiology - therapy
Blood Sedimentation
C-Reactive Protein - analysis
Chi-Square Distribution
Child
Child, Preschool
Female
Finland - epidemiology
Haemophilus Infections - diagnosis
Haemophilus influenzae - isolation & purification
Humans
Infant
Infant, Newborn
Male
Osteomyelitis - diagnosis - epidemiology - microbiology - therapy
Pneumococcal Infections - diagnosis
Prospective Studies
Staphylococcal Infections - diagnosis
Streptococcal Infections - diagnosis
Treatment Outcome
Abstract
The purpose of the study was to evaluate the history, clinical picture and diagnostic difficulties of acute haematogenous osteomyelitis (AHOM) in children. Forty-seven children under the age of 15 with bacteriologically proven AHOM were collected prospectively in Finland in 1981-93. Staphylococcus aureus was responsible for 89% of the cases. The commonest sites affected were the tibia (25%) and the femur (23%) followed by the pelvis (15%) and the calcaneus (11%). Sites other than the long bones increased in frequency in children over the age of 4 years. Most of the children came with a history of a week or less with classic signs and symptoms of AHOM, increased C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values but negative X-rays. Delay in hospital admission was observed in 19%. In 11% antimicrobial therapy was not instituted within 48 hours on ward. All children were clinically healthy at the 1-year check-up with minor X-ray changes seen in 11 patients. We conclude that children in Finland seek treatment early in the course of AHOM and have a good outcome. S. aureus is the main aetiological agent affecting primarily the long bones, but in older children pelvic and calcaneic sites are also frequent. No significant delays affecting the outcome were noticed in admittance to hospital or in the diagnosis of AHOM.
PubMed ID
8292304 View in PubMed
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Acute mastoiditis in children aged 0-16 years--a national study of 678 cases in Sweden comparing different age groups.

https://arctichealth.org/en/permalink/ahliterature122281
Source
Int J Pediatr Otorhinolaryngol. 2012 Oct;76(10):1494-500
Publication Type
Article
Date
Oct-2012
Author
Anita Groth
Frida Enoksson
Malou Hultcrantz
Joacim Stalfors
Karin Stenfeldt
Ann Hermansson
Author Affiliation
Strama Skåne, Grynmalaregatan 1, Lund, Sweden. groth.medical@telia.com
Source
Int J Pediatr Otorhinolaryngol. 2012 Oct;76(10):1494-500
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Age Distribution
Anti-Bacterial Agents - therapeutic use
C-Reactive Protein - analysis
Child
Child, Preschool
Ear, Middle - microbiology
Edema - epidemiology
Fever - epidemiology
Hospitalization
Humans
Incidence
Infant
Infant, Newborn
Length of Stay - statistics & numerical data
Leukocyte Count
Mastoid - surgery
Mastoiditis - complications - epidemiology - therapy
Middle Ear Ventilation - statistics & numerical data
Otitis Media - epidemiology
Pain - epidemiology
Severity of Illness Index
Sweden - epidemiology
Abstract
To compare the characteristics of acute mastoiditis in children in different age groups in order to identify risk groups and risk factors for acute mastoiditis.
Records for all children aged 0-16 years treated for acute mastoiditis during 1993-2007 at 33 Ear, Nose and Throat departments in Sweden were reviewed retrospectively according to defined criteria for acute mastoiditis.
A total of 678 cases fulfilled the inclusion criteria. Acute mastoiditis was most common in children younger than two years of age and this group was characterized by less prior history of other diseases and ear diseases, fewer visits to health care centers and less antibiotic treatment before admission, shorter duration of symptoms before admission, hospitalization for fewer days and lower frequency of complications and mastoidectomies. These children also showed a higher incidence of clinical findings, increased inflammatory markers such as fever and heightened counts of C-reactive protein and white blood cells compared with older children. They also tested positive for significantly more samples of Streptococcus pneumoniae while the older children more often exhibited growth of Streptococcus pyogenes or Pseudomonas aeruginosa or no microbial growth.
The characteristics of pediatric acute mastoiditis differed significantly between age groups. Acute mastoiditis was most common in children younger than two years of age. They showed more rapid progress of symptoms and more distinct signs of acute mastoiditis. This is probably the reason why parents rapidly seek medical care for small children and hospital treatment thus starts earlier in the youngest children, which may in turn explain the excellent outcome. This study showed that younger children have neither more severe acute mastoiditis nor more complications than older ones. The differences between age groups suggest that there are distinctions in the pathophysiology behind the onset and course of acute mastoiditis in younger and older children.
PubMed ID
22832239 View in PubMed
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Acute-phase proteins and incidence of diabetes: a population-based cohort study.

https://arctichealth.org/en/permalink/ahliterature279590
Source
Acta Diabetol. 2016 Dec;53(6):981-989
Publication Type
Article
Date
Dec-2016
Author
Iram Faqir Muhammad
Yan Borné
Bo Hedblad
Peter M Nilsson
Margaretha Persson
Gunnar Engström
Source
Acta Diabetol. 2016 Dec;53(6):981-989
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Acute-Phase Proteins - analysis
Aged
C-Reactive Protein - analysis
Ceruloplasmin - analysis
Diabetes Mellitus - blood - epidemiology
Female
Follow-Up Studies
Haptoglobins - analysis
Humans
Incidence
Male
Middle Aged
Orosomucoid - analysis
Proportional Hazards Models
Risk factors
Sweden - epidemiology
alpha 1-Antitrypsin - analysis
Abstract
To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CC).
The study population consists of 4246 participants (aged 46-67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins.
During a mean follow-up period of 15.6 ± 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83-1.67; p = 0.51), 1.19 (CI: 0.85-1.62; p = 0.10), and 1.40 (CI: 1.01-1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively.
The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.
PubMed ID
27581604 View in PubMed
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[Adequacy of the diet served to Tarahumara children in indigenous boarding schools of northern Mexico].

https://arctichealth.org/en/permalink/ahliterature143615
Source
Salud Publica Mex. 2010 Jan-Feb;52(1):23-9
Publication Type
Article
Author
Joel Monárrez-Espino
Graciela Ivette Béjar-Lío
Guillermo Vázquez-Mendoza
Author Affiliation
Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Chihuahua, México.
Source
Salud Publica Mex. 2010 Jan-Feb;52(1):23-9
Language
Spanish
Publication Type
Article
Keywords
Adolescent
Child
Diet
Dietary Carbohydrates - analysis
Dietary Fats - analysis
Dietary Proteins - analysis
Energy intake
Female
Food Services
Humans
Indians, North American
Male
Menu Planning
Mexico
Micronutrients - analysis
Nutrition Policy
Nutritional Requirements
Residential Facilities
Schools
Abstract
To assess the adequacy and variability of the diet served to Tarahumara children in indigenous boarding schools.
Records of food and drinks served for meals, weighed daily, were obtained from Monday through Friday for 10 consecutive weeks in two selected boarding schools. Nutrient intake for Tuesdays, Wednesdays and Thursdays was calculated and analyzed for weeks 3, 5 and 7.
The number of food items used per week ranged from 33 to 46. The most frequently utilized items were cooking oil, fortified corn tortilla, milk, onion, sugar and beans. Total energy served per day fluctuated between 1309 and 2919 Kcal; proteins comprised 10.5 to 21.2% (45 to 127 g/day), carbohydrates 40.7 to 61.9% (145 to 433 g/day), and lipids 22.5 to 48.1% (45 to 125 g/day) of the total. Daily micronutrient content ranges were: iron 15-33 mg, calcium 686-1795 mg, zinc 8-19 mg, vitamin A 118-756 mcg, vitamin B(9) 42-212 mcg, and vitamin B(12) 0.8-5 mcg.
There was significant daily variability in the diet, which was hypercaloric due to the high lipid content, and yet insufficient in vitamins B(9), B(12) and A.
PubMed ID
20464250 View in PubMed
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Admission interleukin-6 is associated with post resuscitation organ dysfunction and predicts long-term neurological outcome after out-of-hospital ventricular fibrillation.

https://arctichealth.org/en/permalink/ahliterature265459
Source
Resuscitation. 2014 Nov;85(11):1573-9
Publication Type
Article
Date
Nov-2014
Author
Jukka Vaahersalo
Markus B Skrifvars
Kari Pulkki
Mats Stridsberg
Helge Røsjø
Seppo Hovilehto
Marjaana Tiainen
Tero Varpula
Ville Pettilä
Esko Ruokonen
Source
Resuscitation. 2014 Nov;85(11):1573-9
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - blood
C-Reactive Protein - analysis
Cardiopulmonary Resuscitation - adverse effects - methods - mortality
Female
Finland
Hospital Mortality
Humans
Intensive Care Units
Interleukin-6 - blood
Logistic Models
Male
Middle Aged
Multiple Organ Failure - blood - mortality
Multivariate Analysis
Nervous System Diseases - epidemiology - etiology - physiopathology
Out-of-Hospital Cardiac Arrest - blood - mortality - therapy
Patient Admission
Predictive value of tests
Prognosis
Prospective Studies
Risk assessment
S100 Proteins - analysis
Survival Analysis
Time Factors
Treatment Outcome
Ventricular Fibrillation - blood - mortality - therapy
Abstract
To study plasma concentrations of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and S-100B during intensive care after out-of-hospital cardiac arrest from ventricular fibrillation (OHCA-VF), and their associations with the duration of ischemia, organ dysfunction and long-term neurological outcome.
A 12-month prospective observational multicentre study was conducted in 21 Finnish intensive care units in 2011. IL-6, hs-CRP and S-100B were measured at 0-6 h, 24 h, 48 h and 96 h after ICU admission. Associations with the time to return of spontaneous circulation (ROSC), sequential organ failure assessment (SOFA) scores divided into tertiles and 12-month cerebral performance category (CPC) were tested.
Of 186 OHCA-VF patients included in the study, 110 (59.1%) patients survived with good neurological outcome (CPC 1-2) 12 months after cardiac arrest. Admission plasma concentrations of IL-6 but not hs-CRP were higher with prolonged time to ROSC (p
PubMed ID
25238742 View in PubMed
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789 records – page 1 of 79.