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(18)F-fluoride positron emission tomography/computed tomography and bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer patients: study protocol for a multicentre, diagnostic test accuracy study.

https://arctichealth.org/en/permalink/ahliterature276760
Source
BMC Cancer. 2016;16:10
Publication Type
Article
Date
2016
Author
Randi F Fonager
Helle D Zacho
Niels C Langkilde
Lars J Petersen
Source
BMC Cancer. 2016;16:10
Date
2016
Language
English
Publication Type
Article
Keywords
Bone Neoplasms - pathology - radiography
Denmark
Fluorine Radioisotopes - chemistry
Humans
Male
Multimodal Imaging
Neoplasm Metastasis
Neoplasm Staging
Positron-Emission Tomography
Prostatic Neoplasms - pathology - radiography
Risk factors
Tomography, X-Ray Computed
Abstract
For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method with modest specificity. (18)F-fluoride positron emission tomography/computed tomography has shown improved sensitivity and specificity over bone scintigraphy, but because of methodological issues such as retrospective design and verification bias, the existing level of evidence with (18)F-fluoride positron emission tomography/computed tomography is limited. The primary objective is to compare the diagnostic properties of (18)F-fluoride positron emission tomography/computed tomography versus bone scintigraphy on an individual patient basis.
One hundred forty consecutive, high-risk prostate cancer patients will be recruited from several hospitals in Denmark. Sample size was calculated using Hayen's method for diagnostic comparative studies. This study will be conducted in accordance with recommendations of standards for reporting diagnostic accuracy studies. Eligibility criteria comprise the following: 1) biopsy-proven prostate cancer, 2) PSA = 50 ng/ml (equals a prevalence of bone metastasis of ˜ 50% in the study population on bone scintigraphy), 3) patients must be eligible for androgen deprivation therapy, 4) no current or prior cancer (within the past 5 years), 5) ability to comply with imaging procedures, and 6) patients must not receive any investigational drugs. Planar bone scintigraphy and (18)F-fluoride positron emission tomography/computed tomography will be performed within a window of 14 days at baseline. All scans will be repeated after 26 weeks of androgen deprivation therapy, and response of individual lesions will be used for diagnostic classification of the lesions on baseline imaging among responding patients. A response is defined as PSA normalisation or = 80% reduction compared with baseline levels, testosterone below castration levels, no skeletal related events, and no clinical signs of progression. Images are read by blinded nuclear medicine physicians. The protocol is currently recruiting.
To the best of our knowledge, this is one of the largest prospective studies comparing (18)F-fluoride positron emission tomography/computed tomography and bone scintigraphy. It is conducted in full accordance with recommendations for diagnostic accuracy trials. It is intended to provide valid documentation for the use of (18)F-fluoride positron emission tomography/computed tomography for examination of bone metastasis in the staging of prostate cancer.
Notes
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PubMed ID
26753880 View in PubMed
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Topometric, roentgenologic, laboratory and clinical criteria of tumor regression in conservative management of prostatic carcinoma.

https://arctichealth.org/en/permalink/ahliterature27356
Source
Scand J Urol Nephrol Suppl. 1980;55:75-81
Publication Type
Article
Date
1980
Author
V. Korolchook
S. Balter
Source
Scand J Urol Nephrol Suppl. 1980;55:75-81
Date
1980
Language
English
Publication Type
Article
Keywords
Humans
Laboratory Techniques and Procedures
Male
Prostatic Neoplasms - pathology - radiography - therapy
Sweden
USSR
Ultrasonography
United States
Abstract
The assessment of prostatic carcinoma management results requires a complex approach. It is necessary to consider the objective criteria of tumor regression in the primary tumor and metastases to soft tissue, bone as well as indirect signs of tumor process (levels of acid and alkaline phosphatases). Subjective response cannot be assessed accurately. Reliable criteria in prostatic cancer management are: (1) objective regression by 50% or more decrease in all measurable lesions and unequivocal improvement in evaluable but non-measurable lesions with no new lesions developing; (2) Ultrasonotomography is a fine method of objective response assessment in the primary tumor and metastases; (3) Duration of response is the important criteria of tumor regression in conservative management of prostatic carcinoma.
PubMed ID
6938040 View in PubMed
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