Skip header and navigation

2 records – page 1 of 1.

450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.

https://arctichealth.org/en/permalink/ahliterature122072
Source
Environ Health Perspect. 2012 Oct;120(10):1425-31
Publication Type
Article
Date
Oct-2012
Author
Bonnie R Joubert
Siri E Håberg
Roy M Nilsen
Xuting Wang
Stein E Vollset
Susan K Murphy
Zhiqing Huang
Cathrine Hoyo
Øivind Midttun
Lea A Cupul-Uicab
Per M Ueland
Michael C Wu
Wenche Nystad
Douglas A Bell
Shyamal D Peddada
Stephanie J London
Author Affiliation
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Source
Environ Health Perspect. 2012 Oct;120(10):1425-31
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Adult
Basic Helix-Loop-Helix Transcription Factors - genetics - metabolism
Biological Markers - blood
Chromatography, Liquid
Cohort Studies
Cotinine - blood
Cytochrome P-450 CYP1A1 - genetics - metabolism
DNA Methylation
DNA-Binding Proteins - genetics - metabolism
Epigenesis, Genetic
Female
Fetal Blood
Genome-Wide Association Study
Humans
Infant, Newborn
Male
Maternal Exposure
Norway - epidemiology
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced - epidemiology - genetics
Repressor Proteins - genetics - metabolism
Tandem Mass Spectrometry
Tobacco Smoke Pollution - adverse effects
Transcription Factors - genetics - metabolism
United States - epidemiology
Abstract
Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple adverse health outcomes in children, but the underlying mechanisms are unclear.
We investigated epigenome-wide methylation in cord blood of newborns in relation to maternal smoking during pregnancy.
We examined maternal plasma cotinine (an objective biomarker of smoking) measured during pregnancy in relation to DNA methylation at 473,844 CpG sites (CpGs) in 1,062 newborn cord blood samples from the Norwegian Mother and Child Cohort Study (MoBa) using the Infinium HumanMethylation450 BeadChip (450K).
We found differential DNA methylation at epigenome-wide statistical significance (p-value
Notes
Cites: Hum Mol Genet. 2012 Jul 1;21(13):3073-8222492999
Cites: Epigenetics. 2011 Nov;6(11):1284-9421937876
Cites: Mol Cell Biol. 2004 Oct;24(20):8803-1215456856
Cites: Genome Biol. 2004;5(10):R8015461798
Cites: Mol Cell Biol. 2005 Dec;25(23):10338-5116287849
Cites: Biochem Pharmacol. 2006 Jul 28;72(3):267-7916488401
Cites: Eur J Epidemiol. 2006;21(8):619-2517031521
Cites: Int J Epidemiol. 2006 Oct;35(5):1146-5016926217
Cites: Nature. 2007 May 24;447(7143):425-3217522676
Cites: Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13056-6117670942
Cites: Arch Biochem Biophys. 2007 Aug 15;464(2):207-1217481570
Cites: Chem Res Toxicol. 2008 Jan;21(1):102-1618076143
Cites: Pediatr Res. 2008 Jun;63(6):593-818317238
Cites: Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2306-1018768498
Cites: J Clin Invest. 2008 Oct;118(10):3462-918802477
Cites: J Pediatr. 2009 Jan;154(1):17-918990410
Cites: Rapid Commun Mass Spectrom. 2009 May;23(9):1371-919337982
Cites: Genome Res. 2009 Jul;19(7):1165-7419494038
Cites: Am J Respir Crit Care Med. 2009 Sep 1;180(5):462-719498054
Cites: J Cell Physiol. 2010 Feb;222(2):282-519847803
Cites: Virchows Arch. 2010 Jan;456(1):13-2119844740
Cites: Science. 2010 Sep 10;329(5997):1345-820688981
Cites: J Allergy Clin Immunol. 2011 Jan;127(1):262-4, 264.e121094522
Cites: Am J Epidemiol. 2011 Feb 1;173(3):355-921178103
Cites: BMC Public Health. 2011;11(1):4621255390
Cites: Am J Hum Genet. 2011 Apr 8;88(4):450-721457905
Cites: Blood. 2011 Apr 14;117(15):e142-5021343615
Cites: Epigenetics. 2011 Jun;6(6):692-70221593595
Cites: Stem Cells. 2011 Feb;29(2):376-8521732494
Cites: Nat Rev Genet. 2011 Aug;12(8):529-4121747404
Cites: Genomics. 2011 Oct;98(4):288-9521839163
Cites: Semin Immunol. 2011 Oct;23(5):368-7821920773
Cites: J Biol Chem. 2011 Dec 16;286(50):43214-2821984831
Cites: Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):141-5122232023
Cites: Nat Immunol. 2012 Feb;13(2):117-922261961
Cites: Gene. 2012 Feb 15;494(1):36-4322202639
Cites: Environ Health Perspect. 2012 Feb;120(2):296-30222005006
Cites: Environ Health Perspect. 2012 Mar;120(3):355-6022128036
Comment In: Environ Health Perspect. 2012 Oct;120(10):a40223026408
Erratum In: Environ Health Perspect. 2012 Dec;120(12):A455
PubMed ID
22851337 View in PubMed
Less detail

Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy.

https://arctichealth.org/en/permalink/ahliterature264708
Source
Environ Health Perspect. 2014 Oct;122(10):1147-53
Publication Type
Article
Date
Oct-2014
Author
Christina A Markunas
Zongli Xu
Sophia Harlid
Paul A Wade
Rolv T Lie
Jack A Taylor
Allen J Wilcox
Source
Environ Health Perspect. 2014 Oct;122(10):1147-53
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
CpG Islands
DNA Methylation - drug effects
Epigenesis, Genetic
Female
Genome-Wide Association Study
Humans
Infant, Newborn - blood
Male
Maternal Exposure - adverse effects - statistics & numerical data
Norway - epidemiology
Pregnancy
Pregnancy Trimester, First - drug effects
Prenatal Exposure Delayed Effects - chemically induced - epidemiology - genetics
Smoking - adverse effects - epidemiology - genetics
Abstract
Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have long-lasting effects is through epigenetic modifications such as DNA methylation.
We conducted an epigenome-wide association study (EWAS) investigating alterations in DNA methylation in infants exposed in utero to maternal tobacco smoke, using the Norway Facial Clefts Study.
The Illumina HumanMethylation450 BeadChip was used to assess DNA methylation in whole blood from 889 infants shortly after delivery. Of 889 mothers, 287 reported smoking-twice as many smokers as in any previous EWAS of maternal smoking. CpG sites related to maternal smoking during the first trimester were identified using robust linear regression.
We identified 185 CpGs with altered methylation in infants of smokers at genome-wide significance (q-value
Notes
Cites: Nat Rev Genet. 2005 Aug;6(8):597-61016136652
Cites: BMC Bioinformatics. 2012;13:8622568884
Cites: Tob Control. 2006 Dec;15(6):452-717130374
Cites: BMJ. 2007 Mar 3;334(7591):46417259187
Cites: Annu Rev Nutr. 2007;27:363-8817465856
Cites: Arch Gen Psychiatry. 2008 Jun;65(6):683-9318519826
Cites: BMC Med Genet. 2008;9:11319094236
Cites: Toxicol Lett. 2009 Oct 8;190(1):23-3119559774
Cites: Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):748-5320080746
Cites: Am J Prev Med. 2010 Jul;39(1):45-5220547278
Cites: PLoS Genet. 2010 Jun;6(6):e100099220585555
Cites: Development. 2010 Aug;137(16):2643-5220610486
Cites: Nature. 2010 Aug 5;466(7307):707-1320686565
Cites: BMC Bioinformatics. 2010;11:45020822518
Cites: Reprod Toxicol. 2011 Apr;31(3):363-7321256208
Cites: Int J Cancer. 2011 Aug 15;129(4):773-921400503
Cites: Nat Rev Genet. 2011 Aug;12(8):529-4121747404
Cites: Placenta. 2011 Oct;32(10):763-7021803418
Cites: J Biol Chem. 2011 Nov 4;286(44):38159-6721914794
Cites: Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):141-5122232023
Cites: Hum Genet. 2012 Jun;131(6):1009-2122006218
Cites: Pediatr Res. 2012 Jul;72(1):101-722441375
Cites: Drug Alcohol Depend. 2012 Aug 1;124(3):311-822365898
Cites: PLoS One. 2012;7(7):e4136122848472
Cites: Environ Health Perspect. 2012 Oct;120(10):1425-3122851337
Cites: Placenta. 2012 Dec;33(12):1005-1123117232
Cites: Mol Hum Reprod. 2013 Jan;19(1):1-623139402
Cites: Hum Mol Genet. 2013 Mar 1;22(5):843-5123175441
Cites: Biochim Biophys Acta. 2013 Jun;1833(6):1388-9523500900
Cites: PLoS One. 2013;8(5):e6381223691101
Cites: ILAR J. 2012;53(3-4):341-5823744971
Cites: PLoS One. 2013;8(7):e7015923894607
Cites: Cancer Res. 2011 Dec 1;71(23):7270-921990321
Cites: Genome Res. 2000 Nov;10(11):1711-811076856
Cites: Eur Addict Res. 2003 Jul;9(3):120-3012837990
Cites: Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-512883005
Cites: Addict Behav. 2003 Oct;28(8):1447-5214512067
Cites: Toxicol Sci. 2003 Nov;76(1):3-2012883075
Cites: Neuropsychopharmacology. 2004 Aug;29(8):1440-5015039772
Cites: Pediatr Res. 2004 Sep;56(3):311-715240866
Cites: Am J Public Health. 1994 Sep;84(9):1407-138092363
Cites: Arch Toxicol. 1997;71(11):696-7029363843
Cites: Placenta. 2006 Jun-Jul;27(6-7):540-916125225
PubMed ID
24906187 View in PubMed
Less detail