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[Clinical aspects and treatment of "minimal" forms of breast cancer].

https://arctichealth.org/en/permalink/ahliterature242555
Source
Vopr Onkol. 1983;29(5):28-33
Publication Type
Article
Date
1983
Author
V F Semiglazov
A A Orlov
Source
Vopr Onkol. 1983;29(5):28-33
Date
1983
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - diagnosis - epidemiology - therapy
Carcinoma in Situ - diagnosis - epidemiology
Carcinoma, Intraductal, Noninfiltrating - diagnosis - epidemiology
Female
Humans
Mass Screening
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local - epidemiology
Precancerous Conditions - diagnosis - epidemiology - therapy
Russia
Terminology as Topic
Urban Population
Abstract
The data on 262 patients with minimal breast cancer (less than 1 cm in diameter) are presented. The long-term results of treatment of this group were good: 5- and 10-year survival rates were 91.2 and 79.5%, respectively. However, minimal breast cancer tended to produce regional (28.5%) and distant (10.3%) metastases. Organ-saving operation, viz. lumpectomy en bloc with axillary-subclavian adipose tissue was frequently (18.5%) followed by local and regional recurrence development. Adjuvant thiotepa therapy caused a 17.8% decrease in the frequency of recurrence and distant metastases development.
PubMed ID
6305033 View in PubMed
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Treatment of pre-invasive conditions during opportunistic screening and its effectiveness on cervical cancer incidence in one Norwegian county.

https://arctichealth.org/en/permalink/ahliterature22149
Source
Int J Cancer. 1997 Mar 28;71(1):4-8
Publication Type
Article
Date
Mar-28-1997
Author
S. Forsmo
H. Buhaug
F E Skjeldestad
O A Haugen
Author Affiliation
Norwegian Institute for Hospital Research, Trondheim, Norway. sirif@unimed.sintef.no
Source
Int J Cancer. 1997 Mar 28;71(1):4-8
Date
Mar-28-1997
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma in Situ - epidemiology
Female
Humans
Mass Screening
Middle Aged
Norway - epidemiology
Precancerous Conditions - diagnosis - epidemiology - therapy
Regression Analysis
Uterine Cervical Neoplasms - epidemiology - prevention & control
Abstract
Norway had until recently no organized screening programme for cervical cancer, but opportunistic screening was common. This study focuses on the effectiveness of treatment of pre-malignant cervical conditions (CIN III) on cervical-cancer incidence in the county of Sør-Trøndelag in Norway, prior to the introduction of organized mass screening. The study is based on cervical-cancer incidence rates during the years 1965-92 and treatment data for CIN III. The expected number of cervical-cancer cases prevented due to early intervention was expressed in a regression model with 2 unknown parameters: the probability, p, of cancer development in case of CIN III, and the time lag, t, between treatment and when clinical cancer would otherwise have been diagnosed. The estimated probability that a patient treated for CIN III would have developed cervical cancer if not treated was found to be approximately 20%, and the mean time delay was around 16 years. In the last period of study (1988-92), the incidence was reduced by nearly 40% of what would have been expected without early intervention. Based on equal treatment rates as in 1990, parameter estimates were used to predict future incidence reduction. Maximum effectiveness will be achieved around the year 2005, with a nearly 70% reduction. Opportunistic screening and treatment of CIN III seems to have had considerable influence on cervical-cancer incidence. The costs, however, are substantial over-treatment, since our results indicate that 4 of 5 women treated for CIN III would not progress into the invasive state.
PubMed ID
9096657 View in PubMed
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