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A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals.

https://arctichealth.org/en/permalink/ahliterature115422
Source
Hypertension. 2013 May;61(5):987-94
Publication Type
Article
Date
May-2013
Author
Aki S Havulinna
Johannes Kettunen
Olavi Ukkola
Clive Osmond
Johan G Eriksson
Y Antero Kesäniemi
Antti Jula
Leena Peltonen
Kimmo Kontula
Veikko Salomaa
Christopher Newton-Cheh
Author Affiliation
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Source
Hypertension. 2013 May;61(5):987-94
Date
May-2013
Language
English
Publication Type
Article
Keywords
Adult
Blood Pressure - genetics
Cardiovascular Diseases - epidemiology - ethnology - genetics
Cohort Studies
Cross-Sectional Studies
Female
Finland - epidemiology
Follow-Up Studies
Genome-Wide Association Study
Genotype
Humans
Hypertension - genetics
Incidence
Longitudinal Studies
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Prospective Studies
Retrospective Studies
Risk factors
Abstract
Recent genome-wide association studies have identified genetic variants associated with blood pressure (BP). We investigated whether genetic risk scores (GRSs) constructed of these variants would predict incident cardiovascular disease (CVD) events. We genotyped 32 common single nucleotide polymorphisms in several Finnish cohorts, with up to 32,669 individuals after exclusion of prevalent CVD cases. The median follow-up was 9.8 years, during which 2295 incident CVD events occurred. We created GRSs separately for systolic BP and diastolic BP by multiplying the risk allele count of each single nucleotide polymorphism by the effect size estimated in published genome-wide association studies. We performed Cox regression analyses with and without adjustment for clinical factors, including BP at baseline in each cohort. The results were combined by inverse variance-weighted fixed-effects meta-analysis. The GRSs were strongly associated with systolic BP and diastolic BP, and baseline hypertension (all P
Notes
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Comment In: Hypertension. 2013 May;61(5):961-323509079
PubMed ID
23509078 View in PubMed
Less detail

Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study.

https://arctichealth.org/en/permalink/ahliterature123225
Source
Circulation. 2012 Jul 24;126(4):402-9
Publication Type
Article
Date
Jul-24-2012
Author
Jonna Juhola
Mervi Oikonen
Costan G Magnussen
Vera Mikkilä
Niina Siitonen
Eero Jokinen
Tomi Laitinen
Peter Würtz
Samuel S Gidding
Leena Taittonen
Ilkka Seppälä
Antti Jula
Mika Kähönen
Nina Hutri-Kähönen
Terho Lehtimäki
Jorma S A Viikari
Markus Juonala
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland. jopasi@utu.fi
Source
Circulation. 2012 Jul 24;126(4):402-9
Date
Jul-24-2012
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Blood Pressure - genetics
Cardiovascular Diseases - epidemiology - ethnology - etiology
Cohort Studies
Female
Finland
Follow-Up Studies
Humans
Hypertension - epidemiology - ethnology - etiology
Longitudinal Studies
Male
Middle Aged
Obesity - complications - ethnology - genetics
Overweight - complications - ethnology - genetics
Pedigree
Polymorphism, Single Nucleotide - genetics
Predictive value of tests
Prospective Studies
Risk assessment
Risk factors
Social Class
Abstract
Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors to predict adult hypertension and furthermore whether newly identified genetic variants for blood pressure increase the prediction of adult hypertension.
The study cohort included 2625 individuals from the Cardiovascular Risk in Young Finns Study who were followed up for 21 to 27 years since baseline (1980; age, 3-18 years). In addition to dietary factors and biomarkers related to blood pressure, we examined whether a genetic risk score based on 29 newly identified single-nucleotide polymorphisms enhances the prediction of adult hypertension. Hypertension in adulthood was defined as systolic blood pressure = 130 mm Hg and/or diastolic blood pressure = 85 mm Hg or medication for the condition. Independent childhood risk factors for adult hypertension included the individual's own blood pressure (P
PubMed ID
22718800 View in PubMed
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Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature291515
Source
J Hepatol. 2016 Oct; 65(4):784-790
Publication Type
Journal Article
Date
Oct-2016
Author
Emmi Suomela
Mervi Oikonen
Niina Pitkänen
Ari Ahola-Olli
Johanna Virtanen
Riitta Parkkola
Eero Jokinen
Tomi Laitinen
Nina Hutri-Kähönen
Mika Kähönen
Terho Lehtimäki
Leena Taittonen
Päivi Tossavainen
Antti Jula
Britt-Marie Loo
Vera Mikkilä
Risto Telama
Jorma S A Viikari
Markus Juonala
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Electronic address: emkasu@utu.fi.
Source
J Hepatol. 2016 Oct; 65(4):784-790
Date
Oct-2016
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Cardiovascular diseases
Child
Fatty liver
Finland
Genetic Predisposition to Disease
Humans
Lipase
Liver
Longitudinal Studies
Membrane Proteins
Polymorphism, Single Nucleotide
Risk factors
Abstract
Fatty liver is a potentially preventable cause of serious liver diseases. This longitudinal study aimed to identify childhood risk factors of fatty liver in adulthood in a population-based group of Finnish adults.
Study cohort included 2,042 individuals from the Cardiovascular Risk in Young Finns Study aged 3-18years at baseline in 1980. During the latest follow-up in 2011, the liver was scanned by ultrasound. In addition to physical and environmental factors related to fatty liver, we examined whether the genetic risk posed by a single nucleotide polymorphism in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) (rs738409) strengthens prediction of adult fatty liver.
Independent childhood predictors of adult fatty liver were small for gestational age, (odds ratio=1.71, 95% confidence interval=1.07-2.72), variant in PNPLA3 (1.63, 1.29-2.07 per one risk allele), variant in the transmembrane 6 superfamily 2 gene (TM6SF2) (1.57, 1.08-2.30), BMI (1.30, 1.07-1.59 per standard deviation) and insulin (1.25, 1.05-1.49 per standard deviation). Childhood blood pressure, physical activity, C-reactive protein, smoking, serum lipid levels or parental lifestyle factors did not predict fatty liver. Risk assessment based on childhood age, sex, BMI, insulin levels, birth weight, TM6SF2 and PNPLA3 was superior in predicting fatty liver compared with the approach using only age, sex, BMI and insulin levels (C statistics, 0.725 vs. 0.749; p=0.002).
Childhood risk factors on the development of fatty liver were small for gestational age, high insulin and high BMI. Prediction of adult fatty liver was enhanced by taking into account genetic variants in PNPLA3 and TM6SF2 genes.
The increase in pediatric obesity emphasizes the importance of identification of children and adolescents at high risk of fatty liver in adulthood. We used data from the longitudinal Cardiovascular Risk in Young Finns Study to examine the associations of childhood (3-18years) risk variables with fatty liver assessed in adulthood at the age of 34-49years. The findings suggest that a multifactorial approach with both lifestyle and genetic factors included would improve early identification of children with a high risk of adult fatty liver.
PubMed ID
27235307 View in PubMed
Less detail

Common genetic variants associated with sudden cardiac death: the FinSCDgen study.

https://arctichealth.org/en/permalink/ahliterature122139
Source
PLoS One. 2012;7(7):e41675
Publication Type
Article
Date
2012
Author
Annukka M Lahtinen
Peter A Noseworthy
Aki S Havulinna
Antti Jula
Pekka J Karhunen
Johannes Kettunen
Markus Perola
Kimmo Kontula
Christopher Newton-Cheh
Veikko Salomaa
Author Affiliation
Research Programs Unit, Molecular Medicine and Department of Medicine, University of Helsinki, Helsinki, Finland.
Source
PLoS One. 2012;7(7):e41675
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Arrhythmias, Cardiac - complications - genetics
Atrial Fibrillation - complications - genetics
Death, Sudden, Cardiac - epidemiology
Female
Finland - epidemiology
Genetic Predisposition to Disease - genetics
Humans
Male
Meta-Analysis as Topic
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Risk factors
Abstract
Sudden cardiac death (SCD) accounts for up to half of cardiac mortality. The risk of SCD is heritable but the underlying genetic variants are largely unknown. We investigated whether common genetic variants predisposing to arrhythmia or related electrocardiographic phenotypes, including QT-interval prolongation, are associated with increased risk of SCD.
We studied the association between 28 candidate SNPs and SCD in a meta-analysis of four population cohorts (FINRISK 1992, 1997, 2002 and Health 2000, n?=?27,629) and two forensic autopsy series (The Helsinki Sudden Death Study and The Tampere Autopsy Study, n?=?694). We also studied the association between established cardiovascular risk factors and SCD. Causes of death were reviewed using registry-based health and autopsy data. Cox regression and logistic regression models were adjusted for age, sex, and geographic region. The total number of SCDs was 716. Two novel SNPs were associated with SCD: SCN5A rs41312391 (relative risk [RR] 1.27 per minor T allele, 95% CI 1.11-1.45, P?=?3.4×10(-4)) and rs2200733 in 4q25 (RR 1.28 per minor T allele, 95% CI 1.11-1.48, P?=?7.9×10(-4)). We also replicated the associations for 9p21 (rs2383207, RR 1.13 per G allele, 95% CI 1.01-1.26, P?=?0.036), as well as for male sex, systolic blood pressure, diabetes, cigarette smoking, low physical activity, coronary heart disease, and digoxin use (P
Notes
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PubMed ID
22844511 View in PubMed
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Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.

https://arctichealth.org/en/permalink/ahliterature135070
Source
Circ Cardiovasc Genet. 2011 Jun;4(3):305-11
Publication Type
Article
Date
Jun-2011
Author
Peter A Noseworthy
Aki S Havulinna
Kimmo Porthan
Annukka M Lahtinen
Antti Jula
Pekka J Karhunen
Markus Perola
Lasse Oikarinen
Kimmo K Kontula
Veikko Salomaa
Christopher Newton-Cheh
Author Affiliation
Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Source
Circ Cardiovasc Genet. 2011 Jun;4(3):305-11
Date
Jun-2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Death, Sudden, Cardiac
Electrocardiography
Female
Finland
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Abstract
Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD.
We genotyped 15 common (minor allele frequency >1%) candidate single nucleotide polymorphisms (SNPs), based on association with the QT interval in prior studies, in individuals in 2 cohort studies (Health 2000, n = 6597; Mini-Finland, n = 801). After exclusions, we identified 116 incident SCDs from the remaining sample (n = 6808). We constructed a QT genotype score (QT(score)) using the allele copy number and previously reported effect estimates for each SNP. Cox proportional hazards models adjusting for age, sex, and geographical area were used for time to SCD analyses. The QT(score) was a continuous independent predictor of the heart rate-corrected QT interval (P
Notes
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Comment In: Circ Cardiovasc Genet. 2011 Jun;4(3):221-221673310
PubMed ID
21511878 View in PubMed
Less detail

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.

https://arctichealth.org/en/permalink/ahliterature126894
Source
Heart Rhythm. 2012 Jul;9(7):1099-103
Publication Type
Article
Date
Jul-2012
Author
Annukka Marjamaa
Lasse Oikarinen
Kimmo Porthan
Samuli Ripatti
Gina Peloso
Peter A Noseworthy
Matti Viitasalo
Markku S Nieminen
Lauri Toivonen
Kimmo Kontula
Leena Peltonen
Aki S Havulinna
Antti Jula
Christopher J O'Donnell
Christopher Newton-Cheh
Markus Perola
Veikko Salomaa
Author Affiliation
Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland. Annukka.Marjamaa@helsinki.fi
Source
Heart Rhythm. 2012 Jul;9(7):1099-103
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adult
Asian Continental Ancestry Group - genetics
DNA Methylation
Electrocardiography
Electrophysiologic Techniques, Cardiac
Female
Finland
GC Rich Sequence - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Heart Conduction System - physiopathology
Humans
Long QT Syndrome - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Potassium Channels, Inwardly Rectifying - genetics
Abstract
T-peak to T-end (TPE) interval on the electrocardiogram is a measure of myocardial dispersion of repolarization and is associated with an increased risk of ventricular arrhythmias. The genetic factors affecting the TPE interval are largely unknown.
To identify common genetic variants that affect the duration of the TPE interval in the general population.
We performed a genome-wide association study on 1870 individuals of Finnish origin participating in the Health 2000 Study. The TPE interval was measured from T-peak to T-wave end in leads II, V(2), and V(5) on resting electrocardiograms, and the mean of these TPE intervals was adjusted for age, sex, and Cornell voltage-duration product. We sought replication for a genome-wide significant result in the 3745 subjects from the Framingham Heart Study.
We identified a locus on 17q24 that was associated with the TPE interval. The minor allele of the common variant rs7219669 was associated with a 1.8-ms shortening of the TPE interval (P = 1.1 × 10(-10)). The association was replicated in the Framingham Heart Study (-1.5 ms; P = 1.3 × 10(-4)). The overall effect estimate of rs7219669 in the 2 studies was -1.7 ms (P = 5.7 × 10(-14)). The common variant rs7219669 maps downstream of the KCNJ2 gene, in which rare mutations cause congenital long and short QT syndromes.
The common variant rs7219669 is associated with the TPE interval and is thus a candidate to modify repolarization-related arrhythmia susceptibility in individuals carrying the major allele of this polymorphism.
Notes
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PubMed ID
22342860 View in PubMed
Less detail

Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

https://arctichealth.org/en/permalink/ahliterature140745
Source
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2678-83
Publication Type
Article
Date
Dec-2010
Author
Stefan Kiechl
Ross C Laxton
Qingzhong Xiao
Jussi A Hernesniemi
Olli T Raitakari
Mika Kähönen
Bongani M Mayosi
Antti Jula
Leena Moilanen
Johann Willeit
Hugh Watkins
Nilesh J Samani
Terho J Lehtimäki
Bernard Keavney
Qingbo Xu
Shu Ye
Author Affiliation
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Source
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2678-83
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Austria
Biological Markers - blood
Carotid Artery Diseases - blood - genetics - ultrasonography
Carotid Artery, Common - ultrasonography
Chemokine CXCL12 - blood - genetics
Chromosomes, Human, Pair 10
Coronary Artery Disease - genetics
Endothelial Cells - pathology
England
Female
Finland
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Regression Analysis
Risk assessment
Risk factors
Stem Cells - pathology
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Young Adult
Abstract
To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1a (SDF-1a) plasma levels.
Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1a. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health2000 [age range, 46 to 76 years; 55.4% men; n=1237], and essential hypertension in families collected in the region of Oxford [HTO] [age range, 19 to 88 years; 47.9% men; n=770]) for single-nucleotide polymorphism rs501120 at the 10q11.21 locus and conducted a meta-analysis in these cohorts to ascertain a relationship between the polymorphism and carotid IMT. The analysis showed that individuals with the T/T genotype had a significantly higher carotid IMT than individuals with the C/T or C/C genotype (pooled weighted mean difference, 23 µm [95% CI, 9 to 37 µm], P=0.0014 under a fixed-effects model; and 23 µm [95% CI, 6 to 41 µm], P=0.009 under a random-effects model). In the Bruneck cohort, in which data for carotid atherosclerosis and plasma SDF-1a levels were available, we observed an association of the T/T genotype with a higher burden of atherosclerosis and increased susceptibility to the development of atherosclerosis during a 5-year follow-up (multivariable odds ratio, 1.73 [95% CI, 1.18 to 2.52]; P=0.005 for the recessive model) and an association between the T/T genotype and lower SDF-1a levels (2.62 ng/mL for T/T versus 2.74 ng/mL for C/C or C/T; P=0.023).
The coronary heart disease-related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis.
PubMed ID
20847302 View in PubMed
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Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.

https://arctichealth.org/en/permalink/ahliterature128942
Source
Hum Mol Genet. 2012 Mar 15;21(6):1444-55
Publication Type
Article
Date
Mar-15-2012
Author
Taru Tukiainen
Johannes Kettunen
Antti J Kangas
Leo-Pekka Lyytikäinen
Pasi Soininen
Antti-Pekka Sarin
Emmi Tikkanen
Paul F O'Reilly
Markku J Savolainen
Kimmo Kaski
Anneli Pouta
Antti Jula
Terho Lehtimäki
Mika Kähönen
Jorma Viikari
Marja-Riitta Taskinen
Matti Jauhiainen
Johan G Eriksson
Olli Raitakari
Veikko Salomaa
Marjo-Riitta Järvelin
Markus Perola
Aarno Palotie
Mika Ala-Korpela
Samuli Ripatti
Author Affiliation
Institute for Molecular Medicine Finland FIMM, Helsinki University Hospital, FI-00014 University of Helsinki, Helsinki, Finland.
Source
Hum Mol Genet. 2012 Mar 15;21(6):1444-55
Date
Mar-15-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Cohort Studies
Female
Finland - epidemiology
Follow-Up Studies
Genetic Loci - genetics
Genome-Wide Association Study
Humans
Lipid Metabolism - physiology
Lipoproteins - genetics - metabolism
Longitudinal Studies
Magnetic Resonance Spectroscopy
Male
Metabolic Syndrome X - epidemiology - genetics - metabolism
Metabolomics
Middle Aged
Phenotype
Polymorphism, Single Nucleotide - genetics
Quantitative Trait Loci - genetics
Risk factors
Abstract
Almost 100 genetic loci are known to affect serum cholesterol and triglyceride levels. For many of these loci, the biological function and causal variants remain unknown. We performed an association analysis of the reported 95 lipid loci against 216 metabolite measures, including 95 measurements on lipids and lipoprotein subclasses, obtained via serum nuclear magnetic resonance metabolomics and four enzymatic lipid traits in 8330 individuals from Finland. The genetic variation in the loci was investigated using a dense set of 440 807 directly genotyped and imputed variants around the previously identified lead single nucleotide polymorphisms (SNPs). For 30 of the 95 loci, we identified new metabolic or genetic associations (P
PubMed ID
22156771 View in PubMed
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Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature270233
Source
Ann Med. 2015 May;47(3):253-62
Publication Type
Article
Date
May-2015
Author
Atte J W Voipio
Katja A Pahkala
Jorma S A Viikari
Vera Mikkilä
Costan G Magnussen
Nina Hutri-Kähönen
Mika Kähönen
Terho Lehtimäki
Satu Männistö
Britt-Marie Loo
Antti Jula
Jukka Marniemi
Markus Juonala
Olli T Raitakari
Source
Ann Med. 2015 May;47(3):253-62
Date
May-2015
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Cardiovascular diseases - blood - epidemiology - genetics
Contraceptives, Oral - adverse effects
Cross-Sectional Studies
Diet
Dietary Supplements
Female
Finland - epidemiology
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Prevalence
Risk factors
Seasons
Vitamin D - administration & dosage - analogs & derivatives - blood - genetics
Vitamin D Deficiency - blood - epidemiology - genetics - pathology
Abstract
We studied prevalence of hypovitaminosis D, its determinants, and whether achievement of recommended dietary vitamin D intake (10 µg/d) is associated with absence of hypovitaminosis D in adults.
The study is part of the Cardiovascular Risk in Young Finns Study. We collected serum samples of 25-hydroxyvitamin D as part of the 27-year follow-up (994 men and 1,210 women aged 30-45 years). Hypovitaminosis was defined as vitamin D concentration = 50 nmol/L.
Hypovitaminosis D was found in 38% of men and 34% of women. Dietary vitamin D intake (OR 0.90, 95% CI 0.86-0.93), use of vitamin-mineral supplements (0.66, 0.51-0.85), sunny holiday (0.55, 0.41-0.75), and oral contraceptive use in women (0.45, 0.27-0.75) were independently associated with reduced odds of hypovitaminosis. Increase in body mass index (1.06, 1.03-1.09), being a smoker (1.36, 0.97-1.92), investigation month (December versus other) (1.35, 1.12-1.61), and risk alleles in genotypes rs12785878 (1.31, 1.00-1.70) and rs2282679 (2.08, 1.66-2.60) increased odds of hypovitaminosis. Hypovitaminosis D was common also when recommended dietary intake was obtained (men 29%, women 24%).
Several factors were associated with hypovitaminosis D. The condition was common even when recommended vitamin D intake was reported. The results support the importance of vitamin D fortification and nutrient supplement use.
PubMed ID
25906790 View in PubMed
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Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

https://arctichealth.org/en/permalink/ahliterature127437
Source
PLoS One. 2012;7(1):e28931
Publication Type
Article
Date
2012
Author
Jussi A Hernesniemi
Ilkka Seppälä
Leo-Pekka Lyytikäinen
Nina Mononen
Niku Oksala
Nina Hutri-Kähönen
Markus Juonala
Leena Taittonen
Erin N Smith
Nicholas J Schork
Wei Chen
Sathanur R Srinivasan
Gerald S Berenson
Sarah S Murray
Tomi Laitinen
Antti Jula
Johannes Kettunen
Samuli Ripatti
Reijo Laaksonen
Jorma Viikari
Mika Kähönen
Olli T Raitakari
Terho Lehtimäki
Author Affiliation
Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Tampere, Finland. jussi.hernesniemi@uta.fi
Source
PLoS One. 2012;7(1):e28931
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Carotid Intima-Media Thickness
Coronary Artery Disease - epidemiology - genetics - physiopathology
Data Collection
Female
Finland - epidemiology
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Health
Humans
Louisiana - epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Risk factors
Abstract
Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve already known associations and discovered thirteen new SNPs associating with CAD. We examined whether the genetic profiling of these variants improves prediction of subclinical atherosclerosis--i.e., carotid intima-media thickness (CIMT) and carotid artery elasticity (CAE)--beyond classical risk factors.
We genotyped 24 variants found in a population of European ancestry and measured CIMT and CAE in 2001 and 2007 from 2,081, and 2,015 subjects (aged 30-45 years in 2007) respectively, participating in the Cardiovascular Risk in Young Finns Study (YFS). The Bogalusa Heart Study (BHS; n?=?1179) was used as a replication cohort (mean age of 37.5). For additional replication, a sub-sample of 5 SNPs was genotyped for 1,291 individuals aged 46-76 years participating in the Health 2000 population survey. We tested the impact of genetic risk score (GRS(24SNP/CAD)) calculated as a weighted (by allelic odds ratios for CAD) sum of CAD risk alleles from the studied 24 variants on CIMT, CAE, the incidence of carotid atherosclerosis and the progression of CIMT and CAE during a 6-year follow-up.
CIMT or CAE did not significantly associate with GRS(24SNP/CAD) before or after adjusting for classical CAD risk factors (p>0.05 for all) in YFS or in the BHS. CIMT and CAE associated with only one SNP each in the YFS. The findings were not replicated in the replication cohorts. In the meta-analysis CIMT or CAE did not associate with any of the SNPs.
Genetic profiling, by using known CAD risk variants, should not improve risk stratification for subclinical atherosclerosis beyond conventional risk factors among healthy young adults.
Notes
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PubMed ID
22295058 View in PubMed
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