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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites.

https://arctichealth.org/en/permalink/ahliterature95137
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Publication Type
Article
Date
Oct-3-2009
Author
Sorg O.
Zennegg M.
Schmid P.
Fedosyuk R.
Valikhnovskyi R.
Gaide O.
Kniazevych V.
Saurat J-H
Author Affiliation
Dermato-Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland.
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Date
Oct-3-2009
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Biopsy
Drug Residues - analysis - metabolism
Fatal Outcome
Feces - chemistry
Forensic Medicine - methods
Half-Life
Homicide
Humans
Male
Middle Aged
Politics
Substance Abuse Detection - methods
Sweat - chemistry
Tetrachlorodibenzodioxin - analysis - chemistry - metabolism - poisoning
Time Factors
Ukraine
Abstract
BACKGROUND: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a long half-life of 5-10 years in human beings as a result of its high lipophilicity, and little or no metabolism. We monitored TCDD, its form, distribution, and elimination in Victor Yushchenko after he presented with severe poisoning. METHODS: In late December, 2004, a patient presented with TCDD poisoning; the levels in his blood serum (108000 pg/g lipid weight) were more than 50 000-fold greater than those in the general population. We identified TCDD and its metabolites, and monitored their levels for 3 years using gas chromatography and high-resolution mass spectrometry in samples of blood serum, adipose tissue, faeces, skin, urine, and sweat, after they were extracted and cleaned with different organic solvents. FINDINGS: The amount of unmodified TCDD in the samples that were analysed accounted for about 60% of TCDD eliminated from the body during the same period. Two TCDD metabolites-2,3,7-trichloro-8-hydroxydibenzo-p-dioxin and 1,3,7,8-tetrachloro-2-hydroxydibenzo-p-dioxin-were identified in the faeces, blood serum, and urine. The faeces contained the highest concentration of TCDD metabolites, and were the main route of elimination. Altogether, the different routes of elimination of TCDD and its metabolites accounted for 98% of the loss of the toxin from the body. The half-life of TCDD in our patient was 15.4 months. INTERPRETATION: This case of poisoning with TCDD suggests that the design of methods for routine assessment of TCDD metabolites in human beings should be a main aim of TCDD research in the metabolomic era. FUNDING: University of Geneva Dermatology Fund, and Swiss Centre for Applied Human Toxicology.
Notes
Comment In: Lancet. 2009 Oct 3;374(9696):1131-219660808
PubMed ID
19660807 View in PubMed
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[20th century view of Poland by Russian historians. An account of: Pol'sza XX wiekie w: oczerki politiczeskoj istorii [Poland in the twentieth century: political history essays], Indryk, Moskwa, 2012, 949 p].

https://arctichealth.org/en/permalink/ahliterature268856
Source
Organon. 2014;(46):171-93
Publication Type
Article
Date
2014
Author
Daniel Beauvois
Source
Organon. 2014;(46):171-93
Date
2014
Language
French
Publication Type
Article
Keywords
Historiography
History
History, 20th Century
Poland
Politics
Russia
PubMed ID
26638583 View in PubMed
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The 2015 hospital treatment choice reform in Norway: Continuity or change?

https://arctichealth.org/en/permalink/ahliterature285277
Source
Health Policy. 2016 Apr;120(4):350-5
Publication Type
Article
Date
Apr-2016
Author
Ånen Ringard
Ingrid Sperre Saunes
Anna Sagan
Source
Health Policy. 2016 Apr;120(4):350-5
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Choice Behavior
Health Care Reform - organization & administration
Health Expenditures
Health Policy
Health Services Accessibility - economics - organization & administration
Hospitals, Private - economics
Humans
Norway
Patient Preference
Politics
Waiting Lists
Abstract
In several European countries, including Norway, polices to increase patient choice of hospital provider have remained high on the political agenda. The main reason behind the interest in hospital choice reforms in Norway has been the belief that increasing choice can remedy the persistent problem of long waiting times for elective hospital care. Prior to the 2013 General Election, the Conservative Party campaigned in favour of a new choice reform: "the treatment choice reform". This article describes the background and process leading up to introduction of the reform in the autumn of 2015. It also provides a description of the content and discusses possible implications of the reform for patients, providers and government bodies. In sum, the reform contains elements of both continuity and change. The main novelty of the reform lies in the increased role of private for-profit healthcare providers.
PubMed ID
27005300 View in PubMed
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The 2015 National Cancer Program in Sweden: Introducing standardized care pathways in a decentralized system.

https://arctichealth.org/en/permalink/ahliterature284148
Source
Health Policy. 2016 Dec;120(12):1378-1382
Publication Type
Article
Date
Dec-2016
Author
Jens Wilkens
Hans Thulesius
Ingrid Schmidt
Christina Carlsson
Source
Health Policy. 2016 Dec;120(12):1378-1382
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Antineoplastic Protocols - standards
Continuity of Patient Care
Health Care Reform - methods
Health Policy
Humans
National Health Programs
Patient satisfaction
Politics
Sweden
Waiting Lists
Abstract
Starting in 2015, the Swedish government has initiated a national reform to standardize cancer patient pathways and thereby eventually speed up treatment of cancer. Cancer care in Sweden is characterized by high survival rates and a generally high quality albeit long waiting times. The objective with the new national program to standardize cancer care pathways is to reduce these waiting times, increase patient satisfaction with cancer care and reduce regional inequalities. A new time-point for measuring the start of a care process is introduced called well-founded suspicion, which is individually designed for each cancer diagnosis. While medical guidelines are well established earlier, the standardisation is achieved by defining time boundaries for each step in the process. The cancer reform program is a collaborative effort initiated and incentivized by the central government while multi-professional groups develop the time-bound standardized care pathways, which the regional authorities are responsible for implementing. The broad stakeholder engagement and time-bound guidelines are interesting approaches to study for other countries that need to streamline care processes.
PubMed ID
27823827 View in PubMed
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2018 FIFA World Cup: isolating Russia could harm global health.

https://arctichealth.org/en/permalink/ahliterature261158
Source
Lancet. 2015 Feb 28;385(9970):749-50
Publication Type
Article
Date
Feb-28-2015
Author
Sven Daniel Wolfe
Source
Lancet. 2015 Feb 28;385(9970):749-50
Date
Feb-28-2015
Language
English
Publication Type
Article
Keywords
Global health
Humans
International Cooperation
Politics
Public Health
Russia
Soccer
PubMed ID
25752158 View in PubMed
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2020 healthcare management in Canada: a new model home next door.

https://arctichealth.org/en/permalink/ahliterature184152
Source
Healthc Manage Forum. 2003;16(1):6-10, 44-9
Publication Type
Article
Date
2003
Author
D Wayne Taylor
Author Affiliation
Michael G. DeGroote School of Business, McMaster University.
Source
Healthc Manage Forum. 2003;16(1):6-10, 44-9
Date
2003
Language
English
French
Publication Type
Article
Keywords
Canada
Cost Sharing
Efficiency
Employment - statistics & numerical data - trends
Health Care Reform
Health Expenditures - trends
Health Services Needs and Demand - trends
Humans
Models, organizational
National Health Programs - economics - organization & administration - trends
Politics
Population Dynamics
Social Change
Social Values
Taxes - trends
Abstract
The Commission on the Future of Health Care in Canada asked whether Medicare is sustainable in its present form. Well, Medicare is not sustainable for at least six reasons. Given a long list of factors, such as Canada's changing dependency ratio, the phenomenon of diminishing returns from increased taxation, competing provincial expenditure needs, low labour and technological productivity in government-funded healthcare, the expectations held by baby boomers, and the evolving value sets of Canadians--Medicare will impoverish Canada within the next couple of decades if not seriously recast. As distasteful as parallel private-pay, private-choice healthcare may be to some policy makers and providers who grew up in the 1960s, the reality of the 2020s will dictate its necessity as a pragmatic solution to a systemic problem.
PubMed ID
12908160 View in PubMed
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Abortion counseling in a general hospital.

https://arctichealth.org/en/permalink/ahliterature247205
Source
Health Soc Work. 1979 May;4(2):92-103
Publication Type
Article
Date
May-1979
Author
B A Kaminsky
L A Sheckter
Source
Health Soc Work. 1979 May;4(2):92-103
Date
May-1979
Language
English
Publication Type
Article
Keywords
Abortion, Induced - psychology
British Columbia
Counseling - methods
Female
Hospitals, General
Humans
Politics
Pregnancy
Abstract
Given the increase in the number of abortions being performed in hospitals throughout the United States and Canada, there is an obvious need for counseling programs for these patients. The authors describe one such program, and emphasize the importance of close working relationships between the counselors and their supervising staff.
PubMed ID
488841 View in PubMed
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985 records – page 1 of 99.