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238Pu: accumulation, tissue distribution, and excretion in Mayak workers after exposure to plutonium aerosols.

https://arctichealth.org/en/permalink/ahliterature126152
Source
Health Phys. 2012 Mar;102(3):243-50
Publication Type
Article
Date
Mar-2012
Author
Klara G Suslova
Alexandra B Sokolova
Viktor V Khokhryakov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2012 Mar;102(3):243-50
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aerosols
Bone and Bones - metabolism - radiation effects
Health Physics
Humans
Liver - metabolism - radiation effects
Lung - metabolism - radiation effects
Occupational Exposure
Plutonium - administration & dosage - pharmacokinetics - toxicity - urine
Russia
Solubility
Tissue Distribution
Abstract
The alpha spectrometry measurements of specific activity of 238Pu and 239Pu in urine from bioassay examinations of 1,013 workers employed at the radiochemical and plutonium production facilities of the Mayak Production Association and in autopsy specimens of lung, liver, and skeleton from 85 former nuclear workers who died between 1974-2009, are summarized.The accumulation fraction of 238Pu in the body and excreta has not changed with time in workers involved in production of weapons-grade plutonium production (e.g., the plutonium production facility and the former radiochemical facility). The accumulation fraction of 238Pu in individuals exposed to plutonium isotopes at the newer Spent Nuclear Fuel Reprocessing Plant ranged from 0.13% up to 27.5% based on the autopsy data. No statistically significant differences between 238Pu and 239Pu in distribution by the main organs of plutonium deposition were found in the Mayak workers. Based on the bioassay data,the fraction of 238Pu activity in urine is on average 38-69% of the total activity of 238Pu and 239Pu, which correlates with the isotopic composition in workplace air sampled at the Spent Nuclear Fuel Reprocessing Plant. In view of the higher specific activity of 238Pu, the contribution of 238Pu to the total internal dose, particularly in the skeleton and liver, might be expected to continue to increase, and continued surveillance is recommended.
PubMed ID
22420016 View in PubMed
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Uncertainties analysis of doses resulting from chronic inhalation of plutonium at the Mayak production association.

https://arctichealth.org/en/permalink/ahliterature174341
Source
Health Phys. 2005 Jul;89(1):33-45
Publication Type
Article
Date
Jul-2005
Author
M P Krahenbuhl
J D Bess
J L Wilde
V V Vostrotin
K G Suslova
V F Khokhryakov
D M Slaughter
S C Miller
Author Affiliation
University of Utah, 50 So. Central Campus Drive, Rm 1206, Salt Lake City, UT 84112, USA. mpk@nuclear.utah.edu
Source
Health Phys. 2005 Jul;89(1):33-45
Date
Jul-2005
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Air Pollutants, Occupational - pharmacokinetics
Air Pollutants, Radioactive - analysis - pharmacokinetics
Algorithms
Autopsy
Body Burden
Computer simulation
Humans
Models, Biological
Models, Statistical
Nuclear Reactors
Organ Specificity
Plutonium - administration & dosage - pharmacokinetics
Radiation Dosage
Radiation Monitoring - methods
Relative Biological Effectiveness
Reproducibility of Results
Risk Assessment - methods
Risk factors
Russia - epidemiology
Sensitivity and specificity
Time Factors
Whole-Body Counting - methods
Abstract
A method is presented to determine the uncertainties in the reported dose due to incorporated plutonium for the Mayak Worker Cohort. The methodology includes errors generated by both detection methods and modeling methods. To accomplish the task, the method includes classical statistics, Monte Carlo, perturbation, and reliability groupings. Uncertainties are reported in percent of reported dose as a function of total body burden. The cohort was initially sorted into six reliability groups, with "A" being the data set that the investigators are most confident is correct and "G" being the data set with the most ambiguous data. Categories were adjusted based on preliminary calculation of uncertainties using the sorting criteria. Specifically, the impact of transportability (the parameter used to describe the transport of plutonium from the lung to systemic organs) was underestimated, and the structure of the sort was reorganized to reflect the impact of transportability. The finalized categories are designated with Roman numerals I through V, with "I" being the most reliable. Excluding Category V (neither bioassay nor autopsy), the highest uncertainty in lung doses is for individuals from Category IV-which ranged from 90-375% for total body burdens greater than 10 Bq, along with work histories that indicated exposure to more than one transportability class. The smallest estimated uncertainties for lung doses were determined by autopsy. Category I has a 32-38% uncertainty in the lung dose for total body burdens greater than 1 Bq. First, these results provide a further definition and characterization of the cohort and, second, they provide uncertainty estimates for these plutonium exposure categories.
PubMed ID
15951690 View in PubMed
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