Skip header and navigation

Refine By

16369 records – page 1 of 1637.

A 1-year follow-up of low birth weight infants with and without bronchopulmonary dysplasia: health, growth, clinical lung disease, cardiovascular and neurological sequelae.

https://arctichealth.org/en/permalink/ahliterature59584
Source
Early Hum Dev. 1992 Sep;30(2):109-20
Publication Type
Article
Date
Sep-1992

A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults.

https://arctichealth.org/en/permalink/ahliterature56626
Source
Scand J Infect Dis. 2002;34(8):610-4
Publication Type
Article
Date
2002
Author
K. Levie
I. Gjorup
P. Skinhøj
M. Stoffel
Source
Scand J Infect Dis. 2002;34(8):610-4
Date
2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Belgium
Comparative Study
Denmark
Dose-Response Relationship, Drug
Female
Hepatitis B - prevention & control
Hepatitis B Antibodies - analysis
Hepatitis B Surface Antigens - analysis
Hepatitis B vaccines - administration & dosage
Humans
Immunity - physiology
Immunization - methods
Immunization Schedule
Male
Reference Values
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Single-Blind Method
Vaccines, Synthetic - administration & dosage
Abstract
An open-label randomized study was undertaken to compare a 2-dose regimen (Months 0 and 6) of hepatitis B surface antigen (HBsAg) vaccine formulated with a novel adjuvant (HBsAg/AS04) with a standard 3-dose regimen (Months 0, 1 and 6) of licensed recombinant HBsAg vaccine in terms of immunogenicity and reactogenicity when administered to healthy subjects aged between 15 and 40 y. At 1 and 6 months after the full vaccination course there was a 100% seroprotection rate (anti-HBs > or = 10 mIU/ml) with the HBsAg/AS04 vaccine, compared with a 99% response rate with the licensed vaccine. The corresponding geometric mean titres were significantly higher for the novel vaccine compared to the standard vaccine: 15,468 and 2,745 mIU/ml at Months 7 and 12 vs. 6,274 and 1,883 mIU/ml, respectively. There was a higher prevalence of local symptoms with the adjuvant vaccine (90% of doses) than with the standard vaccine (48% of doses). However, these symptoms (pain, swelling and redness) were predominantly of mild-to-moderate intensity and resolved rapidly without treatment. A 2-dose regimen of the new HBsAg/AS04 adjuvant vaccine therefore compared favourably to the standard regimen in healthy young adults. It is anticipated that the simplified vaccination schedule may improve compliance and reduce costs.
PubMed ID
12238579 View in PubMed
Less detail

A 2-year entomological study of potential malaria vectors in central Italy.

https://arctichealth.org/en/permalink/ahliterature150651
Source
Vector Borne Zoonotic Dis. 2009 Dec;9(6):703-11
Publication Type
Article
Date
Dec-2009
Author
Marco Di Luca
Daniela Boccolini
Francesco Severini
Luciano Toma
Francesca Mancini Barbieri
Antonio Massa
Roberto Romi
Author Affiliation
Vector Borne Diseases and International Health Section, Department of Infectious, Parasitic, and Immuno-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy. marco.diluca@iss.it
Source
Vector Borne Zoonotic Dis. 2009 Dec;9(6):703-11
Date
Dec-2009
Language
English
Publication Type
Article
Keywords
Animals
Anopheles - genetics - parasitology - physiology
Culicidae - growth & development
Databases, Nucleic Acid
Ecosystem
Entomology
Female
Geography
Humans
Insect Vectors - genetics - parasitology - physiology
Italy
Longitudinal Studies
Malaria - parasitology - transmission
Polymerase Chain Reaction - veterinary
Population Density
Abstract
Europe was officially declared free from malaria in 1975; nevertheless, this disease remains a potential problem related to the presence of former vectors, belonging to the Anopheles maculipennis complex. Autochthonous-introduced malaria cases, recently reported in European countries, together with the predicted climatic and environmental changes, have increased the concern of health authorities over the possible resurgence of this disease in the Mediterranean Basin. In Italy, to study the distribution and bionomics of indigenous anopheline populations and to assess environmental parameters that could influence their dynamics, an entomological study was carried out in 2005-2006 in an at-risk study area. This model area is represented by the geographical region named the Maremma, a Tyrrhenian costal plain in Central Italy, where malaria was hyperendemic up to the 1950s. Fortnightly, entomological surveys (April-October) were carried out in four selected sites with different ecological features. Morphological and molecular characterization, blood meal identification, and parity rate assessment of the anophelines were performed. In total, 8274 mosquitoes were collected, 7691 of which were anophelines. Six Anopheles species were recorded, the most abundant of which were Anopheles labranchiae and An. maculipennis s.s. An. labranchiae is predominant in the coastal plain, where it is present in scattered foci. However, this species exhibits a wider than expected range: in fact it has been recorded, for the first time, inland where An. maculipennis s.s. is the most abundant species. Both species fed on a wide range of animal hosts, also showing a marked aggressiveness on humans, when available. Our findings demonstrated the high receptivity of the Maremma area, where the former malaria vector, An. labranchiae, occurs at different densities related to the kind of environment, climatic parameters, and anthropic activities.
PubMed ID
19485768 View in PubMed
Less detail

[3, 4, or more. An epidemic of multiple pregnancies]

https://arctichealth.org/en/permalink/ahliterature65051
Source
Lakartidningen. 1991 Jul 10;88(28-29):2435-7
Publication Type
Article
Date
Jul-10-1991
Author
B S Lindberg
Author Affiliation
Kvinnokliniken, Akademiska sjukhuset, Uppsala.
Source
Lakartidningen. 1991 Jul 10;88(28-29):2435-7
Date
Jul-10-1991
Language
Swedish
Publication Type
Article
Keywords
Comparative Study
Costs and Cost Analysis
Female
Great Britain
Humans
Pregnancy
Pregnancy, Multiple - physiology - psychology
Risk factors
Socioeconomic Factors
Sweden
PubMed ID
1857168 View in PubMed
Less detail

A 3-month evaluation of the efficacy of nedocromil sodium in asthma: a randomized, double-blind, placebo-controlled trial of nedocromil sodium conducted by a Canadian multicenter study group.

https://arctichealth.org/en/permalink/ahliterature229565
Source
J Allergy Clin Immunol. 1990 Mar;85(3):612-7
Publication Type
Article
Date
Mar-1990
Author
A S Rebuck
S. Kesten
L P Boulet
A. Cartier
D. Cockcroft
J. Gruber
F. Laberge
E. Lee-Chuy
M. Keshmiri
G F MacDonald
Author Affiliation
Edmonton General Hospital, Canada.
Source
J Allergy Clin Immunol. 1990 Mar;85(3):612-7
Date
Mar-1990
Language
English
Publication Type
Article
Keywords
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects - therapeutic use
Asthma - drug therapy - physiopathology
Canada
Chronic Disease
Double-Blind Method
Drug Therapy, Combination
Drug Tolerance
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Nedocromil
Peak Expiratory Flow Rate - drug effects - physiology
Quinolones - adverse effects - therapeutic use
Randomized Controlled Trials as Topic
Time Factors
Abstract
Nedocromil sodium is a pyranoquinoline dicarboxylic acid derivative, formulated in a metered-dose inhaler. Because nedocromil sodium has in vitro and in vivo anti-inflammatory properties, it was evaluated in a group of steroid-dependent patients with asthma to observe how well it might be tolerated and for evidence of any beneficial effects. In a double-blind, group-comparative study, 127 patients received nedocromil sodium and 61 received placebo, administered as two puffs of 2 mg, four times per day, for 12 weeks. Ten patients developed adverse reactions, seven receiving active drug and three patients receiving placebo. Two patients of each group withdrew because of worsening asthma. Despite selecting patients whose asthma was stable, when they were receiving established therapeutic regimens that included steroids and bronchodilators, it was found that diary-card symptom scores, morning and evening peak expiratory flow rate values, and inhaled beta-agonist usage all demonstrated slight but significant benefit with addition of nedocromil sodium. It is concluded that the inhaled, anti-inflammatory agent, nedocromil sodium, may be added to asthma-treatment regimens with the reasonable expectation of further modest symptomatic benefit.
PubMed ID
2155958 View in PubMed
Less detail

A 3-year physical activity intervention program increases the gain in bone mineral and bone width in prepubertal girls but not boys: the prospective copenhagen school child interventions study (CoSCIS).

https://arctichealth.org/en/permalink/ahliterature91757
Source
Calcif Tissue Int. 2008 Oct;83(4):243-50
Publication Type
Article
Date
Oct-2008
Author
Hasselstrøm H A
Karlsson M K
Hansen S E
Grønfeldt V.
Froberg K.
Andersen L B
Author Affiliation
Institute for Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark. henrietteh62@hotmail.com
Source
Calcif Tissue Int. 2008 Oct;83(4):243-50
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Anthropometry
Bone Density - physiology
Bone Development - physiology
Bone and Bones - chemistry - physiology
Child
Denmark
Exercise
Female
Humans
Longitudinal Studies
Male
Motor Activity - physiology
Prospective Studies
Puberty - physiology
Sex Factors
Abstract
The aim of this study was to evaluate the effect of increasing the amount of time spent in physical education classes on bone mineral accrual and gain in bone size in prepubertal Danish children. A total of 135 boys and 108 girls, aged 6-8 years, were included in a school-based curriculum intervention program where the usual time spent in physical education classes was doubled to four classes (180 min) per week. The control group comprised age-matched children (62 boys and 76 girls) recruited from a separate community who completed the usual Danish school curriculum of physical activity (90 min/week). Dual-energy X-ray absorptiometry was used to evaluate bone mineral content (BMC; g), bone mineral density (g/cm(2)), and bone width at the calcaneus and distal forearm before and after 3 years of intervention. Anthropometrics and Tanner stages were evaluated on the same occasions. General physical activity was measured with an accelerometer worn for 4 days. In girls, the intervention group had a 12.5% increase (P = 0.04) in distal forearm BMC and a 13.2% increase (P = 0.005) in distal forearm scanned area compared with girls in the control group. No differences were found between the intervention and control groups in boys. Increasing the frequency of physical education classes for prepubertal children is associated with a higher accrual of bone mineral and higher gain in bone size after 3 years in girls but not in boys.
PubMed ID
18839047 View in PubMed
Less detail

[4th Congress of the International Perinatal Doppler Society 29-31 August 1991 in Malmö]

https://arctichealth.org/en/permalink/ahliterature59657
Source
Zentralbl Gynakol. 1992;114(4):211-4
Publication Type
Conference/Meeting Material
Date
1992

5-aminolevulinic acid mediated photodynamic therapy of Lewis lung carcinoma: a role of tumor infiltration with different cells of immune system.

https://arctichealth.org/en/permalink/ahliterature17286
Source
Exp Oncol. 2004 Dec;26(4):312-5
Publication Type
Article
Date
Dec-2004
Author
Larisa M Skivka
Oksana B Gorobets
Vadim V Kutsenok
Miron O Lozinsky
Anatoliy N Borisevich
Alexander G Fedorchuk
Vladimir V Kholin
Nikolai F Gamaleya
Author Affiliation
T.G. Shevchenko Kyiv National University, Kyiv, Ukraine. realmed@i.com.ua
Source
Exp Oncol. 2004 Dec;26(4):312-5
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Aminolevulinic Acid - pharmacology
Animals
Carcinoma, Lewis Lung - pathology
Dose-Response Relationship, Drug
Immunologic Factors
Lymphocytes - physiology
Male
Mice
Mice, Inbred C57BL
Monocytes - physiology
Photochemotherapy
Photosensitizing Agents - pharmacology
Abstract
AIM: To investigate the effect of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) as a photosensitizer on the character of infiltration of experimental tumors by different cells of immune system. METHODS: The effect of ALA-PDT on subcutaneously implanted Lewis lung carcinoma in c57Bl/6 mice was studied. ALA at a dose of 500 mg/kg was given per os, and 4 h later tumors were subjected to laser irradiation (632 nm, 150 mW/cm(2), 20 min). The evaluation of the tumor infiltration by myelomonocytic and lymphoid cells and oxygen-dependent metabolism of peritoneal macrophages (NBT-test) were carried out. RESULTS: It is shown that ALA-PDT resulted in fast and massive infiltration of irradiated tumors by myelomonocytic cells, stimulation of the peritoneal macrophages metabolic activity and augmentation of the content of tumor infiltrating lymphocytes. CONCLUSION: The immunomodulation after ALA-PDT occurs via generation of inflammation and direct laser light activation of immune system cells.
PubMed ID
15627065 View in PubMed
Less detail

5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats.

https://arctichealth.org/en/permalink/ahliterature9998
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Publication Type
Article
Date
Mar-29-2002
Author
Nina K Popova
Elena A Ivanova
Author Affiliation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia. npopova@bionet.nsc.ru
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Date
Mar-29-2002
Language
English
Publication Type
Article
Keywords
Acute Disease
Alcohol-Induced Disorders, Nervous System - drug therapy - metabolism - physiopathology
Aminopyridines - pharmacology
Animals
Brain - drug effects - metabolism - physiopathology
Dose-Response Relationship, Drug
Drug Interactions - physiology
Drug Tolerance - physiology
Ethanol - pharmacology
Hypothermia - chemically induced - drug therapy - physiopathology
Male
Mice
Mice, Inbred C3H
Neurons - drug effects - metabolism
Piperazines - pharmacology
Rats
Rats, Wistar
Receptors, Serotonin - drug effects - metabolism
Receptors, Serotonin, 5-HT1
Research Support, Non-U.S. Gov't
Serotonin - metabolism
Serotonin Antagonists - pharmacology
Sleep - drug effects - physiology
Startle Reaction - drug effects - physiology
Abstract
The effect of a selective 5-HT(1A) antagonist, 4-(2'-methoxy-)phenyl-1-[2'-(N-2"-pyridinyl)-p-iodobenzamino-]ethyl-piperazine (p-MPPI), on acute ethanol-induced hypothermia, sleep and suppression of acoustic startle reflex in C3H/He mice and Wistar rats was studied. Administration of p-MPPI at the doses of 0.4, 0.7 and 1.0 mg/kg reduced in a dose-dependent manner the ethanol-induced hypothermia and the sleep time and attenuated the ethanol-induced decrease of acoustic startle reflex magnitude in mice. Similar p-MPPI (0.4 mg/kg) effects on ethanol-induced sleep and hypothermia were obtained in rats. It was concluded that 5-HT(1A) receptors were involved in the mechanisms of the ethanol-induced hypothermia and sleep, and that 5-HT(1A) antagonist increased acute ethanol tolerance.
PubMed ID
11958829 View in PubMed
Less detail

16369 records – page 1 of 1637.