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Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study.

https://arctichealth.org/en/permalink/ahliterature115786
Source
Fertil Steril. 2013 May;99(6):1637-43
Publication Type
Article
Date
May-2013
Author
Sara S Malchau
Anne Loft
Elisabeth C Larsen
Anna-Karina Aaris Henningsen
Steen Rasmussen
Anders Nyboe Andersen
Anja Pinborg
Author Affiliation
Fertility Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. smalchau@hotmail.com
Source
Fertil Steril. 2013 May;99(6):1637-43
Date
May-2013
Language
English
Publication Type
Article
Keywords
Adult
Child
Cohort Studies
Denmark - epidemiology
Female
Humans
Infant, Newborn
Oocyte Donation - methods - trends
Perinatal Care - methods - trends
Pregnancy
Pregnancy Outcome - epidemiology
Abstract
To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC).
National cohort study.
Fertility clinics.
Three hundred seventy-five children born after OD during the period 1995-2010.
None.
Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, cesarean delivery, preeclampsia, and admittance to neonatal intensive care unit.
We found an increased risk of PTB in OD pregnancies. The adjusted odds ratio (AOR) of PTB in OD singletons was 1.8 (95% CI, 1.2-2.69), 2.5 (95% CI, 1.7-3.6), and 3.4 (95% CI, 2.3-4.9) compared with IVF, ICSI, and SC, respectively. The risk of LBW was also increased. The AOR of LBW was 1.4 (95% CI, 0.9-2.2), 1.8 (95% CI, 1.2-2.8), and 2.6 (95% CI, 1.7-4.0) compared with IVF, ICSI, and SC. The risk of preeclampsia was increased in OD pregnancies with an AOR of 2.9 (95% CI, 1.8-4.6), 2.8 (95% CI, 1.7-4.5), and 3.1 (95% CI, 1.9-4.9) compared with IVF, ICSI, and SC. After additional adjustment for preeclampsia, perinatal outcome improved. Among the twins, the difference between the groups was less pronounced.
Pregnancies after OD have a poorer perinatal outcome than those after standard IVF and ICSI mainly because of the high prevalence of preeclampsia.
PubMed ID
23465822 View in PubMed
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