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Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.

https://arctichealth.org/en/permalink/ahliterature150480
Source
Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):713-21
Publication Type
Article
Date
Aug-2009
Author
Bc Carleton
Rl Poole
Ma Smith
Js Leeder
R. Ghannadan
Cjd Ross
Ms Phillips
Mr Hayden
Author Affiliation
Pharmaceutical Outcomes Programme, Children's and Women's Health Centre of British Columbia, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. bcarleton@popi.ubc.ca
Source
Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):713-21
Date
Aug-2009
Language
English
Publication Type
Article
Keywords
Adverse Drug Reaction Reporting Systems - organization & administration
Analgesics, Opioid - poisoning
Anthracyclines - adverse effects
Antibiotics, Antineoplastic - adverse effects
Breast Feeding
Canada - epidemiology
Case-Control Studies
Child
Child Health Services - organization & administration
Child, Preschool
Cisplatin - adverse effects
Codeine - poisoning
Drug Overdose - genetics - mortality
Female
Genetic markers
Hearing Loss - chemically induced
Heart Diseases - chemically induced
Hospitals, Pediatric - organization & administration
Humans
Infant
Infant, Newborn
National health programs - organization & administration
Pharmacogenetics
Program Development
Time Factors
Abstract
Adverse drug reactions (ADRs) rank as the fifth leading cause of death in the western world. The nature and scope of these ADRs in children are not predictable based on post market surveillance reports that rely heavily on adult drug experience. The genotype-specific approaches to therapy in childhood (GATC) national ADR network was established to identify specific ADRs and to improve drug safety through identification of predictive genomic biomarkers of drug risk.
GATC set out to establish a national network of trained surveillance clinicians in pediatric hospitals across Canada. Surveillance clinicians identified, enrolled, and collected clinical data and biological samples from ADR cases and controls. Surveillance was targeted to three ADRs: anthracycline-induced cardiotoxicity, cisplatin-induced hearing impairment, and codeine-induced mortality in breastfed infants.
The initial surveillance site was established in September 2005, with 10 sites fully operational by 2008. In 3 years, GATC enrolled 1836 ADR cases and 13188 controls. Target numbers were achieved for anthracycline-induced cardiotoxicity. Modified target numbers were nearly attained for cisplatin-induced hearing impairment. Codeine-induced infant mortality in a breastfed infant was discovered by GATC investigators. A case-control study was subsequently conducted.
GATC has demonstrated a model of active and targeted surveillance that builds an important step toward the goal of personalized medicine for children. Effective communication, site-specific solutions and long-term sustainability across the network are critical to maintain participation and productivity. GATC may provide a framework of ADR surveillance that can be adapted by other countries and healthcare systems.
PubMed ID
19507171 View in PubMed
Less detail

An implementation strategy for a multicenter pediatric rapid response system in Ontario.

https://arctichealth.org/en/permalink/ahliterature142720
Source
Jt Comm J Qual Patient Saf. 2010 Jun;36(6):271-80, 241
Publication Type
Article
Date
Jun-2010
Author
Anna-Theresa Lobos
Jonathan Costello
Jonathan Gilleland
Rose Gaiteiro
Afrothite Kotsakis
Author Affiliation
Children's Hospital of Eastern Ontario, Department of Pediatrics, Division of Critical Care Medicine. alobos@cheo.on.ca
Source
Jt Comm J Qual Patient Saf. 2010 Jun;36(6):271-80, 241
Date
Jun-2010
Language
English
Publication Type
Article
Keywords
Child
Critical Care - methods - organization & administration
Hospital Rapid Response Team - organization & administration
Hospital Shared Services - organization & administration
Hospitals, Pediatric - organization & administration
Humans
Interdisciplinary Communication
Ontario
Program Development - methods
Safety Management - organization & administration - standards
Social Marketing
Abstract
A rapid response system using a medical emergency team was implemented across four pediatric hospitals in Ontario, Canada, in a social marketing approach.
Notes
Comment In: Jt Comm J Qual Patient Saf. 2010 Jun;36(6):263-5, 24120564887
PubMed ID
20564889 View in PubMed
Less detail

[An improvement of the medical-social activities of pediatric clinics: survey among local doctors].

https://arctichealth.org/en/permalink/ahliterature185683
Source
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2003 Jan-Feb;(1):45-9
Publication Type
Article
Author
L P Chicherin
I A Leshkevich
N Z Zubkova
V A Proshin
M V Asaeva
E V Mikhal'skaia
Source
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2003 Jan-Feb;(1):45-9
Language
Russian
Publication Type
Article
Keywords
Adolescent
Case Management - organization & administration
Child
Child Health Services - organization & administration
Child, Preschool
Humans
Infant
Infant, Newborn
Pediatrics - organization & administration - standards
Primary Health Care - organization & administration
Public Health Administration - standards
Questionnaires
Russia
Social Work - organization & administration
Abstract
The paper considers the topical aspects of the health status and sociomedical needs of children and adolescents; it shows it necessary to transform the activity of primary pediatric service facilities at the stage of reforming the country's public health system. The results of one of the largest sociological studies conducted among district pediatricians as to the organization of therapeutical-and-prophylactic and sociomedical and to children are discussed.
PubMed ID
12712567 View in PubMed
Less detail

[An open letter to the National Board of Health and Welfare about pediatric cardiology]

https://arctichealth.org/en/permalink/ahliterature36322
Source
Lakartidningen. 1993 Mar 24;90(12):1142, 1147
Publication Type
Article
Date
Mar-24-1993

193 records – page 1 of 20.