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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
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PubMed ID
26252778 View in PubMed
Less detail

A 4-year review of severe pediatric trauma in eastern Ontario: a descriptive analysis.

https://arctichealth.org/en/permalink/ahliterature191929
Source
J Trauma. 2002 Jan;52(1):8-12
Publication Type
Article
Date
Jan-2002
Author
Martin H Osmond
Maureen Brennan-Barnes
Allyson L Shephard
Author Affiliation
Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada. osmond@cheo.on.ca
Source
J Trauma. 2002 Jan;52(1):8-12
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Accident prevention
Accidental Falls - prevention & control - statistics & numerical data
Accidents, Traffic - prevention & control - statistics & numerical data
Adolescent
Age Distribution
Athletic Injuries - epidemiology - etiology - prevention & control
Child
Child Abuse - prevention & control - statistics & numerical data
Child, Preschool
Craniocerebral Trauma - epidemiology - etiology - prevention & control
Female
Hospitals, Pediatric - statistics & numerical data
Humans
Infant
Infant, Newborn
Male
Ontario - epidemiology
Retrospective Studies
Sex Distribution
Time Factors
Trauma Centers - statistics & numerical data
Trauma Severity Indices
Wounds and Injuries - epidemiology - etiology - prevention & control
Abstract
The objective of this study was to describe a population of children admitted to a tertiary care pediatric hospital with severe trauma to identify key areas for injury prevention research, and programming.
Retrospective chart review conducted on all children 0-17 years admitted to the Children's Hospital of Eastern Ontario (CHEO) between April 1, 1996, and March 31, 2000, following acute trauma. Each record was reviewed and assigned an ISS using the AIS 1990 revision. All cases with an ISS > 11 were included in the study.
There were 2610 trauma cases admitted to CHEO over the study period. Of these, 237 (9.1%) had severe trauma (ISS > 11). Sixty-two percent were male. Twenty-nine percent were between the ages of 10 and 14 years, 27% between 5 and 9 years, 16% between 15 and 17 years, 15% between 1 and 4 years, and 13% less than 1 year old. The most common mechanisms of injury were due to motor vehicle traffic (39%), falls (24%), child abuse (8%), and sports (5%). Of those resulting from motor vehicle traffic, 53 (57%) were occupants, 22 (24%) were pedestrians, and 18 (19%) were cyclists. When combining traffic and nontraffic mechanisms, 26 (11% of all severe trauma cases) occurred as a result of cycling incidents. The most severe injury in 65% of patients was to the head and neck body region.
Research efforts and activities to prevent severe pediatric trauma in our region should focus on road safety, protection from head injuries, avoidance of falls, and prevention of child abuse.
PubMed ID
11791045 View in PubMed
Less detail

[10-year experience in the activities of the cardio-rheumatological section of the Moscow Society of Pediatricians].

https://arctichealth.org/en/permalink/ahliterature250896
Source
Pediatriia. 1976 Jul;(7):67-71
Publication Type
Article
Date
Jul-1976
Author
B G Leites
Source
Pediatriia. 1976 Jul;(7):67-71
Date
Jul-1976
Language
Russian
Publication Type
Article
Keywords
Child
Humans
Moscow
Pediatrics
Rheumatic heart disease
Societies, Medical
PubMed ID
995574 View in PubMed
Less detail

[22nd Congress of the International Council of Nurses 10 to 15 June in Copenhagen]

https://arctichealth.org/en/permalink/ahliterature30673
Source
Kinderkrankenschwester. 2001 Oct;20(10):429-32
Publication Type
Conference/Meeting Material
Date
Oct-2001
Author
C. Köhlen
Source
Kinderkrankenschwester. 2001 Oct;20(10):429-32
Date
Oct-2001
Language
German
Publication Type
Conference/Meeting Material
Keywords
Child
Denmark
Female
Humans
Male
Pediatric Nursing
Societies, Nursing
PubMed ID
14584163 View in PubMed
Less detail

[25th anniversary of the Lipetsk Children's Sanatorium, "Voskhod"].

https://arctichealth.org/en/permalink/ahliterature251203
Source
Pediatriia. 1976 Apr;(4):72-3
Publication Type
Article
Date
Apr-1976

[25th anniversary of the Moscow Children's Psychiatric Hospital No. 6].

https://arctichealth.org/en/permalink/ahliterature236035
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(10):1557-9
Publication Type
Article
Date
1987

[50th anniversary of the Chair of Pediatrics and Adolescent Medicine of the Order of Lenin central Institute of Graduate Training of Physicians].

https://arctichealth.org/en/permalink/ahliterature240287
Source
Gig Sanit. 1984 Aug;(8):38-40
Publication Type
Article
Date
Aug-1984

2487 records – page 1 of 249.