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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.
PLoS One. 2015;10(8):e0135018
Publication Type
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
PLoS One. 2015;10(8):e0135018
Publication Type
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Cross-Sectional Studies
Dyslipidemias - blood
Fatty Liver - pathology
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Muscles - pathology
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Sex Factors
Subcutaneous Fat - pathology
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
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PubMed ID
26252778 View in PubMed
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