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145 records – page 1 of 15.

The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men.

https://arctichealth.org/en/permalink/ahliterature165637
Source
Bone. 2007 Apr;40(4):1006-12
Publication Type
Article
Date
Apr-2007
Author
Anne Saarinen
Ville-Valtteri Välimäki
Matti J Välimäki
Eliisa Löyttyniemi
Kirsi Auro
Piia Uusen
Mairi Kuris
Anna-Elina Lehesjoki
Outi Mäkitie
Author Affiliation
Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
Source
Bone. 2007 Apr;40(4):1006-12
Date
Apr-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Bone Density - genetics
Calcifediol - blood
Finland
Fractures, Bone - etiology - genetics
Gene Frequency
Humans
LDL-Receptor Related Proteins - genetics
Low Density Lipoprotein Receptor-Related Protein-5
Male
Military Personnel
Osteoporosis - etiology - genetics
Parathyroid Hormone - blood
Polymorphism, Single Nucleotide
Risk factors
Abstract
Polymorphisms in the gene coding for low-density lipoprotein receptor-related protein 5 (LRP5) contribute to variation in bone mass in the general population. Whether this is due to influence on bone mass acquisition or on bone loss thereafter has not been established.
We studied the association of LRP5 polymorphisms with peak bone mass in young men. The study included 235 Finnish men, aged 18.3 to 20.6 years. Lifestyle factors and fracture history were recorded. Bone mineral content (BMC), density (BMD) and scan area were measured for the lumbar spine and proximal femur by dual energy X-ray absorptiometry (DXA). Blood and urine were collected for determination of bone turnover markers, serum 25-OHD and PTH. Genomic DNA was extracted from peripheral blood for genetic analysis of LRP5. Ten single nucleotide polymorphisms in LRP5 were analyzed and correlated with bone parameters.
Only the A1330V polymorphism of LRP5 significantly associated with bone parameters. In comparison with subjects with the AlaAla genotype (n=215), those with AlaVal genotype (n=20) had lower femoral neck BMC (P=0.029) and BMD (P=0.012), trochanter BMC (P=0.0067) and BMD (P=0.015), and total hip BMC (P=0.0044) and BMD (P=0.0089). Fracture history was similar for the genotypes.
The polymorphic valine variant at position 1330 of LRP5 was significantly associated with reduced BMC and BMD values in healthy young Finnish men. The results provide evidence for the crucial role of LRP5 in peak bone mass acquisition.
PubMed ID
17223614 View in PubMed
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Are CSN and NKF-K/DOQI mineral metabolism guidelines for hemodialysis patients achievable? Results from a provincial renal program.

https://arctichealth.org/en/permalink/ahliterature155898
Source
CANNT J. 2008 Apr-Jun;18(2):36-41, 44-50; quiz 42-3, 51-2
Publication Type
Article
Author
Lori D Wazny
Colette B Raymond
Esther M Lesperance
Keevin N Bernstein
Author Affiliation
Department of Pharmaceutical Services, Health Sciences Centre, Winnipeg, MB. Lwazny@hsc.mb.ca
Source
CANNT J. 2008 Apr-Jun;18(2):36-41, 44-50; quiz 42-3, 51-2
Language
English
French
Publication Type
Article
Keywords
Aged
Calcium - blood
Cross-Sectional Studies
Drug Utilization
Female
Guideline Adherence - standards
Hemodialysis Solutions - therapeutic use
Humans
Kidney Failure, Chronic - etiology - metabolism - therapy
Male
Manitoba
Medical Audit
Middle Aged
Monitoring, Physiologic
Outcome Assessment (Health Care)
Parathyroid Hormone - blood
Phosphorus - blood
Practice Guidelines as Topic
Quality Indicators, Health Care
Renal Dialysis - methods - standards
Serum Albumin - metabolism
Treatment Outcome
Abstract
The calcium, phosphorus, and parathyroid hormone targets recommended by the Canadian Society of Nephrology (CSN) encompass a wider range of values as compared to the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) guidelines. We sought to compare mineral metabolism parameters within the Manitoba Renal Program (MRP) to the CSN and NKF-K/DOQI guidelines. Medication use was also examined.
All hemodialysis patients in Manitoba were evaluated. Values for serum albumin, phosphorus, calcium, intact parathyroid hormone (PTH) and pertinent medications were collected.
Five hundred and forty-six patients were included in the analysis. Fifty-three per cent to 81% of MRP patients met individual CSN targets. However, only 26% of patients achieved all targets, despite high usage of phosphate (85.5% calcium carbonate, 16.1% sevelamer, 1.3% aluminum) and PTH-lowering drug therapies (30.2% calcitriol, 2.7% cinacalcet).
Only a small proportion of patients were able to achieve all three CSN mineral metabolism targets simultaneously. The majority of outliers presented with hyperphosphatemia or hypoparathyroidism.
PubMed ID
18669010 View in PubMed
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Are elderly Asians in Britain at a high risk of vitamin D deficiency and osteomalacia?

https://arctichealth.org/en/permalink/ahliterature215659
Source
Age Ageing. 1995 Mar;24(2):103-7
Publication Type
Article
Date
Mar-1995
Author
T. Solanki
R H Hyatt
J R Kemm
E A Hughes
R A Cowan
Author Affiliation
Selly Oak Hospital, Birmingham.
Source
Age Ageing. 1995 Mar;24(2):103-7
Date
Mar-1995
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Asia - ethnology
Calcifediol - blood
Cross-Cultural Comparison
Emigration and Immigration
Ethnic Groups
Female
Geriatric Assessment
Great Britain
Humans
Male
Middle Aged
Osteomalacia - blood - ethnology - prevention & control
Parathyroid Hormone - blood
Risk factors
Vitamin D Deficiency - blood - ethnology - prevention & control
Abstract
Many studies have shown the indigenous elderly population and Asian immigrants to be groups at particular risk of vitamin D deficiency and osteomalacia, but there are no data on the risks in elderly Asians. In this community-based study a group of elderly Asians was compared with control groups of elderly and young whites and young Asians. Levels of 25-hydroxyvitamin D3 (25-OHD3) were significantly lower (p
PubMed ID
7793330 View in PubMed
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The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women.

https://arctichealth.org/en/permalink/ahliterature195328
Source
Osteoporos Int. 2000;11(12):1031-5
Publication Type
Article
Date
2000
Author
G. Sigurdsson
L. Franzson
L. Steingrimsdottir
H. Sigvaldason
Author Affiliation
Department of Internal Medicine, University Hospital, Fossvogur, Reykjavik, Iceland. maria@shr.is
Source
Osteoporos Int. 2000;11(12):1031-5
Date
2000
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon - methods
Aged
Analysis of Variance
Bone Density - physiology
Bone Remodeling - physiology
Calcium - administration & dosage
Cod Liver Oil - administration & dosage
Collagen - urine
Cross-Sectional Studies
Female
Humans
Iceland
Osteocalcin - blood
Parathyroid Hormone - blood
Vitamin D - blood
Abstract
Parathyroid hormone (PTH) may be an important determinant of cortical bone remodeling in the elderly. Vitamin D status is one of the determining factors in this relationship. The aim of this study was to quantify the relationship between serum PTH, vitamin D and bone mineral density (BMD) in elderly women in Reykjavik (64 degrees N), where daily intake of cod liver oil is common and mean calcium intake is high. In PTH correlated inversely with 25(OH)D (r = -0.26, p
PubMed ID
11256894 View in PubMed
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The association between serum parathyroid hormone and bone mineral density, and the impact of smoking: the Tromso Study.

https://arctichealth.org/en/permalink/ahliterature87234
Source
Eur J Endocrinol. 2008 Mar;158(3):401-9
Publication Type
Article
Date
Mar-2008
Author
Sneve Monica
Emaus Nina
Joakimsen Ragnar Martin
Jorde Rolf
Author Affiliation
Department of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. monica.sneve@unn.no
Source
Eur J Endocrinol. 2008 Mar;158(3):401-9
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Aged
Bone Density
Cross-Sectional Studies
Female
Forearm
Hip Joint
Humans
Life Style
Male
Middle Aged
Motor Activity
Norway - epidemiology
Osteoporosis - blood - epidemiology
Parathyroid Hormone - blood
Predictive value of tests
Risk factors
Smoking - epidemiology - metabolism
Abstract
OBJECTIVE: To explore the relation between serum parathyroid hormone (PTH) and bone mineral density (BMD), adjusted for lifestyle factors including smoking. DESIGN: Cross-sectional study. METHODS: The Troms? Study is a population-based study performed for the fifth time in 2001. Serum PTH was measured and the subjects filled in a questionnaire covering lifestyle factors. BMD at the hip, distal and ultradistal forearm was measured. RESULTS: Complete datasets were available in 1442 men and 1368 women. Age, body mass index and serum PTH were strong predictors of BMD level at the hip in both genders. No significant relation was seen between serum PTH and BMD at the distal or ultradistal forearm. When smokers and non-smokers were analysed separately, the relation between PTH and BMD at the hip was significant in current non-smokers only. In males, current non-smokers had significantly higher BMD at all three measurement sites compared with current smokers. Male former smokers had values in between current and never smokers. There was a significant and negative relation between number of years smoked and BMD at the hip. In male former smokers, there was an increase in BMD with increasing years since smoking cessation. CONCLUSION: Serum PTH is negatively associated with BMD at the hip, and the relation seems to be masked, or diminished, by smoking. Smoking reduces BMD at the hip, distal and ultradistal forearm in males, and the effect appears to be mainly time and not dose dependent.
PubMed ID
18299475 View in PubMed
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Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.

https://arctichealth.org/en/permalink/ahliterature183926
Source
Am J Clin Nutr. 2003 Sep;78(3):485-92
Publication Type
Article
Date
Sep-2003
Author
Sulin Cheng
Frances Tylavsky
Heikki Kröger
Merja Kärkkäinen
Arja Lyytikäinen
Arvo Koistinen
Anitta Mahonen
Markku Alen
Jussi Halleen
Kalervo Väänänen
Christel Lamberg-Allardt
Author Affiliation
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. cheng@sport.jyu.fi
Source
Am J Clin Nutr. 2003 Sep;78(3):485-92
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Acid Phosphatase - blood
Biological Markers - blood
Bone Density
Bone Resorption - diagnosis
Calcium - urine
Calcium, Dietary - administration & dosage
Child
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Hyperparathyroidism, Secondary - diagnosis - etiology - metabolism
Isoenzymes - blood
Parathyroid Hormone - blood
Puberty - metabolism
Seasons
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - complications - diagnosis - epidemiology - metabolism
Abstract
Very few studies have evaluated both parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] and their effects on bone mass in children.
We studied the associations of serum 25(OH)D and intact PTH (iPTH) with bone mineral content (BMC) and bone mineral density (BMD) at different bone sites and the relation between serum 25(OH)D and iPTH in early pubertal and prepubertal Finnish girls.
The subjects were 10-12-y-old girls (n = 193) at Tanner stage 1 or 2, who reported a mean (+/- SD) dietary calcium intake of 733 +/- 288 mg/d. 25(OH)D, iPTH, tartrate-resistant acid phosphatase 5b (TRAP 5b), urinary calcium excretion, BMC, areal BMD, and volumetric BMD were assessed by using different methods.
Thirty-two percent of the girls were vitamin D deficient [serum 25(OH)D
Notes
Erratum In: Am J Clin Nutr. 2006 Jan;83(1):174
PubMed ID
12936933 View in PubMed
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Associations between polymorphisms related to calcium metabolism and human height: the Tromsø Study.

https://arctichealth.org/en/permalink/ahliterature126446
Source
Ann Hum Genet. 2012 May;76(3):200-10
Publication Type
Article
Date
May-2012
Author
Rolf Jorde
Johan Svartberg
Ragnar Martin Joakimsen
Guri Grimnes
Author Affiliation
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, Norway. rolf.jorde@unn.no
Source
Ann Hum Genet. 2012 May;76(3):200-10
Date
May-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body Height - genetics
Calcium - blood - metabolism
Female
Humans
Male
Middle Aged
Parathyroid Hormone - blood
Phosphates - blood
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
Vitamin D - analogs & derivatives - blood
Abstract
A number of single nucleotide polymorphisms (SNPs) related to height have been detected. Calcium metabolism is important for the skeleton and accordingly also for adult height. Therefore, in the present study, nine SNPs related to the vitamin D receptor (VDR) gene and serum levels of 25-hydroxyvitamin D (25(OH)D), calcium, phosphate and parathyroid hormone (PTH) were related to height in 9471 subjects. Relation with height was evaluated with linear regression for trend across SNP genotypes with age and gender as covariates. After correcting for multiple testing, significant associations with height were found for two SNPs related to the VDR gene (rs1544410 (Bsml) and rs7975232 (Apal)), one SNP related to serum 25(OH)D (rs3829251 at the DHCR7/NADSYN1 gene), one SNP related to serum calcium (rs1459015 at the PTH gene) and one SNP related to serum phosphate (rs1697421 at the ALPL gene). For rs3829251, the mean differences in height between major and minor homozygotes were 1.5-2.0 cm (P
PubMed ID
22390397 View in PubMed
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Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromsø study.

https://arctichealth.org/en/permalink/ahliterature281100
Source
Eur J Endocrinol. 2017 May;176(5):625-634
Publication Type
Article
Date
May-2017
Author
Gunhild Lerstad
Ellen E Brodin
Johan Svartberg
Rolf Jorde
Jan Brox
Sigrid K Brækkan
John-Bjarne Hansen
Source
Eur J Endocrinol. 2017 May;176(5):625-634
Date
May-2017
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Calcium - blood
Female
Humans
Male
Middle Aged
Norway - epidemiology
Parathyroid Hormone - blood
Proportional Hazards Models
Risk factors
Venous Thromboembolism - blood - epidemiology
Abstract
The relationship between serum levels of calcium, parathyroid hormone (PTH) and risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the associations between serum levels of calcium and PTH, with future risk of VTE in a general adult population.
Population-based cohort.
A total of 27 712 subjects (25-87 years) who participated in Tromsø 4 (1994-1995) and Tromsø 5 (2001-2002) surveys were included in the study, and total calcium and PTH were measured in 27 685 and 8547 subjects respectively. Incident VTE was recorded through December 31, 2012. Cox-regression models with calcium and PTH as time-varying exposures were used to calculate hazard ratios (HR) of VTE by quartiles of calcium and PTH. Quartiles of calcium and PTH were also combined to assess the effect of discordants of both PTH and calcium (e.g. highest and lowest quartiles of both calcium and PTH) on VTE risk using the middle two quartiles as reference.
There were 712 VTEs during 15.0 years of median follow-up. Serum levels of calcium and PTH were not associated with risk of VTE. However, subjects with discordant high serum levels of both calcium and PTH (calcium =2.45?mmol/L and PTH =4.0?pmol/L) had increased risk of VTE compared to those in subjects with normal calcium and PTH (multivariable HR: 1.78, 95% CI: 1.12-2.84).
Serum levels of calcium and PTH separately were not associated with future risk of VTE, but subjects with high levels of both calcium and PTH had increased risk of VTE compared to those in subjects with normal levels.
PubMed ID
28246149 View in PubMed
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Benign familial hyperphosphatasemia in Siberian huskies.

https://arctichealth.org/en/permalink/ahliterature61992
Source
Am J Vet Res. 1996 May;57(5):612-7
Publication Type
Article
Date
May-1996
Author
D F Lawler
D G Keltner
W E Hoffman
R F Nachreiner
R L Hegstad
P A Herndon
B J Fischer
Author Affiliation
Department of Pet Nutrition Research, Ralston Purina Co, St Louis, MO 63264, USA.
Source
Am J Vet Res. 1996 May;57(5):612-7
Date
May-1996
Language
English
Publication Type
Article
Keywords
Alkaline Phosphatase - blood
Animals
Bone and Bones - enzymology
Breeding
Calcium - blood
Diagnosis, Differential
Diet - veterinary
Dog Diseases - blood - diagnosis - genetics
Dogs
Female
Male
Metabolic Diseases - blood - genetics - veterinary
Parathyroid Hormone - blood
Abstract
OBJECTIVE--To evaluate benign familial hyperphosphatasemia involving serum alkaline phosphatase (SAP) in pups. DESIGN--Pups with markedly increased SAP activity were evaluated and compared with unaffected siblings, and with other unaffected Siberian Husky pups from the same colony. ANIMALS--8 related litters of Siberian Husky pups (n = 56). PROCEDURE--At ages 11 and 16 weeks, pups were given physical examinations and blood was obtained for hematologic and serum biochemical analyses (including electrolytes and isoenzymes of alkaline phosphatase), ionized calcium concentration, and serum parathyroid hormone concentration. Diet, growth and health performance, skeletal radiographs, and genealogical data also were evaluated. RESULTS--Of 42 pups tested, 17 had markedly high total SAP values. Mean total SAP activity of affected pups at ages 11 and 16 weeks was over 5 times greater than mean total SAP activity of unaffected siblings and other unaffected Siberian Husky pups of the same age (P
PubMed ID
8723869 View in PubMed
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BMD improvements after operation for primary hyperparathyroidism.

https://arctichealth.org/en/permalink/ahliterature119158
Source
Langenbecks Arch Surg. 2013 Jan;398(1):113-20
Publication Type
Article
Date
Jan-2013
Author
Lars Rolighed
Peter Vestergaard
Lene Heickendorff
Tanja Sikjaer
Lars Rejnmark
Leif Mosekilde
Peer Christiansen
Author Affiliation
Department of Surgery P, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. larsrolighed@gmail.com
Source
Langenbecks Arch Surg. 2013 Jan;398(1):113-20
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Bone Density
Calcium - blood
Cohort Studies
Creatinine - blood
Denmark
Female
Humans
Hyperparathyroidism, Primary - blood - surgery
Male
Middle Aged
Parathyroid Hormone - blood
Parathyroidectomy
Postoperative Complications - blood - diagnosis
Young Adult
Abstract
This study aims to quantify bone mineral density (BMD) changes following surgery in patients with primary hyperparathyroidism (PHPT) and to assess their relationship with clinical and biochemical variables.
A historic cohort of 236 PHPT patients with DXA scans pre- and 1-year postoperatively, clinical data, and biochemical data was analyzed.
The mean age was 60 years (range 19-86) and 81 % of the patients were women. A significant postoperative 2.6 % (95 % CI, 2.1; 3.1) increase in lumbar spine BMD was seen. The increase in BMD was positively associated with preoperative plasma PTH (p?=?0.002), Ca(2+) (p?
PubMed ID
23132462 View in PubMed
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145 records – page 1 of 15.