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[Diagnostic value of tumor markers in ENT oncology]

https://arctichealth.org/en/permalink/ahliterature22069
Source
Orv Hetil. 1997 May 18;138(20):1261-4
Publication Type
Article
Date
May-18-1997
Author
L. Tamás
I. Sziklai
O. Ribári
Author Affiliation
Semmelweis Orvostudományi Egyetem, Fül-Orr-Gégeklinika, Budapest.
Source
Orv Hetil. 1997 May 18;138(20):1261-4
Date
May-18-1997
Language
Hungarian
Publication Type
Article
Keywords
Aged
English Abstract
Female
Humans
Laryngeal Neoplasms - diagnosis - pathology - radiotherapy - surgery
Laryngectomy
Male
Middle Aged
Neoplasm Recurrence, Local - prevention & control
Neoplasm Staging
Palliative Care
Prognosis
Tumor Markers, Biological - diagnostic use
Abstract
Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80%, pH 2) extracts of sera and cancer specimen were gel chromatographed, and the nominally 0.3-5 KDa molecular mass substances were further examined by analytical capillary isotachophoresis (ITP) (LKB. Sweden). Serum samples were also examined after surgery of irradiation therapy. Serum and tumor extracts of each laryngeal cancer patient contained a substance in the molecular mass range of 0.3-5 kDa. This was not detected in the serum of normal control subjects. The marker-candidate substance disappeared from the serum of four out of 8 laryngectomized patients who live tumor-free for years. Recurrence or lymph node metastasis developed in three of the remaining four patients who did not become free of the marker substance after laryngectomy. The concentration of the marker has been increased in the serum after palliative irradiation in all four patients. This marker substance is probably a product of tumor necrosis. The marker may adequately monitor the recurrence of tumor postoperatively of after irradiation therapy.
PubMed ID
9244860 View in PubMed
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