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Interferon-gamma-dependent Immunity in Bacillus Calmette-Guérin Vaccine Osteitis Survivors.

https://arctichealth.org/en/permalink/ahliterature281961
Source
Pediatr Infect Dis J. 2016 06;35(6):690-4
Publication Type
Article
Date
06-2016
Author
Laura Pöyhönen
Liisa Kröger
Heini Huhtala
Johanna Mäkinen
Jussi Mertsola
Ruben Martinez-Barricarte
Jean-Laurent Casanova
Jacinta Bustamante
Qiushui He
Matti Korppi
Source
Pediatr Infect Dis J. 2016 06;35(6):690-4
Date
06-2016
Language
English
Publication Type
Article
Keywords
Adult
BCG Vaccine - administration & dosage - adverse effects
Female
Finland
Humans
Immunologic Factors - genetics
Interferon-gamma - secretion
Interleukin-12 - secretion
Leukocytes, Mononuclear - immunology
Male
Middle Aged
Mycobacterium bovis - immunology
Osteitis - chemically induced - immunology
Survivors
Young Adult
Abstract
Inborn errors of interferon-gamma (IFN-?)-mediated immunity underlie disseminated disease caused by Mycobacterium bovis Bacillus Calmette-Guérin (BCG) live vaccines. We hypothesized that some patients with osteitis after BCG vaccination may have an impaired IFN-? immunity. Our aim was to investigate interleukin (IL)-12 and IFN-? ex vivo production stimulated with BCG and BCG + IFN-? or BCG + IL-12, respectively, in BCG osteitis survivors.
Fresh blood samples were collected from 132 former BCG osteitis Finnish patients now aged 21-49 years, and IL-12 and IFN-? were measured in cell cultures with and without stimulation with BCG and with BCG + IFN-? or BCG + IL-12, respectively. As a pilot study, known disease-causing genes controlling IFN-? immunity (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, IRF8, NEMO and CYBB) were investigated in 20 selected patients by whole exome sequencing.
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Notes
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PubMed ID
26954602 View in PubMed
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