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66 records – page 1 of 7.

A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis.

https://arctichealth.org/en/permalink/ahliterature201582
Source
J Periodontol. 1999 Jun;70(6):657-67
Publication Type
Article
Date
Jun-1999
Author
D. van Steenberghe
B. Rosling
P O Söder
R G Landry
U. van der Velden
M F Timmerman
E F McCarthy
G. Vandenhoven
C. Wouters
M. Wilson
J. Matthews
H N Newman
Author Affiliation
Catholic University, Leuven, Belgium.
Source
J Periodontol. 1999 Jun;70(6):657-67
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Adult
Aggregatibacter actinomycetemcomitans - drug effects
Analysis of Variance
Anti-Bacterial Agents - administration & dosage
Campylobacter - drug effects
Canada
Chronic Disease
Colony Count, Microbial
Dental Plaque Index
Dental Scaling
Double-Blind Method
Eikenella corrodens - drug effects
Europe
Female
Fusobacterium nucleatum - drug effects
Humans
Longitudinal Studies
Male
Middle Aged
Minocycline - administration & dosage
Ointments
Periodontal Index
Periodontal Pocket - drug therapy - microbiology
Periodontitis - drug therapy - microbiology
Porphyromonas gingivalis - drug effects
Prevotella intermedia - drug effects
Statistics, nonparametric
Treatment Outcome
Treponema - drug effects
Abstract
A double-blind, randomized, parallel, comparative study was designed to evaluate the long-term safety and efficacy of subgingivally administered minocycline ointment versus a vehicle control.
One hundred four patients (104) with moderate to severe adult periodontitis (34 to 64 years of age; mean 46 years) were enrolled in the study. Following scaling and root planing, patients were randomized to receive either 2% minocycline ointment or a matched vehicle control. Study medication was administered directly into the periodontal pocket with a specially designed, graduated, disposable applicator at baseline; week 2; and at months 1, 3, 6, 9, and 12. Scaling and root planing was repeated at months 6 and 12. Standard clinical variables (including probing depth and attachment level) were evaluated at baseline and at months 1, 3, 6, 9, 12, and 15. Microbiological sampling using DNA probes was done at baseline; at week 2; and at months 1, 3, 6, 9, 12, and 15.
Both treatment groups showed significant and clinically relevant reductions in the numbers of each of the 7 microorganisms measured during the entire 15-month study period. When differences were detected, sites treated with minocycline ointment always produced statistically significantly greater reductions than sites which received the vehicle control. For initial pockets > or =5 mm, a mean reduction in probing depth of 1.9 mm was seen in the test sites, versus 1.2 mm in the control sites. Sites with a baseline probing depth > or =7 mm and bleeding index >2 showed an average of 2.5 mm reduction with minocycline versus 1.5 mm with the vehicle. Gains in attachment (0.9 mm and 1.1 mm) were observed in minocycline-treated sites, with baseline probing depth > or =5 mm and > or =7 mm, respectively, compared with 0.5 mm and 0.7 mm gain at control sites. Subgingival administration of minocycline ointment was well tolerated.
Overall, the results demonstrate that repeated subgingival administration of minocycline ointment in the treatment of adult periodontitis is safe and leads to significant adjunctive improvement after subgingival instrumentation in both clinical and microbiologic variables over a 15-month period.
PubMed ID
10397521 View in PubMed
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[Air pollution, eczema and asthma in Sør-Varanger. Is the high consumption of corticosteroid ointments caused by increased tendency for eczema?]

https://arctichealth.org/en/permalink/ahliterature16024
Source
Tidsskr Nor Laegeforen. 1993 Jan 20;113(2):218-21
Publication Type
Article
Date
Jan-20-1993
Author
H G Sunde
K A Holtedahl
Author Affiliation
Kommunehelsetjenesten i Sør-Varanger, Bjørnevatn.
Source
Tidsskr Nor Laegeforen. 1993 Jan 20;113(2):218-21
Date
Jan-20-1993
Language
Norwegian
Publication Type
Article
Keywords
Adolescent
Adrenal Cortex Hormones - administration & dosage
Adult
Aged
Air Pollutants, Environmental - adverse effects
Air Pollutants, Occupational - adverse effects
Asthma - chemically induced - drug therapy - epidemiology
Bronchodilator Agents - administration & dosage
Child
Drug Utilization
Eczema - chemically induced - drug therapy - epidemiology
English Abstract
Female
Humans
Male
Middle Aged
Norway - epidemiology
Ointments
Research Support, Non-U.S. Gov't
Abstract
Many investigations suggest that a high degree of air-borne pollution increases the prevalence of diseases like asthma and eczema. Sør-Varanger Municipality in Finnmark County in the north of Norway receives much air-borne pollution from domestic industry and from the metallurgic industry on the Kola peninsula in North-Western Russia. We have investigated indirect parameters of morbidity caused by asthma and eczema by analyzing data on drug consumption and hospital admissions. In Sør-Varanger there is high consumption of corticosteroids for dermatological use. Consumption of anti-asthmatic drugs and number of admissions to hospital for asthma and eczema were no higher than expected. We suspect that air-borne pollution, particularly the heavy metal nickel, increases the prevalence and perhaps worsens the degree of eczema in Sør-Varanger.
PubMed ID
8430405 View in PubMed
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[Aminocaoline complexes and the possibility of their use in pharmaceutical and medical practice]

https://arctichealth.org/en/permalink/ahliterature8965
Source
Farm Zh. 1968;23(5):61-5
Publication Type
Article
Date
1968
Author
A S Lekhan
G S Bashura
D P Salo
Source
Farm Zh. 1968;23(5):61-5
Date
1968
Language
Ukrainian
Publication Type
Article
Keywords
Aluminum Silicates - analysis
Ointments
Pharmaceutic Aids
Rheology
Suspensions
PubMed ID
5721777 View in PubMed
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An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: a randomized controlled trial.

https://arctichealth.org/en/permalink/ahliterature126052
Source
Breastfeed Med. 2012 Dec;7(6):473-9
Publication Type
Article
Date
Dec-2012
Author
Cindy-Lee Dennis
Nancy Schottle
Ellen Hodnett
Karen McQueen
Author Affiliation
Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. cindylee.dennis@utoronto.ca
Source
Breastfeed Med. 2012 Dec;7(6):473-9
Date
Dec-2012
Language
English
Publication Type
Article
Keywords
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Inflammatory Agents - administration & dosage
Antifungal Agents - administration & dosage
Betamethasone - administration & dosage
Breast Diseases - drug therapy - etiology
Breast Feeding - adverse effects
Dermatologic Agents - administration & dosage - pharmacology - therapeutic use
Double-Blind Method
Drug Combinations
Emollients
Female
Humans
Hydrocortisone - administration & dosage
Lanolin - pharmacology - therapeutic use
Miconazole - administration & dosage
Mupirocin - administration & dosage
Nipples - injuries
Ointments
Ontario
Patient satisfaction
Abstract
The negative outcomes associated with painful and damaged nipples have been widely documented in the breastfeeding literature. Numerous studies have been conducted evaluating topical preparations to treat nipple pain and damage with equivocal findings. No studies have evaluated the effectiveness of the increasingly popular all-purpose nipple ointment (APNO). The purpose of this trial is to evaluate the effect of the APNO versus lanolin on nipple pain among breastfeeding women with damaged nipples.
A double-blind, randomized controlled trial was conducted in a large single-site, tertiary-care hospital in Toronto, ON, Canada. Breastfeeding women (n=151) identified as having damage to one or both nipples were randomized to apply either APNO (intervention group) or lanolin (control group) to their nipples according to the trial protocol. The primary outcome was nipple pain at 1 week after randomization measured using the Short Form McGill Pain Questionnaire. Additional outcomes at 1 week after randomization and 12 weeks postpartum included nipple yeast symptoms and/or mastitis, rates of breastfeeding duration and exclusivity, and maternal satisfaction with infant feeding method and treatment ointment.
There were no significant group differences in mean pain scores at 1 week after randomization. Women in the lanolin group reported significantly greater satisfaction with their infant feeding method and had nonsignificantly higher breastfeeding duration and exclusivity rates at 12 weeks postpartum.
Results suggest that APNO is not superior to lanolin in treating painful, damaged nipples.
PubMed ID
22428572 View in PubMed
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[A new approach to the therapy of pyoderma in servicemen: the use of the actoprotector bemitil].

https://arctichealth.org/en/permalink/ahliterature204985
Source
Voen Med Zh. 1998 May;319(5):50-4, 96
Publication Type
Article
Date
May-1998
Author
A V Samtsov
G N Tarasenko
A V Smirnov
Source
Voen Med Zh. 1998 May;319(5):50-4, 96
Date
May-1998
Language
Russian
Publication Type
Article
Keywords
Adjuvants, Immunologic - therapeutic use
Adult
Antibody Formation - drug effects
Benzimidazoles - therapeutic use
Chronic Disease
Drug Evaluation
Humans
Immunity, Cellular - drug effects
Military Personnel
Ointments
Pyoderma - drug therapy - immunology
Recurrence
Russia
Tablets
Abstract
At 51 men at the age from 20 till 30, sick with pyodermatitis, the clinical-immunological aspects and efficiency of-actoprotector, capable to support motor activity and human performance in the extreme environments. Bemitil has appeared more effective in comparison with conventional therapy: by general and combined application the parameters of immunity have been normalized statistically authentically, and at outside application-the places of damage were cleared faster, disappeared painfulness, hyperemia, edema, terms of staying in the hospital were reduced. The clinical recovery was in 86.3 +/- 4.8% of the patients, while effectiveness from conventional means was 62.1 +/- 6.8%.
PubMed ID
9680838 View in PubMed
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[An experimental validation of the clinical use of a nitroglycerin ointment of an original composition]

https://arctichealth.org/en/permalink/ahliterature11574
Source
Lik Sprava. 1994 May-Jun;(5-6):117-8
Publication Type
Article
Author
M V Panchyshyna
Ia M Fedoriv
T A Shuflat
L A Bielova
Iu M Panchyshyn
Source
Lik Sprava. 1994 May-Jun;(5-6):117-8
Language
Ukrainian
Publication Type
Article
Keywords
Administration, Cutaneous
Animals
Coronary Vasospasm - chemically induced - drug therapy
Dermatitis, Allergic Contact - drug therapy - etiology
Dinitrochlorobenzene
Disease Models, Animal
Drug Evaluation, Preclinical
English Abstract
Nitroglycerin - administration & dosage - adverse effects
Ointments
Pituitary Hormones, Posterior
Rats
Abstract
Application employment of the proposed nitroglycerin ointment, original in its composition, permits the attacks of angina pectoris to be controlled, their onset to be prevented and adverse events associated with the use of nitrates to be eliminated. Therapeutic benefit becomes clinically apparent with small doses of nitroglycerin, the ointment itself is good for repeated therapeutic and prophylactic application.
PubMed ID
7530402 View in PubMed
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[An experimental validation of the use of levomycetin preparations for the treatment of burns infected with Pseudomonas aeruginosa]

https://arctichealth.org/en/permalink/ahliterature10610
Source
Mikrobiol Z. 1999 May-Jun;61(3):30-6
Publication Type
Article
Author
V L Tkachenko
A Ia Tsyganenko
N A Liapunov
E P Bezuglaia
V V Minukhin
Author Affiliation
Kharkov State Medical University, Ukraine.
Source
Mikrobiol Z. 1999 May-Jun;61(3):30-6
Language
Russian
Publication Type
Article
Keywords
Animals
Anti-Bacterial Agents - administration & dosage
Burns - complications - drug therapy - microbiology
Chloramphenicol - administration & dosage
Comparative Study
Disease Models, Animal
Drug Evaluation, Preclinical
English Abstract
Gels
Mice
Mice, Inbred CBA
Ointments
Pseudomonas Infections - drug therapy - microbiology
Pseudomonas aeruginosa - isolation & purification
Abstract
Application of 1% of chloramphenicol (gel and cream) for local treatment of Pseudomonas aeruginosa burn infection has been studied in experiment. In vivo, both medical forms show pronounced therapeutic effect, they promote elimination of P. aeruginosa from wounds and decrease inflammation. In noninfected thermal trauma in laboratory animals application of gel and cream of chloramphenicol reduces transition from the phase of inflammation to the phase of reparation by 3-8 days and prevents infection of the burn wound by conditionally pathogenic microflora.
PubMed ID
10483230 View in PubMed
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The association between exit site infection and subsequent peritonitis among peritoneal dialysis patients.

https://arctichealth.org/en/permalink/ahliterature123001
Source
Clin J Am Soc Nephrol. 2012 Aug;7(8):1266-71
Publication Type
Article
Date
Aug-2012
Author
Anouk T N van Diepen
George A Tomlinson
Sarbjit V Jassal
Author Affiliation
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Source
Clin J Am Soc Nephrol. 2012 Aug;7(8):1266-71
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Administration, Topical
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Antibiotic Prophylaxis
Bacitracin - administration & dosage
Catheter-Related Infections - diagnosis - microbiology - prevention & control
Catheters, Indwelling - adverse effects
Drug Combinations
Female
Gramicidin - administration & dosage
Humans
Male
Middle Aged
Mupirocin - administration & dosage
Ointments
Ontario
Peritoneal Dialysis - adverse effects - instrumentation
Peritonitis - diagnosis - microbiology - prevention & control
Polymyxin B - administration & dosage
Proportional Hazards Models
Prospective Studies
Risk assessment
Risk factors
Time Factors
Young Adult
Abstract
Peritonitis is the most common infectious complication seen in peritoneal dialysis (PD). Traditionally, exit site infection (ESI) has been thought to predispose PD patients to peritonitis, although the risks have not been quantified. This study aimed to quantify the risk of PD peritonitis after ESI.
Data from 203 clinically stable PD patients >18 years of age who were followed as part of a randomized controlled trial over 18 months were used to estimate the risk of developing peritonitis within 30 days of an ESI compared with individuals who did not have a recent ESI. Sensitivity analyses were performed at 15, 45, and 60 days.
Patients were mostly male (64.5%) and Caucasian, with a mean age of 60.5 ? 14.4 years. There were 44 ESIs and 87 peritonitis episodes during the 18-month study. Seven patients had an ESI followed by peritonitis within 30 days. Using a frailty model, patients who had an ESI had a significantly higher risk of developing peritonitis within 30 days, even if the ESI was appropriately treated. This risk was maximal early on and diminished with time, with hazard ratios (95% confidence interval) of 11.1 at 15 days (HR=11.1, 95% CI=4.9-25.1), 5.3 at 45 days (2.5-11.3), and 4.9 at 60 days (2.4-9.9). In 2.3% of patients, subsequent peritonitis was caused by the same organism as the previous ESI.
A strong association between a treated ESI and subsequent PD peritonitis was present up to 60 days after initial diagnosis.
Notes
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Comment In: Clin J Am Soc Nephrol. 2012 Aug;7(8):1206-822822015
PubMed ID
22745277 View in PubMed
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Clonal spread among Swedish children of a Staphylococcus aureus strain resistant to fusidic acid.

https://arctichealth.org/en/permalink/ahliterature31237
Source
Scand J Infect Dis. 2002;34(10):729-34
Publication Type
Article
Date
2002
Author
A. Osterlund
T. Eden
B. Olsson-Liljequist
S. Haeggman
G. Kahlmeter
Author Affiliation
Department of Clinical Microbiology, Central Hospital, Växjö, Sweden. osterlund@ltkronoberg.se
Source
Scand J Infect Dis. 2002;34(10):729-34
Date
2002
Language
English
Publication Type
Article
Keywords
Administration, Topical
Age Distribution
Child
Child, Preschool
Drug Resistance, Microbial
Electrophoresis, Gel, Pulsed-Field
Epidemiology, Molecular
Female
Fusidic Acid - pharmacology
Humans
Impetigo - drug therapy - epidemiology - microbiology
Infant
Male
Microbial Sensitivity Tests
Ointments
Prevalence
Probability
Retrospective Studies
Sensitivity and specificity
Sex Distribution
Staphylococcus aureus - drug effects - isolation & purification
Sweden - epidemiology
Abstract
An increased incidence of fusidic acid-resistant Staphylococcus aureus strains causing superficial infections among children in Sweden has been noted since the mid-1990s. Based on routine susceptibility testing data from 10 laboratories representing 8/21 Swedish counties during 1990-2001, the increase was first demonstrated in southern Sweden and subsequently became apparent throughout the country. Epidemiological typing using pulsed-field gel electrophoresis of recent isolates of fusidic acid-resistant S. aureus from 11 laboratories representing 8/21 Swedish counties revealed a high degree of similarity of band patterns, indicating a clonal relationship. Data from 1 of the laboratories demonstrated a close connection between this clone and impetigo. Sales statistics showed a pronounced increase in the use of fusidic acid ointments in the 0-12 y age group from 1998 onwards. There was, however, no statistically significant correlation between sales of fusidic acid ointments and resistance among S. aureus strains to fusidic acid.
PubMed ID
12477322 View in PubMed
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66 records – page 1 of 7.