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5409 records – page 1 of 541.

5-alpha-reductase 2 polymorphisms as risk factors in prostate cancer.

https://arctichealth.org/en/permalink/ahliterature19112
Source
Pharmacogenetics. 2002 Jun;12(4):307-12
Publication Type
Article
Date
Jun-2002
Author
Söderström T
Wadelius M
Andersson S-O
Johansson J-E
Johansson S
Granath F
Rane A
Author Affiliation
Department of Medical Sciences, Clinical Pharmacology, University Hospital, S-751 85 Uppsala, Sweden. torbjorn.soderstrom@lmk.ck.lul.se
Source
Pharmacogenetics. 2002 Jun;12(4):307-12
Date
Jun-2002
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Alleles
Case-Control Studies
Cell Differentiation
DNA - blood - metabolism
DNA Primers - chemistry
European Continental Ancestry Group
Genotype
Heterozygote
Humans
Male
Middle Aged
Neoplasm Staging
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Prostate-Specific Antigen - metabolism
Prostatic Neoplasms - enzymology - etiology - genetics
Research Support, Non-U.S. Gov't
Risk factors
Sweden - epidemiology
Testosterone 5-alpha-Reductase - genetics
Abstract
Prostate cancer is a significant cause of death in Western countries and is under the strong influence of androgens. The steroid 5alpha-reductase 2 catalyzes the metabolism of testosterone into the more potent androgen dihydrotestosterone in the prostate gland. The enzyme is a target in pharmacological treatment of benign prostatic hyperplasia using specific inhibitors such as finasteride. Makridakis et al. have characterized the V89L and A49T polymorphisms in recombinant expression systems. The L allelic variant has a lower Vmax/Km ratio than the V variant. In the A49T polymorphism, the T variant has an increased Vmax/Km ratio. We performed a population-based case-control study of the impact of the SRD5A2 V89L and A49T polymorphisms on the risk of prostate cancer. We also studied the relation between the genotypes and age at diagnosis, tumor, node, metastasis stage, differentiation grade, prostate specific antigen and heredity. The study included 175 prostate cancer patients and 159 healthy controls that were matched for age. There was an association with SRD5A2 V89L LL genotype and metastases at the time of diagnosis, OR 5.67 (95% CI 1.44-22.30) when adjusted for age, differentiation grade, T-stage and prostate specific antigen. Heterozygous prostate cancer cases that carried the SRD5A2 A49T AT genotype were significantly younger than cases that carried the AA genotype, (mean age 66 years vs 71, P = 0.038). The SRD5A2 V89L and A49T polymorphisms were, however, not associated with altered prostate cancer risk. Further studies of the V89L polymorphism may lead to better understanding of the etiology of prostate cancer metastases.
PubMed ID
12042668 View in PubMed
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A 5-year follow-up of occlusal status and radiographic findings in mandibular condyles of the elderly.

https://arctichealth.org/en/permalink/ahliterature187416
Source
Int J Prosthodont. 2002 Nov-Dec;15(6):539-43
Publication Type
Article
Author
Kaija Hiltunen
Miira M Vehkalahti
Jaakko S Peltola
Anja Ainamo
Author Affiliation
Department of Prosthodontics, Institute of Dentistry, University of Helsinki, Finland. kaija.hiltunen@helsinki.fi
Source
Int J Prosthodont. 2002 Nov-Dec;15(6):539-43
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Aged, 80 and over
Chi-Square Distribution
Confidence Intervals
Dentition
Denture, Partial, Fixed
Dentures
Dislocations - classification - radiography
Female
Finland
Follow-Up Studies
Humans
Jaw, Edentulous, Partially - classification - rehabilitation
Logistic Models
Male
Mandibular Condyle - radiography
Odds Ratio
Osteoarthritis - classification - radiography
Osteosclerosis - classification - radiography
Radiography, Panoramic
Risk factors
Sex Factors
Temporomandibular Joint Disorders - classification - radiography
Abstract
The aim of the present 5-year follow-up was to clarify the nature of occlusal support status and radiographic changes in condyles of the elderly, and the association between these two variables.
The present study is part of a comprehensive medical survey of a random sample born in 1904, 1909, and 1914. A total of 364 subjects living in Helsinki participated in the dental part of the examination during 1990 to 1991, and after 5 years a total of 103 were reexamined. Comprehensive data on occlusal support status were available for 94 subjects, and radiographic data were available for 88 subjects. Occlusal support status was assessed on the basis of the Eichner index, radiographic changes were assessed from panoramic radiographs, and symptoms of temporomandibular disorders were assessed using Helkimo's anamnestic index.
The most frequent radiographic finding in the mandibular joint was flattening of the articular surface of the condyle associated with osteoarthrosis, found at baseline in 17% and during follow-up in 13% of the subjects. During the 5-year follow-up, Eichner index for natural dentition remained unaltered in 94% of the subjects and in 85% of the subjects when removable dentures were included. There were no radiographic changes in 92% of the cases. No differences based on age or gender were found. A logistic regression model revealed associations between the selected baseline factors. The odds ratio for baseline Helkimo's anamnestic index was 4.1, 5.7 for Eichner index with the support of removable dentures, and 356 for radiographic findings.
Radiographic changes in condyles of elderly people were small during the 5-year follow-up, but baseline radiographic findings, Helkimo's anamnestic index, and Eichner index with removable dentures were risk factors for radiographic findings at the end of the follow-up.
PubMed ID
12475158 View in PubMed
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5-year morbidity among very preterm infants in relation to level of hospital care.

https://arctichealth.org/en/permalink/ahliterature119186
Source
JAMA Pediatr. 2013 Jan;167(1):40-6
Publication Type
Article
Date
Jan-2013
Author
Liisi Rautava
Janne Eskelinen
Unto Häkkinen
Liisa Lehtonen
Author Affiliation
Department of Pediatrics, Turku University Hospital, 20520 Turku, Finland. liisi.rautava@utu.fi
Source
JAMA Pediatr. 2013 Jan;167(1):40-6
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Child, Preschool
Cohort Studies
Female
Finland - epidemiology
Humans
Incidence
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology - etiology - therapy
Intensive Care, Neonatal
Logistic Models
Male
Odds Ratio
Outcome and Process Assessment (Health Care)
Patient transfer
Registries
Secondary Care
Tertiary Care Centers
Tertiary Healthcare
Abstract
To determine whether birth and care in the highest-level hospitals (level III) compared with birth in or postnatal transfer to lower-level hospitals (level II) are associated with 5-year morbidity in very preterm children.
A cohort study.
Finland.
All surviving 5-year-old children born very preterm (gestational age
PubMed ID
23128961 View in PubMed
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12-month prevalence of depression among single and married mothers in the 1994 National Population Health Survey.

https://arctichealth.org/en/permalink/ahliterature200239
Source
Can J Public Health. 1999 Sep-Oct;90(5):320-4
Publication Type
Article
Author
J. Cairney
C. Thorpe
J. Rietschlin
W R Avison
Author Affiliation
Department of Health Studies, Brock University, St. Catharines, ON.
Source
Can J Public Health. 1999 Sep-Oct;90(5):320-4
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Canada - epidemiology
Depressive Disorder - epidemiology
Female
Humans
Marital status
Middle Aged
Mothers - psychology
Multivariate Analysis
Odds Ratio
Prevalence
Single Parent - psychology
Abstract
While a number of studies have documented higher period prevalence rates of depression among single as compared to married mothers, all of the data have been based upon community surveys of mental illness. In Canada, all of the published work comes from Ontario. As a result, we do not know whether these results hold true for other regions of the country. Using a nationally representative sample, we find, consistent with previous work, that single mothers have almost double the 12-month prevalence rates of married mothers (15.4% versus 6.8%). As well, there are no significant differences in rates of depression between single and married mothers by region/province of the country. Our findings are compared with other epidemiologic data on the mental health of single mothers from Ontario.
PubMed ID
10570576 View in PubMed
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The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients.

https://arctichealth.org/en/permalink/ahliterature168816
Source
Tissue Antigens. 2006 Jul;68(1):78-81
Publication Type
Article
Date
Jul-2006
Author
E. Melum
T H Karlsen
U. Broomé
E. Thorsby
E. Schrumpf
K M Boberg
B A Lie
Author Affiliation
Institute of Immunology, Rikshospitalet University Hospital, Sognsvannsyn 20, 0027 Oslo, Norway.
Source
Tissue Antigens. 2006 Jul;68(1):78-81
Date
Jul-2006
Language
English
Publication Type
Article
Keywords
Alleles
Base Pairing
Case-Control Studies
Cholangitis, Sclerosing - etiology
Confidence Intervals
Disease Progression
Female
Gene Deletion
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Odds Ratio
Receptors, CCR5 - genetics
Scandinavia - epidemiology
Abstract
CCR5 is a chemokine receptor expressed on T-cells and macrophages. A 32-base pair deletion in the chemokine receptor 5 gene (CCR5-Delta32) leads to a non-functional receptor. Conflicting evidence exists whether this deletion is associated with primary sclerosing cholangitis (PSC). We genotyped the CCR5-Delta32 variant in 363 PSC patients and 366 controls. No significant increase in the Delta32 allele frequency was detected in the PSC patients compared to controls (12.7% vs 10.7% OR = 1.22, 95% CI [0.88, 1.68], P = 0.23). Survival analysis did not reveal any significant effects from CCR5-Delta32 genotypes on disease progression. Thus, in this study (power > 90%, given OR = 2, alpha = 0.05), we were unable to replicate previous findings and our results do not support an involvement of CCR5-Delta32 in either PSC susceptibility or progression.
Notes
Erratum In: Tissue Antigens. 2006 Aug;68(2):192
PubMed ID
16774544 View in PubMed
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The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E.

https://arctichealth.org/en/permalink/ahliterature138513
Source
J Appl Genet. 2011 May;52(2):201-7
Publication Type
Article
Date
May-2011
Author
Dimitry A Chistiakov
Natalia V Voronova
Rust I Turakulov
Kirill V Savost'anov
Author Affiliation
Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545, Moscow, Russia. dimitry.chistiakov@lycos.com
Source
J Appl Genet. 2011 May;52(2):201-7
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asthma - genetics
Case-Control Studies
Female
Genetic Association Studies
Genetic markers
Genetic Predisposition to Disease
Genotype
Graves Disease - epidemiology - genetics
Humans
Hypersensitivity - genetics
Immunoglobulin E - blood
Male
Odds Ratio
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Russia - epidemiology
Secretoglobins
Sequence Analysis, DNA
Uteroglobin - blood - genetics
Young Adult
Abstract
The human secretoglobin 3A2 (SCGB3A2) gene encoding secretory uteroglobin-related protein 1 (UGRP1) resides on the chromosome region 5q31-33 that harbors a susceptibility locus to several autoimmune and inflammatory diseases, including asthma and Graves' disease (GD). Recently, association between the marker rs1368408 (-112G?>A), located in the promoter region of the SCGB3A2 gene, and susceptibility to GD was found in Chinese and UK Caucasians. The study aim was to evaluate whether this polymorphism confers GD susceptibility in a large population cohort comprising 1,474 Russian GD patients and 1,619 controls. The marker rs1368408 was studied using a TaqMan allele discrimination assay. Serum levels of UGRP1 and immunoglobulin E (IgE) were assessed using enzyme-linked immunosorbent assay (ELISA) analyses. Association between the allele A of SCGB3A2 and a higher risk of GD (odds ratio [OR] = 1.33, P = 2.9 × 10(-5)) was shown. Both affected and non-affected carriers of the higher risk genotype A/A had significantly decreased levels of serum UGRP1 compared to the subjects homozygous for G/G (93 ± 37 pg/ml vs. 132 ± 45 pg/ml, P = 0.0011 for GD patients; 77 ± 28 pg/ml vs. 119 ± 33 pg/ml, P = 0.0019 for controls). Serum IgE levels were significantly higher in non-affected subjects homozygous for A/A compared to control individuals homozygous for G/G (153 ± 46 IU/ml vs. 122 ± 40 IU/ml, P = 0.0095). Our data suggest that the carriage of the SCGB3A2 -112A/A variant increases the risk for GD in subsets of patients with elevated levels of IgE, a hallmark of allergic asthma. Therefore, the SCGB3A2 -112G?>A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and GD on chromosome 5q31-33.
PubMed ID
21170691 View in PubMed
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The 2000 tularemia outbreak: a case-control study of risk factors in disease-endemic and emergent areas, Sweden.

https://arctichealth.org/en/permalink/ahliterature188853
Source
Emerg Infect Dis. 2002 Sep;8(9):956-60
Publication Type
Article
Date
Sep-2002
Author
Henrik Eliasson
Johan Lindbäck
J Pekka Nuorti
Malin Arneborn
Johan Giesecke
Anders Tegnell
Author Affiliation
Orebro University Hospital, Sweden.
Source
Emerg Infect Dis. 2002 Sep;8(9):956-60
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Agriculture
Animals
Bites and Stings - microbiology
Case-Control Studies
Cat Diseases - microbiology - transmission
Cats
Culicidae - microbiology
Disease Outbreaks
Disease Vectors
Female
Francisella tularensis
Humans
Lymph Nodes - pathology
Male
Multivariate Analysis
Odds Ratio
Questionnaires
Risk factors
Sweden - epidemiology
Tularemia - epidemiology - pathology - transmission
Abstract
A widespread outbreak of tularemia in Sweden in 2000 was investigated in a case-control study in which 270 reported cases of tularemia were compared with 438 controls. The outbreak affected parts of Sweden where tularemia had hitherto been rare, and these "emergent" areas were compared with the disease-endemic areas. Multivariate regression analysis showed mosquito bites to be the main risk factor, with an odds ratio (OR) of 8.8. Other risk factors were owning a cat (OR 2.5) and farm work (OR 3.2). Farming was a risk factor only in the disease-endemic area. Swollen lymph nodes and wound infections were more common in the emergent area, while pneumonia was more common in the disease-endemic area. Mosquito bites appear to be important in transmission of tularemia. The association between cat ownership and disease merits further investigation.
Notes
Cites: Scand J Infect Dis. 1985;17(4):371-54089543
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PubMed ID
12194773 View in PubMed
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The AAA with a challenging neck: outcome of open versus endovascular repair with standard and fenestrated stent-grafts.

https://arctichealth.org/en/permalink/ahliterature88967
Source
J Endovasc Ther. 2009 Apr;16(2):137-46
Publication Type
Article
Date
Apr-2009
Author
Chisci Emiliano
Kristmundsson Thorarinn
de Donato Gianmarco
Resch Timothy
Setacci Francesco
Sonesson Björn
Setacci Carlo
Malina Martin
Author Affiliation
Vascular and Endovascular Surgery Unit, University of Siena, Italy. e.chisci@gmail.com
Source
J Endovasc Ther. 2009 Apr;16(2):137-46
Date
Apr-2009
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - mortality - radiography - surgery
Aortography - methods
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation - adverse effects - instrumentation - mortality
Female
Humans
Italy
Kaplan-Meiers Estimate
Male
Middle Aged
Odds Ratio
Prosthesis Design
Prosthesis Failure
Reoperation
Retrospective Studies
Risk assessment
Stents
Sweden
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Abstract
PURPOSE: To compare the outcome of endovascular aneurysm repair (EVAR) versus conventional open repair (OR) in patients with a short, angulated or otherwise challenging proximal neck. METHODS: The definition of a challenging proximal neck was based on diameter (>or=28 mm), length (or=60 degrees ), shape (reverse tapered or bulging), and thrombus lining (>50%). Between January 2005 and December 2007, 187 consecutive patients (159 men; mean age 73 years, range 48-92) operated for asymptomatic abdominal aortic aneurysm (AAA) were identified as having challenging proximal neck morphology. Of these, 61 patients were treated with OR at center I (group A), 71 with standard EVAR (group B; 45 center I, 29 center II) and 52 with fenestrated EVAR (group C) at center II. Clinical examination and computed tomography were performed at 1 month and yearly thereafter. RESULTS: There was no statistically significant difference between groups A, B, and C regarding primary technical success rate, 30-day mortality, or late AAA-related mortality. The mean length of follow-up was 19.5 months (range 0-40). Freedom from reintervention at 3 years was 91.8%, 79.7%, and 82.7% for groups A, B, and C, respectively (p = 0.042). The only statistically significant difference between standard and fenestrated EVAR was a higher incidence of late sac expansion [9 (12.2%) versus 1 (1.9%), p = 0.036] in the standard stent-graft group. Reinterventions were more frequent after EVAR (p = NS), but open reinterventions were more common after OR. Reinterventions after EVAR were related to the presence of an angulated (p = 0.039) or short neck (p = 0.024). CONCLUSION: The results of EVAR and OR were similar for AAAs with a challenging proximal neck. Endovascular reinterventions were more frequent after EVAR, particularly in patients with an angulated or short neck. Open reinterventions were more common after OR. More patients and long-term data are needed to confirm these findings.
Notes
Comment In: J Endovasc Ther. 2009 Apr;16(2):147-819456195
PubMed ID
19456190 View in PubMed
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Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population.

https://arctichealth.org/en/permalink/ahliterature284958
Source
Hypertension. 2016 Nov;68(5):1115-1122
Publication Type
Article
Date
Nov-2016
Author
Ekim Seven
Betina H Thuesen
Allan Linneberg
Jørgen L Jeppesen
Source
Hypertension. 2016 Nov;68(5):1115-1122
Date
Nov-2016
Language
English
Publication Type
Article
Keywords
Adult
Blood Pressure Determination
Body mass index
Cross-Sectional Studies
Denmark
Female
Humans
Hypertension - diagnosis - epidemiology - etiology
Incidence
Intra-Abdominal Fat - diagnostic imaging - physiopathology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Obesity, Abdominal - complications - diagnostic imaging
Odds Ratio
Prognosis
Prospective Studies
Risk assessment
Severity of Illness Index
Subcutaneous Fat - diagnostic imaging - physiopathology
Ultrasonography, Doppler - methods
Abstract
Abdominal obesity is a major risk factor for hypertension. However, different distributions of abdominal adipose tissue may affect hypertension risk differently. The main purpose of this study was to explore the association of subcutaneous abdominal adipose tissue (SAT) and visceral adipose tissue (VAT) with incident hypertension in a population-based setting. We hypothesized that VAT, rather than SAT, would be associated with incident hypertension. VAT and SAT were determined by ultrasound imagining in 3363 randomly selected Danes (mean age 49 years, 56% women, mean body mass index 25.8 kg/m(2)). We constructed multiple logistic regression models to compute standardized odds ratios with 95% confidence intervals per SD increase in SAT and VAT. Of the 2119 normotensive participants at baseline, 1432, with mean SAT of 2.8 cm and mean VAT of 5.7 cm, returned 5 years later for a follow-up examination and among them 203 had developed hypertension. In models including both VAT and SAT, the Framingham Hypertension Risk Score variables (age, sex, smoking status, family history of hypertension, and baseline blood pressure) and glycated hemoglobin, odds ratio (95% confidence interval) for incident hypertension for 1 SD increase in VAT and SAT was 1.27 (1.08-1.50, P=0.004) and 0.97 (0.81-1.15, P=0.70), respectively. Adjusting for body mass index instead of SAT attenuated the association between VAT and incident hypertension, but it was still significant (odds ratio, 1.22 [1.01-1.48, P=0.041] for each SD increase in VAT). In conclusion, ultrasound-determined VAT, but not SAT, was associated with incident hypertension in a random sample of Danish adults.
PubMed ID
27620395 View in PubMed
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Abdominal aortic diameter is increased in males with a family history of abdominal aortic aneurysms: results from the Danish VIVA-trial.

https://arctichealth.org/en/permalink/ahliterature260407
Source
Eur J Vasc Endovasc Surg. 2014 Dec;48(6):669-75
Publication Type
Article
Date
Dec-2014
Author
T M M Joergensen
K. Houlind
A. Green
J S Lindholt
Source
Eur J Vasc Endovasc Surg. 2014 Dec;48(6):669-75
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Aged
Aorta, Abdominal - ultrasonography
Aortic Aneurysm, Abdominal - epidemiology - genetics - ultrasonography
Chi-Square Distribution
Cross-Sectional Studies
Denmark - epidemiology
Dilatation, Pathologic
Female
Genetic Predisposition to Disease
Heredity
Humans
Linear Models
Male
Multivariate Analysis
Odds Ratio
Pedigree
Phenotype
Predictive value of tests
Prevalence
Questionnaires
Registries
Risk factors
Sex Factors
Time Factors
Abstract
To investigate, at a population level, whether a family history of abdominal aortic aneurysm (AAA) is independently related to increased aortic diameter and prevalence of AAA in men, and to elucidate whether the mean aortic diameter and the prevalence of AAA are different between participants with male and female relatives with AAA.
Observational population-based cross-sectional study.
18,614 male participants screened for AAA in the VIVA-trial 2008-2011 with information on both family history of AAA and maximal aortic diameter.
Standardized ultrasound scan measurement of maximum antero-posterior aortic diameter. Family history obtained by questionnaire. Multivariate regression analysis was used to test for confounders: age, sex, smoking, comorbidity and medication.
From the screened cohort, 569 participants had at least one first degree relative diagnosed with AAA, and 38 had AAA. Participants with a family history of AAA (+FH) had a significantly larger mean maximum aortic diameter (20.50 mm) compared with participants without family history of AAA (-FH) (19.07 mm, p
PubMed ID
25443525 View in PubMed
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5409 records – page 1 of 541.