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Carbon disulfide exposure and neurotoxic sequelae among viscose rayon workers.

https://arctichealth.org/en/permalink/ahliterature103643
Source
Am J Ind Med. 1990;18(1):25-37
Publication Type
Article
Date
1990
Author
O. Aaserud
O J Hommeren
B. Tvedt
P. Nakstad
G. Mowé
J. Efskind
D. Russell
E B Jörgensen
R. Nyberg-Hansen
K. Rootwelt
Author Affiliation
Department of Neurology, Rikshospitalet, National Hospital, University of Oslo, Norway.
Source
Am J Ind Med. 1990;18(1):25-37
Date
1990
Language
English
Publication Type
Article
Keywords
Adult
Aged
Brain Diseases - chemically induced - diagnosis - epidemiology
Carbon Disulfide - adverse effects
Cellulose
Humans
Male
Middle Aged
Morbidity
Norway - epidemiology
Occupational Diseases - chemically induced - diagnosis - epidemiology
Peripheral Nervous System Diseases - chemically induced - diagnosis - epidemiology
Textile Industry
Textiles
Abstract
In Norway's only viscose rayon plant, carbon disulfide (CS2) concentrations in ambient air usually were between 30 and 50 mg/m3 during the first 23 years of production. From 1970/1971 until the factory was closed in 1982, corresponding values were 10-25 mg/m3. Through all of these years, high peak exposures of CS2 and H2S occurred. In 1986, 16 of the 24 men still at work in 1982 and with at least 10 years' experience in the spinning room agreed to participate in this study. Clinical neurological examination demonstrated abnormalities in 15; neuropsychological tests showed impairments of probable organic origin in 14. Thirteen had cerebral atrophy demonstrated by cerebral computed tomography (CT). Electromyography (EMG) was abnormal in six, neurography in 11. Regional cerebral blood flow measurements indicated flow asymmetries in eight, whereas Doppler investigation of the extracranial carotid and vertebral arteries, electroencephalography (EEG), and evoked response investigations were mostly normal. Based on these results and the exposure data, a diagnosis of CS2-induced encephalopathy was reached in eight workers; another six had an encephalopathy in which CS2 exposure was regarded as a partial cause. Correspondingly, seven had a neuropathy probably caused by CS2 exposure alone; in three others, CS2 was found to be the partial cause of a neuropathy. This indicates that long-term, relatively moderate exposure to CS2 in association with high peak exposures to CS2 and H2S involves a substantial risk of developing neurotoxic disease.
PubMed ID
2165741 View in PubMed
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[CHROMOSOMAL DISORDERS IN WORKERS OF CHEMICALLY HAZARDOUS ENTERPRISES WITH THE DIFFERENT HEALTH STATUS].

https://arctichealth.org/en/permalink/ahliterature270128
Source
Gig Sanit. 2015;94(8):31-5
Publication Type
Article
Date
2015
Author
T V Kharchenko
L G Arzhavkina
D A Siniachkin
A V Yazenok
Source
Gig Sanit. 2015;94(8):31-5
Date
2015
Language
Russian
Publication Type
Article
Keywords
Chromosome Disorders - chemically induced - diagnosis - epidemiology
Cytogenetic Analysis
Female
Hazardous Substances - adverse effects
Health status
Humans
Incidence
Male
Occupational Diseases - chemically induced - diagnosis - epidemiology
Occupational Exposure - adverse effects
Russia - epidemiology
Abstract
OBJECTIVES. Chromosomal aberrations (CAs) are the one of the most sensitive biomarikers of biological effects from the hazardous environmental exposure. In this relation the comparison of cytogenetical indices in persons, exposed to the complex of factors of chemically hazard enterprises, with the presence of occupationally caused diseases seems to be very perspective for the understanding of the role of the contribution of genotoxical impact of occupational factors into staff morbidity. METHODS. Cytogenetical analysis was performed in 138 employees of chemically hazardous enterprises, including 84 patients, who need for establishment of the causation of diseases with the work in conditions of chemical plant and 54 persons without need for hospitalization according to results of the previous examination. Comparison group was consisted of 55 persons. There was performed the comparison of cytogenetical indices and commensuration of ratios of persons with individual high CAs levels and also carriers of exchange aberrations of chromosomal type in different groups of examined cases. RESULTS. There was shown statistically significant increase of the rate of CAs level including unexpectedly high level of dicentric and ring chromosomes in the group of 84 hospitalized patients. There was revealed statistically significant gain in the share of persons with CAs rate more then 5% (p
PubMed ID
26856169 View in PubMed
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Clinical and laboratory features of acute sulfur dioxide inhalation poisoning: two-year follow-up.

https://arctichealth.org/en/permalink/ahliterature231309
Source
Am Rev Respir Dis. 1989 Feb;139(2):556-8
Publication Type
Article
Date
Feb-1989
Author
S. Rabinovitch
N D Greyson
W. Weiser
V. Hoffstein
Author Affiliation
Department of Nuclear Medicine, University of Toronto, St. Michael's Hospital, Ontario, Canada.
Source
Am Rev Respir Dis. 1989 Feb;139(2):556-8
Date
Feb-1989
Language
English
Publication Type
Article
Keywords
Accidents, Occupational
Acute Disease
Adult
Blast Injuries - diagnosis
Burns, Chemical - diagnosis
Burns, Inhalation - diagnosis
Canada
Copper
Explosions
Follow-Up Studies
Humans
Lung - drug effects - physiopathology
Lung Injury
Male
Mining
Occupational Diseases - chemically induced - diagnosis - physiopathology
Sulfur Dioxide - poisoning
Abstract
We present clinical and laboratory results (including nuclear imaging) obtained over a period of two years in two nonsmoking miners who were exposed to high concentrations of sulfur dioxide (SO2) after a mine explosion. Within 3 wk of the accident, both miners had evidence of severe airways obstruction, hypoxemia, markedly reduced exercise tolerance, ventilation-perfusion mismatch, and evidence of active inflammation as documented by positive gallium lung scan. Serial ventilation-perfusion scans over the first 12 months showed progressive improvement without returning to normal. After the initial recovery, there has been no significant change over the subsequent two years postinjury. Pulmonary function and exercise tests also displayed a similar pattern of initial improvement. We conclude that (1) acute exposure to high concentrations of SO2 results in severe airways obstruction, (2) pulmonary function abnormalities are partially reversible, and (3) most of the improvement occurs within 12 months after the initial injury.
PubMed ID
2913900 View in PubMed
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