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[Chronic occupational bronchitis in workers of coal extracting enterprises in Kouzbass: role of endogenous factors].

https://arctichealth.org/en/permalink/ahliterature143489
Source
Med Tr Prom Ekol. 2010;(3):37-40
Publication Type
Article
Date
2010
Author
N I Gafarov
V V Zakharenkov
N I Panev
A V Burdein
V P Puzyrev
A A Rudko
Source
Med Tr Prom Ekol. 2010;(3):37-40
Date
2010
Language
Russian
Publication Type
Article
Keywords
Acid Phosphatase - blood
Adult
Biological Markers - blood
Bronchitis, Chronic - blood - epidemiology - genetics
Carboxylesterase - blood
Coal
Coal Mining
Dust
Genetic Predisposition to Disease
Genotype
Haptoglobins - metabolism
Humans
Middle Aged
Occupational Diseases - blood - epidemiology - genetics
Occupational Exposure - adverse effects
Polymorphism, Genetic
Prevalence
Siberia - epidemiology
Vitamin D-Binding Protein - blood
Abstract
The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.
PubMed ID
20480820 View in PubMed
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