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Serum cystatin C and the risk of Alzheimer disease in elderly men.

https://arctichealth.org/en/permalink/ahliterature91831
Source
Neurology. 2008 Sep 30;71(14):1072-9
Publication Type
Article
Date
Sep-30-2008
Author
Sundelöf J.
Arnlöv J.
Ingelsson E.
Sundström J.
Basu S.
Zethelius B.
Larsson A.
Irizarry M C
Giedraitis V.
Rönnemaa E.
Degerman-Gunnarsson M.
Hyman B T
Basun H.
Kilander L.
Lannfelt L.
Author Affiliation
Uppsala University, Department of Public Health/Geriatrics, Uppsala Science Park, Uppsala, Sweden. johan.sundelof@pubcare.uu.se
Source
Neurology. 2008 Sep 30;71(14):1072-9
Date
Sep-30-2008
Language
English
Publication Type
Article
Keywords
Aged
Aging - blood
Alzheimer Disease - blood - epidemiology - physiopathology
Biological Markers - analysis - blood
Brain - metabolism - physiopathology
Causality
Cohort Studies
Cystatin C
Cystatins - analysis - blood
Cytoprotection - physiology
Down-Regulation - physiology
Humans
Hyperlipidemias - epidemiology
Kidney Diseases - epidemiology
Longitudinal Studies
Male
Obesity - epidemiology
Predictive value of tests
Proportional Hazards Models
Risk factors
Smoking - epidemiology
Sweden - epidemiology
Abstract
BACKGROUND: Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD). METHODS: Serum cystatin C levels were analyzed at two examinations of the Uppsala Longitudinal Study of Adult Men, a longitudinal, community-based study of elderly men (age 70 years, n = 1,153 and age 77 years, n = 761, a subset of the age 70 examination). Cox regressions were used to examine associations between serum cystatin C and incident AD. AD cases were identified by cognitive screening and comprehensive medical chart review in all subjects. RESULTS: On follow-up (median 11.3 years), 82 subjects developed AD. At age 70 years, lower cystatin C was associated with higher risk of AD independently of age, APOE4 genotype, glomerular filtration rate, diabetes, hypertension, stroke, cholesterol, body mass index, smoking, education level, and plasma amyloid-beta protein 40 and 42 levels (hazard ratio [HR] for lowest [1.30 micromol/L] tertile = 2.67, 95% CI 1.22-5.83, p
PubMed ID
18824671 View in PubMed
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