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Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?

https://arctichealth.org/en/permalink/ahliterature296906
Source
Environ Health. 2018 02 01; 17(1):11
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Date
02-01-2018
Author
Xindi C Hu
Clifton Dassuncao
Xianming Zhang
Philippe Grandjean
Pál Weihe
Glenys M Webster
Flemming Nielsen
Elsie M Sunderland
Author Affiliation
Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA. xhu@mail.harvard.edu.
Source
Environ Health. 2018 02 01; 17(1):11
Date
02-01-2018
Language
English
Publication Type
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Keywords
Adolescent
Adult
Aged
Alkanesulfonic Acids - blood
Child
Denmark
Environmental Exposure
Environmental monitoring
Environmental pollutants - blood
Female
Fluorocarbons - blood
Humans
Male
Middle Aged
Nutrition Surveys
Prospective Studies
United States
Young Adult
Abstract
Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects.
We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases.
Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure sources in two North American populations, suggesting generalizability of results from the Faroese population.
We conclude that PFAS homologue profiles in serum provide valuable information on major exposure sources. It is essential to compare samples collected at similar time periods and to correct for demographic groups that are highly affected by differences in physiological processes (e.g., pregnancy). Information on PFAS homologue profiles is crucial for attributing adverse health effects to the proper mixtures or individual PFASs.
PubMed ID
29391068 View in PubMed
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Attribute importance segmentation of Norwegian seafood consumers: The inclusion of salient packaging attributes.

https://arctichealth.org/en/permalink/ahliterature291603
Source
Appetite. 2017 Oct 01; 117:214-223
Publication Type
Comparative Study
Journal Article
Validation Studies
Date
Oct-01-2017
Author
Svein Ottar Olsen
Ho Huu Tuu
Klaus G Grunert
Author Affiliation
School of Business and Economics, UiT The Arctic University of Norway, N-9037 Tromsø, Norway. Electronic address: svein.o.olsen@uit.no.
Source
Appetite. 2017 Oct 01; 117:214-223
Date
Oct-01-2017
Language
English
Publication Type
Comparative Study
Journal Article
Validation Studies
Keywords
Adult
Cluster analysis
Consumer Behavior - economics
Cookbooks as Topic - economics
Cooking - economics
Cross-Sectional Studies
Female
Food Packaging - economics
Food Preferences - ethnology
Food Quality
Food, Preserved - adverse effects - economics
Healthy Diet - economics - ethnology - psychology
Humans
Internet
Male
Meals - ethnology
Models, Psychological
Norway
Nutrition Surveys
Nutritive Value
Patient Compliance - ethnology
Seafood - adverse effects - economics
Abstract
The main purpose of this study is to identify consumer segments based on the importance of product attributes when buying seafood for homemade meals on weekdays. There is a particular focus on the relative importance of the packaging attributes of fresh seafood. The results are based on a representative survey of 840 Norwegian consumers between 18 and 80 years of age. This study found that taste, freshness, nutritional value and naturalness are the most important attributes for the home consumption of seafood. Except for the high importance of information about expiration date, most other packaging attributes have only medium importance. Three consumer segments are identified based on the importance of 33 attributes associated with seafood: Perfectionists, Quality Conscious and Careless Consumers. The Quality Conscious consumers feel more self-confident in their evaluation of quality, and are less concerned with packaging, branding, convenience and emotional benefits compared to the Perfectionists. Careless Consumers are important as regular consumers of convenient and pre-packed seafood products and value recipe information on the packaging. The seafood industry may use the results provided in this study to strengthen their positioning of seafood across three different consumer segments.
PubMed ID
28669742 View in PubMed
Less detail