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Accumulation, organ distribution, and excretion kinetics of ²4¹Am in Mayak Production Association workers.

https://arctichealth.org/en/permalink/ahliterature116778
Source
Health Phys. 2013 Mar;104(3):313-24
Publication Type
Article
Date
Mar-2013
Author
Klara G Suslova
Alexandra B Sokolova
Alexander V Efimov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2013 Mar;104(3):313-24
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adult
Aerosols
Aged
Americium - chemistry - pharmacokinetics
Case-Control Studies
Female
Humans
Industry
Kinetics
Liver Diseases - metabolism
Male
Middle Aged
Nuclear Reactors - statistics & numerical data
Occupational Exposure - analysis
Organ Specificity
Plutonium - chemistry - pharmacokinetics
Russia
Tissue Distribution
Abstract
Americium-241 (²4¹Am) is the second most significant radiation hazard after ²³?Pu at some of the Mayak Production Association facilities. This study summarizes current data on the accumulation, distribution, and excretion of americium compared with plutonium in different organs from former Mayak PA workers. Americium and plutonium were measured in autopsy and bioassay samples and correlated with the presence or absence of chronic disease and with biological transportability of the aerosols encountered at different workplaces. The relative accumulation of ²4¹Am was found to be increasing in the workers over time. This is likely from ²4¹Pu that increases with time in reprocessed fuel and from the increased concentrations of ²4¹Am and ²4¹Pu in inhaled alpha-active aerosols. While differences were observed in lung retention with exposures to different industrial compounds with different transportabilities (i.e., dioxide and nitrates), there were no significant differences in lung retention between americium and plutonium within each transportability group. In the non-pulmonary organs, the highest ratios of ²4¹Am/²4¹Am + SPu were observed in the skeleton. The relative ratios of americium in the skeleton versus liver were significantly greater than for plutonium. The relative amounts of americium and plutonium found in the skeleton compared with the liver were even greater in workers with documented chronic liver diseases. Excretion rates of ²4¹Am in ‘‘healthy’’ workers were estimated using bioassay and autopsy data. The data suggest that impaired liver function leads to reduced hepatic ²4¹Am retention, leading to increased ²4¹Am excretion.
PubMed ID
23361427 View in PubMed
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[A comparative study of the immunological (antimicrosomal antibodies) and cytogenetic indices of children living in radioactively contaminated areas of Bryansk Province]

https://arctichealth.org/en/permalink/ahliterature34277
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Publication Type
Article
Author
A P Shinkarkina
A A Zhloba
V K Podgorodnichewnko
A V Sevan'kaev
A M Poverennyi
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Autoantibodies - blood
Cells, Cultured
Child
Chromosome Aberrations
Comparative Study
English Abstract
Humans
Lymphocytes - radiation effects
Microsomes - immunology
Nuclear Reactors
Power Plants
Radioactive Fallout - adverse effects
Russia
Thyroid Gland - immunology - radiation effects
Ukraine
Abstract
The chromosome dicentric aberrations in the lymphocytes and levels of antibodies to human thyroid microsomal antigen in the serum of the children lived in the area of Bryansk Province suffered from the Chernobyl accident was examined. Correlation between those tests was not estimated: the autoantibodies were revealed in group with dicentrics and without those in 4.0% and 4.5% of cases correspondingly. Antimicrosomal antibodies were revealed more frequently (5.0%) and in higher titers in the children from the more polluted Bryansk Province than in those from Kaluga Province (3.1%). These data can testify about the role of inside radiation of thyroid gland in appearance of autoimmune thyroiditis signs.
PubMed ID
9244530 View in PubMed
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Acute effects of the Chernobyl nuclear accident on Irish mortality?

https://arctichealth.org/en/permalink/ahliterature38051
Source
Ir Med J. 1989 Sep;82(3):119-21
Publication Type
Article
Date
Sep-1989
Author
S. Allwright
L. Daly
Source
Ir Med J. 1989 Sep;82(3):119-21
Date
Sep-1989
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Adult
Aged
Air Pollution, Radioactive - adverse effects
Cause of Death
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Ireland
Middle Aged
Nuclear Reactors
Time Factors
Ukraine
Abstract
This report examines the claim that Irish mortality in the second quarter (April-June) of 1986 increased due to the cloud of radioactive material released by the damaged reactor in Chernobyl. Over the period 1971-1987, based on date of registration, the death rates in the second quarter showed marked year to year variation often exceeding that expected on the basis of chance alone. In 1986 the percentage of annual deaths occurring between April and June, and the death rate itself, were both significantly higher than in most other years between 1981 and 1987. The 1986 figures were not however, significantly higher than those observed in years prior to 1981. Since the distribution of mortality by cause was not consistent with the hypothesis relating low level radiation to immediate mortality, and since causality cannot be inferred from a temporal association per se, the Chernobyl accident cannot be implicated in the excess mortality observed in the second quarter of 1986.
PubMed ID
2599835 View in PubMed
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[An epidemiological method for studying the effect of elevated background radiation on the neuropsychic health of children]

https://arctichealth.org/en/permalink/ahliterature36500
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(3):64-8
Publication Type
Article
Date
1993
Author
N K Sukhotina
A A Kashnikova
V B Preis
I N Tatarova
T V Terekhina
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(3):64-8
Date
1993
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Adolescent
Air Pollution, Radioactive - adverse effects - statistics & numerical data
Background Radiation - adverse effects
Child
Child, Preschool
Comparative Study
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects - statistics & numerical data
Epidemiologic Methods
Female
Humans
Infant
Male
Mental Disorders - epidemiology - etiology
Mental health
Nuclear Reactors
Power Plants
Russia
Ukraine
Abstract
The children living in 4 regions of Russia contaminated as a result of the Chernobyl catastrophe were investigated. The control group consisted of the children of 2 regions which did not undergo this influence. The investigations were made 1-3 years after the catastrophe took place. An increase of etiologically non-clear asthenic-vegetative disorders was determined in the regions of radiation contamination. They were observed mainly among the children who had light residual organic cerebral deficiency. The authors cannot exclude the impact of the psychogenic factors.
PubMed ID
8042395 View in PubMed
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[Antibodies to the thyroid microsomal antigen in children and adolescents subjected to radiation exposure as a result of the accident at the Chernobyl Atomic Electric Power Station]

https://arctichealth.org/en/permalink/ahliterature35956
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):3-7
Publication Type
Article
Author
A P Shinkarkina
V K Podgorodnichenko
A M Poverennyi
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):3-7
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Adolescent
Air Pollution, Radioactive - adverse effects
Autoantibodies - blood - radiation effects
Autoantigens - immunology - radiation effects
Child
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects
Humans
Microsomes - immunology - radiation effects
Nuclear Reactors
Power Plants
Russia
Thyroid Gland - immunology - radiation effects
Thyroiditis, Autoimmune - etiology - immunology
Ukraine
Abstract
For evaluation of the possibility of the appearance of autoimmune thyroiditis in children and juveniles lived in the areas of Kaluga Province [correction of region] suffered from the Chernobyl accident the content of antibodies to human thyroid microsomal antigen was investigated. Percentage of positive sera varied from 4.8% to 1.2% during 6 years. There is significant difference in the frequency of the antibody appearance between persons suffered from radioactive iodine and unsuffered ones. Correlation between levels of antimicrosomal antibodies and radiation dose obtained from incorporated radioactive iodine was not estimated.
PubMed ID
8148974 View in PubMed
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Antithyroid autoantibodies in the examined population with iodine prophylaxis after the Chernobyl catastrophe.

https://arctichealth.org/en/permalink/ahliterature37161
Source
Horm Metab Res. 1991 May;23(5):236-8
Publication Type
Article
Date
May-1991
Author
I. Kinalska
W. Zarzycki
I. Krawezuk
A. Gosiewska
M. Górska
A. Zonenberg
Author Affiliation
Department of Endocrinology, Medical School, Bialystok, Poland.
Source
Horm Metab Res. 1991 May;23(5):236-8
Date
May-1991
Language
English
Publication Type
Article
Keywords
Accidents, Occupational
Adolescent
Adult
Autoantibodies - immunology
Child
Child, Preschool
Female
Goiter, Endemic - prevention & control
Humans
Infant
Iodine - therapeutic use
Male
Middle Aged
Nuclear Reactors
Thyroid Gland - immunology
Thyroxine - blood
Triiodothyronine - blood
Ukraine
Abstract
The aim of the present study was the observation of the frequency of antithyroid autoantibodies in the population in low endemic goitre area after mass iodine prophylaxis after the Chernobyl catastrophe and the estimation of TSH and thyroid hormones secretion in this population. On the basis of the investigations carried out we could conclude that the frequency of antithyroid autoantibodies in the population with confirmed endemic goitre is comparable to the frequency of antithyroid autoantibodies in the healthy population. ATA occurrence in children after iodine prophylaxis could confirm the hypothesis that thyroglobulin immunity is higher after iodine intake. The lower T3 concentration observed in the group with antithyroid autoantibodies suggests that autoantibodies may be involved in the thyroid hormones synthesis or peripheral conversion of thyroid hormones.
PubMed ID
1874483 View in PubMed
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[Assessment of radiation risk of leukemia induction based on the analysis of the consequences of population irradiation in Southern Ural].

https://arctichealth.org/en/permalink/ahliterature227404
Source
Vestn Akad Med Nauk SSSR. 1991;(8):23-8
Publication Type
Article
Date
1991
Author
M M Kosenko
M O Degteva
N A Petrushova
Source
Vestn Akad Med Nauk SSSR. 1991;(8):23-8
Date
1991
Language
Russian
Publication Type
Article
Keywords
Air Pollution, Radioactive
Humans
Leukemia, Radiation-Induced - etiology
Nuclear Reactors
Risk factors
Russia
Time Factors
Abstract
The authors provide the results of long-term investigations of the consequences of environmental pollution from the military nuclear plant in the Southern Urals. Altogether 28,100 individuals who received substantial doses of external and internal radiation in the Techa riverside in the early fifties were entered into the study. The increase in the leukemia incidence as compared with unexposed controls has been confirmed on a statistical basis. The majority of excess cases of leukemia were recorded within the 5th to the 20th year after irradiation and may be attributed to the acute and chronic granulocytic types. The level of leukemia risk on the basis of the Techa river data is evaluated as 0.48-1.10 per 10(4) persons/years/Gy.
PubMed ID
1835230 View in PubMed
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Assessment of radiocesium incorporation in Austrians after the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature37261
Source
Health Phys. 1991 Feb;60(2):199-202
Publication Type
Article
Date
Feb-1991
Author
E. Havlik
H. Bergmann
Author Affiliation
Second Department of Internal Medicine, University of Vienna Medical School, Austria.
Source
Health Phys. 1991 Feb;60(2):199-202
Date
Feb-1991
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Adult
Aged
Austria
Body Burden
Cesium Radioisotopes - analysis
Child
Child, Preschool
Female
Food Contamination, Radioactive - analysis
Humans
Infant
Male
Middle Aged
Nuclear Reactors
Population Surveillance
Radioactive fallout
Ukraine
Abstract
Residents of Vienna, Austria were whole-body counted for radiocesium content due to fallout deposited after the Chernobyl accident. Data for a 2-y period were compared with prior estimates of radiocesium body burden based on food consumption. Our results suggest that the prior estimates be revised and the rejection limit be increased by a factor of 2 for contaminated food.
PubMed ID
1989941 View in PubMed
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[Assessment of the immunohematological status of children exposed to low doses of ionizing radiation in the early and late periods after the Chernobyl AES accident]

https://arctichealth.org/en/permalink/ahliterature37396
Source
Pediatriia. 1991;(12):16-20
Publication Type
Article
Date
1991
Author
V G Bebeshko
A A Chumak
E M Bruslova
V V Tal'ko
Zh N Minchenko
D A Bazyka
N M Tsvetkova
A G Bezpalenko
E N Dzhurinskaia
Source
Pediatriia. 1991;(12):16-20
Date
1991
Language
Russian
Publication Type
Article
Keywords
Accidents
Adolescent
Age Factors
Child
Child, Preschool
Comparative Study
English Abstract
Follow-Up Studies
Humans
Infant
Nuclear Reactors
Radiation Dosage
Radiation Injuries - blood - diagnosis - immunology
Time Factors
Ukraine
Abstract
The qualitative and quantitative parameters of hemopoiesis and immunocompetent cells were studied in 365 children in the early "iodine" and long-term periods after the accident. In accordance with primary response, a group consisting of 28 subjects with so-called "radiation injury" was distinguished. The early period was marked by unusual qualitative and quantitative hematological changes which, however, did not lead to the development of the hematological syndrome characteristic of acute radiation injury. Certain deviations that corresponded to somatic pathology were detectable at the late periods after the accident.
PubMed ID
1788014 View in PubMed
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[Assessment of the influence of the Chernobyl nuclear disaster on incidence of thyroid diseases among children in Poland. Preliminary results]

https://arctichealth.org/en/permalink/ahliterature20331
Source
Med Wieku Rozwoj. 1999 Oct-Dec;3(4):561-72
Publication Type
Article
Author
M. Szymborska
Author Affiliation
Zaklad Endokrynologii IMD, Instytut Matki i Dziecka w Warszawie.
Source
Med Wieku Rozwoj. 1999 Oct-Dec;3(4):561-72
Language
Polish
Publication Type
Article
Keywords
Accidents
Autoantibodies - analysis
Child
Child, Preschool
English Abstract
Female
Follow-Up Studies
Goiter - diagnosis - epidemiology
Health status
Humans
Incidence
Infant
Infant, Newborn
Male
Nuclear Reactors
Poland - epidemiology
Sex Distribution
Thyroid Diseases - blood - epidemiology - immunology - ultrasonography
Thyroid Gland - immunology
Thyroid Neoplasms - diagnosis - epidemiology
Thyrotropin - blood
Ukraine
Abstract
It was attempted to assess the incidence of thyroid diseases in Polish children born between 1980-1986, who at the time of the Chernobyl nuclear disaster were 0-6 years old, or whose mothers were in the third trimester of pregnancy. 3071 children have been examined, 1772 girls and 1299 boys. The following were assessed in each child: the health status, the developmental level, the thyroid ultrasound examination, and the level of TSH, FT4, antithyroid antibodies ATM and ATGL in the blood serum. Disorders in thyroid morphology (abnormal echogenicity) have been found in 462 children (15%), almost twice as much in girls than in boys. Goiter has been recognized in 4.6% of all children, an abnormal echogenity in 5.4% and focal changes in 4.8%. 3.9% of children have been found to have a high level of ATM antibodies, and 8.7%--a high level of ATGL antibodies. Among 6 children, who had thyroidectomy, 2 children have been diagnosed to have ca papillary and 4 children--adenoma.
PubMed ID
10910679 View in PubMed
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140 records – page 1 of 14.