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Accumulation, organ distribution, and excretion kinetics of ²4¹Am in Mayak Production Association workers.

https://arctichealth.org/en/permalink/ahliterature116778
Source
Health Phys. 2013 Mar;104(3):313-24
Publication Type
Article
Date
Mar-2013
Author
Klara G Suslova
Alexandra B Sokolova
Alexander V Efimov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2013 Mar;104(3):313-24
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adult
Aerosols
Aged
Americium - chemistry - pharmacokinetics
Case-Control Studies
Female
Humans
Industry
Kinetics
Liver Diseases - metabolism
Male
Middle Aged
Nuclear Reactors - statistics & numerical data
Occupational Exposure - analysis
Organ Specificity
Plutonium - chemistry - pharmacokinetics
Russia
Tissue Distribution
Abstract
Americium-241 (²4¹Am) is the second most significant radiation hazard after ²³?Pu at some of the Mayak Production Association facilities. This study summarizes current data on the accumulation, distribution, and excretion of americium compared with plutonium in different organs from former Mayak PA workers. Americium and plutonium were measured in autopsy and bioassay samples and correlated with the presence or absence of chronic disease and with biological transportability of the aerosols encountered at different workplaces. The relative accumulation of ²4¹Am was found to be increasing in the workers over time. This is likely from ²4¹Pu that increases with time in reprocessed fuel and from the increased concentrations of ²4¹Am and ²4¹Pu in inhaled alpha-active aerosols. While differences were observed in lung retention with exposures to different industrial compounds with different transportabilities (i.e., dioxide and nitrates), there were no significant differences in lung retention between americium and plutonium within each transportability group. In the non-pulmonary organs, the highest ratios of ²4¹Am/²4¹Am + SPu were observed in the skeleton. The relative ratios of americium in the skeleton versus liver were significantly greater than for plutonium. The relative amounts of americium and plutonium found in the skeleton compared with the liver were even greater in workers with documented chronic liver diseases. Excretion rates of ²4¹Am in ‘‘healthy’’ workers were estimated using bioassay and autopsy data. The data suggest that impaired liver function leads to reduced hepatic ²4¹Am retention, leading to increased ²4¹Am excretion.
PubMed ID
23361427 View in PubMed
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[A comparative study of the immunological (antimicrosomal antibodies) and cytogenetic indices of children living in radioactively contaminated areas of Bryansk Province]

https://arctichealth.org/en/permalink/ahliterature34277
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Publication Type
Article
Author
A P Shinkarkina
A A Zhloba
V K Podgorodnichewnko
A V Sevan'kaev
A M Poverennyi
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Autoantibodies - blood
Cells, Cultured
Child
Chromosome Aberrations
Comparative Study
English Abstract
Humans
Lymphocytes - radiation effects
Microsomes - immunology
Nuclear Reactors
Power Plants
Radioactive Fallout - adverse effects
Russia
Thyroid Gland - immunology - radiation effects
Ukraine
Abstract
The chromosome dicentric aberrations in the lymphocytes and levels of antibodies to human thyroid microsomal antigen in the serum of the children lived in the area of Bryansk Province suffered from the Chernobyl accident was examined. Correlation between those tests was not estimated: the autoantibodies were revealed in group with dicentrics and without those in 4.0% and 4.5% of cases correspondingly. Antimicrosomal antibodies were revealed more frequently (5.0%) and in higher titers in the children from the more polluted Bryansk Province than in those from Kaluga Province (3.1%). These data can testify about the role of inside radiation of thyroid gland in appearance of autoimmune thyroiditis signs.
PubMed ID
9244530 View in PubMed
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[An epidemiological method for studying the effect of elevated background radiation on the neuropsychic health of children]

https://arctichealth.org/en/permalink/ahliterature36500
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(3):64-8
Publication Type
Article
Date
1993
Author
N K Sukhotina
A A Kashnikova
V B Preis
I N Tatarova
T V Terekhina
Source
Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(3):64-8
Date
1993
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Adolescent
Air Pollution, Radioactive - adverse effects - statistics & numerical data
Background Radiation - adverse effects
Child
Child, Preschool
Comparative Study
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects - statistics & numerical data
Epidemiologic Methods
Female
Humans
Infant
Male
Mental Disorders - epidemiology - etiology
Mental health
Nuclear Reactors
Power Plants
Russia
Ukraine
Abstract
The children living in 4 regions of Russia contaminated as a result of the Chernobyl catastrophe were investigated. The control group consisted of the children of 2 regions which did not undergo this influence. The investigations were made 1-3 years after the catastrophe took place. An increase of etiologically non-clear asthenic-vegetative disorders was determined in the regions of radiation contamination. They were observed mainly among the children who had light residual organic cerebral deficiency. The authors cannot exclude the impact of the psychogenic factors.
PubMed ID
8042395 View in PubMed
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[Antibodies to the thyroid microsomal antigen in children and adolescents subjected to radiation exposure as a result of the accident at the Chernobyl Atomic Electric Power Station]

https://arctichealth.org/en/permalink/ahliterature35956
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):3-7
Publication Type
Article
Author
A P Shinkarkina
V K Podgorodnichenko
A M Poverennyi
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):3-7
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Adolescent
Air Pollution, Radioactive - adverse effects
Autoantibodies - blood - radiation effects
Autoantigens - immunology - radiation effects
Child
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects
Humans
Microsomes - immunology - radiation effects
Nuclear Reactors
Power Plants
Russia
Thyroid Gland - immunology - radiation effects
Thyroiditis, Autoimmune - etiology - immunology
Ukraine
Abstract
For evaluation of the possibility of the appearance of autoimmune thyroiditis in children and juveniles lived in the areas of Kaluga Province [correction of region] suffered from the Chernobyl accident the content of antibodies to human thyroid microsomal antigen was investigated. Percentage of positive sera varied from 4.8% to 1.2% during 6 years. There is significant difference in the frequency of the antibody appearance between persons suffered from radioactive iodine and unsuffered ones. Correlation between levels of antimicrosomal antibodies and radiation dose obtained from incorporated radioactive iodine was not estimated.
PubMed ID
8148974 View in PubMed
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[Assessment of radiation risk of leukemia induction based on the analysis of the consequences of population irradiation in Southern Ural].

https://arctichealth.org/en/permalink/ahliterature227404
Source
Vestn Akad Med Nauk SSSR. 1991;(8):23-8
Publication Type
Article
Date
1991
Author
M M Kosenko
M O Degteva
N A Petrushova
Source
Vestn Akad Med Nauk SSSR. 1991;(8):23-8
Date
1991
Language
Russian
Publication Type
Article
Keywords
Air Pollution, Radioactive
Humans
Leukemia, Radiation-Induced - etiology
Nuclear Reactors
Risk factors
Russia
Time Factors
Abstract
The authors provide the results of long-term investigations of the consequences of environmental pollution from the military nuclear plant in the Southern Urals. Altogether 28,100 individuals who received substantial doses of external and internal radiation in the Techa riverside in the early fifties were entered into the study. The increase in the leukemia incidence as compared with unexposed controls has been confirmed on a statistical basis. The majority of excess cases of leukemia were recorded within the 5th to the 20th year after irradiation and may be attributed to the acute and chronic granulocytic types. The level of leukemia risk on the basis of the Techa river data is evaluated as 0.48-1.10 per 10(4) persons/years/Gy.
PubMed ID
1835230 View in PubMed
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Behavioral differences of irradiated persons associated with the Kyshtym, Chelyabinsk, and Chernobyl nuclear accidents.

https://arctichealth.org/en/permalink/ahliterature222966
Source
Mil Med. 1992 Oct;157(10):548-52
Publication Type
Article
Date
Oct-1992
Author
D L Collins
Author Affiliation
Armed Forces Radiobiology Research Institute, Bethesda, MD 20889.
Source
Mil Med. 1992 Oct;157(10):548-52
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Accidents - psychology
Behavior - radiation effects
Case-Control Studies
Humans
Longitudinal Studies
Nuclear Reactors
Radiation Injuries - psychology
Russia
Ukraine
Abstract
Three nuclear accidents besides Chernobyl have occurred in the former Soviet Union. The accidents occurred around Kyshtym and Chelyabinsk in the Ural Mountains between 1949 and 1967 and contaminated over one-half million people. The health ministries are now interested in the data previously collected on these irradiated populations in order to examine the health (e.g., psychological, hereditary, genome damage, etc.) implications of long-term radiation exposure.
PubMed ID
1454181 View in PubMed
Less detail

Beyond Chernobyl: the new Russian studies in perspective.

https://arctichealth.org/en/permalink/ahliterature190184
Source
Radiat Environ Biophys. 2002 Mar;41(1):1-4
Publication Type
Article
Date
Mar-2002
Author
A M Kellerer
Source
Radiat Environ Biophys. 2002 Mar;41(1):1-4
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Humans
Nuclear Reactors
Power Plants
Radiation, Ionizing
Radioactive Hazard Release
Russia
Safety
Ukraine
PubMed ID
12014400 View in PubMed
Less detail

Cancer mortality following in utero exposure among offspring of female Mayak Worker Cohort members.

https://arctichealth.org/en/permalink/ahliterature122596
Source
Radiat Res. 2012 Sep;178(3):160-5
Publication Type
Article
Date
Sep-2012
Author
S J Schonfeld
Y V Tsareva
D L Preston
P V Okatenko
E S Gilbert
E. Ron
M E Sokolnikov
N A Koshurnikova
Author Affiliation
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. schonfes@mail.nih.gov
Source
Radiat Res. 2012 Sep;178(3):160-5
Date
Sep-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aging
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Male
Maternal Exposure - adverse effects
Middle Aged
Neoplasms, Radiation-Induced - epidemiology - mortality
Nuclear Reactors
Occupational Exposure - adverse effects
Pregnancy
Risk
Russia
Abstract
Little is known about long-term cancer risks following in utero radiation exposure. We evaluated the association between in utero radiation exposure and risk of solid cancer and leukemia mortality among 8,000 offspring, born from 1948-1988, of female workers at the Mayak Nuclear Facility in Ozyorsk, Russia. Mother's cumulative gamma radiation uterine dose during pregnancy served as a surrogate for fetal dose. We used Poisson regression methods to estimate relative risks (RRs) and 95% confidence intervals (CIs) of solid cancer and leukemia mortality associated with in utero radiation exposure and to quantify excess relative risks (ERRs) as a function of dose. Using currently available dosimetry information, 3,226 (40%) offspring were exposed in utero (mean dose = 54.5 mGy). Based on 75 deaths from solid cancers (28 exposed) and 12 (6 exposed) deaths from leukemia, in utero exposure status was not significantly associated with solid cancer: RR = 0.94, 95% CI 0.58 to 1.49; ERR/Gy = -0.1 (95% CI
Notes
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PubMed ID
22799629 View in PubMed
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The "clinic" medical-dosimetric database of Mayak production association workers: structure, characteristics and prospects of utilization.

https://arctichealth.org/en/permalink/ahliterature157793
Source
Health Phys. 2008 May;94(5):449-58
Publication Type
Article
Date
May-2008
Author
Tamara V Azizova
Richard D Day
Niel Wald
Colin R Muirhead
Jacqueline A O'Hagan
Margarita V Sumina
Zinaida D Belyaeva
Maria B Druzhinina
Igor I Teplyakov
Nadezhda G Semenikhina
Larisa A Stetsenko
Evgenia S Grigoryeva
Larisa N Krupenina
Elena V Vlasenko
Author Affiliation
Southern Urals Biophysics Institute, Ozyorsk, Russia. clinic@ozersk.com
Source
Health Phys. 2008 May;94(5):449-58
Date
May-2008
Language
English
Publication Type
Article
Keywords
Air Pollution, Radioactive
Databases as Topic
Humans
Models, Biological
Nuclear Reactors
Occupational Exposure
Radiation Dosage
Radioactive Hazard Release
Russia
Abstract
To study early (deterministic) and long-term effects of radiation exposure, the "Clinic" medical-dosimetric database for the Mayak Production Association worker cohort has been established at the Southern Urals Biophysics Institute (SUBI). This paper describes the principles of organization, structure and prospects of future utilization of this database.
PubMed ID
18403966 View in PubMed
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77 records – page 1 of 8.