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Lung, liver and bone cancer mortality after plutonium exposure in beagle dogs and nuclear workers.

https://arctichealth.org/en/permalink/ahliterature146964
Source
Health Phys. 2010 Jan;98(1):42-52
Publication Type
Article
Date
Jan-2010
Author
Dulaney A Wilson
Lawrence C Mohr
G Donald Frey
Daniel Lackland
David G Hoel
Author Affiliation
Medical University of South Carolina, Department of Biostatistics, Bioinformatics and Epidemiology, 135 Cannon Street, Charleston, SC 29425, USA. Dulaney.Wilson@pnl.gov
Source
Health Phys. 2010 Jan;98(1):42-52
Date
Jan-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Air Pollutants, Radioactive - toxicity
Animals
Bone Neoplasms - mortality
Cohort Studies
Disease Models, Animal
Dogs
Dose-Response Relationship, Radiation
Female
Humans
Liver Neoplasms - mortality
Lung Neoplasms - mortality
Male
Middle Aged
Neoplasms, Radiation-Induced - mortality
Nitrates - toxicity
Nuclear Reactors
Occupational Exposure
Plutonium - toxicity
Radionuclide Generators
Registries
Risk factors
Russia - epidemiology
Young Adult
Abstract
The Mayak Production Association (MPA) worker registry has shown evidence of plutonium-induced health effects. Workers were potentially exposed to plutonium nitrate [(239)Pu(NO(3))(4)] and plutonium dioxide ((239)PuO(2)). Studies of plutonium-induced health effects in animal models can complement human studies by providing more specific data than is possible in human observational studies. Lung, liver, and bone cancer mortality rate ratios in the MPA worker cohort were compared to those seen in beagle dogs, and models of the excess relative risk of lung, liver, and bone cancer mortality from the MPA worker cohort were applied to data from life-span studies of beagle dogs. The lung cancer mortality rate ratios in beagle dogs are similar to those seen in the MPA worker cohort. At cumulative doses less than 3 Gy, the liver cancer mortality rate ratios in the MPA worker cohort are statistically similar to those in beagle dogs. Bone cancer mortality only occurred in MPA workers with doses over 10 Gy. In dogs given (239)Pu, the adjusted excess relative risk of lung cancer mortality per Gy was 1.32 (95% CI 0.56-3.22). The liver cancer mortality adjusted excess relative risk per Gy was 55.3 (95% CI 23.0-133.1). The adjusted excess relative risk of bone cancer mortality per Gy(2) was 1,482 (95% CI 566.0-5686). Models of lung cancer mortality based on MPA worker data with additional covariates adequately described the beagle dog data, while the liver and bone cancer models were less successful.
PubMed ID
19959950 View in PubMed
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