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Plutonium microdistribution in the lungs of Mayak workers.

https://arctichealth.org/en/permalink/ahliterature179973
Source
Radiat Res. 2004 May;161(5):568-81
Publication Type
Article
Date
May-2004
Author
F F Hahn
S A Romanov
R A Guilmette
A P Nifatov
J H Diel
Y. Zaytseva
Author Affiliation
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. fhahn@lrri.org
Source
Radiat Res. 2004 May;161(5):568-81
Date
May-2004
Language
English
Publication Type
Article
Keywords
Adult
Aged
Air Pollutants, Occupational - analysis
Air Pollutants, Radioactive - analysis
Cadaver
Female
Humans
Lung - metabolism - pathology
Male
Middle Aged
Nuclear Reactors
Nuclear Warfare
Occupational Exposure - analysis
Plutonium - analysis - pharmacokinetics
Radiation Dosage
Radiometry - methods
Registries
Risk Assessment - methods
Russia
Tissue Distribution
Abstract
The degree of nonuniform distribution of plutonium in the human lung has not been determined; thus current dosimetric models do not account for nonuniform irradiation. A better scientific basis is needed for assessing the risk of developing radiation-induced disease from inhaled alpha-particle-emitting radionuclides. We measured the distribution of plutonium activity in the lung by autoradiography and related the activity to specific compartments of the lung. The study materials were lung specimens from deceased workers employed by the Mayak Production Association. The approach to analyzing these lung samples used contemporary stereological sampling and analysis techniques together with quantitative alpha-particle autoradiography. For the first time, plutonium distribution has been quantified in the human lung. The distribution of long-term retained plutonium is nonuniform, and a significant portion of plutonium was retained in pulmonary scars. In addition, a large fraction of plutonium was present in the parenchyma, where it was retained much longer than was estimated previously. The sequestration of plutonium particles in scars would greatly reduce the radiation exposure of the critical target cells and tissues for lung cancer. Thus the prolonged retention of plutonium in lung scars may not increase the dose or risk for lung cancer.
PubMed ID
15161366 View in PubMed
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