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Relative role of plutonium excretion with urine and feces from human body.

https://arctichealth.org/en/permalink/ahliterature180577
Source
Health Phys. 2004 May;86(5):523-7
Publication Type
Article
Date
May-2004
Author
V F Khokhryakov
K G Suslova
T I Kudryavtseva
A E Schadilov
V V Vostrotin
N Yu Lagounova
A Yu Barabanshchikova
Author Affiliation
Southern Ural Biophysics Institute, Federal Research Center of Biophysics, Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia, 456780. khohryakov@lab3.fib.ozersk.ru
Source
Health Phys. 2004 May;86(5):523-7
Date
May-2004
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Aged
Aged, 80 and over
Air Pollutants, Radioactive - analysis - pharmacokinetics - urine
Body Burden
Feces - chemistry
Female
Humans
Male
Metabolic Clearance Rate - physiology
Middle Aged
Models, Biological
Nuclear Reactors
Occupational Exposure - analysis
Plutonium - administration & dosage - analysis - pharmacokinetics - urine
Radiation Dosage
Radiation Protection - methods
Radiometry - methods
Relative Biological Effectiveness
Risk Assessment - methods
Russia
Abstract
The ratio of plutonium content in 35 pairs of daily fecal and urine samples from 19 former MAYAK workers several decades after the end of occupational exposure was measured in clinical conditions. No dependence of the ratio Pu(feces)/Pu(urine) on plutonium aerosol transportability, sex, and age of workers was revealed in the late times after the end of occupational exposure. It was found that at the late times after the end of occupational exposure, the ratio of feces/urine is characterized by the lognormal distribution with the median value, 0.57, and error for this index characterized geometric deviation, sigmag = 1.12 Urinary and fecal excretions were analyzed after chronic exposure to inhaled plutonium compounds of different transportability for another group of 345 workers. During 500-16,000 d after the started chronic inhalation, plutonium biokinetic model ("Doses-2000") used in Southern Ural Biophysics Institute (SUBI) and based on the ICRP Publication 66 overestimated the feces/urine ratio by an order of magnitude as compared with the observed values. It indicates a necessity for further improvement of the biokinetic model used in SUBI.
PubMed ID
15083148 View in PubMed
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Uncertainties analysis of doses resulting from chronic inhalation of plutonium at the Mayak production association.

https://arctichealth.org/en/permalink/ahliterature174341
Source
Health Phys. 2005 Jul;89(1):33-45
Publication Type
Article
Date
Jul-2005
Author
M P Krahenbuhl
J D Bess
J L Wilde
V V Vostrotin
K G Suslova
V F Khokhryakov
D M Slaughter
S C Miller
Author Affiliation
University of Utah, 50 So. Central Campus Drive, Rm 1206, Salt Lake City, UT 84112, USA. mpk@nuclear.utah.edu
Source
Health Phys. 2005 Jul;89(1):33-45
Date
Jul-2005
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Air Pollutants, Occupational - pharmacokinetics
Air Pollutants, Radioactive - analysis - pharmacokinetics
Algorithms
Autopsy
Body Burden
Computer simulation
Humans
Models, Biological
Models, Statistical
Nuclear Reactors
Organ Specificity
Plutonium - administration & dosage - pharmacokinetics
Radiation Dosage
Radiation Monitoring - methods
Relative Biological Effectiveness
Reproducibility of Results
Risk Assessment - methods
Risk factors
Russia - epidemiology
Sensitivity and specificity
Time Factors
Whole-Body Counting - methods
Abstract
A method is presented to determine the uncertainties in the reported dose due to incorporated plutonium for the Mayak Worker Cohort. The methodology includes errors generated by both detection methods and modeling methods. To accomplish the task, the method includes classical statistics, Monte Carlo, perturbation, and reliability groupings. Uncertainties are reported in percent of reported dose as a function of total body burden. The cohort was initially sorted into six reliability groups, with "A" being the data set that the investigators are most confident is correct and "G" being the data set with the most ambiguous data. Categories were adjusted based on preliminary calculation of uncertainties using the sorting criteria. Specifically, the impact of transportability (the parameter used to describe the transport of plutonium from the lung to systemic organs) was underestimated, and the structure of the sort was reorganized to reflect the impact of transportability. The finalized categories are designated with Roman numerals I through V, with "I" being the most reliable. Excluding Category V (neither bioassay nor autopsy), the highest uncertainty in lung doses is for individuals from Category IV-which ranged from 90-375% for total body burdens greater than 10 Bq, along with work histories that indicated exposure to more than one transportability class. The smallest estimated uncertainties for lung doses were determined by autopsy. Category I has a 32-38% uncertainty in the lung dose for total body burdens greater than 1 Bq. First, these results provide a further definition and characterization of the cohort and, second, they provide uncertainty estimates for these plutonium exposure categories.
PubMed ID
15951690 View in PubMed
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