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Risk of various types of cataracts in a cohort of Mayak workers following chronic occupational exposure to ionizing radiation.

https://arctichealth.org/en/permalink/ahliterature298226
Source
Eur J Epidemiol. 2018 Dec; 33(12):1193-1204
Publication Type
Journal Article
Date
Dec-2018
Author
Tamara V Azizova
Nobuyuki Hamada
Evgeniya S Grigoryeva
Evgeny V Bragin
Author Affiliation
Southern Urals Biophysics Institute, Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia, 456780. clinic@subi.su.
Source
Eur J Epidemiol. 2018 Dec; 33(12):1193-1204
Date
Dec-2018
Language
English
Publication Type
Journal Article
Keywords
Adult
Aged
Cataract - epidemiology - etiology
Female
Humans
Male
Middle Aged
Nuclear Reactors
Occupational Diseases - epidemiology - etiology
Occupational Exposure - adverse effects - statistics & numerical data
Radiation Exposure - adverse effects - statistics & numerical data
Radiation, Ionizing
Retrospective Studies
Risk factors
Russia - epidemiology
Young Adult
Abstract
This study is the first to report cataract type specific risks in a cohort of Russian Mayak Production Association workers following chronic occupational exposure to ionizing radiation. In this retrospective cohort study, 22,377 workers (females 25.4%) first employed in 1948-1982 were followed up till the end of 2008. All cataract subtypes were significantly dependent on sex, attained age, diabetes mellitus, myopia and glaucoma. For each of posterior subcapsular (PSC), cortical and nuclear cataracts, the risk of cataract incidence significantly linearly increased with increasing radiation dose. Excess relative risk per unit effective dose (ERR/Sv) from external ?-rays based on the linear model was 0.91 [95% confidence intervals (CIs) 0.67, 1.20] for PSC, 0.63 (95% CIs 0.49, 0.76) for cortical, and 0.47 (95% CIs 0.35, 0.60) for nuclear cataracts. For all three types of cataracts, exclusion of an adjustment for neutron dose as well as inclusion of additional adjustments for body mass index and smoking index decreased ERR/Sv of external ?-rays. Inclusion of an additional adjustment for glaucoma, however, modestly increased incidence risks for cortical and nuclear cataracts, but not PSC cataracts. Inclusion of an adjustment for diabetes mellitus decreased ERR/Sv of external ?-rays only for PSC incidence. Both males and females had increased risks for all three types of cataracts, but ERR/Sv was significantly higher in females than in males (p?
PubMed ID
30306422 View in PubMed
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