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Cancer incidence among nuclear workers in Russia based on data from the Institute of Physics and Power Engineering: a preliminary analysis.

https://arctichealth.org/en/permalink/ahliterature194679
Source
Radiat Res. 2001 Jun;155(6):801-8
Publication Type
Article
Date
Jun-2001
Author
V K Ivanov
A F Tsyb
E M Rastopchin
A I Gorsky
M A Maksyutov
V I Vayzer
Y V Suspitsin
Y V Fedorov
Author Affiliation
Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk, Russia.
Source
Radiat Res. 2001 Jun;155(6):801-8
Date
Jun-2001
Language
English
Publication Type
Article
Keywords
Cohort Studies
Female
Humans
Incidence
Male
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors
Occupational Exposure
Power Plants
Russia - epidemiology
Abstract
One group that has the potential to be exposed to radiation is workers in the nuclear industry. Results of a systematic medical follow-up and dosimetric monitoring of these workers can form the basis for a study of the relationship between cancer incidence and radiation dose. As part of such efforts in Russia, a major institution of the nuclear industry with an established medical care unit, archiving capabilities, and dosimetry department was selected: the Institute of Physics and Power Engineering (IPPE) in Obninsk. In the study, a comparative analysis of cancer incidence rates for the IPPE workers and for the general population of Russia in 1991-1997 was carried out. The subjects were the IPPE workers hired before 1981. This restriction was imposed to reduce the uncertainty associated with the possible latent period in the development of solid cancers. Thus the possibility of including persons who already had the disease at the time when they were hired was minimized. The analysis is based on information about 158 cancer cases, including 24 cancers in persons under individual dosimetric monitoring. A statistically significant excess in cancer incidence was found among the IPPE workers compared with a comparison population (the general population of Russia) for some types of cancers. The SIR values for all cancers (ICD-9: 140-208) is 0.93 (95% CI 0.76, 1.12) for males and 1.42 (95% CI 1.06, 1.87) for females. A statistically significant excess for all cancers was also observed for residents of Obninsk compared to the control comparison population. The corresponding SIR value was 1.20 (95% CI 1.12, 1.28) for males and 1.58 (95% CI 1.49, 1.69) for females. An important reason for the observed excess in cancer incidence compared to the control population may be the higher level of health care in the so-called nuclear cities of Russia which may have resulted in increased diagnosis and registration of cancers. A statistically significant dependence of the cancer incidence on the dose of ionizing radiation was not established. The excess relative risk per gray for all types of cancer was 0.91 (95% CI -2.75, 4.61) for males and 0.40 (95% CI -6.94, 7.83) for females. These estimates should be considered to be preliminary, as the number of cases considered in the analysis of the dose response is small (17 males and 7 females).
PubMed ID
11352762 View in PubMed
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Concept of optimisation of the radiation protection system in the nuclear sector: management of individual cancer risks and providing targeted health care.

https://arctichealth.org/en/permalink/ahliterature166251
Source
J Radiol Prot. 2006 Dec;26(4):361-74
Publication Type
Article
Date
Dec-2006
Author
V K Ivanov
A F Tsyb
A M Agapov
A P Panfilov
O V Kaidalov
A I Gorski
M A Maksioutov
Y V Suspitsin
V I Vaizer
Author Affiliation
Medical Radiological Research Centre of Russian Academy of Medical Sciences, 4 Korolev Street, Obninsk 249036, Russia.
Source
J Radiol Prot. 2006 Dec;26(4):361-74
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Body Burden
Delivery of Health Care - organization & administration
Humans
Incidence
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors - statistics & numerical data
Quality Assurance, Health Care - organization & administration
Radiation Dosage
Radiation Monitoring - statistics & numerical data
Radiation Protection - methods
Relative Biological Effectiveness
Risk Assessment - methods
Risk factors
Russia - epidemiology
Abstract
The paper discusses the provision of targeted health care to nuclear workers in Russia based on radiation-epidemiological estimates of cancer risks. Cancer incidence rates are analysed for the workers of the Institute of Physical Power Engineering (the first nuclear installation in the world) who were subjected to individual dosimetric monitoring from 1950 to 2002. The value of excess relative risk for solid cancers was found to be ERR Gy(-1) = 0.24 (95% CI: -4.22; 7.96). It has been shown that 81.8% of the persons covered by individual dosimetric monitoring have potential attributive risk up to 5%, and the risk is more than 10% for 3.7% of the workers. Among the detected cancer cases, 73.5% of the individuals show an attributive risk up to 5% and the risk is in excess of 10% for 3.9% of the workers. Principles for the provision of targeted health care, given voluntary health insurance, are outlined.
PubMed ID
17146121 View in PubMed
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[Functional status of the pituitary-thyroid system in children and adolescents exposed to radiation as a result of the accident at the Chernobyl Nuclear Power Station]

https://arctichealth.org/en/permalink/ahliterature37343
Source
Med Radiol (Mosk). 1991;36(7):4-7
Publication Type
Article
Date
1991
Author
A F Tsyb
E G Matveenko
V F Gorobets
L M Tsypliakovskaia
V K Ivanov
O E Stadnik
S A Airapetov
E V Nilova
V N Omel'chenko
M P Borovikova
Source
Med Radiol (Mosk). 1991;36(7):4-7
Date
1991
Language
Russian
Publication Type
Article
Keywords
Accidents
Adolescent
Child
English Abstract
Follow-Up Studies
Humans
Nuclear Reactors
Pituitary Gland - physiology - radiation effects
Thyroid Gland - physiology - radiation effects
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
Ukraine
Abstract
The paper is concerned with the results of a follow-up over the period of 1986-1989 of function of the hypophyseo-thyroid system in children and adolescents (approximately 6000 persons), residing in the South-West of the Kaluga Region, where radiation fallouts were observed after the Chernobyl accident. The results were based upon the analysis of medical examinations and determination of the blood levels of TSH, T4 and T3. A certain functional activation of the thyroid system was observed in a majority of the examinees. A conclusion has been made of a necessity of a long-term follow-up of the thyroid of persons who received radioactive iodine in childhood.
PubMed ID
1881288 View in PubMed
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[Health-related evaluation of thyroid irradiation doses in inhabitants of the Ukrainian S.S.R. after the Chernobyl AES accident]

https://arctichealth.org/en/permalink/ahliterature24949
Source
Vestn Akad Med Nauk SSSR. 1991;(8):44-7
Publication Type
Article
Date
1991
Author
A E Romanenko
I A Likhtarev
N K Shandala
G M Gul'ko
I A Kairo
N I Chepurnoi
Source
Vestn Akad Med Nauk SSSR. 1991;(8):44-7
Date
1991
Language
Russian
Publication Type
Article
Keywords
Accidents
Adult
Child
Comparative Study
English Abstract
Humans
Microcomputers
Models, Theoretical
Neoplasms, Radiation-Induced - etiology
Nuclear Reactors
Radiation Dosage
Software
Thyroid Gland - radiation effects
Thyroid Neoplasms - etiology
Ukraine
Abstract
The paper considers the radiation doses of the thyroid gland in the inhabitants from the Ukrainian SSR areas (Kiev, Zhitomir, Chernigov, and Vinnitsa Regions), which have been obtained by instrumental studies of thyroidal radioactivity in May-June, 1986, and calculated by the most conservative single-dose administration model. A hygienic evaluation has been made of the findings, taking into account the age and residence. The cumulative irradiation doses of the thyroid have been estimated for children and adults. Possible late sequelae for the areas in question may account for 1060 and 300 thyroid carcinoma cases during the whole life for children and adults, respectively.
PubMed ID
1950160 View in PubMed
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[Parameters of thyroid status in children and adolescents living in one of the Kaluga regions contaminated with radionuclides]

https://arctichealth.org/en/permalink/ahliterature36154
Source
Probl Endokrinol (Mosk). 1993 Sep-Oct;39(5):10-3
Publication Type
Article
Author
I I Dedov
A F Tsyb
E G Matveenko
N V Omel'chenko
M P Borovikova
V A Peterkova
A N Tiul'pakov
V I Kandror
N P Goncharov
V S Parshin
Source
Probl Endokrinol (Mosk). 1993 Sep-Oct;39(5):10-3
Language
Russian
Publication Type
Article
Keywords
Accidents
Adolescent
Child
Child, Preschool
English Abstract
Environmental health
Female
Humans
Iodine Radioisotopes
Male
Nuclear Reactors
Radioactive Pollutants - adverse effects
Russia
Thyroid Gland - pathology - physiopathology
Thyrotropin - blood
Thyroxine - blood
Ukraine
Abstract
Thyroid status was examined in 1214 children living in the Ulyanov district of the Kaluga region contaminated with radionuclides. Thyroid size and structure were assessed using ultrasonic examination, its function was characterized based on thyrotropin and free thyroxin measurements. Specific autoimmunity was evaluated from assays of antibodies to microsomal antigen and thyroglobulin. The resultant values were assessed with due consideration for the individual dose of 131I absorbed by the thyroid. Thyroid enlargement was detected in 21.2%, nodular goiter in 0.79% of the examinees. A reliable positive correlation was found between the degree of thyroid enlargement and 131I absorbed dose. Functional parameters (thyrotropin and free thyroxin) were within the normal range, no correlation was detected between hormonal parameters, thyroid size, and 131I absorbed dose. Antibodies to microsomal antigen were detected in 4.3%, to thyroglobulin in 7.2%, to both in 2.8% of the examinees, this being within the normal range in the population; but a relationship was detected between antibody production and absorbed dose of 131I. Hence, though no noticeable changes in the thyroid status were detected 5 years after the accident in the population examined, the revealed correlations between thyroid enlargement, presence of antithyroid antibodies, and 131I dose may be indicative of a possible growth of thyroid morbidity.
PubMed ID
8108337 View in PubMed
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[Radiologic consequences and medico-biological problems 4 years after the accident at the Chernobyl Atomic Electric Power Station]

https://arctichealth.org/en/permalink/ahliterature36859
Source
Vestn Akad Med Nauk SSSR. 1992;(2):7-14
Publication Type
Article
Date
1992
Author
A E Romanenko
Source
Vestn Akad Med Nauk SSSR. 1992;(2):7-14
Date
1992
Language
Russian
Publication Type
Article
Keywords
Accidents
Adult
Child
English Abstract
Humans
Nuclear Reactors
Radioactive Pollutants
Ukraine
Vital statistics
Abstract
The data on the assessment of the radiobiological situation and the results of clinical and epidemiological studies into the population health status, exposed to radiation because of the Chernobyl NPP accident are summarized. Appropriate regularities in soil contamination with 137Cs are ascertained. It has been shown that the disease incidence among the children's and adult population of the controlled areas is associated not only with improvement of the disease revealing but with the influence of the accident consequences.
PubMed ID
1626414 View in PubMed
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[Results of the implementation of the program C.27 and priority trends of further research in the elimination of medical sequelae of the Chernobyl AES accident]

https://arctichealth.org/en/permalink/ahliterature24989
Source
Vestn Akad Med Nauk SSSR. 1991;(11):9-13
Publication Type
Article
Date
1991

'Rogue' cells observed in children exposed to radiation from the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature36350
Source
Int J Radiat Biol. 1993 Mar;63(3):361-7
Publication Type
Article
Date
Mar-1993
Author
A V Sevan'kaev
A F Tsyb
D C Lloyd
A A Zhloba
V V Moiseenko
A M Skrjabin
V M Climov
Author Affiliation
Medical Radiological Research Centre, Russian Academy of Medical Science, Obninsk, Kaluga Region.
Source
Int J Radiat Biol. 1993 Mar;63(3):361-7
Date
Mar-1993
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Adult
Byelarus
Child
Child, Preschool
Chromosome Aberrations - genetics
Humans
Infant
Lymphocytes - radiation effects
Nuclear Reactors
Radiation Genetics
Ukraine
Abstract
Eight 'rogue' lymphocyte metaphases containing a large number of aberrant chromosomes were noted during a survey of chromosomal damage in 328 Belarussian children. The study population comprised children of families living in territory contaminated by radiation from the Chernobyl accident. The majority of the sample had been evacuated within 1 week from very heavily polluted territory to areas that had received much less fallout. Two hundred cells were scored per subject and one rogue cell was found in a child exposed in utero; one in a child conceived after the accident and six in the postnatally exposed group. The possibility that the damage was due to exposure to radio-iodine concentrated in the thyroid gland, or to radiation from incorporated 'hot particles' of an alpha or beta/gamma emitter is discussed. It is concluded that the damage to these cells is unlikely to have been caused by radiation.
PubMed ID
8095287 View in PubMed
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[The probable causes of thyroid diseases in the victims of the Chernobyl accident]

https://arctichealth.org/en/permalink/ahliterature23770
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):8-15
Publication Type
Article
Author
A M Poverennyi
Iu S Riabukhin
A F Tsyb
Source
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):8-15
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Air Pollution, Radioactive - adverse effects
Byelarus - epidemiology
Child
Dose-Response Relationship, Radiation
English Abstract
Environmental Exposure - adverse effects
Humans
Iodine Radioisotopes - adverse effects
Neoplasms, Radiation-Induced - diagnosis - epidemiology - etiology
Nuclear Reactors
Power Plants
Risk factors
Thyroid Neoplasms - diagnosis - epidemiology - etiology
Thyroiditis, Autoimmune - diagnosis - epidemiology - etiology
Ukraine - epidemiology
Abstract
Ideas about the thyroid gland diseases development in people suffering from the Chernobyl accident explaining the absence of straight dose dependence of pathologies raise from the irradiation were elaborated. It is supposed that the probable reason for a number of these pathologies can be the inadequate and inopportune preventive iodine administration. It is known that significant amount of iodine being incorporated in children or persons with compromised thyroid gland could lead to a number of pathological changes, primarily to autoimmune thyroiditis which is a reason of other consequent pathologies of this organ. The principal mechanism of the process can be presented as following: iodine transformation (oxidation) in the thyroid gland accompanies with the generation of considerable quantities of various radicals imitating the radiation damage. This hypothesis allows to consider the children suffered from the Chernobyl accident with autoimmune thyroiditis as belonging to the group of risk as the literary data testify that the presence of autoimmune thyroiditis rises 75 time the risk of malignant lympho-proliferated diseases appearance. A simple immunological method of autoimmune thyroiditis diagnostics was developed which informativity is comparable with the method of ultrasound diagnostics. Serial production (the antibodies to microsomal fraction of thyroid gland) was organized. This method can be used in screening investigations.
PubMed ID
8148983 View in PubMed
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10 records – page 1 of 1.