The incidence of birth has been determined for each hour of the day for all births in Norway in 1968-1977 of fetuses of 16 weeks of gestation or older, with resident mothers. The 24-hour incidence variations of births (A) with spontaneous onset and parturition, (B) with spontaneous onset, but delivery intervention, (C) with induced onset, but spontaneous birth, and (D) with induced onset and delivery intervention, are all different. It is shown that the curve for the hourly incidence of birth category A coincides very well with previous results of other workers. When multiple births are excluded and category A is split into first and later births in Northern and Southern Norway, dissimilarities arise between the respective 24-hour incidence curves. The results indicate that the 24-hour birth incidence variation has an underlying endogenous, circadian rhythmicity - possibly synchronized by the sun. The 24-hour rhythmicities of birth categories B, C and D seem to be purely exogenous - reflecting the working activity rhythms of hospital obstetricians and midwives.
BACKGROUND: The intention of this study was to increase the knowledge concerning the rehabilitation of women with drug problems after the birth of a child and to find out how the children developed. MATERIAL AND METHODS: A follow-up study of 31 women, former drug and alcohol abusers and their children, 19 girls and 12 boys born in 1982-1983. The first survey took place when the children were 2-3 years of age, then when they were 7-9 and at last when they were 15-17. The biological mothers, foster or adoptive mothers, the children and their teachers were interviewed. RESULTS: The women got more support and control during the pregnancy than afterwards. Most of the mothers became single. Women with the shortest drug history, a good social network and a stable partner without drug problems kept the care of their children. By the first survey (1985), seven children had been placed in foster homes, in the second (1992) two further children had been taken away from their mothers, and in the third (1999) only one third of the children were living with their biological mothers. Most of the children did well at school and in their families, had friends and leisure activities despite still living by their mothers or in foster/adoption homes. None of the youngsters had been in conflict with the law or were drug abusers, but every second teenage girl needed psychological support. Children who had been stable by their drug-free biological mothers functioned best. INTERPRETATION: Mothers with drug problems do not get sufficient attention after the delivery and when the children grow up. A supporting family should be brought in contact with mother and child after the delivery. Under special circumstances pregnancy can be a positive turning point for women with drug problems.
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple adverse health outcomes in children, but the underlying mechanisms are unclear.
We investigated epigenome-wide methylation in cord blood of newborns in relation to maternal smoking during pregnancy.
We examined maternal plasma cotinine (an objective biomarker of smoking) measured during pregnancy in relation to DNA methylation at 473,844 CpG sites (CpGs) in 1,062 newborn cord blood samples from the Norwegian Mother and Child Cohort Study (MoBa) using the Infinium HumanMethylation450 BeadChip (450K).
We found differential DNA methylation at epigenome-wide statistical significance (p-value
The objective was to investigate prevalence, estimate risk factors, and antenatal suspicion of abnormally invasive placenta (AIP) associated with laparotomy in women in the Nordic countries.
Population-based cohort study.
A 3-year Nordic collaboration among obstetricians to identify and report on uterine rupture, peripartum hysterectomy, excessive blood loss, and AIP from 2009 to 2012 The Nordic Obstetric Surveillance Study (NOSS).
In the NOSS study, clinicians reported AIP cases from maternity wards and the data were validated against National health registries.
Prevalence, risk factors, antenatal suspicion, birth complications, and risk estimations using aggregated national data.
A total of 205 cases of AIP in association with laparotomy were identified, representing 3.4 per 10 000 deliveries. The single most important risk factor, which was reported in 49% of all cases of AIP, was placenta praevia. The risk of AIP increased seven-fold after one prior caesarean section (CS) to 56-fold after three or more CS. Prior postpartum haemorrhage was associated with six-fold increased risk of AIP (95% confidence interval 3.7-10.9). Approximately 70% of all cases were not diagnosed antepartum. Of these, 39% had prior CS and 33% had placenta praevia.
Our findings indicate that a lower CS rate in the population may be the most effective way to lower the incidence of AIP. Focused ultrasound assessment of women at high risk will likely strengthen antenatal suspicion. Prior PPH is a novel risk factor associated with an increased prevalence of AIP.
An ultrasound assessment in women with placenta praevia or prior CS may double the awareness for AIP.
BACKGROUND: The aim of the study was to investigate possible associations between social background, other aspects of childhood environment and induced abortion among young women. MATERIAL AND METHODS: Norwegian girls (N = 2,198), comprising a representative sample, were followed up through three data collections from they were in their teens in 1992 till they were young adult women (20 - 27 years) seven years later. A questionnaire was used to collect the data and the analyses were conducted by Cox regression. The response rate for the first data collection was 97%. The cumulative response rate over all three data collections was 69 %. RESULTS: In young adulthood we uncovered a steady reduction of induced abortion rates with increasing educational level. Women who had grown up in Northern Norway had higher rates than other women. There was a lower risk for induced abortion when parents were well educated and had fairly good jobs. Further, there were associations to parental divorce, weak parental monitoring and parental alcohol abuse. INTERPRETATION: A host of socioeconomic factors are associated with abortion risk. We need more thorough knowledge about these factors. We can, however, conclude that preventive efforts in this area should be targeted towards groups with risk factors.
Comment In: Tidsskr Nor Laegeforen. 2006 Jun 22;126(13):172716794660