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58 records – page 1 of 6.

[Age-related characteristics of contractile vascular reactions and the content of oxygen free radicals and nitric oxide metabolites in BALB/c mice in conditions of alienation zone]

https://arctichealth.org/en/permalink/ahliterature83418
Source
Fiziol Zh. 2005;51(3):32-41
Publication Type
Article
Date
2005
Author
Tkachenko M M
Sahach V F
Baziliuk O V
Kotsiuruba A V
Popereka H M
Stepanenko L H
Seniuk O F
Source
Fiziol Zh. 2005;51(3):32-41
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Aging - metabolism - radiation effects
Animals
Aorta, Thoracic - metabolism - radiation effects
Chernobyl Nuclear Accident
Free Radicals - metabolism
Leukotriene C4 - metabolism
Lipid Peroxides - metabolism
Male
Mice
Mice, Inbred BALB C
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - metabolism - radiation effects
Nitric Oxide - metabolism
Thromboxane B2 - metabolism
Abstract
Peculiarities of changes of the endothelium-dependent and endothelium-independent vascular reactions of relaxation, and the content of oxygen free radicals and stable metabolites of nitric oxide (NO) were studied in the aorta preparations of BALB/c mice of the two age groups (6 and 18 months), which were born and lived in the Chernobyl alienation zone. The results obtained showed no endothelium-dependent reactions of aortal smooth muscles relaxation to acetylcholine and only partially impaired endothelium-independent reactions to sodium nitroprusside in animals of both age groups. There was a significant decrease in the content of high-molecular nitrosothiols (HMNT) in old animals, which may signify a depletion of NO depot in the aorta. A decrease of HMNT levels induced an increase of the shares of anion nitrite and low-molecular nitrosothiols (LMNT) in the total amount of endogenous donors of NO in the aorta of old animals. Exposure of old animals to low doses of radiation resulted in an over 3-fold increase of LMNT. In old mice the levels of oxygen active forms, superoxide and hydroxyl radicals increase, while the level of H2O2 remained unchanged.
PubMed ID
16108223 View in PubMed
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Airway irritation among indoor swimming pool personnel: trichloramine exposure, exhaled NO and protein profiling of nasal lavage fluids.

https://arctichealth.org/en/permalink/ahliterature123142
Source
Int Arch Occup Environ Health. 2013 Jul;86(5):571-80
Publication Type
Article
Date
Jul-2013
Author
Louise Fornander
Bijar Ghafouri
Mats Lindahl
Pål Graff
Author Affiliation
Occupational and Environmental Medicine, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Source
Int Arch Occup Environ Health. 2013 Jul;86(5):571-80
Date
Jul-2013
Language
English
Publication Type
Article
Keywords
Adult
Air Pollutants, Occupational - adverse effects - analysis
Biological Markers - metabolism
Chlorides - adverse effects - analysis
Cross-Sectional Studies
Electrophoresis, Gel, Two-Dimensional
Female
Humans
Immunoblotting
Male
Middle Aged
Nasal Lavage Fluid - chemistry
Nitric Oxide - metabolism
Nitrogen Compounds - adverse effects - analysis
Occupational Diseases - diagnosis - epidemiology - etiology - metabolism
Occupational Exposure - adverse effects - analysis
Prevalence
Proteome - metabolism
Respiratory Tract Diseases - diagnosis - epidemiology - etiology - metabolism
Risk factors
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Sweden - epidemiology
Swimming Pools
Abstract
Occurrence of airway irritation among indoor swimming pool personnel was investigated. The aims of this study were to assess trichloramine exposure levels and exhaled nitric oxide in relation to the prevalence of airway symptoms in swimming pool facilities and to determine protein effects in the upper respiratory tract.
The presence of airway symptoms related to work was examined in 146 individuals working at 46 indoor swimming pool facilities. Levels of trichloramine, as well as exhaled nitric oxide, were measured in five facilities with high prevalence of airway irritation and four facilities with no airway irritation among the personnel. Nasal lavage fluid was collected, and protein profiles were determined by a proteomic approach.
17 % of the swimming pool personnel reported airway symptoms related to work. The levels of trichloramine in the swimming pool facilities ranged from 0.04 to 0.36 mg/m(3). There was no covariance between trichloramine levels, exhaled nitric oxide and prevalence of airway symptoms. Protein profiling of the nasal lavage fluid showed that the levels alpha-1-antitrypsin and lactoferrin were significantly higher, and S100-A8 was significantly lower in swimming pool personnel.
This study confirms the occurrence of airway irritation among indoor swimming pool personnel. Our results indicate altered levels of innate immunity proteins in the upper airways that may pose as potential biomarkers. However, swimming pool facilities with high prevalence of airway irritation could not be explained by higher trichloramine exposure levels. Further studies are needed to clarify the environmental factors in indoor swimming pools that cause airway problems and affect the immune system.
PubMed ID
22729567 View in PubMed
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The air we breathe: three vital respiratory gases and the red blood cell: oxygen, nitric oxide, and carbon dioxide.

https://arctichealth.org/en/permalink/ahliterature135250
Source
Transfusion. 2011 Apr;51(4):676-85
Publication Type
Article
Date
Apr-2011
Author
Walter H Dzik
Author Affiliation
Blood Transfusion Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. sdzik@partners.org
Source
Transfusion. 2011 Apr;51(4):676-85
Date
Apr-2011
Language
English
Publication Type
Article
Keywords
2,3-Diphosphoglycerate - metabolism
Air
Carbon Dioxide - metabolism
Erythrocytes - metabolism
Humans
Nitric Oxide - metabolism
Oxygen - metabolism
Abstract
Three vital respiratory gases-oxygen (O(2)), nitric oxide (NO), and carbon dioxide (CO(2))-intersect at the level of the human red blood cell (RBC). In addition to hemoglobin (Hb)'s central role in O(2) transport, interaction of Hb with the Band 3 metabolon balances RBC energy flow. 2,3-Diphosphoglycerate enhances O(2) transport across the placenta and plays an important role in regulating RBC plasticity. NO is a key mediator of hypoxic vasodilation, but the precise role of RBC Hb remains controversial. In addition to established theories that depend on RBC uptake, delivery, and discharge of NO or its metabolites, an alternative hypothesis based on RBC permeability is suggested. NO depletion by free Hb may account for several clinical features seen during intravascular hemolysis or during deliberate infusion of Hb solutions used as RBC substitutes. CO(2) released by tissues triggers oxygen release through a series of well-coordinated reactions centered on the Band 3 metabolon. While RBC carbonic anhydrase and the Band 3 anion exchanger are central to this process, there is surprisingly little research on the kinetics of CO(2) clearance by transfusion. The three RBC gases are directly related to the three principal gases of Earth's atmosphere. Human fossil fuel consumption dumps 90 million metric tons of carbon into the atmosphere annually. Increasing CO(2) levels are linked to global warming, melting Arctic ice, rising sea levels, and climate instability. Just as individual cells depend on balance of the three vital gases, so too will their balance determine survival of life on Earth.
PubMed ID
21496039 View in PubMed
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[Antioxidant protection, metabolites of nitrogen oxide on the forming of oxidative stress in patients with bronchial asthma]

https://arctichealth.org/en/permalink/ahliterature14993
Source
Lik Sprava. 2005 Jul-Sep;(5-6):36-40
Publication Type
Article
Author
H P Pobed'onna
Source
Lik Sprava. 2005 Jul-Sep;(5-6):36-40
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Antioxidants - metabolism
Asthma - blood - metabolism - physiopathology
Biological Markers - analysis
Breath Tests
Bronchi - physiopathology
Comparative Study
English Abstract
Female
Forced Expiratory Volume - physiology
Humans
Lipid Peroxidation - physiology
Male
Nitrates - analysis
Nitric Oxide - metabolism
Nitrites - analysis
Oxidative Stress
Severity of Illness Index
Abstract
276 Patients with bronchial asthma of different degree of severity have been observed. An increase in processes of lipid peroxidation, depression of antioxidant protection, increase in oxide nitrogen metabolites in blood serum and condensate of exhaled air were detected. These pathological changes may be considered as manifestation of system oxidative stress more expressed in bronchi.
PubMed ID
16396289 View in PubMed
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Antioxidative response for nitric oxide production in breast carcinoma.

https://arctichealth.org/en/permalink/ahliterature17490
Source
Oncol Rep. 2004 Oct;12(4):755-9
Publication Type
Article
Date
Oct-2004
Author
Peeter Karihtala
Vuokko L Kinnula
Ylermi Soini
Author Affiliation
Department of Pathology, University of Oulu and Oulu University Hospital, FIN-90014 Oulu, Finland.
Source
Oncol Rep. 2004 Oct;12(4):755-9
Date
Oct-2004
Language
English
Publication Type
Article
Keywords
Adenocarcinoma, Mucinous - metabolism - pathology
Adult
Aged
Aged, 80 and over
Breast Neoplasms - metabolism - pathology
Carcinoma, Papillary
Catalase - metabolism
Female
Free Radical Scavengers - pharmacology
Humans
Middle Aged
Neoplasms, Ductal, Lobular, and Medullary - metabolism - pathology
Nitric Oxide - metabolism - pharmacology
Nitric Oxide Synthase - metabolism
Oxidants - pharmacology
Oxidation-Reduction
Oxidative Stress
Protein Isoforms
Research Support, Non-U.S. Gov't
Superoxide Dismutase - metabolism
Tyrosine - analogs & derivatives - metabolism
Vascular Endothelial Growth Factor A - metabolism
Abstract
Our aim was to study the role of oxidant and nitric oxide (NO)-derived damage in human breast carcinomas by studying the expression of nitrotyrosine in tumor tissue. To elucidate whether nitrotyrosine levels associate with NO synthesis and have an effect on antioxidative enzyme response or angiogenesis, we also studied the expression of all three nitric oxide synthases (NOS), manganese superoxide dismutase (MnSOD), catalase and vascular endothelial growth factor (VEGF) in the tumors. A large set of breast cancer samples in microarray blocks were stained with antibodies to nitrotyrosine, iNOS, eNOS, nNOS, MnSOD, catalase and VEGF. Nitrotyrosine expression was seen in 56% of the cases. There was a close relationship between the expression of nitrotyrosine and all three NOS isoforms (for all p
PubMed ID
15375496 View in PubMed
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Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.

https://arctichealth.org/en/permalink/ahliterature156745
Source
Am J Hypertens. 2008 Aug;21(8):873-8
Publication Type
Article
Date
Aug-2008
Author
Hannu Päivä
Mika Kähönen
Terho Lehtimäki
Olli T Raitakari
Antti Jula
Jorma Viikari
Georg Alfthan
Markus Juonala
Reijo Laaksonen
Nina Hutri-Kähönen
Author Affiliation
Emergency Department, University Hospital of Tampere, Tampere, Finland. hannu.paiva@pshp.fi
Source
Am J Hypertens. 2008 Aug;21(8):873-8
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Adult
Arginine - analogs & derivatives - blood
Blood Pressure - physiology
Cardiovascular Diseases - epidemiology
Female
Finland - epidemiology
Humans
Kidney - physiology
Lipids - blood
Male
Nitric Oxide - metabolism
Risk factors
Vascular Resistance - physiology
Vasoconstriction - physiology
Young Adult
Abstract
This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivity in experimental but not undoubtedly in physiological settings.
A total of 199 subjects aged 31.4 years (range 24-39 years) were studied. Plasma ADMA and symmetric dimethylarginine (SDMA) were assessed by isocratic high-pressure liquid chromatography using precolumn derivatization with o-phtaldialdehyde at baseline. Blood pressure (BP) was measured by casual measurements in the beginning of the study and after a follow-up period of 2.45 +/- 0.42 years (range, 1.86-3.19 years). Hemodynamic regulation was assessed by noninvasive methods after a follow-up.
Plasma ADMA had a negative association with resting systemic vascular resistance index (SVRI) (r = -0.23, P
PubMed ID
18551100 View in PubMed
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Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization.

https://arctichealth.org/en/permalink/ahliterature273226
Source
J Allergy Clin Immunol. 2016 Jan;137(1):68-74.e4
Publication Type
Article
Date
Jan-2016
Author
Rebecca K Vinding
Jakob Stokholm
Bo L K Chawes
Hans Bisgaard
Source
J Allergy Clin Immunol. 2016 Jan;137(1):68-74.e4
Date
Jan-2016
Language
English
Publication Type
Article
Keywords
Airway Obstruction - blood - epidemiology - metabolism - physiopathology
Allergens - immunology
Asthma - blood - metabolism - physiopathology
Bronchial Hyperreactivity - blood - epidemiology - metabolism - physiopathology
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Female
Forced expiratory volume
Humans
Immunoglobulin E - blood
Infant
Male
Nitric Oxide - metabolism
Rhinitis, Allergic - blood - epidemiology - metabolism - physiopathology
Spirometry
Abstract
Studies of children's blood lipid profiles in relation to asthma are few, and the results are ambiguous.
We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children.
High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were measured at ages 5 to 7 years in the Copenhagen Prospective Studies on Asthma in Childhood2000 at-risk birth cohort. Asthma and allergic rhinitis were diagnosed based on predefined algorithms at age 7 years along with assessments of lung function, bronchial responsiveness, fraction of exhaled nitric oxide (Feno), and allergic sensitization. Associations between lipid levels and clinical outcomes were adjusted for sex, passive smoking, and body mass index.
High levels of low-density lipoprotein cholesterol were associated with concurrent asthma (adjusted odds ratio [aOR], 1.93; 95% CI, 1.06-3.55; P = .03) and airway obstruction: 50% of forced expiratory flow (aß coefficient, -0.13 L/s; 95% CI, -0.24 to -0.03 L/s; P = .01) and specific airway resistance (aß coefficient, 0.06 kPa/s; 95% CI, 0.00-0.11 kPa/s; P = .05). High levels of high-density lipoprotein cholesterol were associated with improved specific airway resistance (aß coefficient, -0.11 kPa/s; 95% CI, -0.21 to -0.02; P = .02), decreased bronchial responsiveness (aß coefficient, 0.53 log-µmol; 95% CI, 0.00-1.60 log-µmol; P = .05), decreased risk of aeroallergen sensitization (aOR, 0.27; 95% CI, 0.01-0.70; P = .01), and a trend of reduced Feno levels (aß coefficient, -0.22 log-ppb; 95% CI, -0.50 to 0.01 log-ppb; P = .06). High triglyceride levels were associated with aeroallergen sensitization (aOR, 2.01; 95% CI, 1.14-3.56; P = .02) and a trend of increased Feno levels (aß coefficient, 0.14 log-ppb; 95% CI, -0.02 to 0.30 log-ppb; P = .08).
The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy are systemic disorders with commonalities with other chronic inflammatory disorders.
PubMed ID
26148797 View in PubMed
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[Changes of nitric oxide system during acute myocardial ischemic reperfusion]

https://arctichealth.org/en/permalink/ahliterature53904
Source
Fiziol Zh. 2000;46(6):3-11
Publication Type
Article
Date
2000
Author
O O Moibenko
M Ia Iuz'kiv
A V Kotsiuruba
O M Bukhanevych
L V Tumanovs'ka
Author Affiliation
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Source
Fiziol Zh. 2000;46(6):3-11
Date
2000
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Arginine - metabolism
Disease Models, Animal
Dogs
English Abstract
Myocardial Ischemia - blood - metabolism - urine
Myocardial Reperfusion
Nitric Oxide - metabolism
Abstract
The reciprocal changes of NOS and arginase activity during acute myocardial ischaemia (90 min) and reperfusion (180 min) was shown in experiments on chest-closed dogs with spontaneous breathing. NOS activity in the ischemia injured myocardial decreased on 60% while arginase activity increased on 487%. Levels of both alternative pathways of L-arginine metabolism altered reciprocally too. NO2(-)-level was reduced on 57%, and urea level increased on 665%. The same changes were in arterial blood, started from 10 min of ischemia. These changes can play an important role for development of acute ischaemia treatment.
PubMed ID
11424561 View in PubMed
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Characterization of lung hyperresponsiveness, inflammation, and alveolar macrophage mediator production in allergy resistant and susceptible rats.

https://arctichealth.org/en/permalink/ahliterature15386
Source
Am J Respir Cell Mol Biol. 2002 May;26(5):579-86
Publication Type
Article
Date
May-2002
Author
Eric Careau
Jocelyne Sirois
Elyse Y Bissonnette
Author Affiliation
Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, Québec, Canada.
Source
Am J Respir Cell Mol Biol. 2002 May;26(5):579-86
Date
May-2002
Language
English
Publication Type
Article
Keywords
Animals
Bronchoalveolar Lavage Fluid - cytology - immunology
Cell Count
Cytokines - metabolism
Disease Progression
Disease Susceptibility - immunology
Eosinophils - metabolism - pathology
Hypersensitivity - immunology - metabolism - pathology
Inflammation Mediators - metabolism
Interleukin-10 - metabolism
Lung - immunology - metabolism - pathology
Macrophages, Alveolar - metabolism - pathology
Neutrophils - cytology - metabolism
Nitric Oxide - metabolism
Ovalbumin
Pneumonia - chemically induced - immunology - metabolism - pathology
Rats
Rats, Inbred BN
Rats, Sprague-Dawley
Research Support, Non-U.S. Gov't
Species Specificity
Tumor Necrosis Factor-alpha - metabolism
Abstract
To better understand asthma pathogenesis, we characterized airway responsiveness, lung inflammation, and mediator production of alveolar macrophages (AM) after allergen sensitization and challenge in two strains of rats showing different susceptibilities in developing airway allergic reactions. Airway responsiveness to acethylcholine was measured 24 h after ovalbumin (OVA) challenge, whereas bronchoalveolar lavages were performed 5 min, 8 h, and 24 h after challenge. Brown Norway rats showed airway hyperresponsiveness after challenge, whereas lung resistance remained unchanged in Sprague-Dawley rats. Interestingly, Sprague-Dawley rats developed a neutrophilic inflammation, whereas both neutrophils and eosinophils were increased in Brown Norway rats. AM mediator production varied with time with a lower tumor necrosis factor (TNF) and interleukin (IL)-10 release at 8 h after challenge. OVA challenge stimulated spontaneous TNF and IL-10 release by AM isolated 24 h after challenge in both strains of rats, although AM from Brown Norway rats released significantly more IL-10 and TNF. Furthermore, nitric oxide production was increased only in OVA-challenged (24 h) Brown Norway rats. Our results suggest that AM may participate to the expansion of Th2 inflammation in Brown Norway rats and that differences in AM mediator production may explain, in part, distinct allergic susceptibilities in these two strains of rats.
PubMed ID
11970910 View in PubMed
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Circulating nitric oxide products do not solely reflect nitric oxide release in cirrhosis and portal hypertension.

https://arctichealth.org/en/permalink/ahliterature133052
Source
Liver Int. 2011 Oct;31(9):1381-7
Publication Type
Article
Date
Oct-2011
Author
Pia Afzelius
Nassim Bazeghi
Peter Bie
Flemming Bendtsen
Jørgen Vestbo
Søren Møller
Author Affiliation
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Source
Liver Int. 2011 Oct;31(9):1381-7
Date
Oct-2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biological Markers - blood
Breath Tests
Case-Control Studies
Denmark
Female
Heart rate
Hemodynamics
Humans
Hypertension, Portal - blood - etiology - physiopathology
Liver Cirrhosis - blood - complications - physiopathology
Male
Middle Aged
Nitrates - blood
Nitric Oxide - metabolism
Nitrites - blood
Portal Pressure
Pulmonary Diffusing Capacity
Renin-Angiotensin System
Respiratory Function Tests
Splanchnic Circulation
Supine Position
Vasodilation
Abstract
Patients with cirrhosis often develop a systemic vasodilatation and a hyperdynamic circulation with activation of vasoconstrictor systems such as the renin-angiotensin-aldosterone system (RAAS), and vasopressin. Increased nitric oxide (NO) synthesis has been implicated in the development of this state of vasodilation and pulmonary dysfunction including increased exhaled NO concentrations. Circulating metabolites (NO(x)) may affect the systemic and pulmonary NO-generation. However, the relations of these abnormalities to the haemodynamic changes remain unclear.
The aims of the present study were to measure changes in exhaled NO in relation to circulating NO(x), RAAS, and haemodynamics.
Twenty patients (eight child class A and 12 class B patients) underwent a liver vein catheterization with determination of splanchnic and systemic haemodynamics. Circulating NO(x) and exhaled NO were determined in the supine and sitting positions and related to haemodynamics, RAAS and lung diffusing capacity (D(L)CO). Eight matched healthy individuals served as controls.
All patients with cirrhosis had portal hypertension. We found no significant difference in exhaled NO between patients and controls and no changes from the supine to the sitting position. Exhaled NO in the patients correlated significantly with plasma volume, heart rate and D(L)CO. NO(x) concentrations were not significantly increased in the patients. NO(x) correlated with portal pressure and haemodynamic indicators of vasodilatation, but not with exhaled NO concentrations.
In patients with moderate cirrhosis, exhaled NO is normal. Circulating NO(x) do not seem to reflect pulmonary and systemic NO release, but NO(x) seems to reflect systemic and splanchnic haemodynamic changes in cirrhosis.
PubMed ID
21745317 View in PubMed
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58 records – page 1 of 6.