Skip header and navigation

2 records – page 1 of 1.

[Humoral autoimmune responses to neurospecific proteins in rats with experimental allergic encephalomyelitis and immunomodulation with allogeneic nervous tissue]

https://arctichealth.org/en/permalink/ahliterature57459
Source
Fiziol Zh. 2002;48(1):15-24
Publication Type
Article
Date
2002
Author
M I Lisianyi
L D Liubych
O V Markova
L M Biel's'ka
Author Affiliation
Acad. A.P. Romodanov Institute of Neurosurgery, AMS of Ukraine, Kiev.
Source
Fiziol Zh. 2002;48(1):15-24
Date
2002
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Autoantibodies - blood - immunology
Brain - cytology
Encephalomyelitis, Autoimmune, Experimental - immunology - physiopathology
English Abstract
Immunotherapy
Myelin Basic Proteins - immunology
Neuroglia - immunology - transplantation
Neurons - immunology - transplantation
Rats
Transplantation, Homologous
Abstract
Possible immunocorrective effect of the embryonic nervous tissue (NT) and using the model of an experimental allergic encephalomyelitis (EAE) in treating patients with demyelinizing diseases is a prospective field of research. EAE was induced by immunization of rats with the mixture of the spinal cord and BCV at paw pillows. Immunocorrective effect of the allogenic NT was studied in the animals with EAE following the intraperitoneal injection of a newborn rat's NT, namely: enriched fractions of glial and neuronal cell populations. Both intact and EAE animals, treated with culture medium, were used as controls. The clinical signs appeared on 12-th day after EAE inducing. The severe clinical course of EAE was accompanied with statistically significant higher titers of the autoantibodies to MBP as compared with the mild clinical course. The results obtained evidence for the possible immunocorrective effect of enriched fractions of the newborn rat's nervous cells on EAE, and for immunosuppressive effect of the neuronal fraction of NT on the immunopathological processes in EAE.
PubMed ID
11928626 View in PubMed
Less detail

[Modeling of experimental allergic encephalomyelitis in rats and immunomodulation with allogeneic brain cells]

https://arctichealth.org/en/permalink/ahliterature57467
Source
Fiziol Zh. 2001;47(5):37-40
Publication Type
Article
Date
2001
Author
M I Lisianyi
O V Markova
L M Bel's'ka
Author Affiliation
Institute of Neurosurgery, Lab. of Neuroimmunology, Ukraine, Kiev.
Source
Fiziol Zh. 2001;47(5):37-40
Date
2001
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Brain - cytology - immunology
Brain Tissue Transplantation
Encephalomyelitis, Autoimmune, Experimental - etiology - immunology - therapy
English Abstract
Freund's Adjuvant - administration & dosage - immunology
Immunization
Immunotherapy - methods
Neuroglia - immunology - transplantation
Neurons - immunology - transplantation
Rats
Spinal Cord - immunology
Transplantation, Homologous
Abstract
We studied the immunocorrective effect of the allogenic new-born brain cells on the model of rats experimental allergic encephalomyelitis (EAE). EAE was induced by the immunization of old rats spinal cord homogenate in Freund's adjuvant. Correction was carried on the 12-th, 14-th, 16-th day after the induction of the EAE by the intraperitoneum injection of rat's new-born brain fractions enriched with neurons and glial cells. A positive clinical effect was achieved by the employment of neurons (the stabilization of encephalomyelitis and the acceleration of the recovery). The glia correction was accompanied by the aggravation in the course of encephalomielitis and by extension of its clinical manifestation period. The obtained results testify to the existence of both an immunoregulative and a neurotrophic influence of the neuron fraction of the new-born brain cells. The mechanism of a corrective effect needs further special investigation.
PubMed ID
11758466 View in PubMed
Less detail