Skip header and navigation

1 records – page 1 of 1.

The 2010 WHO classification of digestive neuroendocrine neoplasms: a critical appraisal four years after its introduction.

https://arctichealth.org/en/permalink/ahliterature260854
Source
Endocr Pathol. 2014 Jun;25(2):186-92
Publication Type
Article
Date
Jun-2014
Author
G. Rindi
G. Petrone
F. Inzani
Source
Endocr Pathol. 2014 Jun;25(2):186-92
Date
Jun-2014
Language
English
Publication Type
Article
Keywords
Digestive System Neoplasms - classification
Humans
Neoplasm Grading - standards
Neoplasm Staging - standards
Neuroendocrine Tumors - classification
World Health Organization
Abstract
This paper briefly illustrates the basis, rules of application, and present outcome of the current World Health Organization (WHO) classification for neuroendocrine neoplasms. Established in 2010 upon the proposal from the European Neuroendocrine Tumor Society (ENETS), the WHO 2010 fostered some definitional changes (most notably the use of neuroendocrine tumor (NET) instead of carcinoid) and indicated the tools of grading and staging. Specific rules for its application were also defined. The data generated from the use of WHO 2010 classification substantially endorsed its rules and prognostic efficacy. In addition, the application demonstrated some issues, among which are the possible re-definition of the cutoff for grading G1 vs G2, as well as the possible identification of cases with somewhat different clinical behavior within the G3 neuroendocrine cancer class. Overall, since the recent introduction of WHO 2010 grading and staging, it appears wise to keep the current descriptors to avoid unnecessary confusion and to generate comparable data. Homogenous data on large series are ultimately needed to solve such issues.
PubMed ID
24699927 View in PubMed
Less detail