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Aging influences multiple incidices of oxidative stress in the aortic media of the Fischer 344/NNiaxBrown Norway/BiNia rat.

https://arctichealth.org/en/permalink/ahliterature82960
Source
Free Radic Res. 2006 Feb;40(2):185-97
Publication Type
Article
Date
Feb-2006
Author
Rice K M
Preston D L
Walker E M
Blough E R
Author Affiliation
Marshall University, Department of Biological Sciences, Huntington, WV 2755-1090, USA.
Source
Free Radic Res. 2006 Feb;40(2):185-97
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Aging - physiology
Animals
Aorta - metabolism
Cell Proliferation
Ethidium - chemistry
Genes, src
JNK Mitogen-Activated Protein Kinases - metabolism
Ki-67 Antigen - metabolism
Mitogen-Activated Protein Kinases - metabolism
Multienzyme Complexes
NF-kappa B - genetics - metabolism
Oxidative Stress
Phenanthridines - chemistry
Phosphorylation
Protein-Serine-Threonine Kinases
Proteins - chemistry - metabolism
Proto-Oncogene Proteins c-bcl-2 - metabolism
Rats
Rats, Inbred BN
Rats, Inbred F344
TNF Receptor-Associated Factor 2 - metabolism
bcl-2-Associated X Protein - metabolism
Abstract
Here, we determine the influence of aging on multiple markers of oxidative stress in the aorta of adult (6-month), aged (30-month) and very aged (36-month) Fischer 344/NNiaHSdxBrown Norway/BiNia (F344/NxBN) rats. Compared to adults, increases in as determined by oxidation of hydroethidine (HE) to ethidium (Et) were increased 79.7+/-7.0% in 36-month aortae and this finding was highly correlated with increases in medal thickness (r=0.773, p
PubMed ID
16390828 View in PubMed
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PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.

https://arctichealth.org/en/permalink/ahliterature150812
Source
Inflamm Bowel Dis. 2009 Oct;15(10):1562-9
Publication Type
Article
Date
Oct-2009
Author
Marco Zucchelli
Leif Torkvist
Francesca Bresso
Jonas Halfvarson
Anna Hellquist
Francesca Anedda
Ghazaleh Assadi
Gunnar B Lindgren
Monika Svanfeldt
Martin Janson
Colin L Noble
Sven Pettersson
Maarit Lappalainen
Paulina Paavola-Sakki
Leena Halme
Martti Färkkilä
Ulla Turunen
Jack Satsangi
Kimmo Kontula
Robert Löfberg
Juha Kere
Mauro D'Amato
Author Affiliation
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Source
Inflamm Bowel Dis. 2009 Oct;15(10):1562-9
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Cohort Studies
Colitis, Ulcerative - genetics
Crohn Disease - genetics
Female
Finland
Genotype
Humans
Male
Middle Aged
NF-kappa B - genetics - metabolism
Nod2 Signaling Adaptor Protein - genetics - metabolism
Polymorphism, Single Nucleotide - genetics
Sweden
Symporters - genetics
Abstract
Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.
Twelve SLC15A1 single nucleotide polymorphisms (SNPs) were genotyped in 1783 individuals from 2 cohorts of Swedish and Finnish IBD patients and controls. An in vitro system was set up to evaluate the potential impact of SLC15A1 polymorphism on PepT1 transporter function by quantification of NOD2-mediated activation of NF-kappaB.
The common allele (C) of a coding polymorphism (rs2297322, Ser117Asn) was associated with CD susceptibility both in Sweden and in Finland, but with genetic effects in opposite directions (risk and protection, respectively). The best evidence of association was found in both populations when the analysis was performed on individuals not carrying NOD2 common risk alleles (Sweden allelic P = 0.0007, OR 1.97, 95% confidence interval [CI] 1.34-2.92; Finland genotype P = 0.0013, OR 0.63, 95% CI 0.44-0.90). The PepT1 variant encoded by the C allele (PepT1-Ser117) was associated with reduced signaling downstream of NOD2 (P
PubMed ID
19462432 View in PubMed
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Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor.

https://arctichealth.org/en/permalink/ahliterature272288
Source
Hum Mol Genet. 2015 Jul 15;24(14):4138-46
Publication Type
Article
Date
Jul-15-2015
Author
Wenche Kristiansen
Robert Karlsson
Trine B Rounge
Thomas Whitington
Bettina K Andreassen
Patrik K Magnusson
Sophie D Fosså
Hans-Olov Adami
Clare Turnbull
Trine B Haugen
Tom Grotmol
Fredrik Wiklund
Source
Hum Mol Genet. 2015 Jul 15;24(14):4138-46
Date
Jul-15-2015
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Cell Line, Tumor
Chromosomes, Human, Pair 17 - genetics
Chromosomes, Human, Pair 19 - genetics
Disease Progression
Genetic Loci
Genetic markers
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotyping Techniques
Humans
Logistic Models
Male
NF-kappa B - genetics - metabolism
Neoplasms, Germ Cell and Embryonal - genetics
Norway
Polymorphism, Single Nucleotide
Sweden
Testicular Neoplasms - genetics
Abstract
Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). A GWA study for TGCT was performed by genotyping 610 240 single-nucleotide polymorphisms (SNPs) in 1326 cases and 6687 controls from Sweden and Norway. No novel genome-wide significant associations were observed in this discovery stage. We put forward 27 SNPs from 15 novel regions and 12 SNPs previously reported, for replication in 710 case-parent triads and 289 cases and 290 controls. Predefined biological pathways and processes, in addition to a custom-built sex-determination gene set, were subject to enrichment analyses using Meta-Analysis Gene Set Enrichment of Variant Associations (M) and Improved Gene Set Enrichment Analysis for Genome-wide Association Study (I). In the combined meta-analysis, we observed genome-wide significant association for rs7501939 on chromosome 17q12 (OR = 0.78, 95% CI = 0.72-0.84, P = 1.1 ? 10(-9)) and rs2195987 on chromosome 19p12 (OR = 0.76, 95% CI: 0.69-0.84, P = 3.2 ? 10(-8)). The marker rs7501939 on chromosome 17q12 is located in an intron of the HNF1B gene, encoding a member of the homeodomain-containing superfamily of transcription factors. The sex-determination gene set (false discovery rate, FDRM
PubMed ID
25877299 View in PubMed
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