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[Adaptation of the myocardium to decreased coronary flow]

https://arctichealth.org/en/permalink/ahliterature54934
Source
Duodecim. 1994;110(8):777-9
Publication Type
Article
Date
1994
Author
K. Ylitalo
K. Peuhkurinen
Author Affiliation
Sisätautien klinikka, Oulu.
Source
Duodecim. 1994;110(8):777-9
Date
1994
Language
Finnish
Publication Type
Article
Keywords
Humans
Myocardial Ischemia - diagnosis - physiopathology
Myocardial Stunning
Myocardium - metabolism - pathology
Necrosis
PubMed ID
8586035 View in PubMed
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Delayed recovery of myocardial perfusion in acute myocardial infarction: a scintigraphic study after early thrombolytic treatment.

https://arctichealth.org/en/permalink/ahliterature54318
Source
Coron Artery Dis. 1998;9(7):443-9
Publication Type
Article
Date
1998
Author
F. Bouvier
J. Höjer
B A Samad
K. Jensen-Urstad
H. Ruiz
J. Hulting
M. Jensen-Urstad
Author Affiliation
Department of Clinical Physiology, Söder Hospital, Stockholm, Sweden. bouvier.info@swipnet.se
Source
Coron Artery Dis. 1998;9(7):443-9
Date
1998
Language
English
Publication Type
Article
Keywords
Adenosine - diagnostic use
Comparative Study
Coronary Circulation - physiology
Female
Fibrinolytic Agents - therapeutic use
Heart - radionuclide imaging
Humans
Male
Middle Aged
Myocardial Infarction - drug therapy - physiopathology - radionuclide imaging
Myocardial Stunning - radionuclide imaging
Prospective Studies
Radiopharmaceuticals - diagnostic use
Streptokinase - therapeutic use
Technetium Tc 99m Sestamibi - diagnostic use
Thrombolytic Therapy
Time Factors
Tissue Plasminogen Activator - therapeutic use
Tomography, Emission-Computed, Single-Photon
Vasodilator Agents - diagnostic use
Abstract
BACKGROUND: Assessments of compromised myocardium and infarct size early after thrombolytic treatment in acute myocardial infarction (AMI) are important for risk stratification and for treatment management. We have therefore evaluated the clinical usefulness of myocardial perfusion scintigraphy (MIBI-SPECT) for the assessment of myocardial viability early after AMI. METHODS: Seventy-one patients [53 men and 18 women, aged 64 +/- 9 years (range 45-75 years)] with AMI treated by thrombolysis took part in this prospective study at University Hospital, Stockholm, Sweden. Sixty of them underwent adenosine-stress and resting MIBI-SPECT 2-4 days after AMI, and 11 were examined only at rest. Six months after the AMI, a repeat MIBI-SPECT at rest was obtained for comparison. RESULTS: All patients had significant perfusion defects compared with an age- and sex-matched healthy reference population. Seventy-six percent of the patients able to undergo a complete adenosine-stress and rest SPECT showed signs of reversible perfusion defects. Defect size (extent) and severity at rest decreased between the tests at 2-5 days and 6 months after AMI (P
PubMed ID
9822863 View in PubMed
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Elevated serum free pregnancy-associated plasma protein-A independently predicts mortality in haemodialysis patients but is not associated with recurrent haemodialysis-induced ischaemic myocardial injury.

https://arctichealth.org/en/permalink/ahliterature268921
Source
Nephron. 2015;129(3):171-8
Publication Type
Article
Date
2015
Author
Helen J Jefferies
Risto Tertti
Saara Wittfooth
James O Burton
Kaj Metsärinne
Kim Pettersson
Christopher W McIntyre
Source
Nephron. 2015;129(3):171-8
Date
2015
Language
English
Publication Type
Article
Keywords
Aged
Biomarkers
Cohort Studies
Female
Finland - epidemiology
Follow-Up Studies
Heart Function Tests
Humans
Inflammation - metabolism
Male
Middle Aged
Myocardial Ischemia - etiology - ultrasonography
Myocardial Stunning - etiology - physiopathology
Predictive value of tests
Pregnancy
Pregnancy-Associated Plasma Protein-A - analysis - metabolism
Renal Dialysis - adverse effects - mortality
Troponin C - blood
Abstract
Pregnancy-associated plasma protein-A (PAPP-A) is a putative marker of atheroma instability and ischaemic myocardial stress prior to necrosis. Total PAPP-A (tPAPP-A) levels in acute coronary syndromes predict adverse outcomes. However, free PAPP-A (fPAPP-A) predominates in the circulation. Ischaemic haemodialysis (HD)-induced cardiac injury (myocardial stunning) is common and is associated with markers of myocardial necrosis, inflammation, cardiovascular events and mortality. Coronary plaque instability in pathophysiology of HD-induced myocardial stunning has not been studied. We aimed to investigate the relationship of fPAPP-A with stunning and mortality.
130 prevalent patients from two HD centres (Finland and UK) were studied. Pre-HD free, complexed and total PAPP-A were measured by immunoassay. A subset of 62 patients underwent echocardiography to assess HD-induced myocardial stunning. The mean duration of follow-up was 407 ± 98 days.
fPAPP-A was elevated (median: 3.45 mIU/l) and correlated with dialysis vintage (r = 0.391, p
PubMed ID
25766334 View in PubMed
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[Stimulation of the delta 1-receptors help to decrease reperfusion induced myocardial stunning]

https://arctichealth.org/en/permalink/ahliterature53349
Source
Izv Akad Nauk Ser Biol. 2004 Mar-Apr;(2):209-16
Publication Type
Article
Author
L N Maslov
Iu B Lishmanov
Author Affiliation
Institute of Cardiology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, ul. Kievskaya 111, Tomsk, 634012 Russia. maslov@cardio.tsu.ru
Source
Izv Akad Nauk Ser Biol. 2004 Mar-Apr;(2):209-16
Language
Russian
Publication Type
Article
Keywords
Animals
Arrhythmia - drug therapy - etiology
Blood Pressure - drug effects
Creatine Kinase - drug effects - metabolism
Electrocardiography
English Abstract
Heart Ventricles - drug effects - physiology
In Vitro
Myocardial Contraction - drug effects
Myocardial Reperfusion Injury - complications - drug therapy
Myocardial Stunning - prevention & control
Myocytes, Cardiac - drug effects - metabolism - pathology
Phenazocine - analogs & derivatives - pharmacology
Rats
Rats, Wistar
Receptors, Opioid, delta - agonists - drug effects
Abstract
In vivo or in vitro administration of a omega 1 receptor agonist d-SKF 10,047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of omega receptors prevents development of reperfusion contracture and release of creatine kinase and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of omega receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.
PubMed ID
15131985 View in PubMed
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