Skip header and navigation

Refine By

12 records – page 1 of 2.

2-h postchallenge plasma glucose predicts cardiovascular events in patients with myocardial infarction without known diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature121853
Source
Cardiovasc Diabetol. 2012;11:93
Publication Type
Article
Date
2012
Author
Loghman Henareh
Stefan Agewall
Author Affiliation
Department of Cardiology Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden. loghman.henareh@karolinska.se
Source
Cardiovasc Diabetol. 2012;11:93
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Angina, Unstable - blood - epidemiology - mortality
Biological Markers - blood
Blood Glucose - metabolism
Chi-Square Distribution
Female
Glucose Tolerance Test
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood - epidemiology - mortality
Predictive value of tests
Prognosis
Proportional Hazards Models
Prospective Studies
Recurrence
Risk assessment
Risk factors
Smoking - adverse effects - epidemiology
Stroke - blood - epidemiology - mortality
Sweden - epidemiology
Time Factors
Abstract
The incidence of cardiovascular events remains high in patients with myocardial infarction (MI) despite advances in current therapies. New and better methods for identifying patients at high risk of recurrent cardiovascular (CV) events are needed. This study aimed to analyze the predictive value of an oral glucose tolerance test (OGTT) in patients with acute myocardial infarction without known diabetes mellitus (DM).
The prospective cohort study consisted of 123 men and women aged between 31-80 years who had suffered a previous MI 3-12 months before the examinations. The exclusion criteria were known diabetes mellitus. Patients were followed up over 6.03???1.36 years for CV death, recurrent MI, stroke and unstable angina pectoris. A standard OGTT was performed at baseline.
2-h plasma glucose (HR, 1.27, 95% CI, 1.00 to 1.62; P?
Notes
Cites: N Engl J Med. 2000 Jan 20;342(3):145-5310639539
Cites: Cardiovasc Diabetol. 2012;11:2122397368
Cites: Am J Med. 2000 Nov;109(7):538-4211063954
Cites: J Clin Invest. 2001 Aug;108(4):635-611518739
Cites: Diabetologia. 2001 Sep;44 Suppl 2:S54-6411587051
Cites: Circulation. 2001 Nov 27;104(22):2673-811723017
Cites: Diabetes Care. 2001 Dec;24(12):2043-811723080
Cites: BMJ. 2002 Jan 12;324(7329):71-8611786451
Cites: Dtsch Med Wochenschr. 2002 May 3;127(18):953-711987015
Cites: Eur Heart J. 2002 Aug;23(16):1267-7512175663
Cites: Diabetes Care. 2002 Oct;25(10):1845-5012351489
Cites: Int J Cardiol. 2004 Oct;97(1):21-415336801
Cites: Eur Heart J. 1985 Mar;6(3):199-2262863148
Cites: J Am Soc Echocardiogr. 1989 Sep-Oct;2(5):358-672698218
Cites: Am J Hypertens. 1994 Jul;7(7 Pt 1):615-227946163
Cites: Lancet. 1994 Nov 19;344(8934):1383-97968073
Cites: BMJ. 1995 Mar 4;310(6979):555-97888928
Cites: Diabetes Care. 1996 Mar;19(3):257-678742574
Cites: Diabetologia. 1996 Dec;39(12):1577-838960845
Cites: Diabetes Care. 1998 Sep;21(9):1529-339727904
Cites: Circ Res. 1999 Mar 19;84(5):489-9710082470
Cites: Diabetes Care. 1999 Jun;22(6):920-410372242
Cites: J Am Coll Cardiol. 1999 Jul;34(1):146-5410400004
Cites: Lancet. 1999 Aug 21;354(9179):617-2110466661
Cites: Eur Heart J. 2004 Nov;25(22):1990-715541834
Cites: Am J Cardiol. 2005 Aug 1;96(3):363-516054458
Cites: Diabet Med. 2005 Sep;22(9):1212-716108851
Cites: Clin Ther. 2005;27 Suppl B:S42-5616519037
Cites: Clin Physiol Funct Imaging. 2007 Jan;27(1):60-617204040
Cites: Circ J. 2007 Jun;71(6):834-4117526977
Cites: Circulation. 2007 Jul 10;116(2):151-717576864
Cites: Circulation. 2007 Nov 27;116(22):2634-5317951284
Cites: Heart Vessels. 2009 Mar;24(2):90-519337791
Cites: Prim Care Diabetes. 2009 Nov;3(4):205-919875348
Cites: Diabetes Care. 2010 Jan;33 Suppl 1:S62-920042775
Cites: Cardiovasc Diabetol. 2010;9:7521070650
Cites: Cardiovasc Diabetol. 2011;10:5621702911
Cites: Hypertension. 2000 Aug;36(2):245-910948085
PubMed ID
22873202 View in PubMed
Less detail

25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies.

https://arctichealth.org/en/permalink/ahliterature121124
Source
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2794-802
Publication Type
Article
Date
Nov-2012
Author
Peter Brøndum-Jacobsen
Marianne Benn
Gorm B Jensen
Børge G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Source
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2794-802
Date
Nov-2012
Language
English
Publication Type
Article
Keywords
Aged
Biological Markers - blood
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood - epidemiology - mortality
Myocardial Ischemia - blood - epidemiology - mortality
Prognosis
Proportional Hazards Models
Prospective Studies
Risk assessment
Risk factors
Time Factors
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - diagnosis - epidemiology - mortality
Abstract
We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death.
We measured baseline plasma 25-hydroxyvitamin D in 10 170 women and men from the Danish general population without vitamin D-fortified food. During 29 years of follow-up, 3100 persons developed ischemic heart disease, 1625 myocardial infarction, and 6747 died. Decreasing plasma 25-hydroxyvitamin D levels were associated with increasing risk of ischemic heart disease, myocardial infarction, and early death as a function of seasonally adjusted percentile categories (P for trend, 2×10(-4)-3×10(-53)). Comparing individuals with plasma 25-hydroxyvitamin D levels at the 1st to 4th percentile with individuals with levels at the 50th to 100th percentile, the multivariable adjusted risk was increased by 40% (95% CI, 14%-72%) for ischemic heart disease, by 64% (25%-114%) for myocardial infarction, by 57% (38%-78%) for early death, and by 81% (40%-135%) for fatal ischemic heart disease/myocardial infarction. In the meta-analyses of 18 and 17 studies, risk of ischemic heart disease and early death were increased by 39% (25%-54%) and 46% (31%-64%) for lowest versus highest quartile of 25-hydroxyvitamin D level.
We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels. These findings were substantiated in meta-analyses.
PubMed ID
22936341 View in PubMed
Less detail

Are regional variations in ischaemic heart disease related to differences in coronary risk factors? The project 'myocardial infarction in mid-Sweden'.

https://arctichealth.org/en/permalink/ahliterature48673
Source
Eur Heart J. 1991 Mar;12(3):309-14
Publication Type
Article
Date
Mar-1991
Author
C. Nerbrand
L. Olsson
K. Svärdsudd
S. Kullman
G. Tibblin
Author Affiliation
Uppsala University, Department of Family Medicine, Sweden.
Source
Eur Heart J. 1991 Mar;12(3):309-14
Date
Mar-1991
Language
English
Publication Type
Article
Keywords
Angina Pectoris - blood - epidemiology - mortality
Body mass index
Diabetes Mellitus - epidemiology
Exercise
Humans
Hypertension - epidemiology
Lipoproteins, HDL Cholesterol - blood
Lipoproteins, LDL Cholesterol - blood
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Prevalence
Questionnaires
Research Support, Non-U.S. Gov't
Risk factors
Smoking - epidemiology
Survival Rate
Sweden - epidemiology
Abstract
In a previous report, a large regional variation was reported in total mortality and mortality rate from ischaemic heart disease (IHD) in mid-Sweden. In this report, IHD prevalence and risk factor data are presented. A postal questionnaire was sent out to a random sample of men aged 45-64 years in each of 40 communities. 14,675 men (88%) responded. Based on a validity study, IHD cases were defined as those with a history of myocardial infarction and/or angina pectoris. Age, smoking habits, antihypertensive treatment, body mass index, food habits, stress and physical activity during leisure time were used as risk factors. IHD prevalence showed the same geographical variation as IHD mortality, with a low prevalence in the east and a high prevalence in the west. There was a moderate variation in risk factor levels over the 40 communities. When this variation was taken into account the geographical IHD variation was somewhat smaller but still substantial. Other factors may involve socio-economics, drinking water qualities, mineral soil content or other environmental factors. Which of these cause the largest IHD variation is at present unknown, but is subject to systematic examination in this project.
PubMed ID
2040312 View in PubMed
Less detail

Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study.

https://arctichealth.org/en/permalink/ahliterature243023
Source
Lancet. 1982 Jul 24;2(8291):175-9
Publication Type
Article
Date
Jul-24-1982
Author
J T Salonen
G. Alfthan
J K Huttunen
J. Pikkarainen
P. Puska
Source
Lancet. 1982 Jul 24;2(8291):175-9
Date
Jul-24-1982
Language
English
Publication Type
Article
Keywords
Adult
Blood pressure
Cardiovascular Diseases - blood - epidemiology - mortality
Cholesterol - blood
Coronary Disease - blood - epidemiology - mortality
Female
Finland
Humans
Longitudinal Studies
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Platelet Aggregation - drug effects
Risk
Selenium - blood - pharmacology
Smoking
Abstract
A case-control study was conducted to investigate the association between serum selenium and risk of death from acute coronary heart disease (CHD) as well as risk of fetal and non-fetal myocardial infarction (MI). Case-control pairs came from a population of 11,000 persons examined in 1972 from two counties in eastern Finland, an area with an exceptionally high mortality from cardiovascular diseases. Cases were aged 35-59 years and had died of CHD or other CVD or had a non-fetal MI during a seven-year follow-up. Controls were matched for sex, age, daily tobacco consumption, serum cholesterol, diastolic blood pressure, and history of angina pectoris. The mean serum selenium concentration for all cases was 51.8 micrograms/l and for all controls 55.3 micrograms/l (p less than 0.01). Serum selenium of less than 45 micrograms/l was associated with an adjusted relative risk of CHD death of 2.9 (p less than 0.01, 95% CI, 1.4-6.0), a relative risk of CVD death of 2.2 (p less than 0.01, 95% CI, 1.2-4.0), and a relative risk of fatal and nonfatal MI of 2.1 (p less than 0.001, 95% Ci, 1.4-3.1). 22% (95% CI, 8-35%) of contrary deaths were attributable to serum selenium in the whole study population.
PubMed ID
6123886 View in PubMed
Less detail

Creatinine, eGFR and association with myocardial infarction, ischemic heart disease and early death in the general population.

https://arctichealth.org/en/permalink/ahliterature265460
Source
Atherosclerosis. 2014 Nov;237(1):67-75
Publication Type
Article
Date
Nov-2014
Author
Kirstine L Sibilitz
Marianne Benn
Børge G Nordestgaard
Source
Atherosclerosis. 2014 Nov;237(1):67-75
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Aged
Body mass index
Creatinine - blood
Denmark
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Male
Mass Spectrometry
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Myocardial Ischemia - blood - epidemiology - mortality
Risk factors
Treatment Outcome
Abstract
We tested the hypothesis that moderately elevated plasma creatinine levels and decreased levels of estimated glomerular filtration rate (eGFR) are associated with increased risk of myocardial infarction, ischemic heart disease, and early death in the general population.
We studied 10,489 individuals with a plasma creatinine measurement and calculated eGFR from the Danish general population, of which 1498 developed myocardial infarction, 3001 ischemic heart disease, and 7573 died during 32 years follow-up.
Cumulative incidences of myocardial infarction and ischemic heart disease as a function of age increased with increasing levels of creatinine, and survival decreased (log-rank trends:
Notes
Comment In: Atherosclerosis. 2014 Nov;237(1):106-725238216
PubMed ID
25222342 View in PubMed
Less detail

Effect of dietary and antismoking advice on the incidence of myocardial infarction: a 16-year follow-up of the Oslo Diet and Antismoking Study after its close.

https://arctichealth.org/en/permalink/ahliterature81505
Source
Nutr Metab Cardiovasc Dis. 2006 Jul;16(5):330-8
Publication Type
Article
Date
Jul-2006
Author
Holme I.
Haaheim L L
Tonstad S.
Hjermann I.
Author Affiliation
Department of Epidemiology, Preventive Medicine Clinic, Ullevål University Hospital, N-407 Oslo, Norway. ingar.holme@uus.no
Source
Nutr Metab Cardiovasc Dis. 2006 Jul;16(5):330-8
Date
Jul-2006
Language
English
Publication Type
Article
Keywords
Cholesterol - blood
Diet
Follow-Up Studies
Health Promotion - methods
Humans
Incidence
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Norway - epidemiology
Proportional Hazards Models
Risk factors
Smoking Cessation
Time Factors
Triglycerides - blood
Abstract
BACKGROUND AND AIM: The Oslo Diet and Antismoking Study was a 5-year randomised controlled trial initiated in 1972-1973 and ended in 1977-1978, which showed that dietary change and smoking cessation reduced the incidence of coronary heart disease among high risk middle-aged men. In an extended follow-up we studied the incidence of myocardial infarction (MI) 16 years after the end of the trial in the intervention and control groups. METHODS: The primary endpoint was the first occurrence of non-fatal and fatal MI including sudden death up to December 31 1993. Cases of fatal MI were identified by linkage to Statistics Norway using each subject's individual personal number. Cases of non-fatal MI were extracted from the hospital records. Cox proportional hazards regression models estimated relationships between changes in total cholesterol and triglyceride concentrations and smoking status and the primary endpoints up to 16 years following the end of the trial. RESULTS: At 5 and 10 years following the end of the trial the incidence of MI among the 604 men in the intervention (I) and 628 in the control (C) group differed significantly (5-year event rate (I/C) =0.059/0.090; P=0.038 and 10-year event rate (I/C) =0.111/0.155; P=0.023), but the difference faded slowly and subsequently (P=0.069 at 16 years). The reduction in MI in the intervention group was primarily explained by the differences in total cholesterol and triglyceride concentrations between the groups. CONCLUSION: This extended follow-up of the Oslo Diet and Antismoking Study found a prolonged benefit of the intervention lasting for at least a decade after the close of the trial. This finding is in accordance with statin and other studies showing that the effect of cholesterol lowering may be prolonged after the end of the intervention.
PubMed ID
16829341 View in PubMed
Less detail

Influence of plasma fibrinogen levels on the incidence of myocardial infarction and death is modified by other inflammation-sensitive proteins: a long-term cohort study.

https://arctichealth.org/en/permalink/ahliterature53966
Source
Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):452-8
Publication Type
Article
Date
Mar-2001
Author
P. Lind
B. Hedblad
L. Stavenow
L. Janzon
K F Eriksson
F. Lindgärde
Author Affiliation
Division of Medical Angiology, Department of Internal Medicine, Division of Epidemiology, Lund University, Malmö University Hospital, Malmö, Sweden. Peter.C.Lind@skane.se
Source
Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):452-8
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
Cardiovascular Diseases - blood - mortality
Ceruloplasmin - metabolism
Cohort Studies
Fibrinogen - metabolism
Follow-Up Studies
Haptoglobins - metabolism
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood - epidemiology - mortality
Orosomucoid - metabolism
Survival Rate
Sweden - epidemiology
Time Factors
alpha 1-Antitrypsin - metabolism
Abstract
Inflammation may play an important role in atherosclerotic disease. Plasma fibrinogen is an established predictor of cardiovascular events. The aim of this study was to evaluate whether other inflammation-sensitive plasma proteins modify this prediction. We studied the incidence of cardiac events and death in men in relation to fibrinogen levels alone and in combination with other proteins. The study was based on 6075 men, who were, on average, 46 years old at the time of the screening examination, which included the quantitative assessment of plasma levels of fibrinogen, orosomucoid, alpha(1)-antitrypsin, haptoglobin, and ceruloplasmin. The concentration of each protein was divided into quartiles for each. This classification made it possible to identify 4 groups, ie, men in the first fibrinogen quartile and at the same time either not belonging to the fourth quartile of any of the other proteins (Q1/No group) or also belonging to the fourth quartile of >/=1 of the additional proteins (Q1/Yes group) and corresponding groups in the fourth fibrinogen quartile (Q4/No and Q4/Yes groups). During the follow-up, which occurred at an average of 16 years, 439 (7.2%) men experienced a cardiac event, and 653 (10.7%) died; 278 of these men died of cardiovascular diseases, with 206 deaths attributed to ischemic heart disease. From the lowest to the highest quartile, there was for each protein a stepwise increase in the incidence of cardiac events and mortality. All-cause mortality and cardiovascular mortality were significantly higher in the Q4/Yes group compared with the Q4/No group, but they were similar in the Q4/No and Q1/Yes groups. The incidence of cardiac events was significantly higher in the Q1/Yes and Q4/Yes groups compared with the Q1/No and Q4/No groups, respectively. The increased cardiovascular mortality and cardiac event rates remained after adjustment for several confounders when the Q4/Yes and Q4/No groups were compared. The results suggest that the incidence of cardiac events and death due to cardiovascular diseases in middle-aged men predicted by plasma levels of fibrinogen is modified by other inflammation-sensitive proteins.
PubMed ID
11231928 View in PubMed
Less detail

Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women.

https://arctichealth.org/en/permalink/ahliterature77213
Source
JAMA. 2007 Jul 18;298(3):299-308
Publication Type
Article
Date
Jul-18-2007
Author
Nordestgaard Børge G
Benn Marianne
Schnohr Peter
Tybjaerg-Hansen Anne
Author Affiliation
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark. brno@heh.regionh.dk
Source
JAMA. 2007 Jul 18;298(3):299-308
Date
Jul-18-2007
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Hypertriglyceridemia
Lipoproteins - blood
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Myocardial Ischemia - blood - epidemiology - mortality
Postprandial Period
Proportional Hazards Models
Prospective Studies
Risk
Triglycerides - blood
Abstract
CONTEXT: Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis. OBJECTIVE: To test the hypothesis that very high levels of nonfasting triglycerides predict myocardial infarction (MI), ischemic heart disease (IHD), and death. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of 7587 women and 6394 men from the general population of Copenhagen, Denmark, aged 20 to 93 years, followed up from baseline (1976-1978) until 2004. MAIN OUTCOME MEASURES: Hazard ratios (HRs) for incident MI, IHD, and total death according to baseline nonfasting triglyceride level categories of 1 to 1.99 mmol/L (88.5-176.1 mg/dL), 2 to 2.99 mmol/L (177.0-264.6 mg/dL), 3 to 3.99 mmol/L (265.5-353.0 mg/dL), 4 to 4.99 mmol/L (354.0-441.6 mg/dL), and 5 mmol/L or more (> or =442.5 mg/dL) vs triglyceride levels of less than 1 mmol/L (
Notes
Comment In: JAMA. 2007 Jul 18;298(3):336-817635897
PubMed ID
17635890 View in PubMed
Less detail

One-year mortality rate after discharge from hospital in relation to whether or not a confirmed myocardial infarction was developed.

https://arctichealth.org/en/permalink/ahliterature48648
Source
Int J Cardiol. 1991 Sep;32(3):381-8
Publication Type
Article
Date
Sep-1991
Author
B W Karlson
J. Herlitz
H. Emanuelsson
N. Edvardsson
O. Wiklund
A. Richter
A. Hjalmarson
Author Affiliation
Department of Medicine I, Sahlgrenska Hospital, Göteborg, Sweden.
Source
Int J Cardiol. 1991 Sep;32(3):381-8
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Angina Pectoris - physiopathology
Angioplasty, Transluminal, Percutaneous Coronary
Aspartate Aminotransferases - blood
Cause of Death
Comparative Study
Coronary Artery Bypass
Electrocardiography
Female
Humans
Hypertension
Male
Multivariate Analysis
Myocardial Infarction - blood - epidemiology - mortality - physiopathology
Patient Discharge
Prognosis
Prospective Studies
Survival Rate
Sweden - epidemiology
Time Factors
Abstract
Consecutive patients admitted to our hospital with suspected acute myocardial infarction during 21 months were prospectively evaluated. One-year mortality after discharge from hospital was related to whether or not an infarction developed (infarct versus non-infarct patients). Of patients discharged alive after developing an infarct, there was a mortality of 17% (n = 777) versus 12% (n = 1830) (P less than 0.001) for all patients not developing infarction. In a high risk group (any of the following: age greater than or equal to 75 years, previous history of myocardial infarction, diabetes mellitus or congestive heart failure) patients developing infarction had a mortality of 24% (n = 457) versus 17% (n = 1221) for those who did not (P less than 0.001). In a low risk group (none of the high risk criteria), the corresponding mortality was 8% (n = 316) for patients suffering infarction and 3% (n = 603) for those not having infarction (P less than 0.001). The difference in mortality between patients with and without infarction was most marked in women (21% vs 11%; P less than 0.01) and in hypertensives (25% vs 12%; P less than 0.001), but less marked in men (16% vs 13%; NS) and in patients without hypertension (13% vs 12%; NS). Among patients not suffering infarction, mortality was particularly high in those with previous congestive heart failure (23%) and diabetes mellitus (21%).
PubMed ID
1791091 View in PubMed
Less detail

Risk factors for myocardial infarction in the Stockholm prospective study. A 14-year follow-up focussing on the role of plasma triglycerides and cholesterol.

https://arctichealth.org/en/permalink/ahliterature55985
Source
Acta Med Scand. 1979;206(5):351-60
Publication Type
Article
Date
1979
Author
L A Carlson
L E Böttiger
P E Ahfeldt
Source
Acta Med Scand. 1979;206(5):351-60
Date
1979
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cholesterol - blood
Coronary Disease - blood - epidemiology
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction - blood - epidemiology - mortality
Prognosis
Prospective Studies
Risk
Sweden
Triglycerides - blood
Abstract
A 14-year follow-up of the Stockholm prospective study is reported. A number of 130 new myocardial infarctions (MI) were found in a prospective group of men (n = 3189) and another 46, i.e. a total of 176 MI, in the total group (n = 3486). Different types of multivariate statistical analyses show that age, blood pressure, smoking, fasting plasma concentrations of cholesterol and triglycerides, ESR and Hb were independent risk factors for MI, while the weight/height index was not. Elevated BP became an important risk factor only after the age of 50. When only age, BP, smoking and the two plasma lipids were entered into the logistic multivariate analysis, plasma triglycerides were more important as a risk factor than cholesterol. Quintile analysis showed that the rate of new MIs increased more with increasing triglyceride than increasing cholesterol levels. In the prospective group, the average rate of new MIs for men below 60 years was 32 per 1000. In the bottom and top quintile these rates were 16 and 65 for plasma triglycerides and 27 and 47 for cholesterol. When the men were divided into 4 groups with regard to both plasma lipids, the rate of new MIs increased successively from group to group along this chain: both lipids normal, only cholesterol high, only triglycerides high and both plasma lipids high.
PubMed ID
525434 View in PubMed
Less detail

12 records – page 1 of 2.