Skip header and navigation

Refine By

67 records – page 1 of 7.

Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report.

https://arctichealth.org/en/permalink/ahliterature55698
Source
Adv Myocardiol. 1985;6:483-90
Publication Type
Article
Date
1985
Author
H M Sami
J R Koke
N. Bittar
Source
Adv Myocardiol. 1985;6:483-90
Date
1985
Language
English
Publication Type
Article
Keywords
Adenosine Diphosphate - metabolism
Adenosine Monophosphate - metabolism - pharmacology
Adenosine Triphosphate - metabolism
Animals
Coronary Disease - drug therapy
Creatine - metabolism
Dogs
Energy Metabolism - drug effects
Female
Male
Myocardial Contraction - drug effects
Nitroprusside - pharmacology
Phosphocreatine - metabolism
Abstract
Experiments were conducted on 18 dogs using an in situ blood-perfused canine heart model. Intracoronary infusion of AMP resulted in increased ATP and total adenine nucleotide levels. On reperfusion following a 15-min period of ischemia, ATP and total adenine nucleotide levels were significantly higher than control. Most important, contractile function recovered more rapidly in the AMP-treated dogs. It is therefore concluded that the delayed functional recovery noted after periods of ischemia is likely to be a direct result of delayed ATP resynthesis.
PubMed ID
3992046 View in PubMed
Less detail

Activation of mu-opiate receptors as a factor of regulation of heart resistance to ischemia-reperfusion and oxidative stress.

https://arctichealth.org/en/permalink/ahliterature53983
Source
Bull Exp Biol Med. 2000 Aug;130(8):752-5
Publication Type
Article
Date
Aug-2000
Author
T V Lasukova
T Y Rebrova
S V Tam
Author Affiliation
Laboratory of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
Source
Bull Exp Biol Med. 2000 Aug;130(8):752-5
Date
Aug-2000
Language
English
Publication Type
Article
Keywords
Animals
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- - pharmacology
In Vitro
Male
Myocardial Contraction - drug effects - physiology
Myocardial Reperfusion Injury - etiology - physiopathology - prevention & control
Oxidative Stress
Rats
Rats, Wistar
Receptors, Opioid, mu - agonists - physiology
Abstract
Intravenous injection of the selective mu-opiate receptor agonist DAMGO (0.1 mg/kg, 15 min before isolation of the heart) improved resistance of isolated perfused rat heart to ischemia (45 min) and reperfusion (60 min) damages. In vivo administration of DAMGO prevented reperfusion-induced damages to cardiomyocytes and decreased the content of conjugated dienes in the myocardium during ischemia-reperfusion in vitro. Furthermore, stimulation of mu-opiate receptors promoted recovery of myocardial contractility during reoxygenation, but had no effect on heart resistance to free radical-induced damages during perfusion of isolated heart with a solution containing Fe2+ and ascorbic acid.
PubMed ID
11177234 View in PubMed
Less detail

Acute administration of a single dose of valsartan improves left ventricular functions: a pilot study to assess the role of tissue velocity echocardiography in patients with systemic arterial hypertension in the TVE-valsartan study I.

https://arctichealth.org/en/permalink/ahliterature80206
Source
Clin Physiol Funct Imaging. 2006 Nov;26(6):351-6
Publication Type
Article
Date
Nov-2006
Author
Govind Satish C
Brodin Lars-Ake
Nowak Jacek
Ramesh S S
Saha Samir K
Author Affiliation
BMJ Heart Center, Department of Non-invasive Cardiology, Bangalore, India.
Source
Clin Physiol Funct Imaging. 2006 Nov;26(6):351-6
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antihypertensive Agents - administration & dosage
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Echocardiography, Doppler, Color
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy - physiopathology - ultrasonography
Image Processing, Computer-Assisted
Male
Middle Aged
Myocardial Contraction - drug effects
Pilot Projects
Research Design
Stroke Volume - drug effects
Sweden
Tetrazoles - administration & dosage
Time Factors
Treatment Outcome
Valine - administration & dosage - analogs & derivatives
Ventricular Function, Left - drug effects
Abstract
BACKGROUND: The advent of colour-coded tissue velocity echocardiography (TVE) has now made it possible to quantify left ventricular (LV) functions in patients with systemic arterial hypertension (HTN). Hypothesis In this project, we have studied the cardiac effects of a single dose of orally administered valsartan in patients with known HTN. METHODS: Fifty-five patients with HTN with a mean age of 56 +/- 10 years were given an early morning dose of 80 mg valsartan withholding regular antihypertensive medications on the day of investigation. TVE images, acquired on VIVID systems were digitized for postprocessing of longitudinal and radial peak systolic velocities, strain rate, and systolic and diastolic time intervals before (pre) and 5 h after (post) administration of the drug. RESULTS: Blood pressure (mmHg) pre and post, respectively, were 147 +/- 15 versus 137 +/- 14 systolic and 90 +/- 7 versus 86 +/- 7 diastolic (all P
PubMed ID
17042901 View in PubMed
Less detail

Age-dependent reduction of the response of rat cardiac muscle to the phosphodiesterase inhibitor milrinone.

https://arctichealth.org/en/permalink/ahliterature46530
Source
Arch Int Physiol Biochim Biophys. 1994 Sep-Oct;102(5):265-9
Publication Type
Article
Author
M. Canepari
B. Polla
M R Gualea
C. Zanardi
C. Reggiani
Author Affiliation
Institute of Human Physiology, University of Pavia, Italy.
Source
Arch Int Physiol Biochim Biophys. 1994 Sep-Oct;102(5):265-9
Language
English
Publication Type
Article
Keywords
Aging - metabolism
Animals
Biomechanics
Comparative Study
Depression, Chemical
In Vitro
Male
Milrinone
Myocardial Contraction - drug effects
Phosphodiesterase Inhibitors - pharmacology
Pyridones - pharmacology
Rats
Rats, Inbred BN
Abstract
This study aimed to investigate whether milrinone effect on cardiac muscle contractility undergoes to age-related changes. Experiments were carried out on papillary muscles isolated from right ventricle of Brown Norway rats belonging to two different age groups: 2 month old and 18 month old. The effect of milrinone (10-100 microM) on rat cardiac muscle in vitro preparations was characterized by a reduction of peak developed tension and of contraction duration. Furthermore, the recovery of contractility after a contractile cycle, i.e. the mechanical restitution was faster in the presence of milrinone than in control conditions. All these effects were reduced in preparations from 18 month old rats compared to preparations from 2 month old rats. The decrease of milrinone effect on the mechanical restitution was particularly pronounced. The reduction of the milrinone effects is likely connected with the reduction of the maximal effect of adrenergic stimulation, although the molecular basis of this link is not yet clearly understood.
PubMed ID
7849274 View in PubMed
Less detail

[Age-related changes in inotropic effects of noradrenaline and acetylcholine on the myocardium of guinea pigs]

https://arctichealth.org/en/permalink/ahliterature11882
Source
Fiziol Zh. 1992 May-Jun;38(3):11-8
Publication Type
Article
Author
S H Kaz'min
S B Dudka
Source
Fiziol Zh. 1992 May-Jun;38(3):11-8
Language
Ukrainian
Publication Type
Article
Keywords
Acetylcholine - pharmacology
Aging - physiology
Animals
Atrial Function
Comparative Study
Culture Media
Depression, Chemical
English Abstract
Guinea Pigs
Heart Atria - drug effects
Heart Ventricles - drug effects - physiology
In Vitro
Models, Cardiovascular
Myocardial Contraction - drug effects - physiology
Norepinephrine - pharmacology
Papillary Muscles - drug effects - physiology
Abstract
The inotropic effects of noradrenaline (10(-7)-10(-5) M) and acetylcholine (10(-8)-10(-6) M) were studied in experiments carried out on preparations of the right atria and on papillary muscles of the right ventricle in adult (4-5 months) and old (18-24 months) guinea pigs. An age-related decrease in inotropic noradrenaline effects and the displacement of dose-effect relationships to the right was revealed. Similar changes of the dose-related effects of acetylcholine superfused against the background of noradrenaline action were observed. The direct inotropic action of the acetylcholine did not change with ageing. A lack of the essential atrial-ventricular differences in age-related changes in myocardial reactivity is apparently very significant for support of effective functional coupling of cardiac chambers in ageing.
PubMed ID
1499755 View in PubMed
Less detail

Aging-dependent depression in the kinetics of force development in rat skinned myocardium.

https://arctichealth.org/en/permalink/ahliterature46273
Source
Am J Physiol. 1999 May;276(5 Pt 2):H1511-9
Publication Type
Article
Date
May-1999
Author
D P Fitzsimons
J R Patel
R L Moss
Author Affiliation
Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA. fitzsimons@physiology.wisc.edu
Source
Am J Physiol. 1999 May;276(5 Pt 2):H1511-9
Date
May-1999
Language
English
Publication Type
Article
Keywords
Acetic Acids - pharmacology
Aging - physiology
Animals
Calcium Chloride - pharmacology
Chelating Agents - pharmacology
Contractile Proteins - analysis
Ethylenediamines - pharmacology
Heart Ventricles - chemistry - cytology - physiology
Kinetics
Male
Muscle Fibers - drug effects - physiology
Myocardial Contraction - drug effects - physiology
Myocardium - chemistry - cytology - metabolism
Myosin Heavy Chains - metabolism
Organ Culture Techniques
Organ Size
Photochemistry
Rats
Rats, Inbred F344
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
Normal aging of the rodent heart results in prominent prolongation of the twitch. We tested the hypothesis that increased expression of beta-myosin heavy chain (MHC), as occurs in the normal aging process in the rodent heart, contributes to the prolongation of the twitch by depressing the kinetics of cross-bridge interaction. Using 3-, 9-, 21-, and 33-mo-old male Fischer 344 x Brown Norway F1 hybrid rats, we examined both the rate of tension development (kCa) and unloaded shortening velocity in chemically skinned myocardium. Although kCa in all four age groups was dependent on the level of Ca2+ activation, both submaximal and maximal kCa were significantly slower in 9-, 21-, and 33-mo-old rats relative to 3-mo-old rats. Furthermore, unloaded shortening velocity was significantly reduced in 9-, 21-, and 33-mo-old rats compared with 3-mo-old rats. Collectively, these data strongly suggest that the aging-related increase in beta-MHC expression results in a progressive slowing of cross-bridge interaction kinetics in skinned myocardium, which most likely contributes to the overall aging-dependent reduction in myocardial functional capacity.
PubMed ID
10330233 View in PubMed
Less detail

Alterative and plastic insufficiency of cardiomyocytes: isoproterenol-induced damage to myocardium during anthracycline cardiomyopathy.

https://arctichealth.org/en/permalink/ahliterature10133
Source
Bull Exp Biol Med. 2001 Jun;131(6):589-94
Publication Type
Article
Date
Jun-2001
Author
E L Lushnikova
L M Nepomnyashchikh
D E Semenov
Author Affiliation
Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.nsk.ma.ru
Source
Bull Exp Biol Med. 2001 Jun;131(6):589-94
Date
Jun-2001
Language
English
Publication Type
Article
Keywords
Animals
Antibiotics, Antineoplastic - toxicity
Cardiomyopathies - chemically induced - pathology - physiopathology
Cardiotonic Agents - pharmacology
Cell Death - drug effects
Daunorubicin - toxicity
Isoproterenol - pharmacology
Myocardial Contraction - drug effects
Myocardium - pathology
Rats
Rats, Wistar
Abstract
The development of regenerative and plastic myocardial insufficiency induced by anthracycline antibiotic rubomycin is accompanied by a decrease in cardiomyocyte sensitivity to damage produced by synthetic catecholamine isoproterenol. The incidence and the size of coagulation necrosis foci of cardiomyocytes developed 6 h after isoproterenol injection significantly decreased with increasing in the interval between rubomycin injection and subsequent administration of isoproterenol. In Wistar rats receiving rubomycin 3-5 days prior to isoproterenol and exhibiting signs of regenerative and plastic insufficiency, no cardiomyocyte contracture, intracellular myocytolysis, or lump degradation characteristic of cardiac insufficiency induced by endo- and exogenous catecholamines were found.
PubMed ID
11586415 View in PubMed
Less detail

Anabolic steroids alter the haemodynamic effects of endurance training on the canine left ventricle.

https://arctichealth.org/en/permalink/ahliterature12553
Source
Pflugers Arch. 1987 Oct;410(3):272-8
Publication Type
Article
Date
Oct-1987
Author
P. Rämö
R. Kettunen
J. Timisjärvi
T. Takala
L. Hirvonen
Author Affiliation
Department of Physiology, University of Oulu, Finland.
Source
Pflugers Arch. 1987 Oct;410(3):272-8
Date
Oct-1987
Language
English
Publication Type
Article
Keywords
Anabolic Agents - pharmacology
Animals
Blood Pressure - drug effects
Dogs
Exertion
Heart Rate - drug effects
Heart Ventricles - physiology
Hemodynamic Processes - drug effects
Isoproterenol - pharmacology
Male
Methandrostenolone - pharmacology
Myocardial Contraction - drug effects
Physical Conditioning, Animal
Physical Endurance - drug effects
Research Support, Non-U.S. Gov't
Stroke Volume - drug effects
Vascular Resistance - drug effects
Abstract
The effects of six week, high-dose anabolic steroid treatment (methandienone, 1.5 mg/kg/day) on the changes in left ventricular function induced in dogs by endurance training were studied by a catheterization technique under anaesthesia. Pacing, isoproterenol and dextran infusions were used as loading tests (respectively). Dogs were randomized into an exercise group (EG, n = 7) and an exercise-steroid group (ESG, n = 7), the latter receiving anabolic steroids as well as participating in the training program. In a standardized submaximal exercise test, the heart rate of unanesthetized dogs was lower both in the EG (p less than 0.001) and in the ESG (p less than 0.01) after the training period than before it. In the EG the resting systemic vascular resistance (SVR) before haemodynamic interventions was lower (p less than 0.05) and left ventricular stroke work (SW) was higher (p less than 0.05) after the training period than before. In the ESG, left ventricular ejection fraction (EF) decreased with training and anabolic steroid treatment (p less than 0.05). After the training period isoproterenol increased the maximum velocity of the cardiac contractile element significantly more (p less than 0.05) in the EG than in the ESG. Also SW increased in the EG (29%, p less than 0.001), but not in the ESG (-11%, NS). Endurance training increased the left ventricular end-diastolic and stroke volumes during isoproterenol infusion, but this training effect was attenuated by simultaneous anabolic steroid treatment (p less than 0.05 between the groups in both cases). During the isoproterenol test SVR decreased less in ESG than in EG (p less than 0.05 between).(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
3684514 View in PubMed
Less detail

[Analysis of heart rate variability in assessment of baroreflex sensitivity in anesthetized rats]

https://arctichealth.org/en/permalink/ahliterature9203
Source
Fiziol Zh. 2005;51(2):46-50
Publication Type
Article
Date
2005
Author
I A Khripachenko
A V Savust'ianenko
L A Kedenko
I I Zinkovych
Author Affiliation
Donetsk Medical University.
Source
Fiziol Zh. 2005;51(2):46-50
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Adrenergic alpha-Agonists - pharmacology
Analysis of Variance
Anesthesia
Animals
Baroreflex - drug effects - physiology
Electrocardiography
English Abstract
Heart Rate - drug effects - physiology
Male
Myocardial Contraction - drug effects - physiology
Phenylephrine - pharmacology
Rats
Abstract
Spectral analysis of the heart rate variability can be used as a measure of baroreflex sensitivity in ketamine anesthetized rats. Stimulation of delta1-receptors with phenylephrine (0.01 mg/kg, i.v.) results in a rise of the strength of heart rate regulation, principally in the low frequency band. Maximal deviations of spectral indexes from basal level were observed on 4-8 min for low (0.2-1 Hz) and high (1-3 Hz) frequencies bands and on 10-15 min for very low (0.08-0.2 Hz) frequency band after phenylephrine injection.
PubMed ID
15943230 View in PubMed
Less detail

[An outpatient study by stress echocardiography with dobutamine of myocardial function in patients with congestive heart failure (the first trial in Russia of the use of the dobutamine-echocardiography test)].

https://arctichealth.org/en/permalink/ahliterature222339
Source
Ter Arkh. 1993;65(12):45-8
Publication Type
Article
Date
1993
Author
G V Volkov
S E Bashchinskii
M A Osipov
Source
Ter Arkh. 1993;65(12):45-8
Date
1993
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Ambulatory Care - statistics & numerical data
Dobutamine - administration & dosage - diagnostic use
Echocardiography, Doppler - methods - statistics & numerical data
Exercise Test - methods - statistics & numerical data
Heart - drug effects - physiopathology
Heart Failure - physiopathology - ultrasonography
Hemodynamics - drug effects
Humans
Infusions, Intravenous
Male
Middle Aged
Moscow
Myocardial Contraction - drug effects
Abstract
Dobutamin stress-echocardiography has been tried outpatiently in the diagnostic center for feasible use in functional assessment of the myocardium in patients with congestive heart failure class 3-4 by classification of New York Heart Association. Eleven outpatients (a mean age 56 +/- 8 years) with left ventricular dilatation and a reduction in the ejection fraction received an increasing dose of dobutamin (5-40 micrograms) min/kg in intravenous infusion in the course of which central hemodynamics and left ventricular segmental contractility were measured with two-dimensional and Doppler echocardiography. By the hemodynamic response to dobutamin infusion reflecting difference in the myocardial reserve, two groups of patients were identified. The authors suggest dobutamin Doppler echocardiography for use in outpatient setting as a safe and effective procedure for assessing contractile myocardial reserve and prognosis of congestive heart failure.
PubMed ID
8146770 View in PubMed
Less detail

67 records – page 1 of 7.