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ß2 -adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66?750 individuals.

https://arctichealth.org/en/permalink/ahliterature131722
Source
J Intern Med. 2012 Mar;271(3):305-14
Publication Type
Article
Date
Mar-2012
Author
M. Thomsen
M. Dahl
A. Tybjaerg-Hansen
B G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Source
J Intern Med. 2012 Mar;271(3):305-14
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aged
Blood Pressure - genetics
Cross-Sectional Studies
Denmark
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
Hypertension - genetics
Male
Middle Aged
Muscle, Skeletal
Myocardial Ischemia - genetics
Myocytes, Smooth Muscle
Polymorphism, Single Nucleotide
Prospective Studies
Questionnaires
Receptors, Adrenergic, beta-2 - genetics
Sex Factors
Abstract
The ß(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of cardiovascular disease (CVD).
A total of 66 750 individuals from two large Danish general population studies were genotyped, and 1943 Thr164Ile heterozygotes and 16 homozygotes were identified.
Thr164Ile genotype was associated with increased systolic and diastolic blood pressure in women (trend: P = 0.04 and 0.02): systolic and diastolic blood pressure increased by 5% and 2%, respectively, in female homozygotes compared with female noncarriers. All female Thr164Ile homozygotes had hypertension compared with 58% of female heterozygotes and 54% of female noncarriers (chi-square: P = 0.001). Female Thr164Ile homozygotes and heterozygotes had odds ratios for ischaemic heart disease (IHD) of 2.93 (0.56-15.5) and 1.28 (1.03-1.61), respectively, compared with female noncarriers (trend: P = 0.007). These differences were not observed in men. Furthermore, Gly16Arg (rs1042713) and Gln27Glu (rs1042714) in the ADRB2 gene were not associated with blood pressure, hypertension or CVD either in the population overall or in women and men separately.
ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population. These findings, particularly for homozygotes, are novel.
PubMed ID
21883537 View in PubMed
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Abnormality of energy metabolism in the skeletal muscle of patients with liver cirrhosis and changes under administration of glucose and branched-chain amino acids.

https://arctichealth.org/en/permalink/ahliterature5271
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Publication Type
Article
Date
Dec-2004
Author
Jun Doi
Koichi Shiraishi
Munetaka Haida
Shohei Matsuzaki
Author Affiliation
Department of Gastroenterology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan.
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Aged
Amino Acids, Branched-Chain - administration & dosage
Case-Control Studies
Citric Acid Cycle
Comparative Study
Energy Metabolism
Exercise
Fasting
Female
Glucose - administration & dosage - metabolism
Humans
Hydrogen-Ion Concentration
Liver Cirrhosis - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal - metabolism
Oxygen - metabolism
Phosphocreatine - metabolism
Spectroscopy, Near-Infrared
Abstract
We assessed changes in skeletal muscle energy metabolism by 31P-magnetic resonance spectroscopy (31P-MRS) and oxygen supply by near-infrared spectroscopy (NIR), after exercise and after administration of glucose and a branched-chain amino acids (BCAA), in healthy volunteers and patients with liver cirrhosis. As for the patients with liver cirrhosis, 4 were classified in Child-Pugh Grade A and the other 4 in Grade B. In patients with liver cirrhosis, the intramuscular pH and PCr index (PCr/PCr + Pi) were lower than in healthy subjects after exercise in the fasting state; the deltapH and deltaPCr index were statistically siginificant (p
PubMed ID
15717491 View in PubMed
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Accumulation and depuration of okadaic acid esters in the European green crab (Carcinus maenas) during a feeding study.

https://arctichealth.org/en/permalink/ahliterature86837
Source
Toxicon. 2008 Mar 1;51(3):468-72
Publication Type
Article
Date
Mar-1-2008
Author
Jørgensen Kevin
Cold Ulrik
Fischer Knud
Author Affiliation
National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860 Søborg, Denmark. kejo@food.dtu.dk
Source
Toxicon. 2008 Mar 1;51(3):468-72
Date
Mar-1-2008
Language
English
Publication Type
Article
Keywords
Animal Feed
Animals
Bivalvia - chemistry
Brachyura - chemistry - metabolism
Diet
Esters - chemistry - metabolism
Marine Toxins - metabolism
Muscle, Skeletal
Okadaic Acid - chemistry - metabolism
Shellfish - analysis
Time Factors
Abstract
Soft shell crab is a seafood delicacy in many parts of the world. In Denmark, it has been investigated whether a commercial production of soft shell European green crabs (Carcinus maenas) would be feasible. In relation to this, a feeding study was performed to examine if occurrence of DSP toxins in the product could be a food safety problem. The crabs were fed with mussels containing DSP toxins (2500 microg total okadaic acid equivalents/kg) for 17 days and then fasted for 19 days. The content of total okadaic acid equivalents in the digestive organs was on average 27 times higher than the corresponding content in the body meat. The highest level of total okadaic acid equivalents measured was 12 microg/kg in body meat and 503 microg/kg in digestive organs. The results show that the content of DSP toxins in a commercial product of soft shell European green crab (without digestive organs) could be regarded as negligible.
PubMed ID
17983637 View in PubMed
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Accumulation and depuration of the synthetic antioxidant ethoxyquin in the muscle of Atlantic salmon (Salmo salar L.).

https://arctichealth.org/en/permalink/ahliterature86374
Source
Food Chem Toxicol. 2008 May;46(5):1834-43
Publication Type
Article
Date
May-2008
Author
Bohne Victoria J Berdikova
Lundebye Anne-Katrine
Hamre Kristin
Author Affiliation
National Institute of Nutrition and Seafood Research (NIFES), Nordnes, Bergen, Norway. victoria.bohne@nifes.no
Source
Food Chem Toxicol. 2008 May;46(5):1834-43
Date
May-2008
Language
English
Publication Type
Article
Keywords
Agriculture
Algorithms
Animal Feed - analysis
Animals
Antioxidants - metabolism
Body Weight - drug effects
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Ethoxyquin - metabolism
Growth - drug effects
Humans
Lipids - analysis
Mice
Muscle, Skeletal - chemistry - metabolism
Norway
Salmo salar - metabolism
Abstract
The biological fate of the fish feed additive, ethoxyquin (EQ) was examined in the muscle of Atlantic salmon during 12 weeks of feeding followed by a 2 weeks depuration period. Parent EQ (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline), quinone imine (2,6-dihydro-2,2,4-trimethyl-6-quinolone), de-ethylated EQ (6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline) and EQDM (EQ dimer or 1,8'-di(1,2-dihydro-6-ethoxy-2,2,4-trimethyl-quinoline) were found to be the ubiquitous metabolites of dietary EQ, with EQDM as a main metabolite. A rapid decrease in the level of EQ (2.4 days of half-life) was balanced by an increase in EQDM, giving an unchanged net sum following 2 weeks of depuration. The mandatory 14 days depuration period prior to slaughtering of farmed salmon in Norway was not sufficient for complete elimination of EQ-derived residuals. Post depuration, EQDM accounted for 99% of sum of the two compounds in all treatment groups; possible toxicological effects of EQDM are not known. The individual concentrations of EQ and EQDM and their sum are dependent on EQ level in the feed, consequently, their residual concentrations may be controlled. The theoretical amount of EQ and EQDM consumed in one meal of farmed salmon would be under the recommended ADI, provided that the fish were raised on feed with no more than 150 mg EQ/kg feed, which is the EU maximum limit for EQ in fish feed.
PubMed ID
18329775 View in PubMed
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[Accumulation of radionuclides in food chains of the Yenisei River after the nuclear power plant shutdown at the mining-and-chemical enterprise].

https://arctichealth.org/en/permalink/ahliterature261756
Source
Radiats Biol Radioecol. 2014 Jul-Aug;54(4):405-14
Publication Type
Article
Author
T A Zotina
E A Trofimova
A D Karpov
A Ia Bolsunovskii
Source
Radiats Biol Radioecol. 2014 Jul-Aug;54(4):405-14
Language
Russian
Publication Type
Article
Keywords
Animals
Biota
Chemical Industry
Fishes - metabolism
Food chain
Industrial Waste - analysis
Mining
Muscle, Skeletal - radionuclide imaging
Nuclear Power Plants
Radiation Monitoring - methods
Radioisotopes - analysis - pharmacokinetics
Rivers - chemistry
Seasons
Siberia
Water Pollutants, Radioactive - analysis - pharmacokinetics
Abstract
Accumulation of artificial and natural radionuclides in the chains of food webs leading to non-predatory and piscivorous fish of the Yenisei River was investigated during one year before and three years after the shutdown of a nuclear power plant at the Mining-and-Chemical Combine (2009-2012). The activity of artificial radionuclides in the samples of biota ofthe Yenisei River (aquatic moss, gammarids, dace, grayling, pike) was estimated. The concentration of radionuclides with induced activity (51Cr, 54Mn, 58Co, 60Co, 65Zn, 141, 144Ce, 152, 154Eu, 239Np) decreased in the biomass of biota after the shutdown of the nuclear power plant; the concentration of 137Cs did not. Analysis of the accumulation factors (C(F)) allows us to expect the effective accumulation of 137Cs in the terminal level of the food web of the Yenisei River--pike (C(F) = 2.0-9.4), i.e. biomagnifications of radiocesium. Accumulation of artificial, radionuclides in non-predatory fish from gammarids was not effective (C(F)
PubMed ID
25775829 View in PubMed
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Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2.

https://arctichealth.org/en/permalink/ahliterature90253
Source
Diabetes Metab Res Rev. 2009 Mar;25(3):279-86
Publication Type
Article
Date
Mar-2009
Author
Wu Miaozong
Desai Devashish H
Kakarla Sunil K
Katta Anjaiah
Paturi Satyanarayana
Gutta Anil K
Rice Kevin M
Walker Ernest M
Blough Eric R
Author Affiliation
Department of Biological Sciences, Marshall University, Huntington, WV 25755-1090, USA.
Source
Diabetes Metab Res Rev. 2009 Mar;25(3):279-86
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Acetaminophen - pharmacology
Aging - drug effects - physiology
Animals
Blood Glucose - drug effects
Enzyme Activation - drug effects
Glucose Transporter Type 4 - metabolism
Hyperglycemia - prevention & control
Liver - drug effects
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3 - metabolism
Muscle, Skeletal - drug effects - physiology
Rats
Rats, Inbred BN
Rats, Inbred F344
Superoxides - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
Abstract
BACKGROUND: Aging-related hyperglycemia is associated with increased oxidative stress and diminished muscle glucose transporter-4 (Glut4) that may be regulated, at least in part, by the mitogen-activated protein kinases (MAPK). METHODS: To test the possibility that aging-related hyperglycemia can be prevented by pharmacological manipulation of MAPK hyperactivation, aged (27-month old) Fischer 344/NNiaHSD x Brown Norway/BiNia F1 (F344BN) rats were administered acetaminophen (30 mg/kg body weight/day) for 6 months in drinking water. RESULTS: Hepatic histopathology, serum aspartate aminotransferase and alanine aminotransferase analyses suggested that chronic acetaminophen did not cause hepatotoxicity. Compared with adult (6-month) and aged (27-month) rats, very aged rats (33-month) had higher levels of blood glucose, phosphorylation of soleus p38-MAPK and extracellular-regulated kinase 1/2 (ERK1/2), superoxide and oxidatively modified proteins (p
PubMed ID
19177471 View in PubMed
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Acute antioxidant supplementation and skeletal muscle vascular conductance in aged rats: role of exercise and fiber type.

https://arctichealth.org/en/permalink/ahliterature101895
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Publication Type
Article
Date
Apr-2011
Author
Daniel M Hirai
Steven W Copp
Peter J Schwagerl
Mark D Haub
David C Poole
Timothy I Musch
Author Affiliation
Department of Anatomy and Physiology, Kansas State University, Manhattan, 66506-5802, USA.
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Date
Apr-2011
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - pharmacology
Blood Pressure - drug effects - physiology
Cyclic N-Oxides - pharmacology
Dietary Supplements
Hindlimb - drug effects - physiology
Male
Muscle Fibers, Skeletal - drug effects - physiology
Muscle, Skeletal - blood supply - drug effects - physiology
Physical Conditioning, Animal - physiology
Rats
Rats, Inbred F344
Regional Blood Flow - drug effects - physiology
Rest - physiology
Spin Labels
Vascular Resistance - drug effects - physiology
Vasodilation - drug effects - physiology
Abstract
Age-related increases in oxidative stress contribute to impaired skeletal muscle vascular control. However, recent evidence indicates that antioxidant treatment with tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) attenuates flow-mediated vasodilation in isolated arterioles from the highly oxidative soleus muscle of aged rats. Whether antioxidant treatment with tempol evokes similar responses in vivo at rest and during exercise in senescent individuals and whether this effect varies based on muscle fiber type composition are unknown. We tested the hypothesis that redox modulation via acute systemic tempol administration decreases vascular conductance (VC) primarily in oxidative hindlimb locomotor muscles at rest and during submaximal whole body exercise (treadmill running at 20 m/min, 5% grade) in aged rats. Eighteen old (25-26 mo) male Fischer 344 x Brown Norway rats were assigned to either rest (n = 8) or exercise (n = 10) groups. Regional VC was determined via radiolabeled microspheres before and after intra-arterial administration of tempol (302 µmol/kg). Tempol decreased mean arterial pressure significantly by 9% at rest and 16% during exercise. At rest, similar VC in 26 out of 28 individual hindlimb muscles or muscle parts following tempol administration compared with control resulted in unchanged total hindlimb muscle VC (control: 0.18 ± 0.02; tempol: 0.17 ± 0.05 ml·min(-1)·100 g(-1)·mmHg(-1); P > 0.05). During exercise, all individual hindlimb muscles or muscle parts irrespective of fiber type composition exhibited either an increase or no change in VC with tempol (i.e., ?11 and ?17 muscles or muscle parts), such that total hindlimb VC increased by 25% (control: 0.93 ± 0.04; tempol: 1.15 ± 0.09 ml·min(-1)·100 g(-1)·mmHg(-1); P = 0.05). These results demonstrate that acute systemic administration of the antioxidant tempol significantly impacts the control of regional vascular tone in vivo presumably via redox modulation and improves skeletal muscle vasodilation independently of fiber type composition during submaximal whole body exercise in aged rats.
PubMed ID
21239634 View in PubMed
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Acute bilateral exercise-induced medial compartment syndrome of the thigh. Correlation of repeated MRI with clinicopathological findings.

https://arctichealth.org/en/permalink/ahliterature49782
Source
Int J Sports Med. 2002 Nov;23(8):610-5
Publication Type
Article
Date
Nov-2002
Author
J. Leppilahti
O. Tervonen
R. Herva
J. Karinen
J. Puranen
Author Affiliation
Dept. of Surgery, Oulu Hospital, Finland. juhana.leppilahti@oulu.fi
Source
Int J Sports Med. 2002 Nov;23(8):610-5
Date
Nov-2002
Language
English
Publication Type
Article
Keywords
Adult
Athletic Injuries - diagnosis - surgery
Compartment Syndromes - diagnosis - etiology - surgery
Follow-Up Studies
Humans
Magnetic Resonance Imaging - methods
Male
Muscle, Skeletal - injuries
Thigh - injuries
Treatment Outcome
Abstract
We present a case report of acute bilateral excercise-induced compartment syndrome in the adductor longus muscles, which was treated with bilateral medial fasciotomies. Postoperatively, the healing process of the adductor muscles was followed up by repeated MR imagings over six months. Myonecrosis was found in peroperative muscle biopsies. Pain and muscle swelling subsided soon after the fasciotomy, correlating with the early postoperative MR findings. Four months postoperatively, the signal intensity of the adductor muscles was normal in T1- and T2-weighted images, but the normal fibre structure of the adductor muscles could only be seen 6 months postoperatively. At six month's control checkup there was no subjective weakness of the adductors, and hyperesthesia had disappeared and the patient was capable of normal activities.
PubMed ID
12439779 View in PubMed
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Acute hamstring injuries in Danish elite football: a 12-month prospective registration study among 374 players.

https://arctichealth.org/en/permalink/ahliterature148168
Source
Scand J Med Sci Sports. 2010 Aug;20(4):588-92
Publication Type
Article
Date
Aug-2010
Author
J. Petersen
K. Thorborg
M B Nielsen
P. Hölmich
Author Affiliation
Department of Orthopaedic Surgery, Amager Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. jesper.petersen@dadlnet.dk
Source
Scand J Med Sci Sports. 2010 Aug;20(4):588-92
Date
Aug-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Athletes
Denmark
Humans
Leg Injuries
Male
Muscle, Skeletal - injuries
Prospective Studies
Soccer - injuries
Young Adult
Abstract
The purpose of the present study was to examine the incidence rates of acute hamstring injuries in Danish elite football sustained during training or match play. Furthermore, it was our intention to document details about the recurrence, severity and the injury seasonal distribution. Hamstring injuries among 374 elite football players were registered prospectively during a 12-month period. A total of 46 first-time and eight recurrent hamstring injuries were registered. The incidence rates for incurring a first-time hamstring injury showed a significantly (P28 days from injury to injury free). Each team sustained a mean of 3.4 hamstring injuries per season, with a mean of 21.5 days missed per injury (range 3-136; median 16 days per injury). The seasonal distribution showed an accumulation of injuries in the first 2 months after a 3.5-month mid-season winter break.
PubMed ID
19804575 View in PubMed
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Acute hamstring injuries in Swedish elite sprinters and jumpers: a prospective randomised controlled clinical trial comparing two rehabilitation protocols.

https://arctichealth.org/en/permalink/ahliterature258296
Source
Br J Sports Med. 2014 Apr;48(7):532-9
Publication Type
Article
Date
Apr-2014
Author
Carl M Askling
Magnus Tengvar
Olga Tarassova
Alf Thorstensson
Author Affiliation
The Swedish School of Sport and Health Sciences, , Stockholm, Sweden.
Source
Br J Sports Med. 2014 Apr;48(7):532-9
Date
Apr-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Athletic Injuries - rehabilitation
Exercise Therapy - methods
Female
Humans
Male
Muscle, Skeletal - injuries
Prospective Studies
Recovery of Function - physiology
Running - injuries
Sprains and Strains - rehabilitation
Sweden
Time Factors
Treatment Outcome
Young Adult
Abstract
Hamstring strain is a common injury in sprinters and jumpers, and therefore time to return to sport and secondary prevention become of particular concern.
To compare the effectiveness of two rehabilitation protocols after acute hamstring injury in Swedish elite sprinters and jumpers by evaluating time needed to return to full participation in the training process.
Prospective randomised comparison of two rehabilitation protocols.
Fifty-six Swedish elite sprinters and jumpers with acute hamstring injury, verified by MRI, were randomly assigned to one of two rehabilitation protocols. Twenty-eight athletes were assigned to a protocol emphasising lengthening exercises, L-protocol, and 28 athletes to a protocol consisting of conventional exercises, C-protocol. The outcome measure was the number of days to return to full training. Re-injuries were registered during a period of 12 months after return.
Time to return was significantly shorter for the athletes in the L-protocol, mean 49 days (1SD±26, range 18-107 days), compared with the C-protocol, mean 86 days (1SD±34, range 26-140 days). Irrespective of protocol, hamstring injuries where the proximal free tendon was involved took a significantly longer time to return than injuries that did not involve the free tendon, L-protocol: mean 73 vs 31 days and C-protocol: mean 116 vs 63 days, respectively. Two reinjuries were registered, both in the C-protocol.
A rehabilitation protocol emphasising lengthening type of exercises is more effective than a protocol containing conventional exercises in promoting time to return in Swedish elite sprinters and jumpers.
PubMed ID
24620041 View in PubMed
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564 records – page 1 of 57.