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Impact of cerebrospinal-fluid oligoclonal immunoglobulin bands and HLA-DRB1 risk alleles on brain magnetic-resonance-imaging lesion load in Swedish multiple sclerosis patients.

https://arctichealth.org/en/permalink/ahliterature120805
Source
J Neuroimmunol. 2013 Jan 15;254(1-2):170-3
Publication Type
Article
Date
Jan-15-2013
Author
Virginija Danylaite Karrenbauer
Robert Prejs
Thomas Masterman
Jan Hillert
Anna Glaser
Kerstin Imrell
Author Affiliation
MS Research Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. virginija.karrenbauer@ki.se
Source
J Neuroimmunol. 2013 Jan 15;254(1-2):170-3
Date
Jan-15-2013
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Brain - pathology
Female
Follow-Up Studies
HLA-DRB1 Chains - genetics
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis - cerebrospinal fluid - genetics - pathology
Oligoclonal Bands - cerebrospinal fluid
Retrospective Studies
Risk factors
Sweden - epidemiology
Young Adult
Abstract
Approximately 95% of Nordic multiple sclerosis (MS) patients display oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid. From a cohort of 2094 MS patients we retrieved well-characterized data from 40 OCB-negative and 60 OCB-positive patients, in an effort to determine whether lesion load on brain magnetic resonance imaging is affected by OCB status and carriage of HLA-DRB1*15 or HLA-DRB1*04. Positivity for OCB did not increase the risk of belonging to higher-lesion-load groups; nor did carrying HLA-DRB1*15 or HLA-DRB1*04. A trend was seen, however, whereby OCB positivity conferred a two-fold risk of displaying higher lesion loads infratentorially.
PubMed ID
22967351 View in PubMed
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